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The map label for this gene is hemC [H]

Identifier: 52141043

GI number: 52141043

Start: 4316228

End: 4317157

Strand: Reverse

Name: hemC [H]

Synonym: BCZK4208

Alternate gene names: 52141043

Gene position: 4317157-4316228 (Counterclockwise)

Preceding gene: 52141041

Following gene: 52141042

Centisome position: 81.44

GC content: 40.11

Gene sequence:

>930_bases
ATGCGCAAAATTATTGTAGGGTCACGAAAGAGTAAATTAGCATTAACGCAAACAAACTGGTTTATTGATCAGTTAAAAGC
GCTAGGTTTACCATATGAATTTGAAGTGAAAGAAATCGTCACAAAAGGTGATGTTATTTTAGATGTTACTCTTTCAAAAG
TAGGCGGAAAAGGTTTGTTTGTGAAAGAGATTGAACATGCGTTACTTACGAAAGAAATTGATATGGCTGTACATAGTATG
AAAGATATGCCGGCCGTACTTCCAGAAGGATTAATGATCGGTTGTACACCAAAGCGTGTTGACCCTCGTGATGCTTTTAT
CTCAAAAAGTGGGGCGTCGTTTAAAGAGTTAGCAGAAGGCGCTATTTTAGGTACGAGTAGTTTAAGACGTAGTGCACAGC
TGCTCGCTGCAAGACCAGATTTACAAGTGAAGTGGATTCGCGGAAATATCGATACACGTTTACGCAAATTAAAAGAAGAA
GATTACGATGCAATCATTTTAGCGACAGCTGGGTTACAAAGAATGGGCTGGGATGATGAAGTTATTACAGAACATTTAGA
TGAGACGTTATGTGTACCTGCTGTAGGACAAGGTGCATTAGCGATTGAGTGCCGTGAAGATGATACAGATTTACTACAGT
TGTTAGCGCATATAAATGATGCAGTAACAGAAAGAACAGTGGCAGCAGAACGAGTATTTCTTCATAAACTTGAAGGTGGG
TGCCAAGTTCCGATCGCTGGATATGCAACTCTTACAGAAAACGATGCAATCGAATTAACAGCTCTTGTCGGGTCTATGGA
CGGTTCTGTTTTGTTGAAAGAGACAGTAGTAGGAACTGATCCAGAGAAAGTAGGATTAGAGGCTGCGGACCGTTTAATTA
AACAAGGCGCAAAAGAACTCATTCTTGCTGCAAATAAGGGGCAACAATAA

Upstream 100 bases:

>100_bases
GTGGAACATTGGGGCATTTCTCGTAATGCTAATTAATATTTTTCTATTAAGCAGTTTATCCAACTTCCACTTTTGGTATT
TATAATGAGGAGAGAAAATT

Downstream 100 bases:

>100_bases
ATATGAACGCTCTCGCTGGCAAAACGGTATTGGTTACACGTGCCCAGCATCAAGCAAAACAAATGAGTGTAGCGGTGAAA
GAAATGAGCGGAATTCCATT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MRKIIVGSRKSKLALTQTNWFIDQLKALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLFVKEIEHALLTKEIDMAVHSM
KDMPAVLPEGLMIGCTPKRVDPRDAFISKSGASFKELAEGAILGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLKEE
DYDAIILATAGLQRMGWDDEVITEHLDETLCVPAVGQGALAIECREDDTDLLQLLAHINDAVTERTVAAERVFLHKLEGG
CQVPIAGYATLTENDAIELTALVGSMDGSVLLKETVVGTDPEKVGLEAADRLIKQGAKELILAANKGQQ

Sequences:

>Translated_309_residues
MRKIIVGSRKSKLALTQTNWFIDQLKALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLFVKEIEHALLTKEIDMAVHSM
KDMPAVLPEGLMIGCTPKRVDPRDAFISKSGASFKELAEGAILGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLKEE
DYDAIILATAGLQRMGWDDEVITEHLDETLCVPAVGQGALAIECREDDTDLLQLLAHINDAVTERTVAAERVFLHKLEGG
CQVPIAGYATLTENDAIELTALVGSMDGSVLLKETVVGTDPEKVGLEAADRLIKQGAKELILAANKGQQ
>Mature_309_residues
MRKIIVGSRKSKLALTQTNWFIDQLKALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLFVKEIEHALLTKEIDMAVHSM
KDMPAVLPEGLMIGCTPKRVDPRDAFISKSGASFKELAEGAILGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLKEE
DYDAIILATAGLQRMGWDDEVITEHLDETLCVPAVGQGALAIECREDDTDLLQLLAHINDAVTERTVAAERVFLHKLEGG
CQVPIAGYATLTENDAIELTALVGSMDGSVLLKETVVGTDPEKVGLEAADRLIKQGAKELILAANKGQQ

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=315, Percent_Identity=46.031746031746, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI66933009, Length=315, Percent_Identity=46.031746031746, Blast_Score=242, Evalue=3e-64,
Organism=Escherichia coli, GI48994974, Length=304, Percent_Identity=48.0263157894737, Blast_Score=258, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=38.6075949367089, Blast_Score=190, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20130425, Length=309, Percent_Identity=41.4239482200647, Blast_Score=204, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33649; Mature: 33649

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIIVGSRKSKLALTQTNWFIDQLKALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLF
CCCEEECCCCCEEEEEEHHHHHHHHHHHCCCCEEHHHHHHCCCCEEEEEEEHHCCCCCEE
VKEIEHALLTKEIDMAVHSMKDMPAVLPEGLMIGCTPKRVDPRDAFISKSGASFKELAEG
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEECCCCCCCCHHHHHCCCCCCHHHHHCC
AILGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLKEEDYDAIILATAGLQRMGWDDE
CEECHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCEEEEEECCHHHCCCCHH
VITEHLDETLCVPAVGQGALAIECREDDTDLLQLLAHINDAVTERTVAAERVFLHKLEGG
HHHHHHHHHEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CQVPIAGYATLTENDAIELTALVGSMDGSVLLKETVVGTDPEKVGLEAADRLIKQGAKEL
CCCCCCCEEEECCCCCEEEEEEEECCCCCEEEEEHHCCCCHHHHCHHHHHHHHHHCHHHE
ILAANKGQQ
EEECCCCCC
>Mature Secondary Structure
MRKIIVGSRKSKLALTQTNWFIDQLKALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLF
CCCEEECCCCCEEEEEEHHHHHHHHHHHCCCCEEHHHHHHCCCCEEEEEEEHHCCCCCEE
VKEIEHALLTKEIDMAVHSMKDMPAVLPEGLMIGCTPKRVDPRDAFISKSGASFKELAEG
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEECCCCCCCCHHHHHCCCCCCHHHHHCC
AILGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLKEEDYDAIILATAGLQRMGWDDE
CEECHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCEEEEEECCHHHCCCCHH
VITEHLDETLCVPAVGQGALAIECREDDTDLLQLLAHINDAVTERTVAAERVFLHKLEGG
HHHHHHHHHEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CQVPIAGYATLTENDAIELTALVGSMDGSVLLKETVVGTDPEKVGLEAADRLIKQGAKEL
CCCCCCCEEEECCCCCEEEEEEEECCCCCEEEEEHHCCCCHHHHCHHHHHHHHHHCHHHE
ILAANKGQQ
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA