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The map label for this gene is leuS [H]

Identifier: 51598511

GI number: 51598511

Start: 255253

End: 257775

Strand: Direct

Name: leuS [H]

Synonym: BG0254

Alternate gene names: 51598511

Gene position: 255253-257775 (Clockwise)

Preceding gene: 51598510

Following gene: 51598512

Centisome position: 28.23

GC content: 30.84

Gene sequence:

>2523_bases
ATGTCTAAATACGAATTCATAAAAATTGAAAAAAAATGGCAAGAATTTTGGGATAATAATAAAACATACAAAGTAAAAGA
AGATCCAAACATTCCTAAAGAAAAAAGATTATACATCCTTGACATGTTCCCCTATCCTTCTGCAAACGGACTTCATGTTG
GCCATCCAGAAGGATACACAGCTACCGACATATTTGGAAGATACAAGCTTTTAAATGGATTTCATGTACTTCATCCAATA
GGATTTGATAGTTTTGGACTGCCTGCTGAAAATTATGCAATACAAACAGGAACTCATCCTCAAAAAAGTACAGAAGAAAA
TATTAATAAGTTTAAAAAACAAATAAAAGCTTTGGGATTTGCCTACGATTGGGATCGAGAAATCAGAACACATGACGAGA
ATTACTATAAATGGACACAATGGATTTTTTTGGAATTATATAAAAAAGGTCTGGCCTATGCAAAAGAAATGCCTGTATGG
TACTGTCCTGAACTTGGAACAGTATTGGCAAATGAAGAGATTATTCAAACTCCAGATGGACCAAAATCTGAGAGAGGATT
TCACAATGTCGAAAAAAAATATTTAAGACAGTGGGTTTTAAAAATCACGAAGTATGCTGAAAGATTGTTAAACGACCTTG
AAGAATTAGAATGGCCTGAATCTGTAAAAGAAATGCAGCGAAATTGGATTGGAAAATCAACAGGGGTTGAAATCGACTTT
GAAATTGAAGGTCACAATGATAAAATCAAAGTTTTTACAACAAGGCCAGACACAATCTTTGGTATCACATATTTAGTAAT
CGCACCAGAAAGCAAGCTAATAGAGAAAATAACAAAAAATAACTTTAAAAGAAATGTCTTAAAATATGTAAAGCACGAAG
AACTAAAAAGTGATCTTAAGAGAACCTCTCTTGAAAAAGATAAATCAGGCGTTTTTACAGGATCTTATGCATTTCATCCA
ATAACAAATGAAAAAATTCCAATTTGGATTGGAAGCTACGTACTAGGAACTTATGGTAGTGGAGCTGTAATGGGTGTTCC
AGCCCACGATGAGAGAGACTTTCAATTTGCTAAAAAGTATAAATTAAAAATTTTGCCTGTAATATCAAAATCGGGAAAAA
ATGAAATATTAGAAAAAGCATTTATTGATGATGGAATTTCAATAAATTCTCCTAATGAATTTAATAATCTTAAAAATTCT
GAAGTAAAAGATAAAGTAATAGAATGGCTTATTAAAAACAAAAAAGGGAAAGAAAAAGTTACCTACAAGCTTAGAGATTG
GATTTTTTCAAGACAAAGATACTGGGGAGAGCCTATACCCATTTTATTTGATAAGCTTGGAAATGCAGTACCTTTAGAAA
AAAATGATCTTCCCTTAAAGCTTCCAAAAACTGCAAACTATAAACCTTCTAGAACGGGAGAATCTCCTTTATCAAGGATT
AAAGATTGGGTAAACCTAAAAGATACAGGCTTTACAAGAGAAACAAACACAATGCCTCAATGGGCAGGCTCTTGTTGGTA
TTATTTAAGATACCTCGATCCTAAAAACCCAAAAGAATTTGCAAGTAAAAAAAAAATTGAATATTGGATGCCAGTTGACC
TATACATAGGTGGAGCTGAACATACGGTATTACACCTACTTTACTCAAGGTTTTGGCACAAGGTTCTTTATGATCTAGGG
TATGTAAATACCAAAGAACCTTTTAAAAAGCTAATAAATCAAGGCATAATAACCGCATTTTCTTATCAAAAAGAAAATGG
GATTTTAATACCTAATGACCAAGTTATAGAAAAAAACAGTAAATTTTTTGACAAAAGGGATAATAAAGAAGTAATCCAAG
TAATTGCCAAGATGTCAAAATCCTTAAAAAATGTAATAAACCCAGACGACATTATTAAAGAATTTGGAGCAGACTCAATA
AGAATTTATGAAATGTTTATGGGTCCACTAACAGATTCTAAACCTTGGAACACCAAAGGTATTATTGGTGTTTTTCGATT
TTTAAACAAAATTTGGAACTTAAGAGAAAAAGAACTATCAAAAGACAATCCTCCAAAAGAAATAATATCTCAACTGCATA
AAGCAATAAAAAAGGTCACAGAAGATACAGAAAAACTAAGCTTCAATACAGCAATCTCAGCGATGATGATATTTGTAAAT
GAGCTTATAAAGTATGAAAAAAATTATTTAAATATATTTAAACCATTCATTATTATTTTATCCCCTTATGCACCCCATTT
AGCAGAAGAGTTATGGGAATATATTGGAGAAACTCCCAGTTTATTTAAAAATTCAAAATGGCCAGAATTCGATGAAAACC
TTATTATTAAAGACGCAAAAGAAATTGTCTTACAAATAAATGGAAAAATGAAAGACAAAATTTTACTAAGCAAAGAGACA
GATGAAGAAGAGTTAAAAGAAATAGCAATGGGAAATAGCAAAATAAAAGCAAACTTATTAAATAAAAAAATTGTAAAAAT
AATTGCAATTAAAAACAAGCTTGTCAACATAGTGATAAAGTAA

Upstream 100 bases:

>100_bases
TCACAGCATCAAAATTGTTAAGTAGCTTATTGAAATAAACACAAATGTGATCCAAAAGGATACTAGAGAATAAATTATAG
ATTAATTTTCAAGAGGACAA

Downstream 100 bases:

>100_bases
AAAAGAGGCATTATATGGACTTTGAAAGTCTAAGCATTAGATATAGGAAAATTATATTCACAATATTTATATTAATTACT
ATTTTTTTAGGGTTTTTTTT

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 840; Mature: 839

Protein sequence:

>840_residues
MSKYEFIKIEKKWQEFWDNNKTYKVKEDPNIPKEKRLYILDMFPYPSANGLHVGHPEGYTATDIFGRYKLLNGFHVLHPI
GFDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAYDWDREIRTHDENYYKWTQWIFLELYKKGLAYAKEMPVW
YCPELGTVLANEEIIQTPDGPKSERGFHNVEKKYLRQWVLKITKYAERLLNDLEELEWPESVKEMQRNWIGKSTGVEIDF
EIEGHNDKIKVFTTRPDTIFGITYLVIAPESKLIEKITKNNFKRNVLKYVKHEELKSDLKRTSLEKDKSGVFTGSYAFHP
ITNEKIPIWIGSYVLGTYGSGAVMGVPAHDERDFQFAKKYKLKILPVISKSGKNEILEKAFIDDGISINSPNEFNNLKNS
EVKDKVIEWLIKNKKGKEKVTYKLRDWIFSRQRYWGEPIPILFDKLGNAVPLEKNDLPLKLPKTANYKPSRTGESPLSRI
KDWVNLKDTGFTRETNTMPQWAGSCWYYLRYLDPKNPKEFASKKKIEYWMPVDLYIGGAEHTVLHLLYSRFWHKVLYDLG
YVNTKEPFKKLINQGIITAFSYQKENGILIPNDQVIEKNSKFFDKRDNKEVIQVIAKMSKSLKNVINPDDIIKEFGADSI
RIYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWNLREKELSKDNPPKEIISQLHKAIKKVTEDTEKLSFNTAISAMMIFVN
ELIKYEKNYLNIFKPFIIILSPYAPHLAEELWEYIGETPSLFKNSKWPEFDENLIIKDAKEIVLQINGKMKDKILLSKET
DEEELKEIAMGNSKIKANLLNKKIVKIIAIKNKLVNIVIK

Sequences:

>Translated_840_residues
MSKYEFIKIEKKWQEFWDNNKTYKVKEDPNIPKEKRLYILDMFPYPSANGLHVGHPEGYTATDIFGRYKLLNGFHVLHPI
GFDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAYDWDREIRTHDENYYKWTQWIFLELYKKGLAYAKEMPVW
YCPELGTVLANEEIIQTPDGPKSERGFHNVEKKYLRQWVLKITKYAERLLNDLEELEWPESVKEMQRNWIGKSTGVEIDF
EIEGHNDKIKVFTTRPDTIFGITYLVIAPESKLIEKITKNNFKRNVLKYVKHEELKSDLKRTSLEKDKSGVFTGSYAFHP
ITNEKIPIWIGSYVLGTYGSGAVMGVPAHDERDFQFAKKYKLKILPVISKSGKNEILEKAFIDDGISINSPNEFNNLKNS
EVKDKVIEWLIKNKKGKEKVTYKLRDWIFSRQRYWGEPIPILFDKLGNAVPLEKNDLPLKLPKTANYKPSRTGESPLSRI
KDWVNLKDTGFTRETNTMPQWAGSCWYYLRYLDPKNPKEFASKKKIEYWMPVDLYIGGAEHTVLHLLYSRFWHKVLYDLG
YVNTKEPFKKLINQGIITAFSYQKENGILIPNDQVIEKNSKFFDKRDNKEVIQVIAKMSKSLKNVINPDDIIKEFGADSI
RIYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWNLREKELSKDNPPKEIISQLHKAIKKVTEDTEKLSFNTAISAMMIFVN
ELIKYEKNYLNIFKPFIIILSPYAPHLAEELWEYIGETPSLFKNSKWPEFDENLIIKDAKEIVLQINGKMKDKILLSKET
DEEELKEIAMGNSKIKANLLNKKIVKIIAIKNKLVNIVIK
>Mature_839_residues
SKYEFIKIEKKWQEFWDNNKTYKVKEDPNIPKEKRLYILDMFPYPSANGLHVGHPEGYTATDIFGRYKLLNGFHVLHPIG
FDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGFAYDWDREIRTHDENYYKWTQWIFLELYKKGLAYAKEMPVWY
CPELGTVLANEEIIQTPDGPKSERGFHNVEKKYLRQWVLKITKYAERLLNDLEELEWPESVKEMQRNWIGKSTGVEIDFE
IEGHNDKIKVFTTRPDTIFGITYLVIAPESKLIEKITKNNFKRNVLKYVKHEELKSDLKRTSLEKDKSGVFTGSYAFHPI
TNEKIPIWIGSYVLGTYGSGAVMGVPAHDERDFQFAKKYKLKILPVISKSGKNEILEKAFIDDGISINSPNEFNNLKNSE
VKDKVIEWLIKNKKGKEKVTYKLRDWIFSRQRYWGEPIPILFDKLGNAVPLEKNDLPLKLPKTANYKPSRTGESPLSRIK
DWVNLKDTGFTRETNTMPQWAGSCWYYLRYLDPKNPKEFASKKKIEYWMPVDLYIGGAEHTVLHLLYSRFWHKVLYDLGY
VNTKEPFKKLINQGIITAFSYQKENGILIPNDQVIEKNSKFFDKRDNKEVIQVIAKMSKSLKNVINPDDIIKEFGADSIR
IYEMFMGPLTDSKPWNTKGIIGVFRFLNKIWNLREKELSKDNPPKEIISQLHKAIKKVTEDTEKLSFNTAISAMMIFVNE
LIKYEKNYLNIFKPFIIILSPYAPHLAEELWEYIGETPSLFKNSKWPEFDENLIIKDAKEIVLQINGKMKDKILLSKETD
EEELKEIAMGNSKIKANLLNKKIVKIIAIKNKLVNIVIK

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=883, Percent_Identity=31.3703284258211, Blast_Score=439, Evalue=1e-123,
Organism=Escherichia coli, GI1786861, Length=873, Percent_Identity=38.717067583047, Blast_Score=594, Evalue=1e-171,
Organism=Escherichia coli, GI1790708, Length=415, Percent_Identity=23.1325301204819, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71997517, Length=797, Percent_Identity=30.7402760351317, Blast_Score=298, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71997510, Length=797, Percent_Identity=30.7402760351317, Blast_Score=298, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI212645227, Length=315, Percent_Identity=32.3809523809524, Blast_Score=146, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323414, Length=882, Percent_Identity=35.1473922902494, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI21355409, Length=842, Percent_Identity=30.5225653206651, Blast_Score=353, Evalue=4e-97,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 98169; Mature: 98037

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYEFIKIEKKWQEFWDNNKTYKVKEDPNIPKEKRLYILDMFPYPSANGLHVGHPEGYT
CCCCEEEEHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEECCCCCCCC
ATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGF
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCC
AYDWDREIRTHDENYYKWTQWIFLELYKKGLAYAKEMPVWYCPELGTVLANEEIIQTPDG
CCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCCEECCCC
PKSERGFHNVEKKYLRQWVLKITKYAERLLNDLEELEWPESVKEMQRNWIGKSTGVEIDF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEE
EIEGHNDKIKVFTTRPDTIFGITYLVIAPESKLIEKITKNNFKRNVLKYVKHEELKSDLK
EEECCCCEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTSLEKDKSGVFTGSYAFHPITNEKIPIWIGSYVLGTYGSGAVMGVPAHDERDFQFAKKY
HHHCCCCCCCEEECCEEECCCCCCCCEEEECCHHHHCCCCCCEEECCCCCCCCHHHHHHC
KLKILPVISKSGKNEILEKAFIDDGISINSPNEFNNLKNSEVKDKVIEWLIKNKKGKEKV
CEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCHHH
TYKLRDWIFSRQRYWGEPIPILFDKLGNAVPLEKNDLPLKLPKTANYKPSRTGESPLSRI
HHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHH
KDWVNLKDTGFTRETNTMPQWAGSCWYYLRYLDPKNPKEFASKKKIEYWMPVDLYIGGAE
HHHCCCCCCCCCCCCCCCCHHHCCCEEEEEECCCCCHHHHHHCCCCEEECCEEEEECCCH
HTVLHLLYSRFWHKVLYDLGYVNTKEPFKKLINQGIITAFSYQKENGILIPNDQVIEKNS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCCCEECCCCHHHHCCC
KFFDKRDNKEVIQVIAKMSKSLKNVINPDDIIKEFGADSIRIYEMFMGPLTDSKPWNTKG
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCCCH
IIGVFRFLNKIWNLREKELSKDNPPKEIISQLHKAIKKVTEDTEKLSFNTAISAMMIFVN
HHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELIKYEKNYLNIFKPFIIILSPYAPHLAEELWEYIGETPSLFKNSKWPEFDENLIIKDAK
HHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEHHHHH
EIVLQINGKMKDKILLSKETDEEELKEIAMGNSKIKANLLNKKIVKIIAIKNKLVNIVIK
HHHEEECCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEC
>Mature Secondary Structure 
SKYEFIKIEKKWQEFWDNNKTYKVKEDPNIPKEKRLYILDMFPYPSANGLHVGHPEGYT
CCCEEEEHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEECCCCCCCC
ATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTHPQKSTEENINKFKKQIKALGF
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCC
AYDWDREIRTHDENYYKWTQWIFLELYKKGLAYAKEMPVWYCPELGTVLANEEIIQTPDG
CCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCCEECCCC
PKSERGFHNVEKKYLRQWVLKITKYAERLLNDLEELEWPESVKEMQRNWIGKSTGVEIDF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEE
EIEGHNDKIKVFTTRPDTIFGITYLVIAPESKLIEKITKNNFKRNVLKYVKHEELKSDLK
EEECCCCEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTSLEKDKSGVFTGSYAFHPITNEKIPIWIGSYVLGTYGSGAVMGVPAHDERDFQFAKKY
HHHCCCCCCCEEECCEEECCCCCCCCEEEECCHHHHCCCCCCEEECCCCCCCCHHHHHHC
KLKILPVISKSGKNEILEKAFIDDGISINSPNEFNNLKNSEVKDKVIEWLIKNKKGKEKV
CEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCHHH
TYKLRDWIFSRQRYWGEPIPILFDKLGNAVPLEKNDLPLKLPKTANYKPSRTGESPLSRI
HHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHH
KDWVNLKDTGFTRETNTMPQWAGSCWYYLRYLDPKNPKEFASKKKIEYWMPVDLYIGGAE
HHHCCCCCCCCCCCCCCCCHHHCCCEEEEEECCCCCHHHHHHCCCCEEECCEEEEECCCH
HTVLHLLYSRFWHKVLYDLGYVNTKEPFKKLINQGIITAFSYQKENGILIPNDQVIEKNS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCCCEECCCCHHHHCCC
KFFDKRDNKEVIQVIAKMSKSLKNVINPDDIIKEFGADSIRIYEMFMGPLTDSKPWNTKG
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCCCH
IIGVFRFLNKIWNLREKELSKDNPPKEIISQLHKAIKKVTEDTEKLSFNTAISAMMIFVN
HHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELIKYEKNYLNIFKPFIIILSPYAPHLAEELWEYIGETPSLFKNSKWPEFDENLIIKDAK
HHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEHHHHH
EIVLQINGKMKDKILLSKETDEEELKEIAMGNSKIKANLLNKKIVKIIAIKNKLVNIVIK
HHHEEECCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA