Click here to switch to the map view.

The map label for this gene is ctaB

Identifier: 51893231

GI number: 51893231

Start: 2233314

End: 2234210

Strand: Reverse

Name: ctaB

Synonym: STH2093

Alternate gene names: 51893231

Gene position: 2234210-2233314 (Counterclockwise)

Preceding gene: 51893241

Following gene: 51893230

Centisome position: 62.65

GC content: 68.67

Gene sequence:

>897_bases
ATGTTCGCGCAGGCTCGCGATCGCCTTCAAAGCGGCCAGGTGGTGCGGGATTACGTGGCGCTCACCAAGCCGCGCATCGT
CATCCTGCTCCTCATCACCGGGTTTGCCGCCATGTGGGTGGCGGCCGGGGGACCGCCGCCGCTGGGCCTGACGGTCGTCA
CCATGATCGGGCTGGCGCTGTCCTGCGGGGCGGCGAACGCCATCAACATGTGGTACGACCGGGACATCGACGCGGTCATG
GCCCGGACCCGACGCAGGCCGCTGCCCGCAGGCCGGCTGACACCGGAGCAGGCCCTGCGCTTCGGCGTGATCACCGGGGC
GCTCAGCTTCCTGGTTCTGCTCACCGTCAACCTGCTCACGGCCCTGCTGGCCACCGCCGGCCTGCTGTTCTACGTGCTGG
TCTACACCATGTGGTTGAAGCGCTCGACGGTGCATAACATCGTCATAGGCGGCGCAGCGGGCGCGGCGCCCCCGCTGGTG
GGCTGGGCCGCGGTCACCGGACGGCTCGACTGGGCCGCTGTCATCATGTTCCTCGTGGTCTTCCTCTGGACGCCGCCCCA
CTTCTGGGCGCTGGCGCTCTTCCGCAGCGAGGATTACGAGCGGGCCGGCGTCCCCATGCTGCCGGTGGTGAGGGGGGAGC
GGGCCACCAAGTGGCAGATCCTGCTCTACTCGCTGCTCCTGATTCCCTCCGCGGCCCTGCTCTACTGGACCGGGACGGTC
GGCCGGCTGTACCTCTGGACATCGGTCGTGCTGGGGTGCGCCATGGTGTCCGCCTCAGTGGGCCTCCTGCGTGAGCGGGC
GCCGCAGATGGACTGGGCCCACCGGACCTACGGCTGGTCTTTGTTGTACCTGTTCGTGATCTTCCTCGCGATGATGCTGG
ACGTGACCCGCGCCTGA

Upstream 100 bases:

>100_bases
GGTGTCCGGGAACGGCACTCGGCGTGCGCGGCCGGGACCCGGTGTCCGGGAACGGCGCGCGGCGTCACGCAGGGATCTTG
AAGGTAAAGGGGGCGGCCCC

Downstream 100 bases:

>100_bases
CGGCGCCGGCGGCAACCCGGGCCGGGCGCCGTCGCGGTGCGCGCCTGCACGCCCGGCGACGGAGGCTCCCCCGCGCCGGG
CGGCCTGGCCGGTGCCCCGG

Product: putative heme O synthase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MFAQARDRLQSGQVVRDYVALTKPRIVILLLITGFAAMWVAAGGPPPLGLTVVTMIGLALSCGAANAINMWYDRDIDAVM
ARTRRRPLPAGRLTPEQALRFGVITGALSFLVLLTVNLLTALLATAGLLFYVLVYTMWLKRSTVHNIVIGGAAGAAPPLV
GWAAVTGRLDWAAVIMFLVVFLWTPPHFWALALFRSEDYERAGVPMLPVVRGERATKWQILLYSLLLIPSAALLYWTGTV
GRLYLWTSVVLGCAMVSASVGLLRERAPQMDWAHRTYGWSLLYLFVIFLAMMLDVTRA

Sequences:

>Translated_298_residues
MFAQARDRLQSGQVVRDYVALTKPRIVILLLITGFAAMWVAAGGPPPLGLTVVTMIGLALSCGAANAINMWYDRDIDAVM
ARTRRRPLPAGRLTPEQALRFGVITGALSFLVLLTVNLLTALLATAGLLFYVLVYTMWLKRSTVHNIVIGGAAGAAPPLV
GWAAVTGRLDWAAVIMFLVVFLWTPPHFWALALFRSEDYERAGVPMLPVVRGERATKWQILLYSLLLIPSAALLYWTGTV
GRLYLWTSVVLGCAMVSASVGLLRERAPQMDWAHRTYGWSLLYLFVIFLAMMLDVTRA
>Mature_298_residues
MFAQARDRLQSGQVVRDYVALTKPRIVILLLITGFAAMWVAAGGPPPLGLTVVTMIGLALSCGAANAINMWYDRDIDAVM
ARTRRRPLPAGRLTPEQALRFGVITGALSFLVLLTVNLLTALLATAGLLFYVLVYTMWLKRSTVHNIVIGGAAGAAPPLV
GWAAVTGRLDWAAVIMFLVVFLWTPPHFWALALFRSEDYERAGVPMLPVVRGERATKWQILLYSLLLIPSAALLYWTGTV
GRLYLWTSVVLGCAMVSASVGLLRERAPQMDWAHRTYGWSLLYLFVIFLAMMLDVTRA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=183, Percent_Identity=35.5191256830601, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1786631, Length=285, Percent_Identity=32.6315789473684, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790473, Length=237, Percent_Identity=30.379746835443, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71998235, Length=224, Percent_Identity=32.1428571428571, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325085, Length=220, Percent_Identity=30.4545454545455, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19921064, Length=202, Percent_Identity=36.6336633663366, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_SYMTH (Q67ML5)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075922.1
- GeneID:   2982576
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2093
- NMPDR:   fig|292459.1.peg.2021
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- BioCyc:   STHE292459:STH2093-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32821; Mature: 32821

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfe0814c)-; HASH(0x13bef90c)-; HASH(0x13b4d21c)-; HASH(0x142be6bc)-; HASH(0xfefc4f4)-; HASH(0x142b91cc)-; HASH(0x142d4648)-; HASH(0x142be800)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAQARDRLQSGQVVRDYVALTKPRIVILLLITGFAAMWVAAGGPPPLGLTVVTMIGLAL
CCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
SCGAANAINMWYDRDIDAVMARTRRRPLPAGRLTPEQALRFGVITGALSFLVLLTVNLLT
HCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLATAGLLFYVLVYTMWLKRSTVHNIVIGGAAGAAPPLVGWAAVTGRLDWAAVIMFLVV
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
FLWTPPHFWALALFRSEDYERAGVPMLPVVRGERATKWQILLYSLLLIPSAALLYWTGTV
HHHCCHHHHHHHHHHCCCCHHCCCCCCCEECCCCCHHHHHHHHHHHHHCCHHHHHEECCH
GRLYLWTSVVLGCAMVSASVGLLRERAPQMDWAHRTYGWSLLYLFVIFLAMMLDVTRA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MFAQARDRLQSGQVVRDYVALTKPRIVILLLITGFAAMWVAAGGPPPLGLTVVTMIGLAL
CCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
SCGAANAINMWYDRDIDAVMARTRRRPLPAGRLTPEQALRFGVITGALSFLVLLTVNLLT
HCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLATAGLLFYVLVYTMWLKRSTVHNIVIGGAAGAAPPLVGWAAVTGRLDWAAVIMFLVV
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
FLWTPPHFWALALFRSEDYERAGVPMLPVVRGERATKWQILLYSLLLIPSAALLYWTGTV
HHHCCHHHHHHHHHHCCCCHHCCCCCCCEECCCCCHHHHHHHHHHHHHCCHHHHHEECCH
GRLYLWTSVVLGCAMVSASVGLLRERAPQMDWAHRTYGWSLLYLFVIFLAMMLDVTRA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA