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The map label for this gene is speA [H]

Identifier: 51894403

GI number: 51894403

Start: 3488821

End: 3490287

Strand: Reverse

Name: speA [H]

Synonym: STH3269

Alternate gene names: 51894403

Gene position: 3490287-3488821 (Counterclockwise)

Preceding gene: 51894413

Following gene: 51894402

Centisome position: 97.87

GC content: 67.35

Gene sequence:

>1467_bases
GTGAATCAGCACGAGACTCCGCTGTTCACCGGGCTGGTGCGGCACGCCGAGCGCAATCCGATCCAGTTTCACATTCCCGG
CCACAAGAAGGGCACAGGGATGGCGCCGGAATTCCGCGCGTACATCGGCGAGCGCGCACTGGCCATTGACCTGATCAACA
TCGCGCCGCTCGACGACCTGCACAACCCCCACGGCATCATCCGGGAGGCGCAGGCCCTGGCCGCCGAGGCCTTCGGGGCG
GACCACTCCTTCTTCAGCGTCCAGGGCACCAGCGGAGCGATCATCGCGATGATCATGACCGTCTGCGGCCCCGGCGACAA
GATTCTGGTCCCCCGCAACGTGCACAAGTCGGTCCTCACCGGCATTGTGCTGTCGGGGGCCCTGCCCATATTCATGAACC
CCGACCTGGACTACGAGCTGGGCATCGCCCATGGGGTGAGCCTGGAGGCGGTGCGCCACGCCCTGGACCAGCACCCCGAC
GCCAAGGGCGTGCTGGTGATCAACCCGACCTATTACGGCGTGGCGGCGGACCTGAAGGGGATCGTCGAGCTGGCCCACTC
CCGCGGGGTGCCGGTCCTGGTGGACGAGGCCCACGGCGTCCACCTGTGCTTTCACGACGAGCTGCCGCTCTCGGCCATGC
AGGCCGGCGCGGACATGGCGGCCACCTCGGTGCACAAGCTGGGCGGTTCGCTGACGCAGACCAGCATCCTCAACGTGCGC
GAGGGGTTCATCAACCCCGGGCGGGTGCAGGCGATTCTGTCCATGCTGACGACCACTTCCACCTCGTACCTGCTGCTGGC
CTCGCTGGACGTCGCCCGCAAGCAACTGGCCACCCGGGGGCGGGAGCTGATCGACCGGGCGGTCCGCCTCGCCGAGCGCG
CCCGCCGGGAGATCGCGGAGATCCCCGGCCTGTACTGCCTCGGGCCCGACGTGGTCGGCCAGTCGTCGTCCCGCTTCGAC
CTCGACCCGACGAAGCTCTGCATCAACGTGAAGGAGCTGGGCGTGACCGGCGTGGAGGTCGAGGCGATCCTCCGGGAGGA
ATTTAACATTGAAGTGGAACTCTCGGACCTCTACAACATCCTGTGCATCATCTCGCTGGGCGACACGGCGGAGGACGTGG
ACGCGCTGGTGGCCGCGCTCGGGGAGATCTCCCGCCGCTTCTACCGGCAGCGCCCGGCCAACGTGGTGAAGGTCAAGGTG
CCTGTGACGCCTATCCTCGCCATGCATCCCCGCACCGCGTTCTACGCGGAGACCGAGGTGGTGCCGATCCGCGAGGCGGA
GGGCCGGGTGATCGCCGAGTCGATCATGGTGTATCCCCCCGGGATCCCCATCCTGCTGCCGGGGGAGATCGTGGCGGAGG
AGAACCTGGATTACCTGGAGGAGTGCATCCAGGCGGGGCTGCCGGTCCAGGGGACCGAGGACCCCGAGATCCGGATGGTA
AAGGTCGTGAAGGACGCTCACCGTTAA

Upstream 100 bases:

>100_bases
ACCTGCCACACTGGGAACCGCGCGGTTGTTTACAGACGGCGGAGTTCTGTTATACTGCGTTAAGATGCAATCGAACGCGC
CCCTGCAGGAGGTGAGGACC

Downstream 100 bases:

>100_bases
ACCTTACGCATGTCGACAGATGATCATAAAGCGCCGGGGACGGCCTGCGGGTCGTCCCCGGTTTGCGCGTCCTGACTGGC
TCGACAAGGAGGGCGGTAGG

Product: arginine/lysine/ornithine decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNQHETPLFTGLVRHAERNPIQFHIPGHKKGTGMAPEFRAYIGERALAIDLINIAPLDDLHNPHGIIREAQALAAEAFGA
DHSFFSVQGTSGAIIAMIMTVCGPGDKILVPRNVHKSVLTGIVLSGALPIFMNPDLDYELGIAHGVSLEAVRHALDQHPD
AKGVLVINPTYYGVAADLKGIVELAHSRGVPVLVDEAHGVHLCFHDELPLSAMQAGADMAATSVHKLGGSLTQTSILNVR
EGFINPGRVQAILSMLTTTSTSYLLLASLDVARKQLATRGRELIDRAVRLAERARREIAEIPGLYCLGPDVVGQSSSRFD
LDPTKLCINVKELGVTGVEVEAILREEFNIEVELSDLYNILCIISLGDTAEDVDALVAALGEISRRFYRQRPANVVKVKV
PVTPILAMHPRTAFYAETEVVPIREAEGRVIAESIMVYPPGIPILLPGEIVAEENLDYLEECIQAGLPVQGTEDPEIRMV
KVVKDAHR

Sequences:

>Translated_488_residues
MNQHETPLFTGLVRHAERNPIQFHIPGHKKGTGMAPEFRAYIGERALAIDLINIAPLDDLHNPHGIIREAQALAAEAFGA
DHSFFSVQGTSGAIIAMIMTVCGPGDKILVPRNVHKSVLTGIVLSGALPIFMNPDLDYELGIAHGVSLEAVRHALDQHPD
AKGVLVINPTYYGVAADLKGIVELAHSRGVPVLVDEAHGVHLCFHDELPLSAMQAGADMAATSVHKLGGSLTQTSILNVR
EGFINPGRVQAILSMLTTTSTSYLLLASLDVARKQLATRGRELIDRAVRLAERARREIAEIPGLYCLGPDVVGQSSSRFD
LDPTKLCINVKELGVTGVEVEAILREEFNIEVELSDLYNILCIISLGDTAEDVDALVAALGEISRRFYRQRPANVVKVKV
PVTPILAMHPRTAFYAETEVVPIREAEGRVIAESIMVYPPGIPILLPGEIVAEENLDYLEECIQAGLPVQGTEDPEIRMV
KVVKDAHR
>Mature_488_residues
MNQHETPLFTGLVRHAERNPIQFHIPGHKKGTGMAPEFRAYIGERALAIDLINIAPLDDLHNPHGIIREAQALAAEAFGA
DHSFFSVQGTSGAIIAMIMTVCGPGDKILVPRNVHKSVLTGIVLSGALPIFMNPDLDYELGIAHGVSLEAVRHALDQHPD
AKGVLVINPTYYGVAADLKGIVELAHSRGVPVLVDEAHGVHLCFHDELPLSAMQAGADMAATSVHKLGGSLTQTSILNVR
EGFINPGRVQAILSMLTTTSTSYLLLASLDVARKQLATRGRELIDRAVRLAERARREIAEIPGLYCLGPDVVGQSSSRFD
LDPTKLCINVKELGVTGVEVEAILREEFNIEVELSDLYNILCIISLGDTAEDVDALVAALGEISRRFYRQRPANVVKVKV
PVTPILAMHPRTAFYAETEVVPIREAEGRVIAESIMVYPPGIPILLPGEIVAEENLDYLEECIQAGLPVQGTEDPEIRMV
KVVKDAHR

Specific function: Catalyzes the formation of agmatine from arginine [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=568, Percent_Identity=25.5281690140845, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786384, Length=569, Percent_Identity=25.3075571177504, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI221142684, Length=372, Percent_Identity=28.7634408602151, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082193, Length=567, Percent_Identity=24.6913580246914, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786909, Length=610, Percent_Identity=23.6065573770492, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 52936; Mature: 52936

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQHETPLFTGLVRHAERNPIQFHIPGHKKGTGMAPEFRAYIGERALAIDLINIAPLDDL
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHCCCEEEEEEEECCCCHHC
HNPHGIIREAQALAAEAFGADHSFFSVQGTSGAIIAMIMTVCGPGDKILVPRNVHKSVLT
CCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCHHHHHHH
GIVLSGALPIFMNPDLDYELGIAHGVSLEAVRHALDQHPDAKGVLVINPTYYGVAADLKG
HHHHHCCCCEEECCCCCEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
IVELAHSRGVPVLVDEAHGVHLCFHDELPLSAMQAGADMAATSVHKLGGSLTQTSILNVR
HHHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHH
EGFINPGRVQAILSMLTTTSTSYLLLASLDVARKQLATRGRELIDRAVRLAERARREIAE
HCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPGLYCLGPDVVGQSSSRFDLDPTKLCINVKELGVTGVEVEAILREEFNIEVELSDLYNI
CCCEEEECCHHCCCCCCCCCCCHHHEEEEHHHHCCCCHHHHHHHHHHCCEEEEHHHHEEE
LCIISLGDTAEDVDALVAALGEISRRFYRQRPANVVKVKVPVTPILAMHPRTAFYAETEV
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCEEEECCCE
VPIREAEGRVIAESIMVYPPGIPILLPGEIVAEENLDYLEECIQAGLPVQGTEDPEIRMV
EEEECCCCCEEEEEEEEECCCCCEEECCHHEECCCHHHHHHHHHCCCCCCCCCCCCCEEE
KVVKDAHR
EEHHHCCC
>Mature Secondary Structure
MNQHETPLFTGLVRHAERNPIQFHIPGHKKGTGMAPEFRAYIGERALAIDLINIAPLDDL
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHCCCEEEEEEEECCCCHHC
HNPHGIIREAQALAAEAFGADHSFFSVQGTSGAIIAMIMTVCGPGDKILVPRNVHKSVLT
CCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCHHHHHHH
GIVLSGALPIFMNPDLDYELGIAHGVSLEAVRHALDQHPDAKGVLVINPTYYGVAADLKG
HHHHHCCCCEEECCCCCEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
IVELAHSRGVPVLVDEAHGVHLCFHDELPLSAMQAGADMAATSVHKLGGSLTQTSILNVR
HHHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHH
EGFINPGRVQAILSMLTTTSTSYLLLASLDVARKQLATRGRELIDRAVRLAERARREIAE
HCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPGLYCLGPDVVGQSSSRFDLDPTKLCINVKELGVTGVEVEAILREEFNIEVELSDLYNI
CCCEEEECCHHCCCCCCCCCCCHHHEEEEHHHHCCCCHHHHHHHHHHCCEEEEHHHHEEE
LCIISLGDTAEDVDALVAALGEISRRFYRQRPANVVKVKVPVTPILAMHPRTAFYAETEV
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCEEEECCCE
VPIREAEGRVIAESIMVYPPGIPILLPGEIVAEENLDYLEECIQAGLPVQGTEDPEIRMV
EEEECCCCCEEEEEEEEECCCCCEEECCHHEECCCHHHHHHHHHCCCCCCCCCCCCCEEE
KVVKDAHR
EEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969500; 9384377; 1697575; 1936936 [H]