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The map label for this gene is bioF [C]

Identifier: 52141375

GI number: 52141375

Start: 3998324

End: 3999511

Strand: Reverse

Name: bioF [C]

Synonym: BCZK3873

Alternate gene names: 52141375

Gene position: 3999511-3998324 (Counterclockwise)

Preceding gene: 52141376

Following gene: 52141377

Centisome position: 75.45

GC content: 37.71

Gene sequence:

>1188_bases
ATGAATCAACCGTGGCGCACACATCTTCAAACTAAATTACAACAATTACATGAGCAAGGGCAGTATCGCAATTTGCATGT
AACAGAACAAGCAGAAGAGACATGGCTTATTCGAGATGAGAAAAGGATGCTAAATTTAGCGTCAAATAATTATTTAGGAT
TATCTGGTGATGAAAGGTTAAAAGAAGCTGCTATTGCAAGCACAAGGAAATATGGAGCTGGGGCGACGGCATCAAGGCTT
GTTGTAGGAAATTATTCACTGTATGAAGAGGTTGAGAGAAGTATATGCGATTGGAAAGGCACTGAAAAAGCCTTAGTTGT
AAGTAGTGGATATACCGCAAATGTTGGAGTGATTTCTTCATTAGCCTGTCGTCACGATATTGTTTTTAGCGATAAATTAA
ATCATGCGAGCATTGTTGATGGAATTATATTAAGCGGGGCAGAGCATAAAAGGTATCGACATAATGATTTAAATCATCTG
GAGGCGTTGTTGAAAACTGCATCTCCTGAAAAGCGAAAATTAATCGTAACAGATACTGTTTTTAGTATGGATGGTGATAC
TGCGTATTTGAGGGAGTTAGTGCAGCTGAAAGAGAAATACGGGGCAATCATTATAGTTGATGAAGCACATGCGAGTGGAA
TATATGGAATTGGTGGAGCAGGATTATCTCATATAGAAAAAGATCTTGCTCAAAAAATAGATATACATATGGGGACGTTT
AGTAAGGCTTTAGGGTGTTATGGTGCGTATTTGACAGGTGATGCAATTTATATAGAGTATTTACAAAATATGATGAGAAG
CTTTATTTTTACTACAGCTTTACCTCCAAGTACGTTAGGAGCAGTGCAAAAAGCAATTGAAATTGTACAAGAAGATCATA
AGAGAAGAGAGAATCTTATAGCAAACGGGGAATACTTCAGGAGTAAATTACGAGAAGCTGGATTTAATATAGGGAATAGT
TCAACTCATATTGTACCGATTGTAGTTGGTTCAAATGAAAATACTTTACGGTTTAGCAAAAGGTTACAAGAGGCAGGTAT
TGCAGCTATTGCAATTCGTCCGCCCACTGTACCGGTCCATAGTTCTCGAATTCGCTTTGCAGTTACATCTGAACATACAA
TAGCTGATTTAAAATGGGCTATTGAACGAATTACCCACATTGCGAAAGAAGAGGAGCTTTTCGTATGA

Upstream 100 bases:

>100_bases
GGCTTATTACCATTCTTTGAAGGTGAGTTTACAAAAAAAGAAGTATTGGAATCTGCTAAAGAATATATAATGATTTCAAA
ATTAGAGGAGTGCATCCGAA

Downstream 100 bases:

>100_bases
AAGAGTTGAAGATCATTTTTATCCCTGGATGGGGAATGGAAGAAAATATTTGGGATTTAGTACTTCCGCATTTTAAAGGA
TATTCTGTTCAATGCATTGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase 2; 7-keto-8-amino-pelargonic acid synthase 2; 7-KAP synthase 2; KAPA synthase 2; 8-amino-7-ketopelargonate synthase 2; Alpha-oxoamine synthase 2; L-alanine--pimeloyl-CoA ligase 2 [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNQPWRTHLQTKLQQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLSGDERLKEAAIASTRKYGAGATASRL
VVGNYSLYEEVERSICDWKGTEKALVVSSGYTANVGVISSLACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHL
EALLKTASPEKRKLIVTDTVFSMDGDTAYLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLIANGEYFRSKLREAGFNIGNS
STHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVHSSRIRFAVTSEHTIADLKWAIERITHIAKEEELFV

Sequences:

>Translated_395_residues
MNQPWRTHLQTKLQQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLSGDERLKEAAIASTRKYGAGATASRL
VVGNYSLYEEVERSICDWKGTEKALVVSSGYTANVGVISSLACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHL
EALLKTASPEKRKLIVTDTVFSMDGDTAYLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLIANGEYFRSKLREAGFNIGNS
STHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVHSSRIRFAVTSEHTIADLKWAIERITHIAKEEELFV
>Mature_395_residues
MNQPWRTHLQTKLQQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLSGDERLKEAAIASTRKYGAGATASRL
VVGNYSLYEEVERSICDWKGTEKALVVSSGYTANVGVISSLACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHL
EALLKTASPEKRKLIVTDTVFSMDGDTAYLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLIANGEYFRSKLREAGFNIGNS
STHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVHSSRIRFAVTSEHTIADLKWAIERITHIAKEEELFV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=34.7701149425287, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=34.7701149425287, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI83977442, Length=347, Percent_Identity=33.7175792507205, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=33.7175792507205, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=33.7175792507205, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=31.7808219178082, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI4502025, Length=346, Percent_Identity=33.2369942196532, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI40316939, Length=346, Percent_Identity=33.2369942196532, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=28.9617486338798, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI5454084, Length=262, Percent_Identity=30.9160305343511, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1790046, Length=394, Percent_Identity=33.502538071066, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1786993, Length=355, Percent_Identity=32.6760563380282, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=33.4183673469388, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI32566772, Length=372, Percent_Identity=31.1827956989247, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=27.2980501392758, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=27.2980501392758, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71982617, Length=285, Percent_Identity=24.9122807017544, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71982625, Length=285, Percent_Identity=24.9122807017544, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=28.8828337874659, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320438, Length=393, Percent_Identity=30.5343511450382, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=30.3370786516854, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=33.5051546391753, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI17137420, Length=363, Percent_Identity=33.6088154269972, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=31.1653116531165, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24653280, Length=285, Percent_Identity=27.3684210526316, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653276, Length=285, Percent_Identity=27.3684210526316, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653278, Length=285, Percent_Identity=27.3684210526316, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 44074; Mature: 44074

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPWRTHLQTKLQQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLSGDERL
CCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEECHHHHHHHCCCCEECCCCHHHH
KEAAIASTRKYGAGATASRLVVGNYSLYEEVERSICDWKGTEKALVVSSGYTANVGVISS
HHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHH
LACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHLEALLKTASPEKRKLIVTDTV
HHHHHCEEECCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEE
FSMDGDTAYLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
EECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
ANGEYFRSKLREAGFNIGNSSTHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVH
CCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCC
SSRIRFAVTSEHTIADLKWAIERITHIAKEEELFV
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQPWRTHLQTKLQQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLSGDERL
CCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEECHHHHHHHCCCCEECCCCHHHH
KEAAIASTRKYGAGATASRLVVGNYSLYEEVERSICDWKGTEKALVVSSGYTANVGVISS
HHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHH
LACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHLEALLKTASPEKRKLIVTDTV
HHHHHCEEECCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEE
FSMDGDTAYLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTF
EECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
ANGEYFRSKLREAGFNIGNSSTHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVH
CCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCC
SSRIRFAVTSEHTIADLKWAIERITHIAKEEELFV
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]