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The map label for this gene is manD [H]

Identifier: 51893075

GI number: 51893075

Start: 2079523

End: 2080728

Strand: Reverse

Name: manD [H]

Synonym: STH1937

Alternate gene names: 51893075

Gene position: 2080728-2079523 (Counterclockwise)

Preceding gene: 51893076

Following gene: 51893074

Centisome position: 58.35

GC content: 73.88

Gene sequence:

>1206_bases
ATGATGCTGTTTACGTGCTCACGGATCCACGCCGAGGGCGGCCTGGTCGACGGCTACGTGCTGGTGGACGGCCGGCGCAT
CGCCGCGGTGGAGGCCGGGCCGGTCCCGGCGGAGCTGCAGGGCGTCGATAGGGTGGACCTGCCGGACTGCGACCTGATCC
CGGGCATGATCGACCTGCACATCCACGGCGCCGGCGGGTGGCCCGTGGAAGGGGCGGACGTCGGGCTGCTGCAGGGGCTC
GGCCGGTTCCTGGCCGGCTTCGGCGTGACGGGCTTCCTGCCCAGCGCCTCCGCGCGGCCCCTGGAGGAGCTGGAGGAGGT
GGCCCGGCAGGTCCGGGCGGCCACGGAGGCGGAATACGACGGCGCCGCCATCCTGGGCCTCCACCTGGAGGGGCCGTTCC
TGAACCCGAAGCGGCCCGGGGCGATGCACATCCACAACCTGCGCACGCCCTCCGTCGCCGAGGCCGAGCGGCTGCTGGCG
GCCGGCGGAGGCACGGTGCGGCGGGTCTCGCTGGCGCCCGAGCTGCCCGGCGCCCCGGAGCTGATCCGCTACCTCGTCGC
GCAGGGGGTGACGGTGGCAGGCGCGCACACCGACGCGACGTACGCAGAGACGGTGGCGGGCATCGAAGCCGGGGTCTCGC
TGGCTACCCACACCTACAACGCGATGCGCGGGCTGCACCACCGGGAGCCCGGGGCGGTGGGGGCGTATCTCACCGATGAC
CGGGTGACCTGCGAGATCATCTGCGACCTGCTGCACGTGCACCCCGCGGCGGTCCGGATCGCGCTGCGGGCGGCGGGCCC
GGACCGGGTGGCCCTGATCTCCGACGCGATCCCCGCGGCGGGGCTGAAGCCCGGCCACTACCTGCTCTGGGGCCGGGACC
TGTACATCGATGAGCAGGGTTACTCGAAGCTGGCCGACGGCACCATCGCGGGATCCACCAAGCTGATGCTCCACGGCCTG
CGCAACCTGGTGGAGGTGCTCGGGGTGCCGTGGGCGGAGGCGGTGCGGATGGCGTCCCTGATTCCGGCCCGCGCCATCGG
GCTCGCCGACCGGAAGGGCAGCCTGGCGCCGGGCAAGGACGCCGACCTGGTGGCCATCGGCCCGGGCTGGCAGGTGGCCT
GGTGCGTCGTCGAGGGCCGGGTGGTGCGCCGGCCGGGGGATCCGCCTCCCGCGTACAACCCGGAGGCAAAGGCGATCGAC
GAGTAG

Upstream 100 bases:

>100_bases
ACGAGGCGCTCTCGGCCCCCAGCGAGCCCGGCTCCGGCGAGCGGCTGGTGGACGCGGCGGCGGACCTGCTGAGCGAGTTG
AAGGCGGAGGTGGCGGGCGC

Downstream 100 bases:

>100_bases
AAGGGGGCAACGGACATGACGATCACGGCGGAACGGTTCTACCAGGCGGCGGACGAGGCGATCGCACGGCTGAAGGCGAC
CCAGCTGCCGGCCATCAAGC

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MMLFTCSRIHAEGGLVDGYVLVDGRRIAAVEAGPVPAELQGVDRVDLPDCDLIPGMIDLHIHGAGGWPVEGADVGLLQGL
GRFLAGFGVTGFLPSASARPLEELEEVARQVRAATEAEYDGAAILGLHLEGPFLNPKRPGAMHIHNLRTPSVAEAERLLA
AGGGTVRRVSLAPELPGAPELIRYLVAQGVTVAGAHTDATYAETVAGIEAGVSLATHTYNAMRGLHHREPGAVGAYLTDD
RVTCEIICDLLHVHPAAVRIALRAAGPDRVALISDAIPAAGLKPGHYLLWGRDLYIDEQGYSKLADGTIAGSTKLMLHGL
RNLVEVLGVPWAEAVRMASLIPARAIGLADRKGSLAPGKDADLVAIGPGWQVAWCVVEGRVVRRPGDPPPAYNPEAKAID
E

Sequences:

>Translated_401_residues
MMLFTCSRIHAEGGLVDGYVLVDGRRIAAVEAGPVPAELQGVDRVDLPDCDLIPGMIDLHIHGAGGWPVEGADVGLLQGL
GRFLAGFGVTGFLPSASARPLEELEEVARQVRAATEAEYDGAAILGLHLEGPFLNPKRPGAMHIHNLRTPSVAEAERLLA
AGGGTVRRVSLAPELPGAPELIRYLVAQGVTVAGAHTDATYAETVAGIEAGVSLATHTYNAMRGLHHREPGAVGAYLTDD
RVTCEIICDLLHVHPAAVRIALRAAGPDRVALISDAIPAAGLKPGHYLLWGRDLYIDEQGYSKLADGTIAGSTKLMLHGL
RNLVEVLGVPWAEAVRMASLIPARAIGLADRKGSLAPGKDADLVAIGPGWQVAWCVVEGRVVRRPGDPPPAYNPEAKAID
E
>Mature_401_residues
MMLFTCSRIHAEGGLVDGYVLVDGRRIAAVEAGPVPAELQGVDRVDLPDCDLIPGMIDLHIHGAGGWPVEGADVGLLQGL
GRFLAGFGVTGFLPSASARPLEELEEVARQVRAATEAEYDGAAILGLHLEGPFLNPKRPGAMHIHNLRTPSVAEAERLLA
AGGGTVRRVSLAPELPGAPELIRYLVAQGVTVAGAHTDATYAETVAGIEAGVSLATHTYNAMRGLHHREPGAVGAYLTDD
RVTCEIICDLLHVHPAAVRIALRAAGPDRVALISDAIPAAGLKPGHYLLWGRDLYIDEQGYSKLADGTIAGSTKLMLHGL
RNLVEVLGVPWAEAVRMASLIPARAIGLADRKGSLAPGKDADLVAIGPGWQVAWCVVEGRVVRRPGDPPPAYNPEAKAID
E

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI224922791, Length=429, Percent_Identity=33.1002331002331, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI21361513, Length=423, Percent_Identity=32.8605200945626, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1786892, Length=388, Percent_Identity=34.7938144329897, Blast_Score=197, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17553768, Length=396, Percent_Identity=31.3131313131313, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19920392, Length=397, Percent_Identity=31.4861460957179, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI281361140, Length=409, Percent_Identity=30.5623471882641, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 42149; Mature: 42149

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLFTCSRIHAEGGLVDGYVLVDGRRIAAVEAGPVPAELQGVDRVDLPDCDLIPGMIDLH
CEEEEEEEEECCCCEEEEEEEECCCEEEEEECCCCCHHHCCCCCCCCCCCCCCCCEEEEE
IHGAGGWPVEGADVGLLQGLGRFLAGFGVTGFLPSASARPLEELEEVARQVRAATEAEYD
EECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GAAILGLHLEGPFLNPKRPGAMHIHNLRTPSVAEAERLLAAGGGTVRRVSLAPELPGAPE
CEEEEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHH
LIRYLVAQGVTVAGAHTDATYAETVAGIEAGVSLATHTYNAMRGLHHREPGAVGAYLTDD
HHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEEECC
RVTCEIICDLLHVHPAAVRIALRAAGPDRVALISDAIPAAGLKPGHYLLWGRDLYIDEQG
CCHHHHHHHHHHCCCHHEEEEEEECCCCCEEEEECCCCCCCCCCCEEEEECCEEEECCCC
YSKLADGTIAGSTKLMLHGLRNLVEVLGVPWAEAVRMASLIPARAIGLADRKGSLAPGKD
CHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCC
ADLVAIGPGWQVAWCVVEGRVVRRPGDPPPAYNPEAKAIDE
CCEEEECCCCEEEEEEEECEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMLFTCSRIHAEGGLVDGYVLVDGRRIAAVEAGPVPAELQGVDRVDLPDCDLIPGMIDLH
CEEEEEEEEECCCCEEEEEEEECCCEEEEEECCCCCHHHCCCCCCCCCCCCCCCCEEEEE
IHGAGGWPVEGADVGLLQGLGRFLAGFGVTGFLPSASARPLEELEEVARQVRAATEAEYD
EECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GAAILGLHLEGPFLNPKRPGAMHIHNLRTPSVAEAERLLAAGGGTVRRVSLAPELPGAPE
CEEEEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHH
LIRYLVAQGVTVAGAHTDATYAETVAGIEAGVSLATHTYNAMRGLHHREPGAVGAYLTDD
HHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEEECC
RVTCEIICDLLHVHPAAVRIALRAAGPDRVALISDAIPAAGLKPGHYLLWGRDLYIDEQG
CCHHHHHHHHHHCCCHHEEEEEEECCCCCEEEEECCCCCCCCCCCEEEEECCEEEECCCC
YSKLADGTIAGSTKLMLHGLRNLVEVLGVPWAEAVRMASLIPARAIGLADRKGSLAPGKD
CHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCC
ADLVAIGPGWQVAWCVVEGRVVRRPGDPPPAYNPEAKAIDE
CCEEEECCCCEEEEEEEECEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969210 [H]