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The map label for this gene is pepA

Identifier: 51892912

GI number: 51892912

Start: 1918330

End: 1919805

Strand: Reverse

Name: pepA

Synonym: STH1774

Alternate gene names: 51892912

Gene position: 1919805-1918330 (Counterclockwise)

Preceding gene: 51892913

Following gene: 51892911

Centisome position: 53.83

GC content: 70.6

Gene sequence:

>1476_bases
ATGAAGGTCGAGGTAACCAGCCAGGCTCTCACCGAAGTCGCCGTGGACGTGCTGATTCTGCCGCTCACCGAGGGCACCCC
GGCGCCGGCCGACGTGAACGAGGCGCTGGGCGGGCTGTGCGCGCAGGTGGTGGGCGCGGACTTCAAGGGCGAGATGGGGC
AGACAACGCTGCTGTACACCGGGGGCCGGCTGCCGGCGCGCAAGGTCCTGCTCCTGGGCCTCGGGAAGGCGGAGAAGGTC
ACCAACCGGTCGCTGCGGCGCGCCGCGGGCATCGGGGCGCGTGCGGCCCGGAAGAGCGGCGCCCGGTCGATCGCCTTCGC
GCTGCCCGGGGCGGTGGAGATGGACGAGGCGGCTGCCGCCCGCTTCATCACCGAGGGGGCGCTGCACGGCCTCTTCCGCT
TGCCTGACTGGAAGTCGGAGAAGAAGCCCCGCCCCGAGGTGGAGGCCGTGCACATCCTGGGCGGCGAGCGAGCCCGGGAA
GGAGCGGAGCACGGCCGCATCGTGGCGGAGGGGGTCAACCTCGCCCGCGCCCTGGCCTGGACGCCGGGCAACCACCTGAC
GGCCGCGAAGCTGGCGGAGCGCGCCGCGGAGATGTGCAGGGAGAACGGCATCGAGGTCGAGGTATACGACAAGAAAGGCT
GCGAGGAGCTGGGCCTGGGCCTGCTGCTTGCCGTAAACCAGGGCTCCCGGGAGGAGCCGCGCTTCATCGTGATGCGGTAC
AAGGGCAACGGCGGCCAGGGGCCGTGGCTGGGCCTGGTGGGCAAGGGACTCACCTTTGACTCCGGCGGAATCTCCATCAA
GCCCACCGAGGGCATGTGGAACATGAAGATGGACATGGGCGGCGCCGCGGCCGTCATCGGCGCCATGCAGGCCATCGCCC
GGCTGAAGGTGAAGGCCGACGTGATGGCGGTCATCCCCTCCACCGACAACATGCCGGACGGCGGCTCGTACAAGCCTGGC
GACGTCGTTTCGGGCCTCTCCGGCAAGACGGTGGAGATCCGCTCCACCGACGCCGAGGGCCGGCTGATCCTGGCCGACGG
CCTGGCGTACGCGGCGAAGCAGGGCTGCCGCAAGATCATCACCGCCTCGACGCTGACGGGCGCCTGCAACATCGCCCTGG
GGCCGATCCGCTACGCCCTGGTGGCCAACGACGACGCCTGGGAGGAAGAGGTCTACCGGGCCGGCGAGGCCGCCGGGGAG
CGGGGCTGGAAGCTGCCCCACGACGAGGAGTACTACGACCTCATCAAGTCTTCGGTCGCGGACATGATCAACGGGACGAA
GAACAGGGCCGCGGGCACCGTGGCAGGCGGTCTCTTCCTCATGAAGCACGTGGGGGACACGCCGTGCGTCCACCTGGACA
TCGCCGCGGTGGCGTGGAAGAGCGGCAGCGACGAGTATGAGGACGAGGGCGCCACCGGCGTCGGGACCCGCACCTTCGTC
GAGGCCGCCCGGCGCTTCGCGGAGGGCCTGCGCTAG

Upstream 100 bases:

>100_bases
TGGTCAAGATCCTGGGCGGCAACTACTTGCGGGTCTTCCAACAGGTTCTGCGGTAGCGGTTCCGGCGCGGTGGCTCGATT
CAGGGAAGGAGGCGTCACAC

Downstream 100 bases:

>100_bases
ATGGTGCGGATTCCGATGCCGCCGCCTCAGGGGCGCGCGGACCTGCACAACCACACCACCGCCTCCGACGGGACGCTGAC
CCCGGCGGAGCAGGTGCGAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MKVEVTSQALTEVAVDVLILPLTEGTPAPADVNEALGGLCAQVVGADFKGEMGQTTLLYTGGRLPARKVLLLGLGKAEKV
TNRSLRRAAGIGARAARKSGARSIAFALPGAVEMDEAAAARFITEGALHGLFRLPDWKSEKKPRPEVEAVHILGGERARE
GAEHGRIVAEGVNLARALAWTPGNHLTAAKLAERAAEMCRENGIEVEVYDKKGCEELGLGLLLAVNQGSREEPRFIVMRY
KGNGGQGPWLGLVGKGLTFDSGGISIKPTEGMWNMKMDMGGAAAVIGAMQAIARLKVKADVMAVIPSTDNMPDGGSYKPG
DVVSGLSGKTVEIRSTDAEGRLILADGLAYAAKQGCRKIITASTLTGACNIALGPIRYALVANDDAWEEEVYRAGEAAGE
RGWKLPHDEEYYDLIKSSVADMINGTKNRAAGTVAGGLFLMKHVGDTPCVHLDIAAVAWKSGSDEYEDEGATGVGTRTFV
EAARRFAEGLR

Sequences:

>Translated_491_residues
MKVEVTSQALTEVAVDVLILPLTEGTPAPADVNEALGGLCAQVVGADFKGEMGQTTLLYTGGRLPARKVLLLGLGKAEKV
TNRSLRRAAGIGARAARKSGARSIAFALPGAVEMDEAAAARFITEGALHGLFRLPDWKSEKKPRPEVEAVHILGGERARE
GAEHGRIVAEGVNLARALAWTPGNHLTAAKLAERAAEMCRENGIEVEVYDKKGCEELGLGLLLAVNQGSREEPRFIVMRY
KGNGGQGPWLGLVGKGLTFDSGGISIKPTEGMWNMKMDMGGAAAVIGAMQAIARLKVKADVMAVIPSTDNMPDGGSYKPG
DVVSGLSGKTVEIRSTDAEGRLILADGLAYAAKQGCRKIITASTLTGACNIALGPIRYALVANDDAWEEEVYRAGEAAGE
RGWKLPHDEEYYDLIKSSVADMINGTKNRAAGTVAGGLFLMKHVGDTPCVHLDIAAVAWKSGSDEYEDEGATGVGTRTFV
EAARRFAEGLR
>Mature_491_residues
MKVEVTSQALTEVAVDVLILPLTEGTPAPADVNEALGGLCAQVVGADFKGEMGQTTLLYTGGRLPARKVLLLGLGKAEKV
TNRSLRRAAGIGARAARKSGARSIAFALPGAVEMDEAAAARFITEGALHGLFRLPDWKSEKKPRPEVEAVHILGGERARE
GAEHGRIVAEGVNLARALAWTPGNHLTAAKLAERAAEMCRENGIEVEVYDKKGCEELGLGLLLAVNQGSREEPRFIVMRY
KGNGGQGPWLGLVGKGLTFDSGGISIKPTEGMWNMKMDMGGAAAVIGAMQAIARLKVKADVMAVIPSTDNMPDGGSYKPG
DVVSGLSGKTVEIRSTDAEGRLILADGLAYAAKQGCRKIITASTLTGACNIALGPIRYALVANDDAWEEEVYRAGEAAGE
RGWKLPHDEEYYDLIKSSVADMINGTKNRAAGTVAGGLFLMKHVGDTPCVHLDIAAVAWKSGSDEYEDEGATGVGTRTFV
EAARRFAEGLR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=441, Percent_Identity=36.734693877551, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI47155554, Length=293, Percent_Identity=36.518771331058, Blast_Score=153, Evalue=4e-37,
Organism=Escherichia coli, GI1790710, Length=451, Percent_Identity=36.5853658536585, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87082123, Length=351, Percent_Identity=32.7635327635328, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17556903, Length=319, Percent_Identity=35.423197492163, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=279, Percent_Identity=27.5985663082437, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20129969, Length=411, Percent_Identity=32.360097323601, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21355725, Length=378, Percent_Identity=29.8941798941799, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24661038, Length=378, Percent_Identity=29.3650793650794, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI161077148, Length=449, Percent_Identity=28.2850779510022, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI20130057, Length=449, Percent_Identity=28.2850779510022, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21355645, Length=409, Percent_Identity=30.0733496332518, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24662223, Length=409, Percent_Identity=30.0733496332518, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24662227, Length=412, Percent_Identity=29.3689320388349, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21357381, Length=280, Percent_Identity=33.9285714285714, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221379063, Length=280, Percent_Identity=33.9285714285714, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221379062, Length=280, Percent_Identity=33.9285714285714, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19922386, Length=432, Percent_Identity=29.6296296296296, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI20129963, Length=406, Percent_Identity=28.5714285714286, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646701, Length=332, Percent_Identity=27.1084337349398, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24646703, Length=332, Percent_Identity=27.1084337349398, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21358201, Length=332, Percent_Identity=27.1084337349398, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_SYMTH (Q67NI4)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075603.1
- ProteinModelPortal:   Q67NI4
- SMR:   Q67NI4
- MEROPS:   M17.010
- GeneID:   2982553
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1774
- NMPDR:   fig|292459.1.peg.1711
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- BioCyc:   STHE292459:STH1774-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51837; Mature: 51837

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 267-267 ACT_SITE 341-341

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVEVTSQALTEVAVDVLILPLTEGTPAPADVNEALGGLCAQVVGADFKGEMGQTTLLYT
CEEEEHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
GGRLPARKVLLLGLGKAEKVTNRSLRRAAGIGARAARKSGARSIAFALPGAVEMDEAAAA
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEECCCCCCHHHHHHH
RFITEGALHGLFRLPDWKSEKKPRPEVEAVHILGGERAREGAEHGRIVAEGVNLARALAW
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCHHHHCHHHHCCEEEHHHHHHHHEEE
TPGNHLTAAKLAERAAEMCRENGIEVEVYDKKGCEELGLGLLLAVNQGSREEPRFIVMRY
CCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCEEEEEECCCCCCCCCEEEEEE
KGNGGQGPWLGLVGKGLTFDSGGISIKPTEGMWNMKMDMGGAAAVIGAMQAIARLKVKAD
ECCCCCCCCCEEECCCCEECCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHEEE
VMAVIPSTDNMPDGGSYKPGDVVSGLSGKTVEIRSTDAEGRLILADGLAYAAKQGCRKII
EEEEECCCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHHHHHH
TASTLTGACNIALGPIRYALVANDDAWEEEVYRAGEAAGERGWKLPHDEEYYDLIKSSVA
HHHHCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DMINGTKNRAAGTVAGGLFLMKHVGDTPCVHLDIAAVAWKSGSDEYEDEGATGVGTRTFV
HHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHH
EAARRFAEGLR
HHHHHHHHCCC
>Mature Secondary Structure
MKVEVTSQALTEVAVDVLILPLTEGTPAPADVNEALGGLCAQVVGADFKGEMGQTTLLYT
CEEEEHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
GGRLPARKVLLLGLGKAEKVTNRSLRRAAGIGARAARKSGARSIAFALPGAVEMDEAAAA
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEECCCCCCHHHHHHH
RFITEGALHGLFRLPDWKSEKKPRPEVEAVHILGGERAREGAEHGRIVAEGVNLARALAW
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCHHHHCHHHHCCEEEHHHHHHHHEEE
TPGNHLTAAKLAERAAEMCRENGIEVEVYDKKGCEELGLGLLLAVNQGSREEPRFIVMRY
CCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCEEEEEECCCCCCCCCEEEEEE
KGNGGQGPWLGLVGKGLTFDSGGISIKPTEGMWNMKMDMGGAAAVIGAMQAIARLKVKAD
ECCCCCCCCCEEECCCCEECCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHEEE
VMAVIPSTDNMPDGGSYKPGDVVSGLSGKTVEIRSTDAEGRLILADGLAYAAKQGCRKII
EEEEECCCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHHHHHH
TASTLTGACNIALGPIRYALVANDDAWEEEVYRAGEAAGERGWKLPHDEEYYDLIKSSVA
HHHHCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DMINGTKNRAAGTVAGGLFLMKHVGDTPCVHLDIAAVAWKSGSDEYEDEGATGVGTRTFV
HHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHH
EAARRFAEGLR
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA