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The map label for this gene is ccpA [H]

Identifier: 52140826

GI number: 52140826

Start: 4528957

End: 4529955

Strand: Reverse

Name: ccpA [H]

Synonym: BCZK4427

Alternate gene names: 52140826

Gene position: 4529955-4528957 (Counterclockwise)

Preceding gene: 52140823

Following gene: 52140829

Centisome position: 85.46

GC content: 38.84

Gene sequence:

>999_bases
ATGAACGTAACAATATATGATGTAGCGCGCGAAGCGAACGTTTCAATGGCTACCGTATCTCGTGTTGTGAACGGTAACCC
AAATGTAAAGCCTACAACAAGAAAGAAAGTATTAGAAGCAATTGATCGTTTAGGATACCGCCCAAATGCGGTAGCACGTG
GATTAGCAAGTAAAAAGACGACTACAGTAGGTGTTATTATTCCTGATATCTCAAATACGTTTTATGCAGAACTTGCTCGT
GGAATTGAAGATATCGCAACAATGTACAAATATAACATCATTTTAAGTAACTCTGACCAAAACAAAGAGAAAGAGTTCCA
TTTATTAAATACGATGCTTGGAAAGCAAGTGGACGGAATTGTTTTCATGGGTGAAGATATTACAGACATTCACATTGAAG
AATTTAAAAAGTCTCCAGTACCAATCGTATTAGCAGCGTCATTTGATGAGCAAAATGAAACGCCATCAGTAAACATTGAT
TATACACAAGCAGCTTACGACGCAATGAAGCACTTTATTGAACAAGGACATAAGCGTATCGGTTTCGTCTCTGGTCCTTT
CATTGATAAAGCGGGAAGTGCGAAGAAGTTACAAGGTTATAGAAAAGCTCTAGAAGAAGCAGGTATTTCATATGATGAAA
ATCTTGTAATCGATGGAGATTACACATATGACTCAGGTATCGAAGCATTCGAAAAGCTTTGGAGCCTTGATGAGAAGCCG
TCAGCAATCTTCGTATCTTCTGACGAAATGGCACTAGGTGTAATCCACGCAGCACAAGACGCTGGATTACACGTACCAAC
TGATGTAGAAGTACTTGGATTCGATAATACACGCCTTGCATTAATGGTTCGTCCGCAACTTTCAACAGTTGTACAACCGA
TGTATGATATCGGTGCAGTAGCAATGCGTCTATTAACAAAGTATATGAACAAAGAAAAAGTGGAAGATCACACTGTTATC
TTACCTCACCGTATCCAATTTAGAGATTCAACGAAGTAA

Upstream 100 bases:

>100_bases
GACGATTGGTGGCATCTGCAAATAGAGTTGATGTCTTTTTTTCATTCAAGTAACCGATACATAAAAATAGATAGCAAAAA
TAGAAGGAGTGTGCGATGAG

Downstream 100 bases:

>100_bases
GTATAAAAAAGCTCACAGCGATTGCTGTGAGCTTTTATTTATATTCAGGATAGTATGTTTGAACTATAGTATCCACCGTT
TCATTTTTCTTAACGTGTAA

Product: catabolite control protein A

Products: NA

Alternate protein names: Glucose-resistance amylase regulator [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MNVTIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIDRLGYRPNAVARGLASKKTTTVGVIIPDISNTFYAELAR
GIEDIATMYKYNIILSNSDQNKEKEFHLLNTMLGKQVDGIVFMGEDITDIHIEEFKKSPVPIVLAASFDEQNETPSVNID
YTQAAYDAMKHFIEQGHKRIGFVSGPFIDKAGSAKKLQGYRKALEEAGISYDENLVIDGDYTYDSGIEAFEKLWSLDEKP
SAIFVSSDEMALGVIHAAQDAGLHVPTDVEVLGFDNTRLALMVRPQLSTVVQPMYDIGAVAMRLLTKYMNKEKVEDHTVI
LPHRIQFRDSTK

Sequences:

>Translated_332_residues
MNVTIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIDRLGYRPNAVARGLASKKTTTVGVIIPDISNTFYAELAR
GIEDIATMYKYNIILSNSDQNKEKEFHLLNTMLGKQVDGIVFMGEDITDIHIEEFKKSPVPIVLAASFDEQNETPSVNID
YTQAAYDAMKHFIEQGHKRIGFVSGPFIDKAGSAKKLQGYRKALEEAGISYDENLVIDGDYTYDSGIEAFEKLWSLDEKP
SAIFVSSDEMALGVIHAAQDAGLHVPTDVEVLGFDNTRLALMVRPQLSTVVQPMYDIGAVAMRLLTKYMNKEKVEDHTVI
LPHRIQFRDSTK
>Mature_332_residues
MNVTIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIDRLGYRPNAVARGLASKKTTTVGVIIPDISNTFYAELAR
GIEDIATMYKYNIILSNSDQNKEKEFHLLNTMLGKQVDGIVFMGEDITDIHIEEFKKSPVPIVLAASFDEQNETPSVNID
YTQAAYDAMKHFIEQGHKRIGFVSGPFIDKAGSAKKLQGYRKALEEAGISYDENLVIDGDYTYDSGIEAFEKLWSLDEKP
SAIFVSSDEMALGVIHAAQDAGLHVPTDVEVLGFDNTRLALMVRPQLSTVVQPMYDIGAVAMRLLTKYMNKEKVEDHTVI
LPHRIQFRDSTK

Specific function: Transcriptional regulator involved in both the repression of carbohydrate utilization genes such as the alpha- amylase (AmyE) and the acetyl-coenzyme A synthetase (AcsA); and in the positive regulation of genes involved in excretion of excess carbon such

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=330, Percent_Identity=36.969696969697, Blast_Score=231, Evalue=3e-62,
Organism=Escherichia coli, GI1787948, Length=329, Percent_Identity=34.3465045592705, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1790194, Length=321, Percent_Identity=32.7102803738318, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1789068, Length=307, Percent_Identity=32.5732899022801, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789202, Length=291, Percent_Identity=32.3024054982818, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788474, Length=302, Percent_Identity=30.1324503311258, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1787580, Length=329, Percent_Identity=26.7477203647416, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI48994940, Length=304, Percent_Identity=27.3026315789474, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786540, Length=333, Percent_Identity=27.6276276276276, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790715, Length=317, Percent_Identity=23.0283911671924, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787906, Length=333, Percent_Identity=23.1231231231231, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789456, Length=354, Percent_Identity=27.4011299435028, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1786268, Length=314, Percent_Identity=25.1592356687898, Blast_Score=98, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006377
- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36967; Mature: 36967

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIDRLGYRPNAVARGLASKKT
CCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCC
TTVGVIIPDISNTFYAELARGIEDIATMYKYNIILSNSDQNKEKEFHLLNTMLGKQVDGI
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCCE
VFMGEDITDIHIEEFKKSPVPIVLAASFDEQNETPSVNIDYTQAAYDAMKHFIEQGHKRI
EEECCCCCCCHHHHHCCCCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHCHHEE
GFVSGPFIDKAGSAKKLQGYRKALEEAGISYDENLVIDGDYTYDSGIEAFEKLWSLDEKP
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCC
SAIFVSSDEMALGVIHAAQDAGLHVPTDVEVLGFDNTRLALMVRPQLSTVVQPMYDIGAV
CEEEEECCCEEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHH
AMRLLTKYMNKEKVEDHTVILPHRIQFRDSTK
HHHHHHHHHCHHCCCCCEEEECCEEECCCCCC
>Mature Secondary Structure
MNVTIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIDRLGYRPNAVARGLASKKT
CCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCC
TTVGVIIPDISNTFYAELARGIEDIATMYKYNIILSNSDQNKEKEFHLLNTMLGKQVDGI
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCCE
VFMGEDITDIHIEEFKKSPVPIVLAASFDEQNETPSVNIDYTQAAYDAMKHFIEQGHKRI
EEECCCCCCCHHHHHCCCCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHCHHEE
GFVSGPFIDKAGSAKKLQGYRKALEEAGISYDENLVIDGDYTYDSGIEAFEKLWSLDEKP
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCC
SAIFVSSDEMALGVIHAAQDAGLHVPTDVEVLGFDNTRLALMVRPQLSTVVQPMYDIGAV
CEEEEECCCEEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHH
AMRLLTKYMNKEKVEDHTVILPHRIQFRDSTK
HHHHHHHHHCHHCCCCCEEEECCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1904524; 9387221; 9384377 [H]