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The map label for this gene is acaB [H]

Identifier: 52140525

GI number: 52140525

Start: 4822725

End: 4823897

Strand: Reverse

Name: acaB [H]

Synonym: BCZK4733

Alternate gene names: 52140525

Gene position: 4823897-4822725 (Counterclockwise)

Preceding gene: 52140524

Following gene: 52140527

Centisome position: 91.0

GC content: 43.22

Gene sequence:

>1173_bases
ATGAGAGAAGCTGTCATTGTTGCGGGAGCAAGAACACCAATTGGAAAAGCAAAGAGGGGTTCATTAAAAACAGTTCGTCC
TGACGATTTAGGGGCGTTAGTAGTAAAAGAAACGTTAAAGCGTGCGAATTATGAAGGACCAATCGATGATTTAATTTTCG
GTTGTGCGATGCCAGAAGCAGAGCAAGGTTTAAATATGGCTCGTAATATCGGCGGATTAGCAGGACTTTCTTACGATGTT
CCAGCTATTACAATTAACCGTTACTGTTCTTCAGGTTTACAAAGTATCGCTTACGGAGCAGAGCGCATTATGCTTGGTCA
CTCGGAAGCGGTATTATCAGGCGGAGCGGAATCAATGAGTTTAGTTCCGATGATGGGACACGTTGTTCGTCCAAATAGTC
GCCTTGTAGAAGCAGCTCCAGAATATTATATGGGTATGGGACATACAGCGGAGCAAGTTGCTGTGAAATATGGAATTTCT
CGTGAAGAGCAAGATGCATTTGCAGTAAGAAGTCATCAACGTGCTGCGAAAGCATTAGCTGCAGGAAACTTTGCTGATGA
AACAGTATCTGTAGATGTAACGTTACGTACTGTTGGAGCAAATAACAAACTGCAAGAAGAAACAATTACTTTTGCGCAAG
ACGAAGGTGTAAGAGCAGAGACGACGCTAGATATTTTAGGTAAATTACGTCCAGCATTTAACGTTCGCGGTTCTGTAACA
GCTGGTAACTCTTCACAAATGAGTGACGGCGCAGCATCTGTACTATTAATGGATCGTGAAAAAGCAGTGAGCGATGGCAT
GAGACCACTTGCGAAATTCCGTTCATTTGCAGTAGCTGGCGTACCACCAGAAGTGATGGGAATCGGCCCAATCGCTGCCA
TTCCAAAAGCGTTAAAATTAGCTGGTTTAGAGCTATCAGATATCGGTCTATTTGAACTAAATGAAGCATTCGCTTCTCAA
TCCATTCAAGTTATTCGTGAACTTGGATTAGATGAAGAAAAAGTAAACGTAAACGGCGGTGCAATCGCACTTGGACATCC
ACTTGGCTGTACAGGAGCAAAACTAACACTATCTCTTATTCACGAAATGAAACGCCGCAACGAACAATTCGGTATCGTAA
CAATGTGTATCGGCGGCGGAATGGGAGCAGCGGGAGTGTTTGAATTACTTTAA

Upstream 100 bases:

>100_bases
TATTAGCTTAGTCAGTGAGATGAAATCACAGGCAAGAATGCAGCACATGCTTGTAAAAGGAAAGCCATTACGTAACTAAT
AACGAGGGGAGATATCGTTC

Downstream 100 bases:

>100_bases
AAAGTGCAGGTGGCTCGTTTAGAACAGGAGGGCGTTGGAAGCCCTGACGAAGAGGCGCTTTTTGCCTCACAGGAAGGGGT
GAAACGACCGACTGTTCTAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MREAVIVAGARTPIGKAKRGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEAEQGLNMARNIGGLAGLSYDV
PAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMSLVPMMGHVVRPNSRLVEAAPEYYMGMGHTAEQVAVKYGIS
REEQDAFAVRSHQRAAKALAAGNFADETVSVDVTLRTVGANNKLQEETITFAQDEGVRAETTLDILGKLRPAFNVRGSVT
AGNSSQMSDGAASVLLMDREKAVSDGMRPLAKFRSFAVAGVPPEVMGIGPIAAIPKALKLAGLELSDIGLFELNEAFASQ
SIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLIHEMKRRNEQFGIVTMCIGGGMGAAGVFELL

Sequences:

>Translated_390_residues
MREAVIVAGARTPIGKAKRGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEAEQGLNMARNIGGLAGLSYDV
PAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMSLVPMMGHVVRPNSRLVEAAPEYYMGMGHTAEQVAVKYGIS
REEQDAFAVRSHQRAAKALAAGNFADETVSVDVTLRTVGANNKLQEETITFAQDEGVRAETTLDILGKLRPAFNVRGSVT
AGNSSQMSDGAASVLLMDREKAVSDGMRPLAKFRSFAVAGVPPEVMGIGPIAAIPKALKLAGLELSDIGLFELNEAFASQ
SIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLIHEMKRRNEQFGIVTMCIGGGMGAAGVFELL
>Mature_390_residues
MREAVIVAGARTPIGKAKRGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEAEQGLNMARNIGGLAGLSYDV
PAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMSLVPMMGHVVRPNSRLVEAAPEYYMGMGHTAEQVAVKYGIS
REEQDAFAVRSHQRAAKALAAGNFADETVSVDVTLRTVGANNKLQEETITFAQDEGVRAETTLDILGKLRPAFNVRGSVT
AGNSSQMSDGAASVLLMDREKAVSDGMRPLAKFRSFAVAGVPPEVMGIGPIAAIPKALKLAGLELSDIGLFELNEAFASQ
SIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLIHEMKRRNEQFGIVTMCIGGGMGAAGVFELL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=47.4358974358974, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=40.547263681592, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=40.7594936708861, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=33.5820895522388, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI4504327, Length=436, Percent_Identity=32.1100917431193, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=34.5268542199489, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI48994986, Length=394, Percent_Identity=46.4467005076142, Blast_Score=320, Evalue=7e-89,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=43.5960591133005, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=43.520782396088, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=40.64039408867, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=35.3221957040573, Blast_Score=215, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI133906874, Length=396, Percent_Identity=40.4040404040404, Blast_Score=276, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=32.0802005012531, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17535921, Length=397, Percent_Identity=34.2569269521411, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=441, Percent_Identity=30.8390022675737, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=28.6802030456853, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=39.7984886649874, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=34.4913151364764, Blast_Score=202, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=42.5742574257426, Blast_Score=297, Evalue=7e-81,
Organism=Drosophila melanogaster, GI17648125, Length=397, Percent_Identity=38.2871536523929, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24640423, Length=400, Percent_Identity=35, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=31.1778290993072, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41142; Mature: 41142

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVAGARTPIGKAKRGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEA
CCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCH
EQGLNMARNIGGLAGLSYDVPAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMS
HHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCHHHEEECCCHHHHCCCCCCEE
LVPMMGHVVRPNSRLVEAAPEYYMGMGHTAEQVAVKYGISREEQDAFAVRSHQRAAKALA
HHHHHHHEECCCCHHHHCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AGNFADETVSVDVTLRTVGANNKLQEETITFAQDEGVRAETTLDILGKLRPAFNVRGSVT
CCCCCCCEEEEEEEEEEECCCCCCHHHHHEEECCCCCCHHHHHHHHHHCCCCCCCCCEEE
AGNSSQMSDGAASVLLMDREKAVSDGMRPLAKFRSFAVAGVPPEVMGIGPIAAIPKALKL
CCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHEEECCCCHHHHCCCCHHHHHHHHHH
AGLELSDIGLFELNEAFASQSIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCHHHHHHHH
HEMKRRNEQFGIVTMCIGGGMGAAGVFELL
HHHHHCCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure
MREAVIVAGARTPIGKAKRGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEA
CCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCH
EQGLNMARNIGGLAGLSYDVPAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMS
HHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCHHHEEECCCHHHHCCCCCCEE
LVPMMGHVVRPNSRLVEAAPEYYMGMGHTAEQVAVKYGISREEQDAFAVRSHQRAAKALA
HHHHHHHEECCCCHHHHCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AGNFADETVSVDVTLRTVGANNKLQEETITFAQDEGVRAETTLDILGKLRPAFNVRGSVT
CCCCCCCEEEEEEEEEEECCCCCCHHHHHEEECCCCCCHHHHHHHHHHCCCCCCCCCEEE
AGNSSQMSDGAASVLLMDREKAVSDGMRPLAKFRSFAVAGVPPEVMGIGPIAAIPKALKL
CCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHEEECCCCHHHHCCCCHHHHHHHHHH
AGLELSDIGLFELNEAFASQSIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCHHHHHHHH
HEMKRRNEQFGIVTMCIGGGMGAAGVFELL
HHHHHCCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]