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The map label for this gene is disA

Identifier: 51894262

GI number: 51894262

Start: 3326336

End: 3327391

Strand: Reverse

Name: disA

Synonym: STH3127

Alternate gene names: 51894262

Gene position: 3327391-3326336 (Counterclockwise)

Preceding gene: 51894263

Following gene: 51894260

Centisome position: 93.31

GC content: 70.45

Gene sequence:

>1056_bases
ATGGAGGACCGAAGCGGCTTCTGGCAGGTGCTGCAGCAACTCGCCCCCGGCACCGCGCTGCGGGAGGGGCTGGAGTCCAT
CCTGCTGGCCAGGACCGGGTCGCTGATCGTCGTCGGCGACTCCCCGGAGGTCCTGGCGCTCGTGGACGGGGGTTTCCGCC
TGGACTGCGAGTTCACGCCCACGCGGCTGTACGAGCTGGCCAAGATGGACGGGGCGATCATCCTCACCCGGGACGCCCAG
CGCATCCTCTATGCGAACGCCATGCTGGTGCCCGACCCGTCGATCCCCACCAGCGAGACGGGCACCCGCCACCGCACGGC
GGAGCGGGTGGCCCGACAGACCGGCGAGTTGGTGATCTCCATCTCCCAGCGCCGGGACCTGATCACGCTGTACAAGGGCC
CGATGAAGTACATCCTGCGGGACTTCGCCGTGGTCCTGACCAAGGCCAACCAGGCCCTGCAGACCCTGGAGAAGTACAAG
CTGGTCCGGGACCAGGCGGTGGCCCGCCTCTCCGCGCTGGAGCTGGACGACATGGTCAGCGCGCTGGATGTGGCGCTGGT
GGTGCAGCGCACCGAGATGTTGCTGCGCATCGGGAAGGAGATCGAGCGGTACATCGTCGAGCTGGGCACGGAGGGCCGGC
TGGTGGCGATGCAGCTGGAGGAGCTGCTGGCCGGCGTGGCGGCGGAGGGGCTGCTCATCATCCGCGACTACGCCAGCACC
GATGACCCTCAGCACGCGGCGGCGCTTCGGCAGCAGATGGCCGAGTGGACGTACGAGGAGCTGCAGGACCTGGCAGCCGT
CGCCCGGCTGCTGGGCGCCGGCGCGCTGGACAGCCCCCTGGGTGCCCGGGGCTACCGCATGCTCCGGCGCATCCCCCGGC
TGCCCGCCGCTGTCATTGAGAACTTGGTGGCCCGGTTTGGCCGGCTGCAGCGCGTGCTCGCCGCCTCGCTGGAGGAGCTG
GACGACGTGGAGGGCATCGGCGAGGTGCGGGCGCGGGCGATCCAGGAGGGGCTGCGCCGGATGCGGATGCAGTTCGCCCT
GGAGCGGCAGCTGTAG

Upstream 100 bases:

>100_bases
CTAAGCATGAAGACCGACGTGGAACTGGTCGGCGTGGAGACGGTGATGGAAGGACTCGAGGCGGCCCTCGGCCGCTGAGC
CGCGCGCAGGGGGTGCGGGG

Downstream 100 bases:

>100_bases
CGCCAACGAAAAAAGCCCGAGCAGCCTGGCTCGGGCCATTTTCCTGTGTCTTGCCTGCCGGGTCAGTCCGCGAAGTTGTA
CAGTCCCAGGGCGCTCAGCT

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MEDRSGFWQVLQQLAPGTALREGLESILLARTGSLIVVGDSPEVLALVDGGFRLDCEFTPTRLYELAKMDGAIILTRDAQ
RILYANAMLVPDPSIPTSETGTRHRTAERVARQTGELVISISQRRDLITLYKGPMKYILRDFAVVLTKANQALQTLEKYK
LVRDQAVARLSALELDDMVSALDVALVVQRTEMLLRIGKEIERYIVELGTEGRLVAMQLEELLAGVAAEGLLIIRDYAST
DDPQHAAALRQQMAEWTYEELQDLAAVARLLGAGALDSPLGARGYRMLRRIPRLPAAVIENLVARFGRLQRVLAASLEEL
DDVEGIGEVRARAIQEGLRRMRMQFALERQL

Sequences:

>Translated_351_residues
MEDRSGFWQVLQQLAPGTALREGLESILLARTGSLIVVGDSPEVLALVDGGFRLDCEFTPTRLYELAKMDGAIILTRDAQ
RILYANAMLVPDPSIPTSETGTRHRTAERVARQTGELVISISQRRDLITLYKGPMKYILRDFAVVLTKANQALQTLEKYK
LVRDQAVARLSALELDDMVSALDVALVVQRTEMLLRIGKEIERYIVELGTEGRLVAMQLEELLAGVAAEGLLIIRDYAST
DDPQHAAALRQQMAEWTYEELQDLAAVARLLGAGALDSPLGARGYRMLRRIPRLPAAVIENLVARFGRLQRVLAASLEEL
DDVEGIGEVRARAIQEGLRRMRMQFALERQL
>Mature_351_residues
MEDRSGFWQVLQQLAPGTALREGLESILLARTGSLIVVGDSPEVLALVDGGFRLDCEFTPTRLYELAKMDGAIILTRDAQ
RILYANAMLVPDPSIPTSETGTRHRTAERVARQTGELVISISQRRDLITLYKGPMKYILRDFAVVLTKANQALQTLEKYK
LVRDQAVARLSALELDDMVSALDVALVVQRTEMLLRIGKEIERYIVELGTEGRLVAMQLEELLAGVAAEGLLIIRDYAST
DDPQHAAALRQQMAEWTYEELQDLAAVARLLGAGALDSPLGARGYRMLRRIPRLPAAVIENLVARFGRLQRVLAASLEEL
DDVEGIGEVRARAIQEGLRRMRMQFALERQL

Specific function: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DISA_SYMTH (Q67JP1)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076953.1
- HSSP:   Q9YC15
- ProteinModelPortal:   Q67JP1
- SMR:   Q67JP1
- GeneID:   2980145
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3127
- NMPDR:   fig|292459.1.peg.2998
- HOGENOM:   HBG292471
- OMA:   ISVSQSM
- ProtClustDB:   PRK13482
- BioCyc:   STHE292459:STH3127-MONOMER
- HAMAP:   MF_01438
- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- SMART:   SM00278

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; PF00633 HHH; SSF47781 RuvA_2_like

EC number: NA

Molecular weight: Translated: 39075; Mature: 39075

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDRSGFWQVLQQLAPGTALREGLESILLARTGSLIVVGDSPEVLALVDGGFRLDCEFTP
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCEEEEECCCH
TRLYELAKMDGAIILTRDAQRILYANAMLVPDPSIPTSETGTRHRTAERVARQTGELVIS
HHHHHHHHCCCCEEEECCHHHHHHHCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEE
ISQRRDLITLYKGPMKYILRDFAVVLTKANQALQTLEKYKLVRDQAVARLSALELDDMVS
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDVALVVQRTEMLLRIGKEIERYIVELGTEGRLVAMQLEELLAGVAAEGLLIIRDYAST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCC
DDPQHAAALRQQMAEWTYEELQDLAAVARLLGAGALDSPLGARGYRMLRRIPRLPAAVIE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
NLVARFGRLQRVLAASLEELDDVEGIGEVRARAIQEGLRRMRMQFALERQL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEDRSGFWQVLQQLAPGTALREGLESILLARTGSLIVVGDSPEVLALVDGGFRLDCEFTP
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCEEEEECCCH
TRLYELAKMDGAIILTRDAQRILYANAMLVPDPSIPTSETGTRHRTAERVARQTGELVIS
HHHHHHHHCCCCEEEECCHHHHHHHCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEE
ISQRRDLITLYKGPMKYILRDFAVVLTKANQALQTLEKYKLVRDQAVARLSALELDDMVS
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDVALVVQRTEMLLRIGKEIERYIVELGTEGRLVAMQLEELLAGVAAEGLLIIRDYAST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCC
DDPQHAAALRQQMAEWTYEELQDLAAVARLLGAGALDSPLGARGYRMLRRIPRLPAAVIE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
NLVARFGRLQRVLAASLEELDDVEGIGEVRARAIQEGLRRMRMQFALERQL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA