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The map label for this gene is alr

Identifier: 51894072

GI number: 51894072

Start: 3160886

End: 3162019

Strand: Reverse

Name: alr

Synonym: STH2936

Alternate gene names: 51894072

Gene position: 3162019-3160886 (Counterclockwise)

Preceding gene: 51894073

Following gene: 51894071

Centisome position: 88.67

GC content: 72.66

Gene sequence:

>1134_bases
ATGGATCTGGACGGCATGCGCCCGACGTGGGCGGAGGTCGATCTGAACGCGGTCCGGGCGAACATCCGGGCGTTGAAGCG
GATCTCGAAGGCTCCTCGACTGATGGCGGTGGTGAAGGCGAATGGCTACGGGCACGGCGCCGTGCCCGTGGCGACGGCGG
CCATCGAGGCCGGGGCGGACTGGCTGGGCGTCGCGTCGGTGGAGGAGGGCGTGACCCTGCGTCGCCACGGCATCTCCGCG
CCCATCCTGGTGCTGGGTTACGTGTCCCCCGGCCAGGCCGAGGCCGTGCTGACGGAGGGGCTGCGGGTAGCCCTCTTCGA
CGGCGAACTGGGGCAGGCCCTGAACCGGGAGGGGCGCAGGCTGGGCCGCTGGGCCCGCGTCCACCTGAAGGTGGACACCG
GCATGGGGCGCATCGGCCTGCAGCCCGCCGAGGTGGGCCGCCTCGGCCGCGAACTGGCCAGGCTGGACCATGTGGAGGTG
GAGGGGGTCTTCACCCACCTGGCGACCGCCGATGAGCCGGGGAACCCGTACACCCGTCTGCAGCTGGAGCGGTACGAGGC
GGCCCTGGCGGAGCTGGCGGCGGCGGGTGTCCGGCCCGCCATCCGGCACGCCGCCAACAGCGCGGGGCTCATGCTCCACC
CGGAGGCGCACTACGACATGGTGCGCAGCGGCATCGCGGTGGTGGGGCTGCCCCCGGCGCCGGGCGTGGCGTGGCCCGTG
AAGCTCGCCCCCGCCCTCACCTGGAAGACCCGGGTGGGGCTGGTGAAGTGGCTGGAGGCCGGCCACTCGATCTCCTACGG
CTGCACCTACACGACCGCCCGCCGCGAGCAGATCGCAACCTTGCCGGTGGGCTACGCGGACGGCTACCCCCGGAGACTCT
CCAACCGGGCGCAGGTCTTGATCCGGGGCCGGCGGTGCCCCGTGGTCGGTGTGGTGACCATGGACCAGATGATGGTCCGG
GTGCCGGACGATCTGCCGGTCCGGGTCGGGGACGAGGTGGTGCTGATCGGGCGGCAGGGCGGCGAGGAGATCACGGCGAC
GGAGCTGGCCGGGCTGGCGGACACGATCAGCTACGAGATCGTCTGCGGCATCTCGCGGCGGGTGCCCCGTTTTTACGGCG
GGGAGACCGCGTGA

Upstream 100 bases:

>100_bases
CCGCCGAGGTGCCCGCTGCCCAGCAGGCCGTGCGGGAGGGGCTGCCGGATCTGATTGAGGAGTTCGTGGGCTAGAGACTG
GACGGACGGGAGGAGCCAAG

Downstream 100 bases:

>100_bases
ACCCCGGGCCTTCCGATGACCATTCGCACGGCCGGCGTATAGACTGCTACTGAGGGTCGTATCCGGAGGAGGTTCCCCAT
GGCCGCTGTCCGGCGCATTC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MDLDGMRPTWAEVDLNAVRANIRALKRISKAPRLMAVVKANGYGHGAVPVATAAIEAGADWLGVASVEEGVTLRRHGISA
PILVLGYVSPGQAEAVLTEGLRVALFDGELGQALNREGRRLGRWARVHLKVDTGMGRIGLQPAEVGRLGRELARLDHVEV
EGVFTHLATADEPGNPYTRLQLERYEAALAELAAAGVRPAIRHAANSAGLMLHPEAHYDMVRSGIAVVGLPPAPGVAWPV
KLAPALTWKTRVGLVKWLEAGHSISYGCTYTTARREQIATLPVGYADGYPRRLSNRAQVLIRGRRCPVVGVVTMDQMMVR
VPDDLPVRVGDEVVLIGRQGGEEITATELAGLADTISYEIVCGISRRVPRFYGGETA

Sequences:

>Translated_377_residues
MDLDGMRPTWAEVDLNAVRANIRALKRISKAPRLMAVVKANGYGHGAVPVATAAIEAGADWLGVASVEEGVTLRRHGISA
PILVLGYVSPGQAEAVLTEGLRVALFDGELGQALNREGRRLGRWARVHLKVDTGMGRIGLQPAEVGRLGRELARLDHVEV
EGVFTHLATADEPGNPYTRLQLERYEAALAELAAAGVRPAIRHAANSAGLMLHPEAHYDMVRSGIAVVGLPPAPGVAWPV
KLAPALTWKTRVGLVKWLEAGHSISYGCTYTTARREQIATLPVGYADGYPRRLSNRAQVLIRGRRCPVVGVVTMDQMMVR
VPDDLPVRVGDEVVLIGRQGGEEITATELAGLADTISYEIVCGISRRVPRFYGGETA
>Mature_377_residues
MDLDGMRPTWAEVDLNAVRANIRALKRISKAPRLMAVVKANGYGHGAVPVATAAIEAGADWLGVASVEEGVTLRRHGISA
PILVLGYVSPGQAEAVLTEGLRVALFDGELGQALNREGRRLGRWARVHLKVDTGMGRIGLQPAEVGRLGRELARLDHVEV
EGVFTHLATADEPGNPYTRLQLERYEAALAELAAAGVRPAIRHAANSAGLMLHPEAHYDMVRSGIAVVGLPPAPGVAWPV
KLAPALTWKTRVGLVKWLEAGHSISYGCTYTTARREQIATLPVGYADGYPRRLSNRAQVLIRGRRCPVVGVVTMDQMMVR
VPDDLPVRVGDEVVLIGRQGGEEITATELAGLADTISYEIVCGISRRVPRFYGGETA

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=370, Percent_Identity=32.4324324324324, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1790487, Length=364, Percent_Identity=31.043956043956, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_SYMTH (Q67K79)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076763.1
- HSSP:   P0A4X2
- ProteinModelPortal:   Q67K79
- SMR:   Q67K79
- GeneID:   2981006
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2936
- NMPDR:   fig|292459.1.peg.2810
- HOGENOM:   HBG712172
- OMA:   HEMALEV
- BioCyc:   STHE292459:STH2936-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 40523; Mature: 40523

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 39-39 ACT_SITE 266-266

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLDGMRPTWAEVDLNAVRANIRALKRISKAPRLMAVVKANGYGHGAVPVATAAIEAGAD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCC
WLGVASVEEGVTLRRHGISAPILVLGYVSPGQAEAVLTEGLRVALFDGELGQALNREGRR
EEEECCHHCCCEEECCCCCCCEEEEEECCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
LGRWARVHLKVDTGMGRIGLQPAEVGRLGRELARLDHVEVEGVFTHLATADEPGNPYTRL
HCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHCCCCCCCCCHHEE
QLERYEAALAELAAAGVRPAIRHAANSAGLMLHPEAHYDMVRSGIAVVGLPPAPGVAWPV
EHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEECCHHHHHHHHCCEEEEECCCCCCCCCCE
KLAPALTWKTRVGLVKWLEAGHSISYGCTYTTARREQIATLPVGYADGYPRRLSNRAQVL
ECCCEEEHHHHHHHHHHHHCCCCEECCEEEEHHHHHHHEEECCCCCCCCHHHHCCCEEEE
IRGRRCPVVGVVTMDQMMVRVPDDLPVRVGDEVVLIGRQGGEEITATELAGLADTISYEI
EECCCCCEEEEEEHHHHHEECCCCCCEEECCEEEEEECCCCCEEHHHHHHHHHHHHCEEE
VCGISRRVPRFYGGETA
EECHHHCCCCCCCCCCC
>Mature Secondary Structure
MDLDGMRPTWAEVDLNAVRANIRALKRISKAPRLMAVVKANGYGHGAVPVATAAIEAGAD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCC
WLGVASVEEGVTLRRHGISAPILVLGYVSPGQAEAVLTEGLRVALFDGELGQALNREGRR
EEEECCHHCCCEEECCCCCCCEEEEEECCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
LGRWARVHLKVDTGMGRIGLQPAEVGRLGRELARLDHVEVEGVFTHLATADEPGNPYTRL
HCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHCCCCCCCCCHHEE
QLERYEAALAELAAAGVRPAIRHAANSAGLMLHPEAHYDMVRSGIAVVGLPPAPGVAWPV
EHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEECCHHHHHHHHCCEEEEECCCCCCCCCCE
KLAPALTWKTRVGLVKWLEAGHSISYGCTYTTARREQIATLPVGYADGYPRRLSNRAQVL
ECCCEEEHHHHHHHHHHHHCCCCEECCEEEEHHHHHHHEEECCCCCCCCHHHHCCCEEEE
IRGRRCPVVGVVTMDQMMVRVPDDLPVRVGDEVVLIGRQGGEEITATELAGLADTISYEI
EECCCCCEEEEEEHHHHHEECCCCCCEEECCEEEEEECCCCCEEHHHHHHHHHHHHCEEE
VCGISRRVPRFYGGETA
EECHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA