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The map label for this gene is moaA [H]

Identifier: 52140778

GI number: 52140778

Start: 4572130

End: 4573143

Strand: Reverse

Name: moaA [H]

Synonym: BCZK4475

Alternate gene names: 52140778

Gene position: 4573143-4572130 (Counterclockwise)

Preceding gene: 52140776

Following gene: 52140777

Centisome position: 86.27

GC content: 38.17

Gene sequence:

>1014_bases
ATGCAGGAGATGGTTACAGATTTTTTTGGACGCCCACTTCAAGATTTACGCATATCTGTCATTGATCGTTGCAATTTTAG
ATGTACATATTGTATGCCAGCGGAAGTGTTTGGGCCAGATTATGCTTTTTTGAAAGATGAGTTTTTACTGACGTTTGATG
AAATTGAGCGTGTAGCAAAACTATTTGTTAGCATCGGTGTACGAAAAATTAGACTTACTGGTGGCGAGCCACTACTTCGT
AAAGATTTAGCAAAACTTATTGCACGTCTCGTGAAAATTGACGGGCTATTAGATATAGGGTTAACGACCAATGCAATTCA
TTTAACAAAGCAAGCGAAAGTATTAAAAGAAGCTGGATTACATAGGGTAAATGTTAGTTTGGATGCAATAGATGATGATG
TATTTAAGGCTATTAATGGCCGGAATATTAATACGAAACCTGTTATAAAGGGGATTATGGCTGCAAAAGAAGCAGGACTT
GATGTAAAGGTAAACATGGTTGTGAAAAAAGGGATGAACGATCATCAAGTACTTCCGATGGCTACGTATTTTAAAGAGCA
AGGAATCCCGCTTAGGTTCATTGAGTTTATGGATGTTGGTAGTACAAATGGATGGAACTTTGATCAGGTCGTTACGAAGC
GAGAGTTAATTGAGATGATTCATCGCGTGTATCCGCTTGAGCCAGCTGAAGGGCATTATTTTGGTGAAGTTGCGAAGCGA
TATCGTTACGTTGGAACAAATATTGAAGTCGGTTTTATTACTTCTGTTTCTGAGTCCTTTTGTTCTTCTTGTACGAGAGC
GAGAATTTCGGCAGATGGAAAGTTTTATACTTGTTTGTTTGCGACAGAAGGTCTCGACATAAGGGAACTTCTTAGAGCAA
AGCTTTCAGATGATGAGCTATTAAGCGTTATACAAGATGTATGGATGAATAGAAAAGATAGGTATTCGGATGAACGGACA
GAAGAAAGTGCGAAAAATCGTCCGAAAATTGAAATGTCTTATATAGGAGGATAA

Upstream 100 bases:

>100_bases
GGAAAGTTTTACTTTATTCACATGAGTAAAAACATCGCAGTTCGAAAATATATTATAATAGAATGAAAAGAGAGAAATTT
GGCAGAAAGGGAGGGTGGCG

Downstream 100 bases:

>100_bases
GAAGGGAGGCTATCGTATGCAGGAGCGATATTCAAGGCAAATATTATTTTCTGGTGTTGGAGAAGAAGGACAGAGAAAAA
TTAGAGAGAAGCATGTGCTT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGVRKIRLTGGEPLLR
KDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKVLKEAGLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGL
DVKVNMVVKKGMNDHQVLPMATYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEGHYFGEVAKR
YRYVGTNIEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDDELLSVIQDVWMNRKDRYSDERT
EESAKNRPKIEMSYIGG

Sequences:

>Translated_337_residues
MQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGVRKIRLTGGEPLLR
KDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKVLKEAGLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGL
DVKVNMVVKKGMNDHQVLPMATYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEGHYFGEVAKR
YRYVGTNIEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDDELLSVIQDVWMNRKDRYSDERT
EESAKNRPKIEMSYIGG
>Mature_337_residues
MQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAKLFVSIGVRKIRLTGGEPLLR
KDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKVLKEAGLHRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGL
DVKVNMVVKKGMNDHQVLPMATYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEGHYFGEVAKR
YRYVGTNIEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDDELLSVIQDVWMNRKDRYSDERT
EESAKNRPKIEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=336, Percent_Identity=39.5833333333333, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI22027536, Length=336, Percent_Identity=39.5833333333333, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1786999, Length=346, Percent_Identity=34.6820809248555, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32566329, Length=336, Percent_Identity=35.4166666666667, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=328, Percent_Identity=35.6707317073171, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=332, Percent_Identity=35.5421686746988, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28574488, Length=334, Percent_Identity=35.9281437125749, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=36.3057324840764, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38300; Mature: 38300

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAK
CHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCHHHHHHHHEEEHHHHHHHHH
LFVSIGVRKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKVLKEAGL
HHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEHHHHHHHHHHCCC
HRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGLDVKVNMVVKKGMNDHQVLPM
EEEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHH
ATYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEGHYFGEVAKR
HHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
YRYVGTNIEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDDEL
HHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHCCHHHH
LSVIQDVWMNRKDRYSDERTEESAKNRPKIEMSYIGG
HHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure
MQEMVTDFFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLKDEFLLTFDEIERVAK
CHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCHHHHHHHHEEEHHHHHHHHH
LFVSIGVRKIRLTGGEPLLRKDLAKLIARLVKIDGLLDIGLTTNAIHLTKQAKVLKEAGL
HHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEHHHHHHHHHHCCC
HRVNVSLDAIDDDVFKAINGRNINTKPVIKGIMAAKEAGLDVKVNMVVKKGMNDHQVLPM
EEEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHH
ATYFKEQGIPLRFIEFMDVGSTNGWNFDQVVTKRELIEMIHRVYPLEPAEGHYFGEVAKR
HHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
YRYVGTNIEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGLDIRELLRAKLSDDEL
HHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHCCHHHH
LSVIQDVWMNRKDRYSDERTEESAKNRPKIEMSYIGG
HHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA