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The map label for this gene is thl [H]

Identifier: 52141468

GI number: 52141468

Start: 3917775

End: 3918950

Strand: Reverse

Name: thl [H]

Synonym: BCZK3780

Alternate gene names: 52141468

Gene position: 3918950-3917775 (Counterclockwise)

Preceding gene: 52141465

Following gene: 52141470

Centisome position: 73.93

GC content: 40.9

Gene sequence:

>1176_bases
ATGCATAATGTTGTTATTACAGCTGCAGTTCGTTCGCCAATTGGAACTTTTGGGGGAGCGCTAAAAAATGTAACGCCAGT
AGAATTAGCTGTTCCTGTACTTCAGGAAGCTGTAAAACGAGGCGGGGTAGAACCACACGAAGTTGATGAAGTAATTTTAG
GTCATTGTATTCAAAGAACTGATGAAGCAAATACGGCGAGAACGGCTGCATTAGCTGCAGGGTTTCCTGACACAGTTACA
GGTTATACAATCCAACGCCAATGTTCTTCAGGTATGCAAGCAATTATGTCGGCTGCAATGCAAATTCAATTAGGTGTAAG
TGAAGTTGTCGTTGCAGGTGGAGTAGAAGCAATGAGTTCAAGCCCTTATGCATTGAAACAACACCGCTGGGGACAACGCC
TACAACACGGAGAAATTCGTGATACGGTGTGGGAAGTATTAGAAGATCCAATTCATCATATTATGATGGGGGAAACAGCG
GAAAATTTAGTTGAACAATATGAAATTACAAGAGAGGAACAAGATGAAGTTGCGCTTCGCAGTCATACATTGGCATTGAA
GGCAATCGAGTCTGGATACTTTGACGATCAAATTGTTCCTATTACAATAAAAGAACGTAGAAAAGAAGTAGTATTTTCGA
AGGATGAACATCCACGTGCTGATATTACAGCAGAAAAATTAGCAGGATTAAAACCAGCTTTCCGTAAAGGCGGATCTGTA
ACGGCAGGGAATGCATCTGGTCTGAATGACGGAAGTGCGGTTCTAGTATTAATGAGCGAAGAAAAAGCGAAAGAAAAAGG
CTTACAACCGTTAGCTAGAATTGTTGGATATTCAGTAGCTGGAGTAGATCCAAAAATTATGGGGATTGGACCAGCACCAG
CAATTCGTAAAGGATTAGAAAAAGTAGATTGGTCATTAGAAGATGCAGATTTATTTGAAATTAATGAAGCTTTCGCTGCA
CAATACTTAGCTGTAGAGAAAGAATTAGGTTTAGACCGTGAGAAAGTGAATGTAAACGGTAGTGGTGTAGGACTTGGACA
TCCAATCGGTTGTACAGGAGCTCGTATCACTGTAAGTTTAATTCATGAATTGAAAAGACGCGGGTTAGAAAAAGGAATTG
CCTCTCTATGCGTCGGCGGCGGTATTGGGGTAGCATTATTTATAGAAGCACTATAA

Upstream 100 bases:

>100_bases
GATTTTTTAGTATGTTTATAGTATGATAGGTGTAGACATACATCTTATGGAATTTCACCTAAAAACTGACTAGGGTACAT
AAGAGAGGGGCAAGTGCAAA

Downstream 100 bases:

>100_bases
AAAAGAAGCAGCAATCGCTGCTTCTTTTTTTTAAGAATTGAATAAATGATGAAATAATCGATCACGATTTTCAAAGAAAA
GTTTCGTTGTTTGGTAATGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPDTVT
GYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETA
ENLVEQYEITREEQDEVALRSHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKGGSV
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLEKVDWSLEDADLFEINEAFAA
QYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLEKGIASLCVGGGIGVALFIEAL

Sequences:

>Translated_391_residues
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPDTVT
GYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETA
ENLVEQYEITREEQDEVALRSHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKGGSV
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLEKVDWSLEDADLFEINEAFAA
QYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLEKGIASLCVGGGIGVALFIEAL
>Mature_391_residues
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPDTVT
GYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETA
ENLVEQYEITREEQDEVALRSHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKGGSV
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLEKVDWSLEDADLFEINEAFAA
QYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLEKGIASLCVGGGIGVALFIEAL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=44.1326530612245, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=44.4730077120823, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=40.6091370558376, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=39.7984886649874, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=35.0467289719626, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=29.8200514138817, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=49.1094147582697, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=46.7005076142132, Blast_Score=345, Evalue=2e-96,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=42.643391521197, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=39.6039603960396, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788683, Length=401, Percent_Identity=30.4239401496259, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=49.4845360824742, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=36.7609254498715, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=37.2151898734177, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.3943661971831, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=29.8469387755102, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=38.8059701492537, Blast_Score=252, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=38.4039900249377, Blast_Score=238, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=47.1938775510204, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=44.5012787723785, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=41.4758269720102, Blast_Score=281, Evalue=6e-76,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=35.1415094339623, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41860; Mature: 41860

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRT
CCCEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
DEANTARTAALAAGFPDTVTGYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSS
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHCC
SPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETAENLVEQYEITREEQDEVALR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKGGSV
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLE
ECCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHCCHHCCCCCEEEECCCCHHHHHHHH
KVDWSLEDADLFEINEAFAAQYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCHHHHHHH
IHELKRRGLEKGIASLCVGGGIGVALFIEAL
HHHHHHHHHHHHHHHHHHCCCCEEHHHEECC
>Mature Secondary Structure
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRT
CCCEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
DEANTARTAALAAGFPDTVTGYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSS
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHCC
SPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETAENLVEQYEITREEQDEVALR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKGGSV
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLE
ECCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHCCHHCCCCCEEEECCCCHHHHHHHH
KVDWSLEDADLFEINEAFAAQYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCHHHHHHH
IHELKRRGLEKGIASLCVGGGIGVALFIEAL
HHHHHHHHHHHHHHHHHHCCCCEEHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]