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The map label for this gene is tlpA [C]

Identifier: 52140489

GI number: 52140489

Start: 4860467

End: 4862158

Strand: Direct

Name: tlpA [C]

Synonym: BCZK4769

Alternate gene names: 52140489

Gene position: 4860467-4862158 (Clockwise)

Preceding gene: 52140490

Following gene: 52140487

Centisome position: 91.69

GC content: 36.41

Gene sequence:

>1692_bases
ATGAATTTTATTAGCATTCGAAAAAAACTAATGTTTATGATGGGAACGATTTGCGCTTTATTTGGCATCGCCTTAGCTTT
TATTTTATTTTTTACCATGGATCAATCTCGTCAAACTGAAGCATTACAAAAAGAAATCTCTCCTCTTGCAACACAATTAA
AAGAGCGCGGAGATGCTTATCAAGTACAGCTCTCTGCTTTAAGAGGTTATTTATTACAACATGATCAGGTCGAATTAGAC
AAATTTAACTCGATGAGTAAACTTCTTGAAGATAAGAAAGAGCAACTTCTTTCAAATCCTAACCTTTCTGAATCTGTAAA
AAATACAATGGAATCAGGATCCAATTGGAGAAAATTCATTGAAGAGAAAGTTTTCACTCTTGCAAAAGAACAAAAGTGGG
AAGAGGCACTACAAGTAGCTTATGCAGAAAATAATACTGTATATAAAGTAATTGGTGACTTCACAAATTACAGTAATGAA
CAGGCTAAATTACGTGATCAATCTATTAAAAAAATTGATCAATCTTCACTACAAATTGAATATGTTGTCTTCTTATCACT
TGTTATTTGCATTATCGTAGCTATCATTCTTGCATGGTGGTTCTCTGGTAAACTTGTAAAACCAATTCAACAAATTGATA
GTAAACTAAAAGAATTATCATCTCAAGAAGGTGACTTAACAGCCCGCCTACAAGTAAACAGTAATGATGAAATTGGTACG
ATCGCAACATCATTTAATAAAATGTTAGAAAACCTACAACATATCATTAACCGTGTTCAAAAAACATCTGTAGAAGTACA
AAACGCTTCTGAAAACATGCTAGAAAAGACGAATATATCACGCGAGGCAACGATAAGAGTTCAAAGCACAATGTCCAACT
TAAATGAGAGTATTCAATCGCAAGCCGCTAGCATGGAAGAAAGCTCAACTGCAATGGACGATATGGCAGTAAGTGTTCAG
CGCATTGCTGAATCTGCCACATCTGTAACTGAACTTGCTGTAGCTACATCTGAACAAGCTAACGACGGAAGTTCGGTTAT
TCAAAAATCCGTTTCACAAATGACAACGATACACGACGCTGTAAATGCTACGTCAGAAGTGGTCGAACGTCTAATCACTC
ACACGAAATATATTGATACAGCTGTACAATCTATTTCTAATATCGCGGAACAAACAAACTTACTTGCTTTAAATGCATCT
ATCGAAGCAGCTCGTGCTGGCGAACAAGGAAAAGGCTTCGCTGTCGTAGCTGACGAAGTTAGAAAACTTGCTGAACAATC
TAAAACTGCTGCAACAGATATTAACCAATTACTACATCAAATTCAACAAGACACTGAAACTGCGAGCTCTATGATGTCAC
AAGGGCGTTCTGAAGCATTTGAAGGCATTCATGTCATTCGTGAAGCTGGCAATTCTTTCACAACAATTGTGGAGCAAGTA
AATAAAGTATCTACTCAAATGCAAGACATCTCAGCAACTGCTGAAGAAATGGCTGCAAGTGCTGAAGAAATGAACGCTTC
ACTGAATAACATCGCTTCTATTTCGACTGAAGTATCTAGTGAAACAGCGGCAACAGCACAATCTGCTGAGCAAAAAGTCA
TTACGATGAATGAGATGACACAAACAGCTAAACAAATGAAACAAACAGTTGAAGAATTAGATCAACTCGTATCACACTTC
AAAACTGAATAG

Upstream 100 bases:

>100_bases
AAAGAAGAAAGCTTTGTTCCATCTGGAGTAAAGCTTTCTTTCAATTTTTTAAATTTATTAATTCTAATACTAAGATTTCA
CAAAGGAGGCTTTTTATCAT

Downstream 100 bases:

>100_bases
CCTTTAAAAAATATCCCTCTTCCAAAAGGGATATTTTTTTGAGCTCATTCCCTGCATATTATACACATTTCCGTTATAAT
GAGAATCGATATCATTAAAA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 563; Mature: 563

Protein sequence:

>563_residues
MNFISIRKKLMFMMGTICALFGIALAFILFFTMDQSRQTEALQKEISPLATQLKERGDAYQVQLSALRGYLLQHDQVELD
KFNSMSKLLEDKKEQLLSNPNLSESVKNTMESGSNWRKFIEEKVFTLAKEQKWEEALQVAYAENNTVYKVIGDFTNYSNE
QAKLRDQSIKKIDQSSLQIEYVVFLSLVICIIVAIILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGT
IATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIRVQSTMSNLNESIQSQAASMEESSTAMDDMAVSVQ
RIAESATSVTELAVATSEQANDGSSVIQKSVSQMTTIHDAVNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNAS
IEAARAGEQGKGFAVVADEVRKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQV
NKVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMTQTAKQMKQTVEELDQLVSHF
KTE

Sequences:

>Translated_563_residues
MNFISIRKKLMFMMGTICALFGIALAFILFFTMDQSRQTEALQKEISPLATQLKERGDAYQVQLSALRGYLLQHDQVELD
KFNSMSKLLEDKKEQLLSNPNLSESVKNTMESGSNWRKFIEEKVFTLAKEQKWEEALQVAYAENNTVYKVIGDFTNYSNE
QAKLRDQSIKKIDQSSLQIEYVVFLSLVICIIVAIILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGT
IATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIRVQSTMSNLNESIQSQAASMEESSTAMDDMAVSVQ
RIAESATSVTELAVATSEQANDGSSVIQKSVSQMTTIHDAVNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNAS
IEAARAGEQGKGFAVVADEVRKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQV
NKVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMTQTAKQMKQTVEELDQLVSHF
KTE
>Mature_563_residues
MNFISIRKKLMFMMGTICALFGIALAFILFFTMDQSRQTEALQKEISPLATQLKERGDAYQVQLSALRGYLLQHDQVELD
KFNSMSKLLEDKKEQLLSNPNLSESVKNTMESGSNWRKFIEEKVFTLAKEQKWEEALQVAYAENNTVYKVIGDFTNYSNE
QAKLRDQSIKKIDQSSLQIEYVVFLSLVICIIVAIILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGT
IATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIRVQSTMSNLNESIQSQAASMEESSTAMDDMAVSVQ
RIAESATSVTELAVATSEQANDGSSVIQKSVSQMTTIHDAVNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNAS
IEAARAGEQGKGFAVVADEVRKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQV
NKVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMTQTAKQMKQTVEELDQLVSHF
KTE

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=345, Percent_Identity=28.695652173913, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1787690, Length=584, Percent_Identity=23.458904109589, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788194, Length=360, Percent_Identity=30, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789453, Length=314, Percent_Identity=28.6624203821656, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788195, Length=299, Percent_Identity=28.4280936454849, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 62405; Mature: 62405

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFISIRKKLMFMMGTICALFGIALAFILFFTMDQSRQTEALQKEISPLATQLKERGDAY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
QVQLSALRGYLLQHDQVELDKFNSMSKLLEDKKEQLLSNPNLSESVKNTMESGSNWRKFI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHH
EEKVFTLAKEQKWEEALQVAYAENNTVYKVIGDFTNYSNEQAKLRDQSIKKIDQSSLQIE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YVVFLSLVICIIVAIILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
IATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIRVQSTMSNLNESIQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QAASMEESSTAMDDMAVSVQRIAESATSVTELAVATSEQANDGSSVIQKSVSQMTTIHDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNASIEAARAGEQGKGFAVVADEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHCCCCCCCEEHHHHHH
RKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHH
NKVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTAKQMKQTVEELDQLVSHFKTE
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFISIRKKLMFMMGTICALFGIALAFILFFTMDQSRQTEALQKEISPLATQLKERGDAY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
QVQLSALRGYLLQHDQVELDKFNSMSKLLEDKKEQLLSNPNLSESVKNTMESGSNWRKFI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHH
EEKVFTLAKEQKWEEALQVAYAENNTVYKVIGDFTNYSNEQAKLRDQSIKKIDQSSLQIE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YVVFLSLVICIIVAIILAWWFSGKLVKPIQQIDSKLKELSSQEGDLTARLQVNSNDEIGT
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
IATSFNKMLENLQHIINRVQKTSVEVQNASENMLEKTNISREATIRVQSTMSNLNESIQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QAASMEESSTAMDDMAVSVQRIAESATSVTELAVATSEQANDGSSVIQKSVSQMTTIHDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VNATSEVVERLITHTKYIDTAVQSISNIAEQTNLLALNASIEAARAGEQGKGFAVVADEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHCCCCCCCEEHHHHHH
RKLAEQSKTAATDINQLLHQIQQDTETASSMMSQGRSEAFEGIHVIREAGNSFTTIVEQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHH
NKVSTQMQDISATAEEMAASAEEMNASLNNIASISTEVSSETAATAQSAEQKVITMNEMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTAKQMKQTVEELDQLVSHFKTE
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA