| Definition | Bacillus cereus E33L, complete genome. |
|---|---|
| Accession | NC_006274 |
| Length | 5,300,915 |
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The map label for this gene is ytbE [H]
Identifier: 52141397
GI number: 52141397
Start: 3981360
End: 3982298
Strand: Reverse
Name: ytbE [H]
Synonym: BCZK3853
Alternate gene names: 52141397
Gene position: 3982298-3981360 (Counterclockwise)
Preceding gene: 52141395
Following gene: 52141399
Centisome position: 75.12
GC content: 35.68
Gene sequence:
>939_bases ATGTGTATAAATTTATTATGTAAACTGTACATATGTTTTGACTTTTTGGTTAAATCTTGTTCAAATAAAGTGGTGGCTTA TAAAAAATGTAATAATGAAAGGGAGACGACTGTGCACATTCCAACAACTACACTTCATAATGGCGTAAAAATGCCGATGA TTGGTTTAGGCGTTTATAAAGCGAAAGAAGGCGACGAAGTAAAACAAGCAGTAAAAACAGCGTTAGAAGTTGGATACCGT TCGATTGATACAGCAACTGTATATGAAAATGAAAGCGGTGTCGGAGAAGCGGTTCGTGAATCAGGAATTCCGAGAGAAGA CATCTTTATTACAACAAAAGTTTGGAACGACGATCAAGGATACGAGGAAACACTTGAGGCGTTTGAGAAAAGCTTAAAAA AATTACAAATGGACTATGTAGATTTATATTTAATACATTGGCCAATAAGAGGGAAGTATGTTGATACGTACCGAGCATTA GAAAAACTGTATGAAGAAGGTAAAGTGCGCGCAATTGGTGTTTCGAATTTTCATAAACATCATTTAGAACTGCTATTACC AAATTGCAAAATAAAGCCGATGGTAAACCAAGTGGAACTTCATCCCATGTTAACACAATTTGAATTGCGTAATTTCTGTC AAGGTGAGCAAATTCAAATGGAAGCATGGAGCCCATTAATGAGAGGCGGAGAAGTATTTCAGCACCCGATTATTCAGGCC ATTGCTACTAAATATGAAAAAACACCTGCGCAAGTTATATTAAGGTGGGATATTCAAAGCGGGATTGTAACGATTCCTAA GTCTGTTACACCATCTCGCATTCAGGAGAATTTTTCTATCTTTGACTTTTCACTAACAGAAGAAGAGATGACTCAAATTA ATACGTTAAATCGTAATTTACATGTAGGAACGAATCCTGATAAATATGATACGTTATAA
Upstream 100 bases:
>100_bases TATATTCGGAAGGGAAAACTGCGTTTGTACGTAATGTTGATGAAAAAGCGAAGAAATGGATAGAAAATAACGTGAATGAA TGAGTTCGTATTATTTTTGA
Downstream 100 bases:
>100_bases AAAGACGCTACCAGTATGGTAGCGTCTTTTTAACGATGTAAAGCGTACGTATCACATTTAGCGATTTGCTGAAGCTGTAT ATATTCTTCTGTTGTTAACT
Product: aldo/keto reductase family oxidoreductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 312; Mature: 312
Protein sequence:
>312_residues MCINLLCKLYICFDFLVKSCSNKVVAYKKCNNERETTVHIPTTTLHNGVKMPMIGLGVYKAKEGDEVKQAVKTALEVGYR SIDTATVYENESGVGEAVRESGIPREDIFITTKVWNDDQGYEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTYRAL EKLYEEGKVRAIGVSNFHKHHLELLLPNCKIKPMVNQVELHPMLTQFELRNFCQGEQIQMEAWSPLMRGGEVFQHPIIQA IATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQENFSIFDFSLTEEEMTQINTLNRNLHVGTNPDKYDTL
Sequences:
>Translated_312_residues MCINLLCKLYICFDFLVKSCSNKVVAYKKCNNERETTVHIPTTTLHNGVKMPMIGLGVYKAKEGDEVKQAVKTALEVGYR SIDTATVYENESGVGEAVRESGIPREDIFITTKVWNDDQGYEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTYRAL EKLYEEGKVRAIGVSNFHKHHLELLLPNCKIKPMVNQVELHPMLTQFELRNFCQGEQIQMEAWSPLMRGGEVFQHPIIQA IATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQENFSIFDFSLTEEEMTQINTLNRNLHVGTNPDKYDTL >Mature_312_residues MCINLLCKLYICFDFLVKSCSNKVVAYKKCNNERETTVHIPTTTLHNGVKMPMIGLGVYKAKEGDEVKQAVKTALEVGYR SIDTATVYENESGVGEAVRESGIPREDIFITTKVWNDDQGYEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTYRAL EKLYEEGKVRAIGVSNFHKHHLELLLPNCKIKPMVNQVELHPMLTQFELRNFCQGEQIQMEAWSPLMRGGEVFQHPIIQA IATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQENFSIFDFSLTEEEMTQINTLNRNLHVGTNPDKYDTL
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=41.8685121107266, Blast_Score=239, Evalue=2e-63, Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=41.8685121107266, Blast_Score=239, Evalue=2e-63, Organism=Homo sapiens, GI223468663, Length=292, Percent_Identity=43.8356164383562, Blast_Score=225, Evalue=4e-59, Organism=Homo sapiens, GI310109922, Length=278, Percent_Identity=40.6474820143885, Blast_Score=209, Evalue=3e-54, Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=38.1578947368421, Blast_Score=209, Evalue=4e-54, Organism=Homo sapiens, GI5174695, Length=295, Percent_Identity=40.3389830508475, Blast_Score=207, Evalue=1e-53, Organism=Homo sapiens, GI5453543, Length=298, Percent_Identity=39.261744966443, Blast_Score=204, Evalue=1e-52, Organism=Homo sapiens, GI45446745, Length=298, Percent_Identity=39.5973154362416, Blast_Score=204, Evalue=1e-52, Organism=Homo sapiens, GI4503285, Length=298, Percent_Identity=39.5973154362416, Blast_Score=204, Evalue=1e-52, Organism=Homo sapiens, GI310109920, Length=298, Percent_Identity=39.261744966443, Blast_Score=203, Evalue=2e-52, Organism=Homo sapiens, GI4502049, Length=293, Percent_Identity=43.0034129692833, Blast_Score=203, Evalue=2e-52, Organism=Homo sapiens, GI291291012, Length=281, Percent_Identity=41.6370106761566, Blast_Score=202, Evalue=2e-52, Organism=Homo sapiens, GI24497583, Length=295, Percent_Identity=37.9661016949153, Blast_Score=197, Evalue=9e-51, Organism=Homo sapiens, GI24497585, Length=293, Percent_Identity=37.542662116041, Blast_Score=189, Evalue=4e-48, Organism=Homo sapiens, GI300116273, Length=275, Percent_Identity=37.8181818181818, Blast_Score=178, Evalue=6e-45, Organism=Homo sapiens, GI300116271, Length=273, Percent_Identity=38.8278388278388, Blast_Score=170, Evalue=2e-42, Organism=Homo sapiens, GI310109924, Length=157, Percent_Identity=38.8535031847134, Blast_Score=115, Evalue=4e-26, Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=46.4912280701754, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=45.6140350877193, Blast_Score=100, Evalue=2e-21, Organism=Escherichia coli, GI87082198, Length=268, Percent_Identity=48.134328358209, Blast_Score=277, Evalue=7e-76, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=35.6862745098039, Blast_Score=163, Evalue=2e-41, Organism=Escherichia coli, GI1788081, Length=262, Percent_Identity=31.6793893129771, Blast_Score=132, Evalue=3e-32, Organism=Escherichia coli, GI1788070, Length=317, Percent_Identity=25.5520504731861, Blast_Score=78, Evalue=7e-16, Organism=Escherichia coli, GI87081735, Length=175, Percent_Identity=32, Blast_Score=69, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17537077, Length=297, Percent_Identity=40.0673400673401, Blast_Score=209, Evalue=2e-54, Organism=Caenorhabditis elegans, GI71998625, Length=268, Percent_Identity=41.4179104477612, Blast_Score=205, Evalue=2e-53, Organism=Caenorhabditis elegans, GI17564128, Length=295, Percent_Identity=38.6440677966102, Blast_Score=203, Evalue=7e-53, Organism=Caenorhabditis elegans, GI17537075, Length=305, Percent_Identity=39.344262295082, Blast_Score=201, Evalue=4e-52, Organism=Caenorhabditis elegans, GI17561298, Length=277, Percent_Identity=36.101083032491, Blast_Score=185, Evalue=3e-47, Organism=Caenorhabditis elegans, GI17550248, Length=282, Percent_Identity=38.6524822695035, Blast_Score=183, Evalue=1e-46, Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=39.3382352941176, Blast_Score=182, Evalue=2e-46, Organism=Caenorhabditis elegans, GI17566692, Length=293, Percent_Identity=37.542662116041, Blast_Score=181, Evalue=3e-46, Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=36.231884057971, Blast_Score=169, Evalue=2e-42, Organism=Caenorhabditis elegans, GI17561300, Length=274, Percent_Identity=37.956204379562, Blast_Score=158, Evalue=3e-39, Organism=Caenorhabditis elegans, GI17552492, Length=263, Percent_Identity=31.9391634980989, Blast_Score=158, Evalue=3e-39, Organism=Caenorhabditis elegans, GI17537079, Length=304, Percent_Identity=31.25, Blast_Score=155, Evalue=2e-38, Organism=Saccharomyces cerevisiae, GI6324694, Length=286, Percent_Identity=40.5594405594406, Blast_Score=213, Evalue=2e-56, Organism=Saccharomyces cerevisiae, GI6319625, Length=302, Percent_Identity=40.3973509933775, Blast_Score=199, Evalue=4e-52, Organism=Saccharomyces cerevisiae, GI6320576, Length=288, Percent_Identity=38.1944444444444, Blast_Score=198, Evalue=9e-52, Organism=Saccharomyces cerevisiae, GI6321896, Length=306, Percent_Identity=35.9477124183007, Blast_Score=178, Evalue=8e-46, Organism=Saccharomyces cerevisiae, GI6322556, Length=257, Percent_Identity=35.408560311284, Blast_Score=172, Evalue=4e-44, Organism=Saccharomyces cerevisiae, GI6320079, Length=286, Percent_Identity=34.2657342657343, Blast_Score=144, Evalue=3e-35, Organism=Drosophila melanogaster, GI24663317, Length=286, Percent_Identity=41.958041958042, Blast_Score=220, Evalue=8e-58, Organism=Drosophila melanogaster, GI24657054, Length=282, Percent_Identity=43.6170212765958, Blast_Score=215, Evalue=3e-56, Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=38.3333333333333, Blast_Score=211, Evalue=4e-55, Organism=Drosophila melanogaster, GI24662789, Length=295, Percent_Identity=40, Blast_Score=206, Evalue=1e-53, Organism=Drosophila melanogaster, GI21356425, Length=290, Percent_Identity=42.0689655172414, Blast_Score=206, Evalue=1e-53, Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=35.9375, Blast_Score=204, Evalue=8e-53, Organism=Drosophila melanogaster, GI45553081, Length=288, Percent_Identity=39.9305555555556, Blast_Score=198, Evalue=3e-51, Organism=Drosophila melanogaster, GI20129731, Length=290, Percent_Identity=39.3103448275862, Blast_Score=196, Evalue=1e-50, Organism=Drosophila melanogaster, GI24662781, Length=280, Percent_Identity=41.0714285714286, Blast_Score=186, Evalue=2e-47, Organism=Drosophila melanogaster, GI24662785, Length=279, Percent_Identity=40.8602150537634, Blast_Score=182, Evalue=2e-46, Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=38.8888888888889, Blast_Score=169, Evalue=3e-42,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 35872; Mature: 35872
Theoretical pI: Translated: 6.42; Mature: 6.42
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.2 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 5.1 %Cys+Met (Translated Protein) 2.2 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 5.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MCINLLCKLYICFDFLVKSCSNKVVAYKKCNNERETTVHIPTTTLHNGVKMPMIGLGVYK CHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCHHHCCCCCCCEEECEEEE AKEGDEVKQAVKTALEVGYRSIDTATVYENESGVGEAVRESGIPREDIFITTKVWNDDQG CCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCCHHEEEEEEECCCCCC YEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTYRALEKLYEEGKVRAIGVSNFHKH HHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHH HLELLLPNCKIKPMVNQVELHPMLTQFELRNFCQGEQIQMEAWSPLMRGGEVFQHPIIQA HHHEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCHHHHHHHHHH IATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQENFSIFDFSLTEEEMTQINTLNRNL HHHHHCCCCCCEEEEEECCCCEEECCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHCCCE HVGTNPDKYDTL EECCCCCCCCCC >Mature Secondary Structure MCINLLCKLYICFDFLVKSCSNKVVAYKKCNNERETTVHIPTTTLHNGVKMPMIGLGVYK CHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCHHHCCCCCCCEEECEEEE AKEGDEVKQAVKTALEVGYRSIDTATVYENESGVGEAVRESGIPREDIFITTKVWNDDQG CCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCCHHEEEEEEECCCCCC YEETLEAFEKSLKKLQMDYVDLYLIHWPIRGKYVDTYRALEKLYEEGKVRAIGVSNFHKH HHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHH HLELLLPNCKIKPMVNQVELHPMLTQFELRNFCQGEQIQMEAWSPLMRGGEVFQHPIIQA HHHEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCHHHHHHHHHH IATKYEKTPAQVILRWDIQSGIVTIPKSVTPSRIQENFSIFDFSLTEEEMTQINTLNRNL HHHHHCCCCCCEEEEEECCCCEEECCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHCCCE HVGTNPDKYDTL EECCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]