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The map label for this gene is degS [H]

Identifier: 51894356

GI number: 51894356

Start: 3435429

End: 3436862

Strand: Reverse

Name: degS [H]

Synonym: STH3221

Alternate gene names: 51894356

Gene position: 3436862-3435429 (Counterclockwise)

Preceding gene: 51894357

Following gene: 51894355

Centisome position: 96.37

GC content: 71.27

Gene sequence:

>1434_bases
ATGCGGCGGCAGGAGGCGTCAGGCCGGCCGAGGCTGCGCGTTTTCGGCATCCGGGCCAAGCTGATCTCCGTGCTTCTGGC
GCTCACCATTGCGCTGGGGCTTGTCTCCATTCTCCAGCTGCAGGCGACCCTGCCCCGGACGTTGCGGGAGGAGCTGGACA
AGCGGGCGCTCTCCATCGCCCGCAACGTCGCCCTGCGGGTGACCGACCCGCTCCTGACGGCCAATCCGTTGGAGGTACGG
GAGATCCTGGCCGACGTGCAGGCCACCAACCCCGACGTCCGGTACGCGTTCGTGCTGGACAGCCGGGGGCGGCTGGTGGC
CCACACGTTTGCCGGGGGCTTTCCCCGGGATCTGCTGACCCAGCGCCCGGCCGCTCCTGACCGGACCGAGGACGTGCAGT
GGCTCCTCTCGGAGGAAGGGGTGATCCACGACGCGACCGCCCTGATCGTGGACGGACTGGCCGGGCACGTGCGGGTCGGG
CTGTCCGAGGCGCATCTGATGGCGATGCTCCGGGACATGCGGCGCCGGCAGATGCTGACGCTGGCGCTGGCCTGCGTGCT
GGCGGTCCTGCTCGGCTACCTGGGCATCTGGAAGGTGACCGTCCGGGTGCCGCAGCTGGTCCGCGCCGCCCAGGCGGTGG
GCCGGGGCGACCTGACCGTGCGGGTGCGGCCCGGCCCGGCCGACGAGTTCGGGCACCTGGCAGAGGCCTTTAACCAGATG
GTTCGGGACCTGGCCCGCACCCGCGCCCTGGTGGTCCGGAAGGAGGCCGCCCGCAAGGCCTTGCTGCAGAAGGTGCTCAC
GGCACAGGAGGAGGAGCGGGCGCGGATCTCCCGGGAACTGCACGACGAGGTCGGCCAGGCGCTGACCGGCCTGATCGTCG
GTCTGCGGGTCCTGGAAGAGGGGGATGCGGAGCGCCAGAGTCAGGTGACGTACCTGCGCGACCTGGCCGCCGGCACGCTG
GAGTCGGTGCGGCGGCTCTCCCGCGACCTGCGCCCGGCGGTGCTGGACGACATCGGGCTCGTCGCGGCGATCCGGCGCTA
TGCCGGCGACTTCGCCCGCTACCACGGCATCGAGGGGACGGTCCAGGTGGTGGGCGATGAGTCCGTCCGCCTCCCTCCGG
TGGTGGAGACAACGCTCTACCGGATCACGCAGGAGGCGCTCACCAACGTGGCCCGCCACAGCCAGGCCCGCCACTTCGGC
ATCGTGCTGGACCTGCGCGGGCCGGACGTGCGGCTGGTGATCGAGGACGACGGCCGGGGGTTCGATCCGGGCGCGCCCCG
GGAGGGAACCGGCCTGACCGGGATCAGCGAGCGGCTGGCGCTGGTGAGTGGCCGCATGACCATCGAATCCAGTCCGGAAA
GCGGCACCACCCTGTTTATCGCGGTCCCGCGCGAGAAGGAGGACGAGTCGGATGCGCATCTTGATCGCCGATGA

Upstream 100 bases:

>100_bases
TGCTGCAGAGCTTGCGCCTGGACCGTTTCGTCGCTCCGGATCCCGCCTGGTACGAACCGATCAGGCTCATGCTGGAAGAG
GTGGAGGCGAGCAAGTGAGG

Downstream 100 bases:

>100_bases
TCATCGGGTCGTCAGGACGGGGCTGCGGATGCTGCTGGAGAGCCATCCCGACTTCGAAGTGGTCGGGGAGGCGTCCAGCG
GGCCGGAGACGGTGCAGAAG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MRRQEASGRPRLRVFGIRAKLISVLLALTIALGLVSILQLQATLPRTLREELDKRALSIARNVALRVTDPLLTANPLEVR
EILADVQATNPDVRYAFVLDSRGRLVAHTFAGGFPRDLLTQRPAAPDRTEDVQWLLSEEGVIHDATALIVDGLAGHVRVG
LSEAHLMAMLRDMRRRQMLTLALACVLAVLLGYLGIWKVTVRVPQLVRAAQAVGRGDLTVRVRPGPADEFGHLAEAFNQM
VRDLARTRALVVRKEAARKALLQKVLTAQEEERARISRELHDEVGQALTGLIVGLRVLEEGDAERQSQVTYLRDLAAGTL
ESVRRLSRDLRPAVLDDIGLVAAIRRYAGDFARYHGIEGTVQVVGDESVRLPPVVETTLYRITQEALTNVARHSQARHFG
IVLDLRGPDVRLVIEDDGRGFDPGAPREGTGLTGISERLALVSGRMTIESSPESGTTLFIAVPREKEDESDAHLDRR

Sequences:

>Translated_477_residues
MRRQEASGRPRLRVFGIRAKLISVLLALTIALGLVSILQLQATLPRTLREELDKRALSIARNVALRVTDPLLTANPLEVR
EILADVQATNPDVRYAFVLDSRGRLVAHTFAGGFPRDLLTQRPAAPDRTEDVQWLLSEEGVIHDATALIVDGLAGHVRVG
LSEAHLMAMLRDMRRRQMLTLALACVLAVLLGYLGIWKVTVRVPQLVRAAQAVGRGDLTVRVRPGPADEFGHLAEAFNQM
VRDLARTRALVVRKEAARKALLQKVLTAQEEERARISRELHDEVGQALTGLIVGLRVLEEGDAERQSQVTYLRDLAAGTL
ESVRRLSRDLRPAVLDDIGLVAAIRRYAGDFARYHGIEGTVQVVGDESVRLPPVVETTLYRITQEALTNVARHSQARHFG
IVLDLRGPDVRLVIEDDGRGFDPGAPREGTGLTGISERLALVSGRMTIESSPESGTTLFIAVPREKEDESDAHLDRR
>Mature_477_residues
MRRQEASGRPRLRVFGIRAKLISVLLALTIALGLVSILQLQATLPRTLREELDKRALSIARNVALRVTDPLLTANPLEVR
EILADVQATNPDVRYAFVLDSRGRLVAHTFAGGFPRDLLTQRPAAPDRTEDVQWLLSEEGVIHDATALIVDGLAGHVRVG
LSEAHLMAMLRDMRRRQMLTLALACVLAVLLGYLGIWKVTVRVPQLVRAAQAVGRGDLTVRVRPGPADEFGHLAEAFNQM
VRDLARTRALVVRKEAARKALLQKVLTAQEEERARISRELHDEVGQALTGLIVGLRVLEEGDAERQSQVTYLRDLAAGTL
ESVRRLSRDLRPAVLDDIGLVAAIRRYAGDFARYHGIEGTVQVVGDESVRLPPVVETTLYRITQEALTNVARHSQARHFG
IVLDLRGPDVRLVIEDDGRGFDPGAPREGTGLTGISERLALVSGRMTIESSPESGTTLFIAVPREKEDESDAHLDRR

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=235, Percent_Identity=33.6170212765957, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52593; Mature: 52593

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRQEASGRPRLRVFGIRAKLISVLLALTIALGLVSILQLQATLPRTLREELDKRALSIA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RNVALRVTDPLLTANPLEVREILADVQATNPDVRYAFVLDSRGRLVAHTFAGGFPRDLLT
HHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHH
QRPAAPDRTEDVQWLLSEEGVIHDATALIVDGLAGHVRVGLSEAHLMAMLRDMRRRQMLT
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCHHHEECHHHHHHHHHHHHHHHHHHHH
LALACVLAVLLGYLGIWKVTVRVPQLVRAAQAVGRGDLTVRVRPGPADEFGHLAEAFNQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHH
VRDLARTRALVVRKEAARKALLQKVLTAQEEERARISRELHDEVGQALTGLIVGLRVLEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDAERQSQVTYLRDLAAGTLESVRRLSRDLRPAVLDDIGLVAAIRRYAGDFARYHGIEGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VQVVGDESVRLPPVVETTLYRITQEALTNVARHSQARHFGIVLDLRGPDVRLVIEDDGRG
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCC
FDPGAPREGTGLTGISERLALVSGRMTIESSPESGTTLFIAVPREKEDESDAHLDRR
CCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRQEASGRPRLRVFGIRAKLISVLLALTIALGLVSILQLQATLPRTLREELDKRALSIA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RNVALRVTDPLLTANPLEVREILADVQATNPDVRYAFVLDSRGRLVAHTFAGGFPRDLLT
HHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHH
QRPAAPDRTEDVQWLLSEEGVIHDATALIVDGLAGHVRVGLSEAHLMAMLRDMRRRQMLT
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCHHHEECHHHHHHHHHHHHHHHHHHHH
LALACVLAVLLGYLGIWKVTVRVPQLVRAAQAVGRGDLTVRVRPGPADEFGHLAEAFNQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHH
VRDLARTRALVVRKEAARKALLQKVLTAQEEERARISRELHDEVGQALTGLIVGLRVLEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDAERQSQVTYLRDLAAGTLESVRRLSRDLRPAVLDDIGLVAAIRRYAGDFARYHGIEGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VQVVGDESVRLPPVVETTLYRITQEALTNVARHSQARHFGIVLDLRGPDVRLVIEDDGRG
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEECCCCC
FDPGAPREGTGLTGISERLALVSGRMTIESSPESGTTLFIAVPREKEDESDAHLDRR
CCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]