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The map label for this gene is yvcT [H]

Identifier: 52140625

GI number: 52140625

Start: 4735161

End: 4736153

Strand: Direct

Name: yvcT [H]

Synonym: BCZK4635

Alternate gene names: 52140625

Gene position: 4735161-4736153 (Clockwise)

Preceding gene: 52140621

Following gene: 52140620

Centisome position: 89.33

GC content: 38.37

Gene sequence:

>993_bases
ATGCGTGATAAAGCGAAAGGGGATGGAACCGTGAAACCAAAAGTTTATATTGCTGAACCAGTTCCAACATTTGTAGAAAA
CTATTTATCAGAACACTGTGATTATGAAAAATGGGAGCAAAATGAGAAGGTACCTCGTGATGTTCTACTAGAGAAAATAC
AAGATAAAGATGGTTTATTAAATTTTGGATCTGCTATTAATGAAGAATTATTGGAGGCGGCTCCTAACTTAAAAGTAGTA
AGCAACATTTCTGTCGGTTACGATAATTTTGATTTACAAGCGATGGAAAAACGCAATGTCATCGGAACGAATACACCATA
CGTACTAGATGACACAGTAGCTGACCTCGTTTTCGCTCTTATGTTATCTGCTGGTCGTCGTGTTTGTGAACTCGACTCCT
ACGTAAAAAATGGTGAATGGAATGCCGAAATTGGAAAAGAACACTTTGGGCTAGATGTACATCATAGTACAATCGGCATT
ATCGGTATGGGCCGAATTGGAGAAGCTGTTGCAAAACGAGCGAAATTCGGATTTGATATGGATGTTCTTTATTATAACCG
TCGCCGAAAAGAAGAAGCTGAACAAAAATTCGACGCTACATATTGTGATTTACAGACACTACTTAAACAGTCTGACTTTA
TCGTTCTTCTTACTCCATTAACAGATGAAACGTATCACCTTATCGGAGAAAAGGAATTTTCATTCATGAAAGAAACAGCT
ATCTTCATTAATGCTTCTCGCGGGAAAACAGTCGATGAAGAAGCGTTAATCGATGCGTTAACTGAAAAGAAAATCTTTGC
AGCAGGCATCGATACGTTTACACAAGAGCCAATTCAAAAAGATAATCCGCTCTTATCCTTACAAAATGTTGTGACTTTAC
CACATATCGGATCTGCAACATTAAAAACTAGGCAGCAAATGGCTATGACCGCCGCTGAAAATTTAGTTGCAGGGTTACAA
GGAAAAACACCACCGAATATTGTTCGCGGGTAA

Upstream 100 bases:

>100_bases
GTTGATCTCCCACCTCACTTCTTTGTCTCAACCGTCTTTTTAGGTGGGAGTCTTACTGCTCGTTAAAGCGGGGTAAAGTG
AAACTTAATCAGTGGAAAAA

Downstream 100 bases:

>100_bases
TATGGAATAAACGAAAGGCAAGATGACATCGTCATCTTGCCTTTTTTTGTTAACATATTTTCTTTTCTCTTGGAGATGAT
ATGAACAAAAATCAATGGAG

Product: gluconate 2-dehydrogenase

Products: NA

Alternate protein names: 2KR [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLLNFGSAINEELLEAAPNLKVV
SNISVGYDNFDLQAMEKRNVIGTNTPYVLDDTVADLVFALMLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGI
IGMGRIGEAVAKRAKFGFDMDVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSATLKTRQQMAMTAAENLVAGLQ
GKTPPNIVRG

Sequences:

>Translated_330_residues
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLLNFGSAINEELLEAAPNLKVV
SNISVGYDNFDLQAMEKRNVIGTNTPYVLDDTVADLVFALMLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGI
IGMGRIGEAVAKRAKFGFDMDVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSATLKTRQQMAMTAAENLVAGLQ
GKTPPNIVRG
>Mature_330_residues
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLLNFGSAINEELLEAAPNLKVV
SNISVGYDNFDLQAMEKRNVIGTNTPYVLDDTVADLVFALMLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGI
IGMGRIGEAVAKRAKFGFDMDVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSATLKTRQQMAMTAAENLVAGLQ
GKTPPNIVRG

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=318, Percent_Identity=41.1949685534591, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=28.6206896551724, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI145580578, Length=266, Percent_Identity=30.4511278195489, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4557499, Length=266, Percent_Identity=30.4511278195489, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4557497, Length=268, Percent_Identity=29.8507462686567, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=29.3233082706767, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=30.4511278195489, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI87082289, Length=326, Percent_Identity=49.6932515337423, Blast_Score=321, Evalue=4e-89,
Organism=Escherichia coli, GI1789279, Length=273, Percent_Identity=31.5018315018315, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1787645, Length=263, Percent_Identity=29.277566539924, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI87081824, Length=236, Percent_Identity=25.4237288135593, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=281, Percent_Identity=31.3167259786477, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=270, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=254, Percent_Identity=35.4330708661417, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322116, Length=294, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320925, Length=287, Percent_Identity=28.9198606271777, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=28.0632411067194, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=171, Percent_Identity=30.4093567251462, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=279, Percent_Identity=27.9569892473118, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551003, Length=314, Percent_Identity=41.4012738853503, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24585514, Length=314, Percent_Identity=41.4012738853503, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI28574282, Length=314, Percent_Identity=41.4012738853503, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI28574284, Length=314, Percent_Identity=41.4012738853503, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI45552429, Length=314, Percent_Identity=41.4012738853503, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI28574286, Length=319, Percent_Identity=38.871473354232, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=37.9421221864952, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=34.9358974358974, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI19921140, Length=286, Percent_Identity=28.6713286713287, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=30.9963099630996, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=30.9963099630996, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=30.9963099630996, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=30.9963099630996, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=31.7164179104478, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.215 [H]

Molecular weight: Translated: 36939; Mature: 36939

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLL
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHCCCCCCC
NFGSAINEELLEAAPNLKVVSNISVGYDNFDLQAMEKRNVIGTNTPYVLDDTVADLVFAL
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
MLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGIIGMGRIGEAVAKRAKFGFDM
HHHCCCHHHHHHHHHHCCCCCCCCCHHHCCCEEECCEEEEEECCHHHHHHHHHHHCCCCC
DVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCHHHHHHHHEE
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSAT
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHEEECCCCCCHH
LKTRQQMAMTAAENLVAGLQGKTPPNIVRG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLL
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHCCCCCCC
NFGSAINEELLEAAPNLKVVSNISVGYDNFDLQAMEKRNVIGTNTPYVLDDTVADLVFAL
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
MLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGIIGMGRIGEAVAKRAKFGFDM
HHHCCCHHHHHHHHHHCCCCCCCCCHHHCCCEEECCEEEEEECCHHHHHHHHHHHCCCCC
DVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCHHHHHHHHEE
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSAT
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHEEECCCCCCHH
LKTRQQMAMTAAENLVAGLQGKTPPNIVRG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]