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The map label for this gene is mdtG [H]

Identifier: 51893150

GI number: 51893150

Start: 2152847

End: 2154079

Strand: Reverse

Name: mdtG [H]

Synonym: STH2012

Alternate gene names: 51893150

Gene position: 2154079-2152847 (Counterclockwise)

Preceding gene: 51893153

Following gene: 51893147

Centisome position: 60.4

GC content: 70.64

Gene sequence:

>1233_bases
ATGACGGAAAGAAGGCGCCATAACGAGATGGAACCCTGGCGGAGAAACGTGGCGGTCCTCTGGATCGCGGTCTTCATCGC
AGCATCCGCATGGACAATGGTCATGCCGTTCATGCCGGTTTTTCTGAGCGAGGACCTGGGTGTGGGGGCTGGTGTCACGG
TGTGGGCCGGCCTGCTGGGCGCGGTCAACTCGGGCTTCTCGGCGCTCACCGCCCCGATCTGGGGCGCCCTGGGCGACCGC
TGGGGCCGCAAGGCGATGATGGTGCGCGCCGGCATCTTCCTGGGTTCCGCCTACGTGCTGATGGCCTTCGTCCGCAACCC
CTACGAGCTGCTGGGCGTCCGGGTCATGATCGGCGCCCTGACCGGGTTCATCCCGACCGCGACGGCGCTGGTGGCCACGA
CCACCCCGGAGCGCCACATGGGACAGGCCCTGTCGCTGGTGGCCACCGGCAATCAGGCGGGGTCGATCCTGGGGCCGATG
CTGGGCGGCTTCCTGGCCGACCTGATCGGCATCCGCAATACCATGGCCCTGAGCGGCGTCGCCGTGTTCGCCGCGACGCT
GCTGGTGGTGTTCGCGGTCCGGGAGCAGTTCCAGCGGCCGGCGCGGCAGCCGGCGCACTTCCTGAGCGACATGCGGCAGG
TGCTGCAGGGCGGGCCGTTGATCGTGGTGCTGGCCATGTCCCTGCTCCTGCAGATGTCCCAGTCGGCGATGGAGCCGGTG
CTGATCCCCCATATCCGCCAGCTCCTGGGCTCCGGCAGCCCCAACTGGATGGCCGGCGTGATCTACTCCGTGCCGGGCAT
CGCCTTCGTGCTGGCCGCCCCGTCGTGGGCGAGGCTCGGCGAGCGCTGGGGCTACACCACCACGGTGACCATCGGCCTGG
CGGGCGGCGCGCTGTTCACACTGCCGCAGGCCCTGGTGCAGAGCGGTCTGGGCATGGGGAGCTTCCGCCTGAGTGCCGGC
CTCGCGCTCGCCGCCGTCACCCCCGGCATCTCCGCCCTGATCGCCGCATCGGTCCCGCGGGAGCAGCGGGGCAAGGCCTT
TGGGCTCAACCAGTCCGCGTTCAACGTCGGGGCCATGCTGGGTCCGCTCCTGGGCGGCGTGCTGGGCGACCGGGTCGGGA
TCCGGTGGGTCTTCCCGGCCACGGCGCTGCTGCTCCTGTTCGCCGCGGGCTGGTGCTGGTCCCTGGTGCGGGCGCGCGTC
CGGCAGCACCGGGATTCGCAGCTCACCGCCTGA

Upstream 100 bases:

>100_bases
TACATGCCGGTTTCCCTGCTGGAGCCGACGGGATTTTGCAGTGACCCGTAGACAACGGCGGGATTCCGGCCTATAGTCAT
TTCGTCAACGCGAGTTCAGT

Downstream 100 bases:

>100_bases
CCGCCCCGCGCCGGCGCTCAGGGCCCGCCTCAGGCTTCGGCCTGCTCCCGCGCCGCCTGCTCGGCGGCTTCCCGCTCCCG
CCGGCGCCGCCGGTGGGCTG

Product: putative multidrug efflux protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTERRRHNEMEPWRRNVAVLWIAVFIAASAWTMVMPFMPVFLSEDLGVGAGVTVWAGLLGAVNSGFSALTAPIWGALGDR
WGRKAMMVRAGIFLGSAYVLMAFVRNPYELLGVRVMIGALTGFIPTATALVATTTPERHMGQALSLVATGNQAGSILGPM
LGGFLADLIGIRNTMALSGVAVFAATLLVVFAVREQFQRPARQPAHFLSDMRQVLQGGPLIVVLAMSLLLQMSQSAMEPV
LIPHIRQLLGSGSPNWMAGVIYSVPGIAFVLAAPSWARLGERWGYTTTVTIGLAGGALFTLPQALVQSGLGMGSFRLSAG
LALAAVTPGISALIAASVPREQRGKAFGLNQSAFNVGAMLGPLLGGVLGDRVGIRWVFPATALLLLFAAGWCWSLVRARV
RQHRDSQLTA

Sequences:

>Translated_410_residues
MTERRRHNEMEPWRRNVAVLWIAVFIAASAWTMVMPFMPVFLSEDLGVGAGVTVWAGLLGAVNSGFSALTAPIWGALGDR
WGRKAMMVRAGIFLGSAYVLMAFVRNPYELLGVRVMIGALTGFIPTATALVATTTPERHMGQALSLVATGNQAGSILGPM
LGGFLADLIGIRNTMALSGVAVFAATLLVVFAVREQFQRPARQPAHFLSDMRQVLQGGPLIVVLAMSLLLQMSQSAMEPV
LIPHIRQLLGSGSPNWMAGVIYSVPGIAFVLAAPSWARLGERWGYTTTVTIGLAGGALFTLPQALVQSGLGMGSFRLSAG
LALAAVTPGISALIAASVPREQRGKAFGLNQSAFNVGAMLGPLLGGVLGDRVGIRWVFPATALLLLFAAGWCWSLVRARV
RQHRDSQLTA
>Mature_409_residues
TERRRHNEMEPWRRNVAVLWIAVFIAASAWTMVMPFMPVFLSEDLGVGAGVTVWAGLLGAVNSGFSALTAPIWGALGDRW
GRKAMMVRAGIFLGSAYVLMAFVRNPYELLGVRVMIGALTGFIPTATALVATTTPERHMGQALSLVATGNQAGSILGPML
GGFLADLIGIRNTMALSGVAVFAATLLVVFAVREQFQRPARQPAHFLSDMRQVLQGGPLIVVLAMSLLLQMSQSAMEPVL
IPHIRQLLGSGSPNWMAGVIYSVPGIAFVLAAPSWARLGERWGYTTTVTIGLAGGALFTLPQALVQSGLGMGSFRLSAGL
ALAAVTPGISALIAASVPREQRGKAFGLNQSAFNVGAMLGPLLGGVLGDRVGIRWVFPATALLLLFAAGWCWSLVRARVR
QHRDSQLTA

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=398, Percent_Identity=33.9195979899498, Blast_Score=225, Evalue=4e-60,
Organism=Drosophila melanogaster, GI62471713, Length=349, Percent_Identity=24.0687679083095, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI62471717, Length=349, Percent_Identity=24.0687679083095, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43501; Mature: 43370

Theoretical pI: Translated: 11.95; Mature: 11.95

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TERRRHNEMEPWRRNVAVLWIAVFIAASAWTMVMPFMPVFLSEDLGVGAGVTVWAGLLG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
AVNSGFSALTAPIWGALGDRWGRKAMMVRAGIFLGSAYVLMAFVRNPYELLGVRVMIGAL
HHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
TGFIPTATALVATTTPERHMGQALSLVATGNQAGSILGPMLGGFLADLIGIRNTMALSGV
HHHHHHHHHHHEECCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AVFAATLLVVFAVREQFQRPARQPAHFLSDMRQVLQGGPLIVVLAMSLLLQMSQSAMEPV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCH
LIPHIRQLLGSGSPNWMAGVIYSVPGIAFVLAAPSWARLGERWGYTTTVTIGLAGGALFT
HHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHCCCEEEEEEEECCCHHHH
LPQALVQSGLGMGSFRLSAGLALAAVTPGISALIAASVPREQRGKAFGLNQSAFNVGAML
HHHHHHHCCCCCCCHHHHHCCHHHHHCCCHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHH
GPLLGGVLGDRVGIRWVFPATALLLLFAAGWCWSLVRARVRQHRDSQLTA
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA