Click here to switch to the map view.

The map label for this gene is ispA [C]

Identifier: 51892982

GI number: 51892982

Start: 1990002

End: 1990895

Strand: Reverse

Name: ispA [C]

Synonym: STH1844

Alternate gene names: 51892982

Gene position: 1990895-1990002 (Counterclockwise)

Preceding gene: 51892983

Following gene: 51892981

Centisome position: 55.83

GC content: 72.6

Gene sequence:

>894_bases
TTGAGGGGCGAGTTTCAGCAGTACATGGCCGCGCGGCGGCAGCAGGTGGAGGCGGCGCTGGACCGGTACACCGCCGGGCT
CGACGCGCCTTCCCGGCTGGTGGAGGCCATGCGGTACAGCCTCCTTGCCGGAGGCAAGCGGCTCCGGCCGATCCTGACCA
TTGCCGCGTCCGAGCTCTTCGGTCTGGAGGCGGCCGACGTGATGCCCGGCGCCTGCGCCCTGGAGATGATTCACACCTAC
TCGCTCATCCACGACGACCTGCCCTGCATGGACGACGACGACCTGCGCCGGGGCCGTCCCACCTGCCACAAGGTCTACGG
CGAGGCCATGGCTGTGCTCGCGGGGGACGCGCTGCTCACCCAGGCCTTCGCGCTGATGGCCGAGCAGGCAGCCGTCCCGC
GCGTCGGGCCGGCGCGCGCGGTGCGGGCTGCCGCGGAGCTCGCCCACGCCGCGGGAGCCGAGGGCATGGTCGGCGGGCAG
GTGGAGGACTTGGCGTGGGAGGGCCGCCAGGCGGACGAACCGCAGCTCAGGCGGATCCACTCCCTGAAGACCGGCGCGCT
GTTCCGCGCCGCCGTGCGTATGGGCGGCATCCTCGCCGGTGCAGGCGAGGAGGACCTGGACCGGCTGGGGCGCTACGCGA
CGCACTTCGGGCTTGCCTTCCAGATCTGGGACGACGTGCTGGACGTGACCGGCGACGCCGCCCTGACGGGGAAGGGCGTC
GGCCGCGACGCCCGGCTGGACAAGTCCACCTACGTCACCCTGCACGGCGTGGAAGGCGCGCGCGAGCGCGCCTACCAGGC
CGTCCGACTGGCGCTGGAGGAGCTGGAGCCCTTCGGCGGAGCGGGCTGGGTGCTCAGGGCCTTGGCAGAATCTGTGGTTG
ACCGCGTCGCCTGA

Upstream 100 bases:

>100_bases
GCTGGATCGGGCCGAGGCGCGCATCGAGCAGCTGCTGGAGCGCGACGGCGGGGTCGAGACCCTTCCCTTCGAGCCGGAAT
GACGTAGGGGGACGACGAGT

Downstream 100 bases:

>100_bases
CGGGTGCTATCATCGTTTGGTGACGAAGCGAGTCACTCATGATCGCGGATTATGGGTGGCGCAGTATCCTAGTCAGTACT
ACCTTTTCCGAAGGCGGGCC

Product: geranylgeranyl pyrophosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRGEFQQYMAARRQQVEAALDRYTAGLDAPSRLVEAMRYSLLAGGKRLRPILTIAASELFGLEAADVMPGACALEMIHTY
SLIHDDLPCMDDDDLRRGRPTCHKVYGEAMAVLAGDALLTQAFALMAEQAAVPRVGPARAVRAAAELAHAAGAEGMVGGQ
VEDLAWEGRQADEPQLRRIHSLKTGALFRAAVRMGGILAGAGEEDLDRLGRYATHFGLAFQIWDDVLDVTGDAALTGKGV
GRDARLDKSTYVTLHGVEGARERAYQAVRLALEELEPFGGAGWVLRALAESVVDRVA

Sequences:

>Translated_297_residues
MRGEFQQYMAARRQQVEAALDRYTAGLDAPSRLVEAMRYSLLAGGKRLRPILTIAASELFGLEAADVMPGACALEMIHTY
SLIHDDLPCMDDDDLRRGRPTCHKVYGEAMAVLAGDALLTQAFALMAEQAAVPRVGPARAVRAAAELAHAAGAEGMVGGQ
VEDLAWEGRQADEPQLRRIHSLKTGALFRAAVRMGGILAGAGEEDLDRLGRYATHFGLAFQIWDDVLDVTGDAALTGKGV
GRDARLDKSTYVTLHGVEGARERAYQAVRLALEELEPFGGAGWVLRALAESVVDRVA
>Mature_297_residues
MRGEFQQYMAARRQQVEAALDRYTAGLDAPSRLVEAMRYSLLAGGKRLRPILTIAASELFGLEAADVMPGACALEMIHTY
SLIHDDLPCMDDDDLRRGRPTCHKVYGEAMAVLAGDALLTQAFALMAEQAAVPRVGPARAVRAAAELAHAAGAEGMVGGQ
VEDLAWEGRQADEPQLRRIHSLKTGALFRAAVRMGGILAGAGEEDLDRLGRYATHFGLAFQIWDDVLDVTGDAALTGKGV
GRDARLDKSTYVTLHGVEGARERAYQAVRLALEELEPFGGAGWVLRALAESVVDRVA

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=232, Percent_Identity=31.0344827586207, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786623, Length=297, Percent_Identity=47.1380471380471, Blast_Score=207, Evalue=5e-55,
Organism=Escherichia coli, GI1789578, Length=258, Percent_Identity=33.7209302325581, Blast_Score=124, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31941; Mature: 31941

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGEFQQYMAARRQQVEAALDRYTAGLDAPSRLVEAMRYSLLAGGKRLRPILTIAASELF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GLEAADVMPGACALEMIHTYSLIHDDLPCMDDDDLRRGRPTCHKVYGEAMAVLAGDALLT
CCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
QAFALMAEQAAVPRVGPARAVRAAAELAHAAGAEGMVGGQVEDLAWEGRQADEPQLRRIH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
SLKTGALFRAAVRMGGILAGAGEEDLDRLGRYATHFGLAFQIWDDVLDVTGDAALTGKGV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCC
GRDARLDKSTYVTLHGVEGARERAYQAVRLALEELEPFGGAGWVLRALAESVVDRVA
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGEFQQYMAARRQQVEAALDRYTAGLDAPSRLVEAMRYSLLAGGKRLRPILTIAASELF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GLEAADVMPGACALEMIHTYSLIHDDLPCMDDDDLRRGRPTCHKVYGEAMAVLAGDALLT
CCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
QAFALMAEQAAVPRVGPARAVRAAAELAHAAGAEGMVGGQVEDLAWEGRQADEPQLRRIH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
SLKTGALFRAAVRMGGILAGAGEEDLDRLGRYATHFGLAFQIWDDVLDVTGDAALTGKGV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCC
GRDARLDKSTYVTLHGVEGARERAYQAVRLALEELEPFGGAGWVLRALAESVVDRVA
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]