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The map label for this gene is ndoA [H]

Identifier: 51894070

GI number: 51894070

Start: 3160182

End: 3160544

Strand: Reverse

Name: ndoA [H]

Synonym: STH2934

Alternate gene names: 51894070

Gene position: 3160544-3160182 (Counterclockwise)

Preceding gene: 51894071

Following gene: 51894069

Centisome position: 88.63

GC content: 62.26

Gene sequence:

>363_bases
ATGAGCAAGCCACTTCAGATTCGACGGGGCGACGTCTTCTACGCGGACCTGAGCCCGGTGATCGGCTCGGAGCAGGGAGG
CGTGCGGCCCGTTCTGATCCTGCAGAATGATGTCGGCAATAAGTACAGCCCCACGGTCATCGTCTCGGCGATCACCAGCC
AGATCGAGAAGGCGAAGCTGCCGATTCACGTCGAGCTGGACGGGGAAACCTATGGCCTCGAGCGGGATTCCGTCATCCTG
CTGGAACAGGTCCGCACCATCGACAAGCGGCGGCTGCGCGAGCGGGTGACGCACCTGGGCAGCGACATCATGCGCCAGGT
GGACGAGGCCCTGATGATCAGCCTCGGACTCAAGGAGTTTTGA

Upstream 100 bases:

>100_bases
GGCGGGGCTATCGGGAGATGTCCCGCATCAACCTGACTCTTGCGGAGGAAGGGCCGATCTTCGAGCGGATCGGCAGTTTG
CCCTGAGCGGTCCCGGCCGT

Downstream 100 bases:

>100_bases
CGGGCCGCCGGGGCACCTCCGCGGCGAACCCGGGAGTCCAAAGGAGTGTGGACCCCCGGGTTCGCATGCTTATCAAGGCG
CCGGACGCGAAGGAGGATGA

Product: growth inhibitor

Products: NA

Alternate protein names: Endoribonuclease EndoA; Toxin EndoA [H]

Number of amino acids: Translated: 120; Mature: 119

Protein sequence:

>120_residues
MSKPLQIRRGDVFYADLSPVIGSEQGGVRPVLILQNDVGNKYSPTVIVSAITSQIEKAKLPIHVELDGETYGLERDSVIL
LEQVRTIDKRRLRERVTHLGSDIMRQVDEALMISLGLKEF

Sequences:

>Translated_120_residues
MSKPLQIRRGDVFYADLSPVIGSEQGGVRPVLILQNDVGNKYSPTVIVSAITSQIEKAKLPIHVELDGETYGLERDSVIL
LEQVRTIDKRRLRERVTHLGSDIMRQVDEALMISLGLKEF
>Mature_119_residues
SKPLQIRRGDVFYADLSPVIGSEQGGVRPVLILQNDVGNKYSPTVIVSAITSQIEKAKLPIHVELDGETYGLERDSVILL
EQVRTIDKRRLRERVTHLGSDIMRQVDEALMISLGLKEF

Specific function: Part of a toxin-antitoxin (TA) module. Has specificity for UAC sequences, yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single

COG id: COG2337

COG function: function code T; Growth inhibitor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemK/MazF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003477
- InterPro:   IPR011067 [H]

Pfam domain/function: PF02452 PemK [H]

EC number: NA

Molecular weight: Translated: 13472; Mature: 13341

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPLQIRRGDVFYADLSPVIGSEQGGVRPVLILQNDVGNKYSPTVIVSAITSQIEKAKL
CCCCCCEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
PIHVELDGETYGLERDSVILLEQVRTIDKRRLRERVTHLGSDIMRQVDEALMISLGLKEF
CEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKPLQIRRGDVFYADLSPVIGSEQGGVRPVLILQNDVGNKYSPTVIVSAITSQIEKAKL
CCCCCEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
PIHVELDGETYGLERDSVILLEQVRTIDKRRLRERVTHLGSDIMRQVDEALMISLGLKEF
CEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]