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The map label for this gene is pepQ [H]

Identifier: 52141299

GI number: 52141299

Start: 4072325

End: 4073386

Strand: Reverse

Name: pepQ [H]

Synonym: BCZK3951

Alternate gene names: 52141299

Gene position: 4073386-4072325 (Counterclockwise)

Preceding gene: 52141297

Following gene: 52141298

Centisome position: 76.84

GC content: 38.7

Gene sequence:

>1062_bases
ATGGAGAAAATCGAAAGATTAAGAAGTGCATTTGATGAGGCTGGTATTGACGGTGTTTTGTTAACAAATGAACATAGTCG
TAGATATATGGCTAATTTCACAGGAACAGCTGGTGTTGTACTGATTTCGAAAAAACGCGCTCAATTTATTACAGATTTCC
GTTACGTAGAGCAGGCTAGTAAACAAGCGGTTGGATACGAGATTGTACAGCATGCAGGATTAATTATCGATGAAGTTGCA
AAGCAAGTGAAAGAACTAGGAATTCAAAAGCTTGGCTTTGAGCAAGATACTCTTACATATAGTTCTTATTCAGCTCATAA
AGAAGTGATCGATGCTGAATTTATCCCAACTTCTGGGCTTGTAGAAAAGTTACGCTTGATAAAGACTGATTCAGAGATTA
AGATATTAAAGGAAGCTGCACAGATTGCAGATGCTGCCTTTGAACATATTCTATCATTCATTCGCCCGGGAGTATCTGAA
ATTGAAGTGTCAAATGAACTTGAATTTTTCATGAGAAAACAAGGAGCAACATCTTCTTCGTTTGATATTATCGTTGCTTC
AGGTCTTCGTTCGGCATTACCGCACGGCGTGGCATCTGAAAAAGTGATAGAAACAGGAGATTTCGTTACATTAGACTTCG
GGGCTTATTACAAAGGATATTGCTCTGATATTACTCGTACGATCGCAGTTGGTGAACCATCTGATAAATTGAAAGAAATT
TATAATGTCGTTTTAGAAGCACAACTACGTGGTGTGAACGGTATTAAAGCTGGTTTAACTGGCCGTGAAGCGGATGCGTT
AACGCGTGATTACATAACGGAAAAAGGATACGGTGAATACTTCGGACATTCTACTGGTCATGGAATCGGTCTTGAAATCC
ATGAAGCACCAGGTTTAGCATTCCGTTCTGATACAGTACTTGAACCAGGTATGGCTGTAACAGTAGAGCCAGGTATTTAT
ATTCCAGGTATTGGCGGCGTACGTATTGAAGATGATATCATTGTGACAAGTGAAGGTAATGAAGTAATTACGAAATCACC
AAAAGAACTTATTATTTTGTAA

Upstream 100 bases:

>100_bases
ACGGCAGCTGTTTGTGCGGGACAGATTGTTGGATTTGGTTTTTATGGCTATAAGTTAGCGTTATTTGCATTAATGGAGAA
ATTGAGGGAGGCATAAAGTA

Downstream 100 bases:

>100_bases
TACACAGGAGGATTTTTTTACATGATTTCAGTAAACGATTTTCGTACAGGTTTAACAATTGCAGTGGATAATGGACTTTG
GCAAGTACTTGATTTCCAAC

Product: proline dipeptidase, Xaa-Pro dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MEKIERLRSAFDEAGIDGVLLTNEHSRRYMANFTGTAGVVLISKKRAQFITDFRYVEQASKQAVGYEIVQHAGLIIDEVA
KQVKELGIQKLGFEQDTLTYSSYSAHKEVIDAEFIPTSGLVEKLRLIKTDSEIKILKEAAQIADAAFEHILSFIRPGVSE
IEVSNELEFFMRKQGATSSSFDIIVASGLRSALPHGVASEKVIETGDFVTLDFGAYYKGYCSDITRTIAVGEPSDKLKEI
YNVVLEAQLRGVNGIKAGLTGREADALTRDYITEKGYGEYFGHSTGHGIGLEIHEAPGLAFRSDTVLEPGMAVTVEPGIY
IPGIGGVRIEDDIIVTSEGNEVITKSPKELIIL

Sequences:

>Translated_353_residues
MEKIERLRSAFDEAGIDGVLLTNEHSRRYMANFTGTAGVVLISKKRAQFITDFRYVEQASKQAVGYEIVQHAGLIIDEVA
KQVKELGIQKLGFEQDTLTYSSYSAHKEVIDAEFIPTSGLVEKLRLIKTDSEIKILKEAAQIADAAFEHILSFIRPGVSE
IEVSNELEFFMRKQGATSSSFDIIVASGLRSALPHGVASEKVIETGDFVTLDFGAYYKGYCSDITRTIAVGEPSDKLKEI
YNVVLEAQLRGVNGIKAGLTGREADALTRDYITEKGYGEYFGHSTGHGIGLEIHEAPGLAFRSDTVLEPGMAVTVEPGIY
IPGIGGVRIEDDIIVTSEGNEVITKSPKELIIL
>Mature_353_residues
MEKIERLRSAFDEAGIDGVLLTNEHSRRYMANFTGTAGVVLISKKRAQFITDFRYVEQASKQAVGYEIVQHAGLIIDEVA
KQVKELGIQKLGFEQDTLTYSSYSAHKEVIDAEFIPTSGLVEKLRLIKTDSEIKILKEAAQIADAAFEHILSFIRPGVSE
IEVSNELEFFMRKQGATSSSFDIIVASGLRSALPHGVASEKVIETGDFVTLDFGAYYKGYCSDITRTIAVGEPSDKLKEI
YNVVLEAQLRGVNGIKAGLTGREADALTRDYITEKGYGEYFGHSTGHGIGLEIHEAPGLAFRSDTVLEPGMAVTVEPGIY
IPGIGGVRIEDDIIVTSEGNEVITKSPKELIIL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=261, Percent_Identity=32.5670498084291, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI260593665, Length=289, Percent_Identity=27.681660899654, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI149589008, Length=289, Percent_Identity=27.681660899654, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI264681563, Length=189, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI93141226, Length=187, Percent_Identity=35.2941176470588, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI260593663, Length=287, Percent_Identity=27.5261324041812, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI264681565, Length=186, Percent_Identity=31.7204301075269, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI164420681, Length=261, Percent_Identity=21.8390804597701, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI40385867, Length=281, Percent_Identity=22.7758007117438, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788728, Length=359, Percent_Identity=41.7827298050139, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI1789275, Length=276, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786364, Length=205, Percent_Identity=26.3414634146341, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790282, Length=303, Percent_Identity=25.0825082508251, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508215, Length=294, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17509539, Length=250, Percent_Identity=28, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71989583, Length=263, Percent_Identity=24.3346007604563, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321118, Length=346, Percent_Identity=26.878612716763, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320922, Length=244, Percent_Identity=27.0491803278689, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322999, Length=310, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323273, Length=230, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19920384, Length=277, Percent_Identity=29.9638989169675, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21357079, Length=293, Percent_Identity=30.7167235494881, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI21355531, Length=187, Percent_Identity=22.9946524064171, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137632, Length=183, Percent_Identity=32.7868852459016, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 38614; Mature: 38614

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIERLRSAFDEAGIDGVLLTNEHSRRYMANFTGTAGVVLISKKRAQFITDFRYVEQAS
CCHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCEEEEEECHHHHHHHHHHHHHHHH
KQAVGYEIVQHAGLIIDEVAKQVKELGIQKLGFEQDTLTYSSYSAHKEVIDAEFIPTSGL
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCCCEEECCHHHHHHHHCCCCCCCHHH
VEKLRLIKTDSEIKILKEAAQIADAAFEHILSFIRPGVSEIEVSNELEFFMRKQGATSSS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHHHHHHHHHHHCCCCCCC
FDIIVASGLRSALPHGVASEKVIETGDFVTLDFGAYYKGYCSDITRTIAVGEPSDKLKEI
CEEEEECCHHHHCCCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHEEECCCCHHHHHHH
YNVVLEAQLRGVNGIKAGLTGREADALTRDYITEKGYGEYFGHSTGHGIGLEIHEAPGLA
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEECCCCCE
FRSDTVLEPGMAVTVEPGIYIPGIGGVRIEDDIIVTSEGNEVITKSPKELIIL
ECCCCCCCCCCEEEECCCEEECCCCCEEEECCEEEECCCCEEECCCCCCEEEC
>Mature Secondary Structure
MEKIERLRSAFDEAGIDGVLLTNEHSRRYMANFTGTAGVVLISKKRAQFITDFRYVEQAS
CCHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCEEEEEECHHHHHHHHHHHHHHHH
KQAVGYEIVQHAGLIIDEVAKQVKELGIQKLGFEQDTLTYSSYSAHKEVIDAEFIPTSGL
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCCCEEECCHHHHHHHHCCCCCCCHHH
VEKLRLIKTDSEIKILKEAAQIADAAFEHILSFIRPGVSEIEVSNELEFFMRKQGATSSS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHHHHHHHHHHHCCCCCCC
FDIIVASGLRSALPHGVASEKVIETGDFVTLDFGAYYKGYCSDITRTIAVGEPSDKLKEI
CEEEEECCHHHHCCCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHEEECCCCHHHHHHH
YNVVLEAQLRGVNGIKAGLTGREADALTRDYITEKGYGEYFGHSTGHGIGLEIHEAPGLA
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEECCCCCE
FRSDTVLEPGMAVTVEPGIYIPGIGGVRIEDDIIVTSEGNEVITKSPKELIIL
ECCCCCCCCCCEEEECCCEEECCCCCEEEECCEEEECCCCEEECCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]