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The map label for this gene is rnz [H]

Identifier: 52141354

GI number: 52141354

Start: 4019882

End: 4020805

Strand: Reverse

Name: rnz [H]

Synonym: BCZK3895

Alternate gene names: 52141354

Gene position: 4020805-4019882 (Counterclockwise)

Preceding gene: 161763548

Following gene: 52141357

Centisome position: 75.85

GC content: 37.12

Gene sequence:

>924_bases
GTGGAATTTGTATTTTTAGGAACTGGTGCAGGTGTTCCTTCAAAAGGAAGGAATGTTTCGGCAATTGCTTTGCAATTGTT
AGAAGAACGAGGACAGACTTGGTTATTTGATTGTGGTGAGGCGACGCAACATCAAATATTACATACATCAGTACGTCCAC
GCCGCATTGAAAAAATATTTATTACGCATTTACATGGTGATCATATTTTTGGTTTGCCTGGTTTATTAGGAAGCCGTTCG
TTCCAAGGAGGGACTACACCTTTAACAGTGTATGGACCAAAAGGAATTAAACAGTTTATTGAAGTTGCATTATCAGTAAG
CACGACACATGTAAAATACCCGCTTGAAATTGTTGAGATAACAGAAGAAGGTACTGTGTTTGAAGATAATGAATTTCATG
TGGAAACGAAAAGATTGTCACACGGTATTGAATGTTTTGGGTATCGTATTATAGAGAAAGATATACAAGGCGCCCTTTTA
GTCGATAAATTGCTGGAGATGGGTGTGAAACCAGGTCCACTCTTTAAACGTTTAAAAGATGGAGAAGTGGTTGAATTGGA
AAATGGTACGATATTAAACGGAAAAGATTTTATCGGCCCACCTCAAAAGGGAAGAGTTATTACCATTTTAGGTGATACGA
GATATTGTGAAGCGAGTAGAGAGCTAGCACAAGACGCTGACGTACTTGTTCATGAAGCAACTTTTGCAGCAGAAGATGAA
CAACAAGCATATGATTATTTTCATTCCACATCTAAGCAAGCTGCAAGTATTGCACTTCAGGCAAATGCAAAACGATTAAT
ATTGACTCATATTAGTTCTCGTTATCAAGGAGATACATATAAGGAATTATTGAAAGAGGCAAGAGAGCTATTTTCTAATA
CAGAAATAGCTACAGATTTAAAATCATTTCCAGTGGACAGATAA

Upstream 100 bases:

>100_bases
ATAGTTGTCTAGATGATTGGTTATGTAAATTCGATTTGCCATTTGAAATAACATTCCGTAAGATGAAAGATAGATTATAT
AAAGAGCTGGAGGAAAGAAA

Downstream 100 bases:

>100_bases
TAATGTTGTGAAAAAATGGTGACGAAAGGTTGCCATTTTTTTATTTCTAAAAAAAAATAAAAATAAAACTGTTATCATTT
TATGCTTATATAGGATGAAA

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MEFVFLGTGAGVPSKGRNVSAIALQLLEERGQTWLFDCGEATQHQILHTSVRPRRIEKIFITHLHGDHIFGLPGLLGSRS
FQGGTTPLTVYGPKGIKQFIEVALSVSTTHVKYPLEIVEITEEGTVFEDNEFHVETKRLSHGIECFGYRIIEKDIQGALL
VDKLLEMGVKPGPLFKRLKDGEVVELENGTILNGKDFIGPPQKGRVITILGDTRYCEASRELAQDADVLVHEATFAAEDE
QQAYDYFHSTSKQAASIALQANAKRLILTHISSRYQGDTYKELLKEARELFSNTEIATDLKSFPVDR

Sequences:

>Translated_307_residues
MEFVFLGTGAGVPSKGRNVSAIALQLLEERGQTWLFDCGEATQHQILHTSVRPRRIEKIFITHLHGDHIFGLPGLLGSRS
FQGGTTPLTVYGPKGIKQFIEVALSVSTTHVKYPLEIVEITEEGTVFEDNEFHVETKRLSHGIECFGYRIIEKDIQGALL
VDKLLEMGVKPGPLFKRLKDGEVVELENGTILNGKDFIGPPQKGRVITILGDTRYCEASRELAQDADVLVHEATFAAEDE
QQAYDYFHSTSKQAASIALQANAKRLILTHISSRYQGDTYKELLKEARELFSNTEIATDLKSFPVDR
>Mature_307_residues
MEFVFLGTGAGVPSKGRNVSAIALQLLEERGQTWLFDCGEATQHQILHTSVRPRRIEKIFITHLHGDHIFGLPGLLGSRS
FQGGTTPLTVYGPKGIKQFIEVALSVSTTHVKYPLEIVEITEEGTVFEDNEFHVETKRLSHGIECFGYRIIEKDIQGALL
VDKLLEMGVKPGPLFKRLKDGEVVELENGTILNGKDFIGPPQKGRVITILGDTRYCEASRELAQDADVLVHEATFAAEDE
QQAYDYFHSTSKQAASIALQANAKRLILTHISSRYQGDTYKELLKEARELFSNTEIATDLKSFPVDR

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=349, Percent_Identity=36.676217765043, Blast_Score=210, Evalue=1e-54,
Organism=Escherichia coli, GI87082078, Length=306, Percent_Identity=49.6732026143791, Blast_Score=309, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71985814, Length=285, Percent_Identity=28.0701754385965, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71985808, Length=285, Percent_Identity=28.0701754385965, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 34213; Mature: 34213

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFVFLGTGAGVPSKGRNVSAIALQLLEERGQTWLFDCGEATQHQILHTSVRPRRIEKIF
CEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCHHEEEEE
ITHLHGDHIFGLPGLLGSRSFQGGTTPLTVYGPKGIKQFIEVALSVSTTHVKYPLEIVEI
EEEECCCEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCEEEEECCEEEEEE
TEEGTVFEDNEFHVETKRLSHGIECFGYRIIEKDIQGALLVDKLLEMGVKPGPLFKRLKD
ECCCCEEECCCEEEEHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHCCC
GEVVELENGTILNGKDFIGPPQKGRVITILGDTRYCEASRELAQDADVLVHEATFAAEDE
CCEEEECCCEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEHHHHCCCCH
QQAYDYFHSTSKQAASIALQANAKRLILTHISSRYQGDTYKELLKEARELFSNTEIATDL
HHHHHHHHHCCHHHHEEEEECCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
KSFPVDR
HHCCCCC
>Mature Secondary Structure
MEFVFLGTGAGVPSKGRNVSAIALQLLEERGQTWLFDCGEATQHQILHTSVRPRRIEKIF
CEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCHHEEEEE
ITHLHGDHIFGLPGLLGSRSFQGGTTPLTVYGPKGIKQFIEVALSVSTTHVKYPLEIVEI
EEEECCCEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCEEEEECCEEEEEE
TEEGTVFEDNEFHVETKRLSHGIECFGYRIIEKDIQGALLVDKLLEMGVKPGPLFKRLKD
ECCCCEEECCCEEEEHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHCCC
GEVVELENGTILNGKDFIGPPQKGRVITILGDTRYCEASRELAQDADVLVHEATFAAEDE
CCEEEECCCEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEHHHHCCCCH
QQAYDYFHSTSKQAASIALQANAKRLILTHISSRYQGDTYKELLKEARELFSNTEIATDL
HHHHHHHHHCCHHHHEEEEECCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
KSFPVDR
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA