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The map label for this gene is murA3

Identifier: 51894438

GI number: 51894438

Start: 3529286

End: 3530560

Strand: Reverse

Name: murA3

Synonym: STH3304

Alternate gene names: 51894438

Gene position: 3530560-3529286 (Counterclockwise)

Preceding gene: 51894439

Following gene: 51894437

Centisome position: 99.0

GC content: 70.43

Gene sequence:

>1275_bases
TTGACGACGTTGAGGATTCGCGGCGGCCGCCCGCTGCAGGGGACGATTCGGGTCGGCGGGCGGAAGAACGCCACGCTTCC
GTTGATCGCCGCCACACTGCTCGCGGATGGGACGAGCCGGCTGGAGAACGTTCCCCAGATTCACGACGTGATGGTGTACC
GGAAGCTGCTCACCGGACTGGGCGCCCGGGTCGACTGGGACCCGGTGCACGGCATCCTCACGGTACATACCGGCGGGGTC
CGTCCCGGCGAGCCGGACTACCACCTGGCGTCGTCGATCCGCGCGTCCTACTACCTGCTCGGGGTGATGCTCGCCCGCTA
CGGTGAGGCGAGCGTGCCCATGCCCGGCGGCGACAACATCGGCCACCGCCCGGTCGACCAGCACTTCAAAGGGTTGTCGG
CCCTGGGCGCGGAGATCTGGATGGACCGCGGGATCATCCGGGCCCGGGCCCGGCGGCTGCGGGGGGCGCACGTGTACCTG
GACATCATCAGCGTCGGCGCCACGATTCAGGTGATGCTGGCGGCGTCGCTCGCGGAGGGCACCACCGTCATCCAGAACTG
CGCCCGGGAGCCGCACGTGGTGGCGGTCGCCAACTTCATCAACGCCTGCGGCGGCAAGGTGACCGGCGCGGGGACCGACA
CGATCCGGGTCAGGGGCGTCGACCGGCTGGTCGGCGCGACCCAGACGGTCATCCCGGACGACATCGAGGCGGGCACCTGG
ATGATGGCGGCGGCGATGACGCAGGGCGACGTGACCCTGCAGAACGTGATTCCCACGCACATCACGCCGATCATGGCGAA
GCTCCGGGAGGCGGGGGTCGAGGTCCACGAGCTGGGCGACGCGGTGCGGGTGGTCGGCCGCGAGAGGCCGAAGGCCATCA
ACGTGAAGACCCTGCCGTACCCCGGCTTCCCGACGGACGCCCAGAGCCAGATGACGGCCCTGCTCTCCCTGGCCGAGGGG
ACGAGCTACATCACCGAGACGCTCTACGAGGACCGGTTCCGGTTCGTGCCGGAGCTGGTGCGCATGGGCGCGCAGATCCG
GGTGGAGGGGCGCACGGCCATCGTGAAGGGCGTGGAGCAGCTGTACGGGGCGCCCGTGGAGGCCACCGACATCCGGGCCG
GCGCCGCCCTGGTCATCGCCGGGCTGGCCGCGGAGGGCGAGACGACCATCTACGGCATGGAGCACGTGCAGCGCGGGTAC
GAGAAGCTGGAGCAGAAGCTGCTGGCCCTGGGCGCTGACGTGCAGATGGAGCGGCAGGGAGCGGCGGTGGTCTAG

Upstream 100 bases:

>100_bases
ACAACGGTCAGGTCTATTATGTAAACGCCTTCAACGGTGAACTCGAATCATGACTTGGGTGCCCCAGTAAGTGTGGCCAG
ACCGGCAAGGAGGAAACGCT

Downstream 100 bases:

>100_bases
CGGAACACTAGAGGCGGTGCCCGGGAGGGCACCGCCTCATGCGTGCACGGGAGGTGGCGGCTTGCGGATCCGGCTGGTGA
CGGTGGGCAAGGTGAAGGAG

Product: UDP-N-acetylglucosamine enolpyruvyl transferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 3; UDP-N-acetylglucosamine enolpyruvyl transferase 3; EPT 3

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTTLRIRGGRPLQGTIRVGGRKNATLPLIAATLLADGTSRLENVPQIHDVMVYRKLLTGLGARVDWDPVHGILTVHTGGV
RPGEPDYHLASSIRASYYLLGVMLARYGEASVPMPGGDNIGHRPVDQHFKGLSALGAEIWMDRGIIRARARRLRGAHVYL
DIISVGATIQVMLAASLAEGTTVIQNCAREPHVVAVANFINACGGKVTGAGTDTIRVRGVDRLVGATQTVIPDDIEAGTW
MMAAAMTQGDVTLQNVIPTHITPIMAKLREAGVEVHELGDAVRVVGRERPKAINVKTLPYPGFPTDAQSQMTALLSLAEG
TSYITETLYEDRFRFVPELVRMGAQIRVEGRTAIVKGVEQLYGAPVEATDIRAGAALVIAGLAAEGETTIYGMEHVQRGY
EKLEQKLLALGADVQMERQGAAVV

Sequences:

>Translated_424_residues
MTTLRIRGGRPLQGTIRVGGRKNATLPLIAATLLADGTSRLENVPQIHDVMVYRKLLTGLGARVDWDPVHGILTVHTGGV
RPGEPDYHLASSIRASYYLLGVMLARYGEASVPMPGGDNIGHRPVDQHFKGLSALGAEIWMDRGIIRARARRLRGAHVYL
DIISVGATIQVMLAASLAEGTTVIQNCAREPHVVAVANFINACGGKVTGAGTDTIRVRGVDRLVGATQTVIPDDIEAGTW
MMAAAMTQGDVTLQNVIPTHITPIMAKLREAGVEVHELGDAVRVVGRERPKAINVKTLPYPGFPTDAQSQMTALLSLAEG
TSYITETLYEDRFRFVPELVRMGAQIRVEGRTAIVKGVEQLYGAPVEATDIRAGAALVIAGLAAEGETTIYGMEHVQRGY
EKLEQKLLALGADVQMERQGAAVV
>Mature_423_residues
TTLRIRGGRPLQGTIRVGGRKNATLPLIAATLLADGTSRLENVPQIHDVMVYRKLLTGLGARVDWDPVHGILTVHTGGVR
PGEPDYHLASSIRASYYLLGVMLARYGEASVPMPGGDNIGHRPVDQHFKGLSALGAEIWMDRGIIRARARRLRGAHVYLD
IISVGATIQVMLAASLAEGTTVIQNCAREPHVVAVANFINACGGKVTGAGTDTIRVRGVDRLVGATQTVIPDDIEAGTWM
MAAAMTQGDVTLQNVIPTHITPIMAKLREAGVEVHELGDAVRVVGRERPKAINVKTLPYPGFPTDAQSQMTALLSLAEGT
SYITETLYEDRFRFVPELVRMGAQIRVEGRTAIVKGVEQLYGAPVEATDIRAGAALVIAGLAAEGETTIYGMEHVQRGYE
KLEQKLLALGADVQMERQGAAVV

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=418, Percent_Identity=46.88995215311, Blast_Score=373, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA3_SYMTH (Q67J65)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_077129.1
- ProteinModelPortal:   Q67J65
- SMR:   Q67J65
- GeneID:   2981478
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3304
- NMPDR:   fig|292459.1.peg.3172
- HOGENOM:   HBG482701
- OMA:   FKYVDEL
- BioCyc:   STHE292459:STH3304-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45498; Mature: 45367

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: ACT_SITE 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLRIRGGRPLQGTIRVGGRKNATLPLIAATLLADGTSRLENVPQIHDVMVYRKLLTGL
CCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHC
GARVDWDPVHGILTVHTGGVRPGEPDYHLASSIRASYYLLGVMLARYGEASVPMPGGDNI
CCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GHRPVDQHFKGLSALGAEIWMDRGIIRARARRLRGAHVYLDIISVGATIQVMLAASLAEG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCHHHHHHHHHHHHCC
TTVIQNCAREPHVVAVANFINACGGKVTGAGTDTIRVRGVDRLVGATQTVIPDDIEAGTW
HHHHHHHCCCCCEEHHHHHHHHCCCCEECCCCCEEEEECHHHHHCCCCCCCCCCCCCCCC
MMAAAMTQGDVTLQNVIPTHITPIMAKLREAGVEVHELGDAVRVVGRERPKAINVKTLPY
HHHHHHCCCCEEHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCC
PGFPTDAQSQMTALLSLAEGTSYITETLYEDRFRFVPELVRMGAQIRVEGRTAIVKGVEQ
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
LYGAPVEATDIRAGAALVIAGLAAEGETTIYGMEHVQRGYEKLEQKLLALGADVQMERQG
HHCCCCCHHHCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEECCCC
AAVV
CCCC
>Mature Secondary Structure 
TTLRIRGGRPLQGTIRVGGRKNATLPLIAATLLADGTSRLENVPQIHDVMVYRKLLTGL
CEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHC
GARVDWDPVHGILTVHTGGVRPGEPDYHLASSIRASYYLLGVMLARYGEASVPMPGGDNI
CCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GHRPVDQHFKGLSALGAEIWMDRGIIRARARRLRGAHVYLDIISVGATIQVMLAASLAEG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCHHHHHHHHHHHHCC
TTVIQNCAREPHVVAVANFINACGGKVTGAGTDTIRVRGVDRLVGATQTVIPDDIEAGTW
HHHHHHHCCCCCEEHHHHHHHHCCCCEECCCCCEEEEECHHHHHCCCCCCCCCCCCCCCC
MMAAAMTQGDVTLQNVIPTHITPIMAKLREAGVEVHELGDAVRVVGRERPKAINVKTLPY
HHHHHHCCCCEEHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCC
PGFPTDAQSQMTALLSLAEGTSYITETLYEDRFRFVPELVRMGAQIRVEGRTAIVKGVEQ
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
LYGAPVEATDIRAGAALVIAGLAAEGETTIYGMEHVQRGYEKLEQKLLALGADVQMERQG
HHCCCCCHHHCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEECCCC
AAVV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA