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The map label for this gene is patB [H]

Identifier: 52140619

GI number: 52140619

Start: 4737501

End: 4738652

Strand: Direct

Name: patB [H]

Synonym: BCZK4638

Alternate gene names: 52140619

Gene position: 4737501-4738652 (Clockwise)

Preceding gene: 52140620

Following gene: 52140616

Centisome position: 89.37

GC content: 37.85

Gene sequence:

>1152_bases
ATGCAACTATTTCATAAAACAGTCAATCGACGTGGAACTCATAGTATAAAATGGGATACATATAAAAACGAAGAACTTAT
CCATGCTTGGATTGCGGATATGGATTTTGAAGTACCACAACCAATTCAAACTGCTTTAAAGAAACGTATCGAGCATCCTA
TTTTCGGCTATACACTTCCTCCCGAAAATATTGGCGATATTATTTGTAACTGGACAAAAAAACAGTACAACTGGGATATT
CAAAAAGAATGGATTGTCTTTAGCGCCGGAATCGTTCCAGCCCTTAGTACGAGCATACAGGCCTTCACAAAGGAAAACGA
ATCCGTTCTCGTACAACCACCTATTTATCCCCCATTTTTCGAAATGGTCACAACAAATAACAGACAATTATGCGTAAGTC
CATTACAGAAACAAAATGATACATATGCGATAGACTTCGAGCATTTAGAAAAGCAATTTCAACAAGGCGTCAAACTCATG
CTTCTTTGCAGTCCTCACAATCCGATAGGGCGTGTTTGGATGAAAGAGGAACTAACAAAGCTTGGATCTTTATGTACCAA
ATATAATGTAATCGTTGTCGCAGATGAAATTCATTCCGATATTATTTACGCAGATCATACACACACACCGTTCGCTTCTT
TATCTGAAGAATTAGCCGCGCGCACGATTACTTGTATGGCTCCGAGTAAAACATTTAATATCGCGGGATTACAAGCATCG
ATTATTATCATTCCGAATGAAAAACTCCGTCAAGCCTTTACATCTATCCAATATAGACAAGGCTTCCACGGATTAAATAT
ATTCGCCTATACAGCGATGCAAAGTGCCTATACAGAATGTAACGATTGGCTAAATGAAATTCGATTCTATATAGAAGATA
ACGCTAAGTTCGCTTGTGAATATATTAAAGATCACATACCTACTCTTTCCGTAACGAAGCCAGAAGGTAGCTTTTTATTA
TGGATTGATTGTTCTGCCCTAAACCTTTCTCAAGACGAGCGCACTAAATTGCTTGAGGAAAAAGGGAAAATTATCGTTGA
ACCTGGTGAGAAATACGGATTAGGCGGAGAAGAACATATTCGAATTAACATCGGCTGTCCAAGATCTGTTTTAGAAGAAA
TTTTAAATAGACTGCGCCATACGTTTTCATAA

Upstream 100 bases:

>100_bases
ACTTTTTAATACTTTTCTTTATCCTATCACATCAGCTATTCTATAAGAAGAGAGAGAACTTTTATAACTTAACGGTTTTA
CAGAAGAAGGGGGCAAACTT

Downstream 100 bases:

>100_bases
TAAAAAGGAGGCTATTTGGGACAGCTTCCTTTGTCAAATTTTGTCGGTAAGTCGATATATTTTAAAAATCGCTGATATAT
TTCGAGTTACGGTCGATATA

Product: aminotransferase, classes I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MQLFHKTVNRRGTHSIKWDTYKNEELIHAWIADMDFEVPQPIQTALKKRIEHPIFGYTLPPENIGDIICNWTKKQYNWDI
QKEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPFFEMVTTNNRQLCVSPLQKQNDTYAIDFEHLEKQFQQGVKLM
LLCSPHNPIGRVWMKEELTKLGSLCTKYNVIVVADEIHSDIIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQAS
IIIIPNEKLRQAFTSIQYRQGFHGLNIFAYTAMQSAYTECNDWLNEIRFYIEDNAKFACEYIKDHIPTLSVTKPEGSFLL
WIDCSALNLSQDERTKLLEEKGKIIVEPGEKYGLGGEEHIRINIGCPRSVLEEILNRLRHTFS

Sequences:

>Translated_383_residues
MQLFHKTVNRRGTHSIKWDTYKNEELIHAWIADMDFEVPQPIQTALKKRIEHPIFGYTLPPENIGDIICNWTKKQYNWDI
QKEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPFFEMVTTNNRQLCVSPLQKQNDTYAIDFEHLEKQFQQGVKLM
LLCSPHNPIGRVWMKEELTKLGSLCTKYNVIVVADEIHSDIIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQAS
IIIIPNEKLRQAFTSIQYRQGFHGLNIFAYTAMQSAYTECNDWLNEIRFYIEDNAKFACEYIKDHIPTLSVTKPEGSFLL
WIDCSALNLSQDERTKLLEEKGKIIVEPGEKYGLGGEEHIRINIGCPRSVLEEILNRLRHTFS
>Mature_383_residues
MQLFHKTVNRRGTHSIKWDTYKNEELIHAWIADMDFEVPQPIQTALKKRIEHPIFGYTLPPENIGDIICNWTKKQYNWDI
QKEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPFFEMVTTNNRQLCVSPLQKQNDTYAIDFEHLEKQFQQGVKLM
LLCSPHNPIGRVWMKEELTKLGSLCTKYNVIVVADEIHSDIIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQAS
IIIIPNEKLRQAFTSIQYRQGFHGLNIFAYTAMQSAYTECNDWLNEIRFYIEDNAKFACEYIKDHIPTLSVTKPEGSFLL
WIDCSALNLSQDERTKLLEEKGKIIVEPGEKYGLGGEEHIRINIGCPRSVLEEILNRLRHTFS

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=187, Percent_Identity=28.8770053475936, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI56713254, Length=181, Percent_Identity=28.7292817679558, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI95147551, Length=261, Percent_Identity=24.904214559387, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI169881279, Length=261, Percent_Identity=24.904214559387, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI169881281, Length=235, Percent_Identity=25.1063829787234, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1787909, Length=387, Percent_Identity=31.5245478036176, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1788627, Length=357, Percent_Identity=24.9299719887955, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786816, Length=357, Percent_Identity=19.8879551820728, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17567663, Length=382, Percent_Identity=22.7748691099476, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17567369, Length=170, Percent_Identity=27.6470588235294, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=349, Percent_Identity=21.7765042979943, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=349, Percent_Identity=21.7765042979943, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=403, Percent_Identity=25.5583126550869, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28573069, Length=195, Percent_Identity=26.1538461538462, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646114, Length=195, Percent_Identity=26.1538461538462, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573067, Length=195, Percent_Identity=26.1538461538462, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573065, Length=195, Percent_Identity=26.1538461538462, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859735, Length=310, Percent_Identity=21.6129032258065, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44069; Mature: 44069

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLFHKTVNRRGTHSIKWDTYKNEELIHAWIADMDFEVPQPIQTALKKRIEHPIFGYTLP
CCHHHHHHCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECC
PENIGDIICNWTKKQYNWDIQKEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPFF
CCCCCHHEECCCCHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCHH
EMVTTNNRQLCVSPLQKQNDTYAIDFEHLEKQFQQGVKLMLLCSPHNPIGRVWMKEELTK
HHHCCCCCEEEECCHHCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHH
LGSLCTKYNVIVVADEIHSDIIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQAS
HHHHHHHCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHEEEEECCCCEEEEECEEEE
IIIIPNEKLRQAFTSIQYRQGFHGLNIFAYTAMQSAYTECNDWLNEIRFYIEDNAKFACE
EEEECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHEEEEECCCHHHHH
YIKDHIPTLSVTKPEGSFLLWIDCSALNLSQDERTKLLEEKGKIIVEPGEKYGLGGEEHI
HHHHCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCHHCCCCCCCEE
RINIGCPRSVLEEILNRLRHTFS
EEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLFHKTVNRRGTHSIKWDTYKNEELIHAWIADMDFEVPQPIQTALKKRIEHPIFGYTLP
CCHHHHHHCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECC
PENIGDIICNWTKKQYNWDIQKEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPFF
CCCCCHHEECCCCHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCHH
EMVTTNNRQLCVSPLQKQNDTYAIDFEHLEKQFQQGVKLMLLCSPHNPIGRVWMKEELTK
HHHCCCCCEEEECCHHCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHH
LGSLCTKYNVIVVADEIHSDIIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQAS
HHHHHHHCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHEEEEECCCCEEEEECEEEE
IIIIPNEKLRQAFTSIQYRQGFHGLNIFAYTAMQSAYTECNDWLNEIRFYIEDNAKFACE
EEEECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHEEEEECCCHHHHH
YIKDHIPTLSVTKPEGSFLLWIDCSALNLSQDERTKLLEEKGKIIVEPGEKYGLGGEEHI
HHHHCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCHHCCCCCCCEE
RINIGCPRSVLEEILNRLRHTFS
EEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]