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The map label for this gene is ppnK

Identifier: 51892975

GI number: 51892975

Start: 1983744

End: 1984595

Strand: Reverse

Name: ppnK

Synonym: STH1837

Alternate gene names: 51892975

Gene position: 1984595-1983744 (Counterclockwise)

Preceding gene: 51892978

Following gene: 51892974

Centisome position: 55.65

GC content: 72.42

Gene sequence:

>852_bases
ATGCCCAAGTACGCCCTCGTCATCAACGAAGACAAGCCCATGGCCGTAACGACCGGGGAAGAGATCCTGCAGCGGCTCGA
GGCGAGCGGTGCCGCCGTCCTGCTTCACCCCGCGGCGGCCGGCCGCCTGGGCAGGCCCGACCTGGCCGCGCCCGAGGGGC
CGGCCTGGGGCGAGGTCGACATGCTGATCGTACTGGGCGGCGACGGCACCCTGATCCGGGCGGTGCAGCGGGTCGCGCCC
TACGGCGTGCCGGTGCTGGGCATCAACACCGGCCACCTGGGGTTCCTCACCGCCATGGAGAGCGGCGATGCCCTGGCGGA
GCTCGACCGGGTCCTGGCGGGGAGCTACCTGCTGGAGGAGCGCATGATGCTGGAGGCGACGGTGGTCCGGGACGGGCTTG
CCCTGGCGACCATGCCCGCGCTCAACGACGCCGTCATCTCCAAGGGTCCCCGCGCCCGGATGGTGCACCTGGAGGTCTCG
GTGGGCGAGACGGTGGTAGCCCGTTACCGGGCCGACGGCGTCATCGTCGCGACGCCGACCGGGTCCACCGCGTACTCGCT
CTCGGCGGGCGGGCCCGTCGTCGAGCCCACGGTGGATTGTCTGCTGGTCACGCCGATCTGCCCCCACACCATGAGCGCCC
GCTCCATCGTGGTGGGGGCTGACGTCGCGTTGGCGATCCGCGTCGCGGCCAGCCCCGGCGAGGTGGGCCTCTCGGCGGAC
GGGTCTGACCCGTTCCCGCTGCTGCCCGGCGACGTGGTCCGGGTGGGCCGTGCGCCGTACACGGCGCGGCTGGTGCGGCT
TCCGGGCTATCGCTTCTACGATGTGCTGCGGCAGAAGCTGTCCGGCACGTAG

Upstream 100 bases:

>100_bases
GGCGCGGCCCGGATCCGGGCGCCCGGGGCGGTAAGAGGAAGGATGAGGAAGGAAGCGAATACTACTCAAAGATGTCTGCC
CGCGGGGAGGCCGAGCCGGG

Downstream 100 bases:

>100_bases
CGGAAATGCACCGCTGTATATGCAAGTATGCGAATGAATATGCAGGGATTGCCGGGCGTTCCGCCGAATTGGCAGGGGAG
ATGGCCGCCGCTTCGGGCAC

Product: hypothetical protein

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPKYALVINEDKPMAVTTGEEILQRLEASGAAVLLHPAAAGRLGRPDLAAPEGPAWGEVDMLIVLGGDGTLIRAVQRVAP
YGVPVLGINTGHLGFLTAMESGDALAELDRVLAGSYLLEERMMLEATVVRDGLALATMPALNDAVISKGPRARMVHLEVS
VGETVVARYRADGVIVATPTGSTAYSLSAGGPVVEPTVDCLLVTPICPHTMSARSIVVGADVALAIRVAASPGEVGLSAD
GSDPFPLLPGDVVRVGRAPYTARLVRLPGYRFYDVLRQKLSGT

Sequences:

>Translated_283_residues
MPKYALVINEDKPMAVTTGEEILQRLEASGAAVLLHPAAAGRLGRPDLAAPEGPAWGEVDMLIVLGGDGTLIRAVQRVAP
YGVPVLGINTGHLGFLTAMESGDALAELDRVLAGSYLLEERMMLEATVVRDGLALATMPALNDAVISKGPRARMVHLEVS
VGETVVARYRADGVIVATPTGSTAYSLSAGGPVVEPTVDCLLVTPICPHTMSARSIVVGADVALAIRVAASPGEVGLSAD
GSDPFPLLPGDVVRVGRAPYTARLVRLPGYRFYDVLRQKLSGT
>Mature_282_residues
PKYALVINEDKPMAVTTGEEILQRLEASGAAVLLHPAAAGRLGRPDLAAPEGPAWGEVDMLIVLGGDGTLIRAVQRVAPY
GVPVLGINTGHLGFLTAMESGDALAELDRVLAGSYLLEERMMLEATVVRDGLALATMPALNDAVISKGPRARMVHLEVSV
GETVVARYRADGVIVATPTGSTAYSLSAGGPVVEPTVDCLLVTPICPHTMSARSIVVGADVALAIRVAASPGEVGLSADG
SDPFPLLPGDVVRVGRAPYTARLVRLPGYRFYDVLRQKLSGT

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=253, Percent_Identity=30.0395256916996, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788968, Length=270, Percent_Identity=34.4444444444444, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320794, Length=241, Percent_Identity=32.3651452282158, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322509, Length=242, Percent_Identity=33.0578512396694, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6325068, Length=208, Percent_Identity=33.1730769230769, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI28573828, Length=239, Percent_Identity=34.7280334728033, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28573826, Length=239, Percent_Identity=34.7280334728033, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28573830, Length=239, Percent_Identity=34.7280334728033, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI161077047, Length=239, Percent_Identity=34.7280334728033, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28573832, Length=239, Percent_Identity=34.7280334728033, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653422, Length=261, Percent_Identity=30.2681992337165, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI20129957, Length=261, Percent_Identity=30.2681992337165, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281363323, Length=261, Percent_Identity=30.2681992337165, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281363321, Length=261, Percent_Identity=30.2681992337165, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653424, Length=261, Percent_Identity=30.2681992337165, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_SYMTH (Q67NC1)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075666.1
- ProteinModelPortal:   Q67NC1
- SMR:   Q67NC1
- GeneID:   2981942
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1837
- NMPDR:   fig|292459.1.peg.1772
- HOGENOM:   HBG713904
- OMA:   CVPEGFD
- BioCyc:   STHE292459:STH1837-MONOMER
- BRENDA:   2.7.1.23
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 29481; Mature: 29349

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYALVINEDKPMAVTTGEEILQRLEASGAAVLLHPAAAGRLGRPDLAAPEGPAWGEVD
CCCEEEEEECCCCEEEECHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEE
MLIVLGGDGTLIRAVQRVAPYGVPVLGINTGHLGFLTAMESGDALAELDRVLAGSYLLEE
EEEEECCCCHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
RMMLEATVVRDGLALATMPALNDAVISKGPRARMVHLEVSVGETVVARYRADGVIVATPT
HHHHHHHHHHCCCEEEECCCCCHHHHCCCCCEEEEEEEEECCCEEEEEECCCCEEEECCC
GSTAYSLSAGGPVVEPTVDCLLVTPICPHTMSARSIVVGADVALAIRVAASPGEVGLSAD
CCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCEEEEEEEECCCCCCCEECC
GSDPFPLLPGDVVRVGRAPYTARLVRLPGYRFYDVLRQKLSGT
CCCCCCCCCCHHEEECCCCCEEEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PKYALVINEDKPMAVTTGEEILQRLEASGAAVLLHPAAAGRLGRPDLAAPEGPAWGEVD
CCEEEEEECCCCEEEECHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEE
MLIVLGGDGTLIRAVQRVAPYGVPVLGINTGHLGFLTAMESGDALAELDRVLAGSYLLEE
EEEEECCCCHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
RMMLEATVVRDGLALATMPALNDAVISKGPRARMVHLEVSVGETVVARYRADGVIVATPT
HHHHHHHHHHCCCEEEECCCCCHHHHCCCCCEEEEEEEEECCCEEEEEECCCCEEEECCC
GSTAYSLSAGGPVVEPTVDCLLVTPICPHTMSARSIVVGADVALAIRVAASPGEVGLSAD
CCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCEEEEEEEECCCCCCCEECC
GSDPFPLLPGDVVRVGRAPYTARLVRLPGYRFYDVLRQKLSGT
CCCCCCCCCCHHEEECCCCCEEEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA