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The map label for this gene is argH [H]

Identifier: 52140878

GI number: 52140878

Start: 4482842

End: 4484230

Strand: Reverse

Name: argH [H]

Synonym: BCZK4374

Alternate gene names: 52140878

Gene position: 4484230-4482842 (Counterclockwise)

Preceding gene: 52140876

Following gene: 52140877

Centisome position: 84.59

GC content: 38.44

Gene sequence:

>1389_bases
GTGAGCAAACTTTGGGGCGGACGTTTTACTGAAGAAGCGGAAGCGTGGGTTGAAGAGTTCGGGGCATCCATCTCCTTCGA
TCAACAATTAGTAAATCAAGATATAAACGGGAGTATTGCACACGTAACGATGCTAGCAAAGCAGGGCATCGTTACGAAAG
AAGAAGCAGAGAAAATAAAGATAGGTCTTCAATATTTATTAGAAGAAGCGAAACAAAATAAATTGAATTTTTCGGTTGAA
GCTGAAGACATTCATTTGAATATTGAAAAGATGTTAATTGAAAAAATCGGTGAAGTAGGCGGGAAACTTCATACTGGCCG
AAGTCGTAATGATCAAGTAGCGACAGATATGCACTTATATTTAAAAGAAAAAGTAGAACATATTATGAAAGCTACAAAAC
AATTGCAAACTGTTCTTGTTCATCAAGCAGAAAATAATATTGAAACGATTATGCCTGGCTATACGCATTTGCAGCGTGCT
CAACCAATTTCATTTGCTCATCATATTCTCGCTTATTTTTGGATGTTAGAGCGTGATGTGAATCGTTATGAAGATTCGTT
AAAGCGTATTAACATTTCGCCATTAGGAGCAGGGGCGTTAGCAGGGACAACATTCCCGATTGACCGAGAATATAGTGCGG
AGCTTCTTGGATTTAATGGAATCTATGAAAATAGTTTAGATGCAGTAAGCGATCGTGATTTCATACTGGAGTTCCTAAGT
AACTCATCTATCCTTATGATGCACTTATCGCGCTTTTGCGAAGAACTTATTTTATGGAGTAGCCAAGAGTTTCAATTTAT
TGAAATGAGCGATCAATATGCAACGGGAAGCAGCATTATGCCGCAAAAGAAAAACCCGGATATGGCAGAACTTATTCGTG
GTAAAACAGGCAGAGTGTACGGTAATTTATTTAGTTTACTTACAGTCATGAAAGGATTACCGCTCGCTTACAATAAAGAT
TTGCAAGAAGATAAAGAGGGAATGTTTGATACAGTAAAAACAGTAGAAGGATGCCTTCATATTATGGCAGGCATGTTAGA
GACGATGACTGTAAACAAAGAAAAAATGGGGCAAGCTGTAACGCAAGATTTCTCTAACGCAACAGAAATTGCCGACTACT
TAGCAAGTAAAGGACTACCATTCCGTCAAGCTCATGAAATTGTTGGGAAGCTAGTGCTACACTGTACACAAAAAGGAATT
TATTTAGTAGATGTCCCACTTGAAACGTATAAAGAAATGAGCTCGTTATTTGAAGAAGATTTGTATGAAGTGCTGTCACC
ATATGCAGCTGTAAAGCGTCGTAACAGTGCTGGCGGGACTGGGTTTGAGCAAATTGAAAAAGCTTTGGAGAAGGCGAAGG
GATTAACGAAAGAAGCTATTAAGAATTGA

Upstream 100 bases:

>100_bases
CCCAGGACGAGTTTAATCATGATGCAGCAGTTGGATTCATTTCATTATTCGGTTTACCGACGAAAGTATACAGCCAAGTG
AACCAAAAGAAGGTGGAAGC

Downstream 100 bases:

>100_bases
GTTGAAAAGTACGCCAGTCTGTTAAAGTCGGGCGTACTTTCTTTTTTACTAGTATTTAAGTTATGATATAGTGAAAAATA
ACAATTTAGGGGAAGTCTAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLNFSVE
AEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRA
QPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGFNGIYENSLDAVSDRDFILEFLS
NSSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKD
LQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTQDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGI
YLVDVPLETYKEMSSLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN

Sequences:

>Translated_462_residues
MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLNFSVE
AEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRA
QPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGFNGIYENSLDAVSDRDFILEFLS
NSSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKD
LQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTQDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGI
YLVDVPLETYKEMSSLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN
>Mature_461_residues
SKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLNFSVEA
EDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRAQ
PISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGFNGIYENSLDAVSDRDFILEFLSN
SSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKDL
QEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTQDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGIY
LVDVPLETYKEMSSLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=453, Percent_Identity=44.3708609271523, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303542, Length=453, Percent_Identity=44.3708609271523, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303549, Length=453, Percent_Identity=41.9426048565121, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI68303547, Length=453, Percent_Identity=41.7218543046358, Blast_Score=360, Evalue=2e-99,
Organism=Escherichia coli, GI1790398, Length=452, Percent_Identity=49.5575221238938, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17553882, Length=226, Percent_Identity=27.8761061946903, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321806, Length=454, Percent_Identity=46.2555066079295, Blast_Score=402, Evalue=1e-113,
Organism=Drosophila melanogaster, GI221473854, Length=459, Percent_Identity=39.4335511982571, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI78706858, Length=459, Percent_Identity=39.4335511982571, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52145; Mature: 52014

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIK
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
IGLQYLLEEAKQNKLNFSVEAEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
NRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGFNGIYENSLDAVSDRDFILEFLS
HHHHHHHHEECCCCCCCCHHCCCCCCCCCCCCHHHHCCCCCCCCCCHHHCHHHHHHHHHC
NSSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TQDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGIYLVDVPLETYKEMSSLFEED
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
SKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIK
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
IGLQYLLEEAKQNKLNFSVEAEDIHLNIEKMLIEKIGEVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LKEKVEHIMKATKQLQTVLVHQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
NRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGFNGIYENSLDAVSDRDFILEFLS
HHHHHHHHEECCCCCCCCHHCCCCCCCCCCCCHHHHCCCCCCCCCCHHHCHHHHHHHHHC
NSSILMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TQDFSNATEIADYLASKGLPFRQAHEIVGKLVLHCTQKGIYLVDVPLETYKEMSSLFEED
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA