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The map label for this gene is gltC [H]

Identifier: 52140856

GI number: 52140856

Start: 4503426

End: 4504268

Strand: Reverse

Name: gltC [H]

Synonym: BCZK4394

Alternate gene names: 52140856

Gene position: 4504268-4503426 (Counterclockwise)

Preceding gene: 52140855

Following gene: 52140858

Centisome position: 84.97

GC content: 38.2

Gene sequence:

>843_bases
ATGGATTTGGAGGCAGTACGATCGTTTATTGAAGTAAAGAATACGCGAAGTTTATCAAAGGCGAGTAAGATTTTACATAT
TTCTCAGCCGGCGCTTAGTAAACAGATTCAAAGGTTAGAGGCCGATTTAGAAGTTACTTTACTGAAGCGTTCCGCGCAAG
GAGTGGAATTAACACGTGCTGGAGAGCTATTTATAAAAAGAATGTTACCGATTTTGGAACACATACATGAAGTGAAAGCC
GAGATGAAGAAATTTCAAGAGAAGCGGAACATTTCGATAGGCATATTGCCAAGTTTAGCAGCACATTACATATCAAAATG
TAAAGATATGTTAGGTGACGGGTTCGAAGTAGAATGGAAAATTGAGCATACGAAAGTACTGATGGGGCTCTTTAAAGAAC
GGAAGATTGAAGCGATGTTCATCGATTCAGTAGTAGAAGGTGCTACGTGTATAAAAGAAATACGAGAAGAAAAAATTGTT
TGTGTCGTTTCAAATGATCATCTTTATAAAGAGAAAACAGTAATTCGAATGGAAGATTTGCAAAATGAAAAGTTAATCGT
ATACCCAGAAATCTGCGATGTAAGGAAAATGATTACGAATATGTTTCAAGGGATAGGTGCGAAACCAATTATTGCATTTG
AAACTTCTTATGCAGAACCGATGCTTGCGATGGTCGGTGCTGGACTTGGCATCACGTTACTTCCAGAAATATCAGTAGAG
CAAGCGGTAAGGCAAGGAAATGTGCATGCAATTTCTATTGAACCGCCACTTGTGCGCAAAATTTATTTCGTATCTCATAT
GGAAGAAGGCCCTTTAGTGCATTCATTTCATGATGAGAGGTAA

Upstream 100 bases:

>100_bases
GTTATAGTAAGTTGATGAAATAAGTATAAAGAGTAATTGTTTATAGAAGGAAATACTGATTTTTTATGACAGTTATAACT
TTTTGTTAGAGGTGTGTACG

Downstream 100 bases:

>100_bases
TCCAAACGGAATATTGAGAAAGATTACAATTGCATTGAAAGAAACATGAAATTTTAAAAAAAACTAGGTCAAAAACAAGC
CATTACATGGTATGATTAGT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTRAGELFIKRMLPILEHIHEVKA
EMKKFQEKRNISIGILPSLAAHYISKCKDMLGDGFEVEWKIEHTKVLMGLFKERKIEAMFIDSVVEGATCIKEIREEKIV
CVVSNDHLYKEKTVIRMEDLQNEKLIVYPEICDVRKMITNMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEISVE
QAVRQGNVHAISIEPPLVRKIYFVSHMEEGPLVHSFHDER

Sequences:

>Translated_280_residues
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTRAGELFIKRMLPILEHIHEVKA
EMKKFQEKRNISIGILPSLAAHYISKCKDMLGDGFEVEWKIEHTKVLMGLFKERKIEAMFIDSVVEGATCIKEIREEKIV
CVVSNDHLYKEKTVIRMEDLQNEKLIVYPEICDVRKMITNMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEISVE
QAVRQGNVHAISIEPPLVRKIYFVSHMEEGPLVHSFHDER
>Mature_280_residues
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTRAGELFIKRMLPILEHIHEVKA
EMKKFQEKRNISIGILPSLAAHYISKCKDMLGDGFEVEWKIEHTKVLMGLFKERKIEAMFIDSVVEGATCIKEIREEKIV
CVVSNDHLYKEKTVIRMEDLQNEKLIVYPEICDVRKMITNMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEISVE
QAVRQGNVHAISIEPPLVRKIYFVSHMEEGPLVHSFHDER

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=272, Percent_Identity=27.2058823529412, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788887, Length=286, Percent_Identity=27.972027972028, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367136, Length=240, Percent_Identity=23.75, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI157672245, Length=267, Percent_Identity=22.8464419475655, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI145693105, Length=276, Percent_Identity=23.1884057971014, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=24.3027888446215, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787601, Length=97, Percent_Identity=39.1752577319588, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31834; Mature: 31834

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTRA
CCHHHHHHHHHHHHCHHHHHHHHHEECCCHHHHHHHHHHHCCHHHEEEHHCCCCCEEHHH
GELFIKRMLPILEHIHEVKAEMKKFQEKRNISIGILPSLAAHYISKCKDMLGDGFEVEWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEE
IEHTKVLMGLFKERKIEAMFIDSVVEGATCIKEIREEKIVCVVSNDHLYKEKTVIRMEDL
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEHHHHEEEECCC
QNEKLIVYPEICDVRKMITNMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEISVE
CCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCEEEECCCCHH
QAVRQGNVHAISIEPPLVRKIYFVSHMEEGPLVHSFHDER
HHHHCCCEEEEEECCHHHHHHHHHHHCCCCCEECCCCCCC
>Mature Secondary Structure
MDLEAVRSFIEVKNTRSLSKASKILHISQPALSKQIQRLEADLEVTLLKRSAQGVELTRA
CCHHHHHHHHHHHHCHHHHHHHHHEECCCHHHHHHHHHHHCCHHHEEEHHCCCCCEEHHH
GELFIKRMLPILEHIHEVKAEMKKFQEKRNISIGILPSLAAHYISKCKDMLGDGFEVEWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEE
IEHTKVLMGLFKERKIEAMFIDSVVEGATCIKEIREEKIVCVVSNDHLYKEKTVIRMEDL
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEHHHHEEEECCC
QNEKLIVYPEICDVRKMITNMFQGIGAKPIIAFETSYAEPMLAMVGAGLGITLLPEISVE
CCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCEEEECCCCHH
QAVRQGNVHAISIEPPLVRKIYFVSHMEEGPLVHSFHDER
HHHHCCCEEEEEECCHHHHHHHHHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]