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The map label for this gene is accB

Identifier: 51597862

GI number: 51597862

Start: 4250726

End: 4251235

Strand: Direct

Name: accB

Synonym: YPTB3571

Alternate gene names: 51597862

Gene position: 4250726-4251235 (Clockwise)

Preceding gene: 51597861

Following gene: 51597863

Centisome position: 89.59

GC content: 48.82

Gene sequence:

>510_bases
ATGATGGGTATAATTGCAACACACAAAGAGTACGGAATCACACTTATGGATATTCGTAAGATTAAGAAACTGATCGAACT
GGTTGAAGAGTCTGGTATTTCAGAGCTGGAAATCTCAGAAGGCGAAGAGTCAGTACGTATCAGTCGTGCTCCTGCCGCAC
CGAATTACCCAATGATGCAACAGCCTTATGCTTTTGCTGCACCACAACAGCAGCCAGCGCTGGCAGCCGCAGTCGCCCCA
GCACCCGTTGCTGAAGCCGCACCGGCAGCGATAAGTGGCCATATCGTATGTTCCCCAATGGTCGGTACGTTCTACCGCAC
CCCTAGCCCAGATGCCAAAGCCTTCGTTGAAGTCGGTCAGAAAGTTTCTGTTGGTGATACTCTTTGCATCGTTGAAGCGA
TGAAAATGATGAACCAAATCGAAGCAGACAAATCCGGTACTGTAAAAGCCATTCTGGTTGAAAACGGCCAACCGGTTGAA
TTCGACGAGCCTCTTGTCGTCATCGAATAA

Upstream 100 bases:

>100_bases
TCGAGTTACAGGAAGGCGGCAACTGAGCGAATCCCCACGAGCTTACATAGGTAAGTGACTGGGGTGAACGAAGGCAGCCA
ACGCACATGCAACTCGAAGT

Downstream 100 bases:

>100_bases
CGAGGCGTTCCATGCTTGATAAAATCGTAATCGCTAACCGCGGTGAGATTGCGCTGCGGATCCTACGGGCTTGTAAGGAG
CTGGGGATCAAGACTGTCGC

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MMGIIATHKEYGITLMDIRKIKKLIELVEESGISELEISEGEESVRISRAPAAPNYPMMQQPYAFAAPQQQPALAAAVAP
APVAEAAPAAISGHIVCSPMVGTFYRTPSPDAKAFVEVGQKVSVGDTLCIVEAMKMMNQIEADKSGTVKAILVENGQPVE
FDEPLVVIE

Sequences:

>Translated_169_residues
MMGIIATHKEYGITLMDIRKIKKLIELVEESGISELEISEGEESVRISRAPAAPNYPMMQQPYAFAAPQQQPALAAAVAP
APVAEAAPAAISGHIVCSPMVGTFYRTPSPDAKAFVEVGQKVSVGDTLCIVEAMKMMNQIEADKSGTVKAILVENGQPVE
FDEPLVVIE
>Mature_169_residues
MMGIIATHKEYGITLMDIRKIKKLIELVEESGISELEISEGEESVRISRAPAAPNYPMMQQPYAFAAPQQQPALAAAVAP
APVAEAAPAAISGHIVCSPMVGTFYRTPSPDAKAFVEVGQKVSVGDTLCIVEAMKMMNQIEADKSGTVKAILVENGQPVE
FDEPLVVIE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=158, Percent_Identity=83.5443037974684, Blast_Score=241, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 18068; Mature: 18068

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGIIATHKEYGITLMDIRKIKKLIELVEESGISELEISEGEESVRISRAPAAPNYPMMQ
CCCEEECCHHHCEEHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCCCCC
QPYAFAAPQQQPALAAAVAPAPVAEAAPAAISGHIVCSPMVGTFYRTPSPDAKAFVEVGQ
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCEEECCCCHHEECCCCCCHHHHHHCCC
KVSVGDTLCIVEAMKMMNQIEADKSGTVKAILVENGQPVEFDEPLVVIE
CCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEC
>Mature Secondary Structure
MMGIIATHKEYGITLMDIRKIKKLIELVEESGISELEISEGEESVRISRAPAAPNYPMMQ
CCCEEECCHHHCEEHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCCCCC
QPYAFAAPQQQPALAAAVAPAPVAEAAPAAISGHIVCSPMVGTFYRTPSPDAKAFVEVGQ
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCEEECCCCHHEECCCCCCHHHHHHCCC
KVSVGDTLCIVEAMKMMNQIEADKSGTVKAILVENGQPVEFDEPLVVIE
CCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]