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The map label for this gene is 51892171

Identifier: 51892171

GI number: 51892171

Start: 1149670

End: 1150542

Strand: Reverse

Name: 51892171

Synonym: STH1033

Alternate gene names: NA

Gene position: 1150542-1149670 (Counterclockwise)

Preceding gene: 51892173

Following gene: 51892166

Centisome position: 32.26

GC content: 74.8

Gene sequence:

>873_bases
ATGGGCCGGACGATATGGCGGACACCCCCCTGGCACATCCGCCGGACCGGCTTTCCCGAGGCCTGGCGGCTCCTTCGGCT
GCGCAGGCGGCGCCGCGGCCCGGTGGAGATCGGCCTGCTGGACAGCGGCGTGGACCTGACCCACCCCTACCTGCGGGACC
TGCTCGGACCGGGAATCAACCTGCTCTCTCCCGGCGACCTGCCCCACGACGATCACGGCCACGGGACCCATGTGGCCGGC
ATCCTGGCGGTGGCGTCGGGAGCGGTAGGCGGGCAGCGGCCGGTCTGGCCGCCGCCCCTGCGCATCCGGCCGGTCAAGAT
CTTCGACCGGCAAGGCTACGGCCGCATCCGGGACATCATCGCGGGGCTGCAGTGGTGCCGCGCGCAGGGCTGCGAGATCG
TCAACCTCAGCTTCGGCACCGACCGGCGCGCCAGCGAGGAACTGGCGGAGGCCATCCGCGCGCTGGAGAAGGCCGGCATC
CTGCTGGTAGGCGCGGCCGGCAACGACGGCCGGGGCGGGGCGGTGGACACGCCGGGGAAGTACCCCGAGGTGCTGGCTGT
GGCGGCCATCAACCGGCGCGACCGGCTCGCCCGCTTCTCCAGCCGCGGGCCCGAGGTCGACCTGGTGGCCCCGGGCGCGG
GCCTCTTCTCGCTGGCCCCGGGCGGCCGGTTCTGCCGCATGAGCGGCACCTCCATGGCCGCGCCCCACGTGACGGCCGCC
GCAGCGATGCTGCTCTCGGTCCGCCCGGGCCTCACCCCCGCGGCCGTGCGGGCGCACCTGAAGCACACCGCCGAATGGCT
CCCCCAGATCCACGCCTCTGCGCAGGGCGCCGGCCTGCTGCGGGCAGACCGGCTCCTGCGGGAGGAACCGTGA

Upstream 100 bases:

>100_bases
GTATTATACGAGCGATACCATAAAAAGTAAAGTCCCGGAGTGGCATTGCCCTCCGACCCGCCGTAATGATGGTCCAGACT
CGGCGGGAGGAGCGAAACCG

Downstream 100 bases:

>100_bases
AGGGGCCGGCGGCGACCACAAAGGCTGGCGCATCATCCTGCGCCAGCCTGCACCTTATCTGTATCTCGGTTATTGCATTC
CCCGCTCGACAGCGGCAGAC

Product: subtilisin-like alkaline serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MGRTIWRTPPWHIRRTGFPEAWRLLRLRRRRRGPVEIGLLDSGVDLTHPYLRDLLGPGINLLSPGDLPHDDHGHGTHVAG
ILAVASGAVGGQRPVWPPPLRIRPVKIFDRQGYGRIRDIIAGLQWCRAQGCEIVNLSFGTDRRASEELAEAIRALEKAGI
LLVGAAGNDGRGGAVDTPGKYPEVLAVAAINRRDRLARFSSRGPEVDLVAPGAGLFSLAPGGRFCRMSGTSMAAPHVTAA
AAMLLSVRPGLTPAAVRAHLKHTAEWLPQIHASAQGAGLLRADRLLREEP

Sequences:

>Translated_290_residues
MGRTIWRTPPWHIRRTGFPEAWRLLRLRRRRRGPVEIGLLDSGVDLTHPYLRDLLGPGINLLSPGDLPHDDHGHGTHVAG
ILAVASGAVGGQRPVWPPPLRIRPVKIFDRQGYGRIRDIIAGLQWCRAQGCEIVNLSFGTDRRASEELAEAIRALEKAGI
LLVGAAGNDGRGGAVDTPGKYPEVLAVAAINRRDRLARFSSRGPEVDLVAPGAGLFSLAPGGRFCRMSGTSMAAPHVTAA
AAMLLSVRPGLTPAAVRAHLKHTAEWLPQIHASAQGAGLLRADRLLREEP
>Mature_289_residues
GRTIWRTPPWHIRRTGFPEAWRLLRLRRRRRGPVEIGLLDSGVDLTHPYLRDLLGPGINLLSPGDLPHDDHGHGTHVAGI
LAVASGAVGGQRPVWPPPLRIRPVKIFDRQGYGRIRDIIAGLQWCRAQGCEIVNLSFGTDRRASEELAEAIRALEKAGIL
LVGAAGNDGRGGAVDTPGKYPEVLAVAAINRRDRLARFSSRGPEVDLVAPGAGLFSLAPGGRFCRMSGTSMAAPHVTAAA
AMLLSVRPGLTPAAVRAHLKHTAEWLPQIHASAQGAGLLRADRLLREEP

Specific function: Shows keratinolytic activity [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=271, Percent_Identity=27.3062730627306, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI31317307, Length=301, Percent_Identity=28.9036544850498, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319893, Length=256, Percent_Identity=31.25, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324576, Length=225, Percent_Identity=29.3333333333333, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320775, Length=291, Percent_Identity=26.8041237113402, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45550681, Length=274, Percent_Identity=28.4671532846715, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020
- InterPro:   IPR010259 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 31256; Mature: 31124

Theoretical pI: Translated: 11.45; Mature: 11.45

Prosite motif: PS00136 SUBTILASE_ASP ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRTIWRTPPWHIRRTGFPEAWRLLRLRRRRRGPVEIGLLDSGVDLTHPYLRDLLGPGIN
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCC
LLSPGDLPHDDHGHGTHVAGILAVASGAVGGQRPVWPPPLRIRPVKIFDRQGYGRIRDII
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHH
AGLQWCRAQGCEIVNLSFGTDRRASEELAEAIRALEKAGILLVGAAGNDGRGGAVDTPGK
HHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCC
YPEVLAVAAINRRDRLARFSSRGPEVDLVAPGAGLFSLAPGGRFCRMSGTSMAAPHVTAA
CHHHHHHHHHCHHHHHHHHHCCCCCEEEECCCCCEEEECCCCCEEEECCCCCCCCHHHHH
AAMLLSVRPGLTPAAVRAHLKHTAEWLPQIHASAQGAGLLRADRLLREEP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
GRTIWRTPPWHIRRTGFPEAWRLLRLRRRRRGPVEIGLLDSGVDLTHPYLRDLLGPGIN
CCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCC
LLSPGDLPHDDHGHGTHVAGILAVASGAVGGQRPVWPPPLRIRPVKIFDRQGYGRIRDII
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHH
AGLQWCRAQGCEIVNLSFGTDRRASEELAEAIRALEKAGILLVGAAGNDGRGGAVDTPGK
HHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCC
YPEVLAVAAINRRDRLARFSSRGPEVDLVAPGAGLFSLAPGGRFCRMSGTSMAAPHVTAA
CHHHHHHHHHCHHHHHHHHHCCCCCEEEECCCCCEEEECCCCCEEEECCCCCCCCHHHHH
AAMLLSVRPGLTPAAVRAHLKHTAEWLPQIHASAQGAGLLRADRLLREEP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1369007; 11058132; 1370008 [H]