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The map label for this gene is nucA

Identifier: 51598666

GI number: 51598666

Start: 422805

End: 423686

Strand: Direct

Name: nucA

Synonym: BG0412

Alternate gene names: NA

Gene position: 422805-423686 (Clockwise)

Preceding gene: 51598665

Following gene: 51598667

Centisome position: 46.76

GC content: 25.62

Gene sequence:

>882_bases
ATGAAAAAAAGATCAAAATTTTTTCTTTACTGCTATATTTTATGTCTAGCAGGATTTTTATTTTTTTCCTTAAATCCAAA
AGTCCTAAAACAAATTAAACACAAAATTAATGACTATTTAGAGATAATAGAAAATAAATATATTAAAATTACAAAATCTA
TTCCAATAAAAGAATCCCAATTAATACCTAAAGGATATCTTACTACCCAAATAATAAGTAAAAAACACTATACCTTGGGA
TATGCTGAAAGCGCAAGACAATCCGAATGGGCTGCTTATCCGCTTAAAAGAGAAATGGTGGAACTAGCATTAACTTTGTT
AAAATCAAAAAAAATTAAAAGGAGTCCTAAATTCTTTGAAGACACCAATATCAAAGGCATTTTTCCAAAACTTGAAGATT
ACTTTAAAAGCGGTTATGACAGAGGACACATAGTAAGTTCTGCAGACATGTCTTTTTCTGAAAATGCAATGAAAGATACA
TATTTTTTATCAAATATGTCACCCCAAAAAAGCGAATTTAATTCTGGGATTTGGCTAAAACTTGAAAAATTAGTAAGAGA
ATGGGCAATCTTAAAAGGATATATATATATCATAAGTGCTGGAATTTTAACGGAAAATAAAGGATTTATTGGTAAAAACA
AAATTTTGATACCTAAAAATTTTTATAAAATAGTACTAGCAATTAATAATAAAAATTTTTATGACATAATCTCTTTTATT
ATCCCAAATGAAAAAGCAAAAGACTTGAATTTGAAAAATTACGTTGTCAACGTAGATTTAATTGAAAAAAAAACAAAAAT
AGATTTTTTTGCAAAACTTGATTCAAAAATTAAAAAAAATATCAAAAAAATAAAAACCACGCATTCTTGGAGGTTTAAAT
GA

Upstream 100 bases:

>100_bases
GATTAGACTTTAAAATTGATTTTTTATTTTTAGATACATTTAACATTTCTTTTAATTTCACTATTAGATATAATCTTAAG
GACGAAAAAGAGATGGAAAC

Downstream 100 bases:

>100_bases
AATCAATATTTACAAAGTTAAACGCTTCTATTAATCTCTTTCTCTTTATAATTTTTATTTTAGCAACACTAGTTATACTG
ATTTTCTCTTATAAAATAAA

Product: endonuclease precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKKRSKFFLYCYILCLAGFLFFSLNPKVLKQIKHKINDYLEIIENKYIKITKSIPIKESQLIPKGYLTTQIISKKHYTLG
YAESARQSEWAAYPLKREMVELALTLLKSKKIKRSPKFFEDTNIKGIFPKLEDYFKSGYDRGHIVSSADMSFSENAMKDT
YFLSNMSPQKSEFNSGIWLKLEKLVREWAILKGYIYIISAGILTENKGFIGKNKILIPKNFYKIVLAINNKNFYDIISFI
IPNEKAKDLNLKNYVVNVDLIEKKTKIDFFAKLDSKIKKNIKKIKTTHSWRFK

Sequences:

>Translated_293_residues
MKKRSKFFLYCYILCLAGFLFFSLNPKVLKQIKHKINDYLEIIENKYIKITKSIPIKESQLIPKGYLTTQIISKKHYTLG
YAESARQSEWAAYPLKREMVELALTLLKSKKIKRSPKFFEDTNIKGIFPKLEDYFKSGYDRGHIVSSADMSFSENAMKDT
YFLSNMSPQKSEFNSGIWLKLEKLVREWAILKGYIYIISAGILTENKGFIGKNKILIPKNFYKIVLAINNKNFYDIISFI
IPNEKAKDLNLKNYVVNVDLIEKKTKIDFFAKLDSKIKKNIKKIKTTHSWRFK
>Mature_293_residues
MKKRSKFFLYCYILCLAGFLFFSLNPKVLKQIKHKINDYLEIIENKYIKITKSIPIKESQLIPKGYLTTQIISKKHYTLG
YAESARQSEWAAYPLKREMVELALTLLKSKKIKRSPKFFEDTNIKGIFPKLEDYFKSGYDRGHIVSSADMSFSENAMKDT
YFLSNMSPQKSEFNSGIWLKLEKLVREWAILKGYIYIISAGILTENKGFIGKNKILIPKNFYKIVLAINNKNFYDIISFI
IPNEKAKDLNLKNYVVNVDLIEKKTKIDFFAKLDSKIKKNIKKIKTTHSWRFK

Specific function: Unknown

COG id: COG1864

COG function: function code F; DNA/RNA endonuclease G, NUC1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA/RNA non-specific endonuclease family [H]

Homologues:

Organism=Homo sapiens, GI53759134, Length=213, Percent_Identity=26.7605633802817, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI224451073, Length=228, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI224451075, Length=187, Percent_Identity=29.9465240641711, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17505967, Length=248, Percent_Identity=27.8225806451613, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322253, Length=198, Percent_Identity=34.3434343434343, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129899, Length=239, Percent_Identity=25.5230125523013, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24581065, Length=212, Percent_Identity=24.0566037735849, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018524
- InterPro:   IPR001604
- InterPro:   IPR020821 [H]

Pfam domain/function: PF01223 Endonuclease_NS [H]

EC number: NA

Molecular weight: Translated: 34342; Mature: 34342

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS01070 NUCLEASE_NON_SPEC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRSKFFLYCYILCLAGFLFFSLNPKVLKQIKHKINDYLEIIENKYIKITKSIPIKESQ
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHC
LIPKGYLTTQIISKKHYTLGYAESARQSEWAAYPLKREMVELALTLLKSKKIKRSPKFFE
CCCCCHHHHHHHCCCCCEECCHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
DTNIKGIFPKLEDYFKSGYDRGHIVSSADMSFSENAMKDTYFLSNMSPQKSEFNSGIWLK
CCCCCEECHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHEECCCCCCHHHCCCCHHEE
LEKLVREWAILKGYIYIISAGILTENKGFIGKNKILIPKNFYKIVLAINNKNFYDIISFI
HHHHHHHHHHHHHEEEEEEECEEECCCCCCCCCEEEECCCEEEEEEEECCCCHHHHHHHH
IPNEKAKDLNLKNYVVNVDLIEKKTKIDFFAKLDSKIKKNIKKIKTTHSWRFK
CCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKRSKFFLYCYILCLAGFLFFSLNPKVLKQIKHKINDYLEIIENKYIKITKSIPIKESQ
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHC
LIPKGYLTTQIISKKHYTLGYAESARQSEWAAYPLKREMVELALTLLKSKKIKRSPKFFE
CCCCCHHHHHHHCCCCCEECCHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
DTNIKGIFPKLEDYFKSGYDRGHIVSSADMSFSENAMKDTYFLSNMSPQKSEFNSGIWLK
CCCCCEECHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHEECCCCCCHHHCCCCHHEE
LEKLVREWAILKGYIYIISAGILTENKGFIGKNKILIPKNFYKIVLAINNKNFYDIISFI
HHHHHHHHHHHHHEEEEEEECEEECCCCCCCCCEEEECCCEEEEEEEECCCCHHHHHHHH
IPNEKAKDLNLKNYVVNVDLIEKKTKIDFFAKLDSKIKKNIKKIKTTHSWRFK
CCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]