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The map label for this gene is spoIIAB [H]

Identifier: 51892951

GI number: 51892951

Start: 1957776

End: 1958207

Strand: Reverse

Name: spoIIAB [H]

Synonym: STH1813

Alternate gene names: 51892951

Gene position: 1958207-1957776 (Counterclockwise)

Preceding gene: 51892952

Following gene: 51892950

Centisome position: 54.91

GC content: 69.44

Gene sequence:

>432_bases
GTGATCCTGGAACTGGCTGCCATCCCGGAGAACGTCGGCGTCGCCCGGCTCATGGCCGCGGTGGTCGCGGCCCAGGGGGA
GTTCACCGTGGCCGAGGTCGACGAGGTGAAGCTGGCGGTCTCCGAGGCGGTGACCAACGCCATCGTGCACGGCTACCGGT
GCGACGGCAGCCGGATGGTGCGGATGGAGGCGGCTTTGGAGGACGGCGAGCTCGTGATCGTCGTCATCGACCACGGCAGG
GGCATCGAGGACGTCGCCATGGCCATGCAGCCGGCGGTCACCACGGATCCCGAACGGATGGGGCTGGGCTTCTCGTTCAT
GGAGGCCCACATGGACCACGTGGAGGTGACGTCGCAGGTCGGACAGGGCACCCGGGTGGTCATGCGGAAGCGGCCCGCGG
CCAGGGACGTCGCCTCGCTGAAGGGCAGCTGA

Upstream 100 bases:

>100_bases
GCACCATGGAGGAGTTCCGTTCGGAGCAGGAGGCGCTCTCCGCGGACCGGGCGGGGAGCGGCGCAGGAGAGGGGGCAGTG
TGATGGTCACGCACAACCGG

Downstream 100 bases:

>100_bases
TCGGGCGATGGCTGAGGAGAACACCCTGGAGGAGCGGGGCTGGCCCGATGAGGAGGTCCGGCGGCTGGTGGCCCTGGCCA
GGGCGGGGGACAAGGAGGCC

Product: anti-sigma F factor

Products: NA

Alternate protein names: Stage II sporulation protein AB [H]

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MILELAAIPENVGVARLMAAVVAAQGEFTVAEVDEVKLAVSEAVTNAIVHGYRCDGSRMVRMEAALEDGELVIVVIDHGR
GIEDVAMAMQPAVTTDPERMGLGFSFMEAHMDHVEVTSQVGQGTRVVMRKRPAARDVASLKGS

Sequences:

>Translated_143_residues
MILELAAIPENVGVARLMAAVVAAQGEFTVAEVDEVKLAVSEAVTNAIVHGYRCDGSRMVRMEAALEDGELVIVVIDHGR
GIEDVAMAMQPAVTTDPERMGLGFSFMEAHMDHVEVTSQVGQGTRVVMRKRPAARDVASLKGS
>Mature_143_residues
MILELAAIPENVGVARLMAAVVAAQGEFTVAEVDEVKLAVSEAVTNAIVHGYRCDGSRMVRMEAALEDGELVIVVIDHGR
GIEDVAMAMQPAVTTDPERMGLGFSFMEAHMDHVEVTSQVGQGTRVVMRKRPAARDVASLKGS

Specific function: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases si

COG id: COG2172

COG function: function code T; Anti-sigma regulatory factor (Ser/Thr protein kinase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-factor family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010194
- InterPro:   IPR003594 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 15262; Mature: 15262

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
7.0 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILELAAIPENVGVARLMAAVVAAQGEFTVAEVDEVKLAVSEAVTNAIVHGYRCDGSRMV
CEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCEECCCCEEE
RMEAALEDGELVIVVIDHGRGIEDVAMAMQPAVTTDPERMGLGFSFMEAHMDHVEVTSQV
EEEEECCCCCEEEEEEECCCCHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHH
GQGTRVVMRKRPAARDVASLKGS
CCCEEEEEECCCCHHHHHHCCCC
>Mature Secondary Structure
MILELAAIPENVGVARLMAAVVAAQGEFTVAEVDEVKLAVSEAVTNAIVHGYRCDGSRMV
CEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCEECCCCEEE
RMEAALEDGELVIVVIDHGRGIEDVAMAMQPAVTTDPERMGLGFSFMEAHMDHVEVTSQV
EEEEECCCCCEEEEEEECCCCHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHH
GQGTRVVMRKRPAARDVASLKGS
CCCEEEEEECCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]