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The map label for this gene is mrdA [H]

Identifier: 51893269

GI number: 51893269

Start: 2277140

End: 2278894

Strand: Reverse

Name: mrdA [H]

Synonym: STH2131

Alternate gene names: 51893269

Gene position: 2278894-2277140 (Counterclockwise)

Preceding gene: 51893270

Following gene: 51893268

Centisome position: 63.9

GC content: 69.91

Gene sequence:

>1755_bases
GTGGAGGCGGCGGTCTGGACAAGCCGGGCCATCGCCCAGAACTACATCGAGCTGCCCAGCTTCGGGCCGCGGGGCGCCAT
CTACGATCGGGACGGCCGGCCGCTGGCGACCAGCGAGCCGGTCTATGCCGCGCTCCTGTACGACCAGGATCCCGACCACG
TGGCGGCGATCCTGCCGGAGCTGAGCAAGCTGCTGGCCGAGGGCGACCCCGTCCTGGCCGAGGGGATCAGCGAGTATGTG
ACCGAGCGGGTGCGGCTGCATCAGAAGTGGGGCCGCCAGGCCGAGGACCTGGTGATCCGGTCAGGGCTCTCCCATGAGAC
CGTGGCCGAGTTCATCGAGCGGCAGCACGAGTTCCCCGGGGTCACCATCGTCACCCAGTCGGTGCGCCGTTACCCCAACG
GCAAGGTGGCCGGCAACGTGATCGGCTACGTCCAGCCCATCTCCGAGGAGCAGCTGGAGAGCGAGCAGTTCAAGGGCTAT
CACCCGGACTCGGTGGTCGGCAAGGACGGCATCGAGCTGGCCTACGAGGCCGTGCTGCAGGGGCGCACCGGCAAGCGGGT
GAAGGCGGTTGACCCCGCGGGCCGGCCGCTGGGGCTGGTGGAGGAGGTCGACCCGGAGCCGGGGTACGATCTCACCCTGA
CCCTGGACCTGGACCTGCAGCGGGCGGCGGAGCAGGCCCTGGCCGGCAACGTGGAGTGGATCAAGGCGCAGAACGATCCG
GAGGCCCAGCCGATCCGGGCGTCCCTGATCGCGCTGGACGTGAAGACCGGCGCCGTGCTGGCCATGGCCCAGGTGCCCAG
CTACGATCCGAACCTCTTCATCAAGGCGATGACGGTGGGGCTCTCGGCGCAGGAGTACAACGAGAGCGTGAACATCCCCG
GCTCGCCGCTCATCAACTGGTCGATCCAGGGCTTTGCGCCGGGCAGCACCTACAAGATGGGCGTCGGACTCGCCGGCGTG
AGCACCGGCGTGATCGGCCCGTACGAGACGGTGCACTGCAACACCACGTACTTCCGGGACCCCACCCGGAAGAACTGGTA
CCCCGTGGACCAGGGGCACCTGGCCCTGGACATGGCCCTGGCGCAGTCGTGCAACCCGTACTTCTACGAGATCGGCCACC
GGCTGGGCATCGACGGCCTGGCCGAGTACCTGACGCAGTTCGGCTTCGGCCAGAGGACCGGCATTGACCTGCCGTTCGAG
GACCCCGGCCTGCTGCCCACCCAGGCGTCCTACGGCGACCGGTGGCAGCCCGGCCACGTCTACTCGGTGGCCATCGGCCA
GGGCGACGTGCTGGTCACGCCGCTGCAGCTGGCCGTGTACGCCTCCACCATCGCCAACCGGGGCGTGCGGTACGAGCCTT
ACCTGGTGGAGGAGATCCGCAGCAGCACCGGCGAGGTGGTCCGGCGGCACGAGCCGGTGGTGGCGGGCACCGTGGAGGCG
CCTGAGGAGGCCTGGCGGCAGGTCTTCGAGGGCATGCGCAAGGGCGGCGCGCACCCGCTGGGCACGGCCTACTGGGTGTT
CCAGGACTTCCCGATCCCGGTGGCCGTCAAGACCGGTTCGGCCGAGACGGGCAAGGCGTACGCGGACGCGATCACGGTCG
CCTTCGCCCCCATCGACGATCCCCAGATCGCGGTGGCGGTCTTCGTCGAGGGCGGCGCCCACGGCTCGTGGGTGGCCCCG
TCGGCCCGGGCGGTCTTCGCCGCGTACTTCGGGATCGAGGACAAGGGCCCGGCCCGCATCAACAAGGCCGACTGA

Upstream 100 bases:

>100_bases
GGTGGAGGTGCGGAGCGAGCAGAAGCGCGTGCTCATCCTGCTGGGCGCCGTGGTCCTGGCGATCGGCGTGATGGGCACCC
GGCTCTACCGTCTGACGGTG

Downstream 100 bases:

>100_bases
GCAGCTGATGGGCGGAAACCGCCAGGCCCCGACCGCAACGGTCGGGGCCTGTTTCATGCGCACCCGGGTCCTCGGGCGGC
CGCCCTCGGGTGGCGGCCCT

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MEAAVWTSRAIAQNYIELPSFGPRGAIYDRDGRPLATSEPVYAALLYDQDPDHVAAILPELSKLLAEGDPVLAEGISEYV
TERVRLHQKWGRQAEDLVIRSGLSHETVAEFIERQHEFPGVTIVTQSVRRYPNGKVAGNVIGYVQPISEEQLESEQFKGY
HPDSVVGKDGIELAYEAVLQGRTGKRVKAVDPAGRPLGLVEEVDPEPGYDLTLTLDLDLQRAAEQALAGNVEWIKAQNDP
EAQPIRASLIALDVKTGAVLAMAQVPSYDPNLFIKAMTVGLSAQEYNESVNIPGSPLINWSIQGFAPGSTYKMGVGLAGV
STGVIGPYETVHCNTTYFRDPTRKNWYPVDQGHLALDMALAQSCNPYFYEIGHRLGIDGLAEYLTQFGFGQRTGIDLPFE
DPGLLPTQASYGDRWQPGHVYSVAIGQGDVLVTPLQLAVYASTIANRGVRYEPYLVEEIRSSTGEVVRRHEPVVAGTVEA
PEEAWRQVFEGMRKGGAHPLGTAYWVFQDFPIPVAVKTGSAETGKAYADAITVAFAPIDDPQIAVAVFVEGGAHGSWVAP
SARAVFAAYFGIEDKGPARINKAD

Sequences:

>Translated_584_residues
MEAAVWTSRAIAQNYIELPSFGPRGAIYDRDGRPLATSEPVYAALLYDQDPDHVAAILPELSKLLAEGDPVLAEGISEYV
TERVRLHQKWGRQAEDLVIRSGLSHETVAEFIERQHEFPGVTIVTQSVRRYPNGKVAGNVIGYVQPISEEQLESEQFKGY
HPDSVVGKDGIELAYEAVLQGRTGKRVKAVDPAGRPLGLVEEVDPEPGYDLTLTLDLDLQRAAEQALAGNVEWIKAQNDP
EAQPIRASLIALDVKTGAVLAMAQVPSYDPNLFIKAMTVGLSAQEYNESVNIPGSPLINWSIQGFAPGSTYKMGVGLAGV
STGVIGPYETVHCNTTYFRDPTRKNWYPVDQGHLALDMALAQSCNPYFYEIGHRLGIDGLAEYLTQFGFGQRTGIDLPFE
DPGLLPTQASYGDRWQPGHVYSVAIGQGDVLVTPLQLAVYASTIANRGVRYEPYLVEEIRSSTGEVVRRHEPVVAGTVEA
PEEAWRQVFEGMRKGGAHPLGTAYWVFQDFPIPVAVKTGSAETGKAYADAITVAFAPIDDPQIAVAVFVEGGAHGSWVAP
SARAVFAAYFGIEDKGPARINKAD
>Mature_584_residues
MEAAVWTSRAIAQNYIELPSFGPRGAIYDRDGRPLATSEPVYAALLYDQDPDHVAAILPELSKLLAEGDPVLAEGISEYV
TERVRLHQKWGRQAEDLVIRSGLSHETVAEFIERQHEFPGVTIVTQSVRRYPNGKVAGNVIGYVQPISEEQLESEQFKGY
HPDSVVGKDGIELAYEAVLQGRTGKRVKAVDPAGRPLGLVEEVDPEPGYDLTLTLDLDLQRAAEQALAGNVEWIKAQNDP
EAQPIRASLIALDVKTGAVLAMAQVPSYDPNLFIKAMTVGLSAQEYNESVNIPGSPLINWSIQGFAPGSTYKMGVGLAGV
STGVIGPYETVHCNTTYFRDPTRKNWYPVDQGHLALDMALAQSCNPYFYEIGHRLGIDGLAEYLTQFGFGQRTGIDLPFE
DPGLLPTQASYGDRWQPGHVYSVAIGQGDVLVTPLQLAVYASTIANRGVRYEPYLVEEIRSSTGEVVRRHEPVVAGTVEA
PEEAWRQVFEGMRKGGAHPLGTAYWVFQDFPIPVAVKTGSAETGKAYADAITVAFAPIDDPQIAVAVFVEGGAHGSWVAP
SARAVFAAYFGIEDKGPARINKAD

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=591, Percent_Identity=32.994923857868, Blast_Score=269, Evalue=4e-73,
Organism=Escherichia coli, GI1786272, Length=568, Percent_Identity=26.7605633802817, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 63464; Mature: 63464

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAAVWTSRAIAQNYIELPSFGPRGAIYDRDGRPLATSEPVYAALLYDQDPDHVAAILPE
CCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
LSKLLAEGDPVLAEGISEYVTERVRLHQKWGRQAEDLVIRSGLSHETVAEFIERQHEFPG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC
VTIVTQSVRRYPNGKVAGNVIGYVQPISEEQLESEQFKGYHPDSVVGKDGIELAYEAVLQ
EEEEEHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
GRTGKRVKAVDPAGRPLGLVEEVDPEPGYDLTLTLDLDLQRAAEQALAGNVEWIKAQNDP
CCCCCEEEEECCCCCCCCCHHHCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEECCCC
EAQPIRASLIALDVKTGAVLAMAQVPSYDPNLFIKAMTVGLSAQEYNESVNIPGSPLINW
CCCCEEEEEEEEEECCCEEEEEEECCCCCCCEEEEEEEECCCHHHHCCCCCCCCCCEEEE
SIQGFAPGSTYKMGVGLAGVSTGVIGPYETVHCNTTYFRDPTRKNWYPVDQGHLALDMAL
EEEECCCCCCEEECCEECCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCCCCHHHHHH
AQSCNPYFYEIGHRLGIDGLAEYLTQFGFGQRTGIDLPFEDPGLLPTQASYGDRWQPGHV
HHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
YSVAIGQGDVLVTPLQLAVYASTIANRGVRYEPYLVEEIRSSTGEVVRRHEPVVAGTVEA
EEEEECCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCC
PEEAWRQVFEGMRKGGAHPLGTAYWVFQDFPIPVAVKTGSAETGKAYADAITVAFAPIDD
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCCCHHHEEEEEEEECCCC
PQIAVAVFVEGGAHGSWVAPSARAVFAAYFGIEDKGPARINKAD
CCEEEEEEEECCCCCCCCCCCHHEEEHHEECCCCCCCCCCCCCC
>Mature Secondary Structure
MEAAVWTSRAIAQNYIELPSFGPRGAIYDRDGRPLATSEPVYAALLYDQDPDHVAAILPE
CCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
LSKLLAEGDPVLAEGISEYVTERVRLHQKWGRQAEDLVIRSGLSHETVAEFIERQHEFPG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC
VTIVTQSVRRYPNGKVAGNVIGYVQPISEEQLESEQFKGYHPDSVVGKDGIELAYEAVLQ
EEEEEHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
GRTGKRVKAVDPAGRPLGLVEEVDPEPGYDLTLTLDLDLQRAAEQALAGNVEWIKAQNDP
CCCCCEEEEECCCCCCCCCHHHCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEECCCC
EAQPIRASLIALDVKTGAVLAMAQVPSYDPNLFIKAMTVGLSAQEYNESVNIPGSPLINW
CCCCEEEEEEEEEECCCEEEEEEECCCCCCCEEEEEEEECCCHHHHCCCCCCCCCCEEEE
SIQGFAPGSTYKMGVGLAGVSTGVIGPYETVHCNTTYFRDPTRKNWYPVDQGHLALDMAL
EEEECCCCCCEEECCEECCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCCCCHHHHHH
AQSCNPYFYEIGHRLGIDGLAEYLTQFGFGQRTGIDLPFEDPGLLPTQASYGDRWQPGHV
HHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
YSVAIGQGDVLVTPLQLAVYASTIANRGVRYEPYLVEEIRSSTGEVVRRHEPVVAGTVEA
EEEEECCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCC
PEEAWRQVFEGMRKGGAHPLGTAYWVFQDFPIPVAVKTGSAETGKAYADAITVAFAPIDD
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCCCHHHEEEEEEEECCCC
PQIAVAVFVEGGAHGSWVAPSARAVFAAYFGIEDKGPARINKAD
CCEEEEEEEECCCCCCCCCCCHHEEEHHEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]