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The map label for this gene is uxaA

Identifier: 51597768

GI number: 51597768

Start: 4141383

End: 4142873

Strand: Reverse

Name: uxaA

Synonym: YPTB3476

Alternate gene names: 51597768

Gene position: 4142873-4141383 (Counterclockwise)

Preceding gene: 51597769

Following gene: 51597767

Centisome position: 87.32

GC content: 49.77

Gene sequence:

>1491_bases
ATGCAAAATATTATAAAGATTCACCCGCTGGATAATGTGGCCGTTGCCCTGCAAGATCTGGCTGCAGATGAGCGGATCGA
GAGCGGTGAGTTTAGCGTCAAACTGGCTCAGCCCGTGGTTCGTGGGCATAAATTCGCGTTAACCGCTATCGAACCGGGGC
AGATGATCGTCAAGTATGGTTTGCCTATCGGCCATGCATTGACCTTGATCCAACCGGGCGAACATATTCATTCACAGAAC
GCCAAAACTAATCTGAGCGATTTGGATGAGTATGAATATCAGCCAGAGTTCAGTTCTCTACCGCCACAAATGGCTGATCG
TGACGTGCAAATTTATCGTCGGCCAAAGGGTGAAGTGGGGATCCGTAATGAACTGTGGATCATACCAACGGTTGGTTGCG
TTAATGGGATCGCCCGTCAGATCCAGCAACGTTTCCTGAAAGAGACACAGGATGCTGAAGGGATTGATGGTGTTTACCTG
TTCAGCCATCCATTTGGCTGCTCGCAACTGGGGCAGGATCATGAAAATACCCGCACTATGCTACAAAACATGGTGCGTCA
CCCGAATGCGGGGGCGGTACTGGTCATTGGCTTAGGCTGTGAAAACAATCAGGTAGATGTTTTCCAAACGACATTGGGCA
AGGTTGACGAAGAGCGCGTACGCTTTATGGTTTGCCAGCAGCATGATGATGAGGTTGAAGCCGGTTTAGAGCATTTACAT
GCTCTGTATCAGGTCATGCGTCATGATCGCCGGGAACCCGGCCAGTTAAGTGAACTGAAATTTGGCCTGGAATGTGGGGG
GTCTGATGGGCTGTCCGGTATTACGGCCAACCCATTACTGGGACGTTTCTCTGACTATGTGATTGCCAACGACGGAACAT
CGGTACTGACCGAAGTGCCGGAAATGTTTGGCGCAGAACGTATTCTGATGAGCCGCTGCCGTGATGAAGCCACGTTTGAA
AAAACGGTCAGCATGGTCAATGACTTCAAACAGTACTTTATTGCGCACGACCAACCGATTTATGAAAACCCATCACCGGG
TAATAAAGCGGGGGGGATCACCACGCTGGAAGAAAAATCTCTCGGTTGTACGCAAAAAGCGGGTCAGAGCCAAGTGGTTG
ATGTGCTGAAGTATGGTGAGCGCTTACAGCGCCCAGGACTGAATTTACTCAGTGCGCCGGGCAATGATGCGGTTGCGACC
AGCGCATTAGCAGGTGCGGGCTGCCATATGGTGCTGTTCAGTACTGGCCGTGGCACACCATACGGAGGTTTTGTACCAAC
AGTGAAACTGGCAACTAACAGTGAACTGGCGGCGAAAAAGCCACATTGGATCGATTTTGATGCGGGTAAGCTGATCCATG
GCACCTCAATGGATACCTTGCTGAACGAGTTTGTTGATCTGATTGTTGAGATTGCTAATGGTAAACCTGCCCGTAATGAA
GTGAATGACTTCCGTGAATTAGCCATTTTTAAGAGCGGTGTAACCTTGTAA

Upstream 100 bases:

>100_bases
GCGGTGCCTCAACTGGCTAATCAGGTGACAGAGCAACTGCAAACCATCCTTAGCCGTGGCATGAGAGCGGCGGTCGCGGC
ATATAGCTAAAGGCTTAACT

Downstream 100 bases:

>100_bases
AAAATACGCCATTTCGTTAATATGAAACGGCGTTCTGTTTTTTATGGAAACGCACTTCCCCTTCACACTTTAAGCTGTAG
GGGGAGTGCGCTGTTTGCTT

Product: altronate hydrolase

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MQNIIKIHPLDNVAVALQDLAADERIESGEFSVKLAQPVVRGHKFALTAIEPGQMIVKYGLPIGHALTLIQPGEHIHSQN
AKTNLSDLDEYEYQPEFSSLPPQMADRDVQIYRRPKGEVGIRNELWIIPTVGCVNGIARQIQQRFLKETQDAEGIDGVYL
FSHPFGCSQLGQDHENTRTMLQNMVRHPNAGAVLVIGLGCENNQVDVFQTTLGKVDEERVRFMVCQQHDDEVEAGLEHLH
ALYQVMRHDRREPGQLSELKFGLECGGSDGLSGITANPLLGRFSDYVIANDGTSVLTEVPEMFGAERILMSRCRDEATFE
KTVSMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEEKSLGCTQKAGQSQVVDVLKYGERLQRPGLNLLSAPGNDAVAT
SALAGAGCHMVLFSTGRGTPYGGFVPTVKLATNSELAAKKPHWIDFDAGKLIHGTSMDTLLNEFVDLIVEIANGKPARNE
VNDFRELAIFKSGVTL

Sequences:

>Translated_496_residues
MQNIIKIHPLDNVAVALQDLAADERIESGEFSVKLAQPVVRGHKFALTAIEPGQMIVKYGLPIGHALTLIQPGEHIHSQN
AKTNLSDLDEYEYQPEFSSLPPQMADRDVQIYRRPKGEVGIRNELWIIPTVGCVNGIARQIQQRFLKETQDAEGIDGVYL
FSHPFGCSQLGQDHENTRTMLQNMVRHPNAGAVLVIGLGCENNQVDVFQTTLGKVDEERVRFMVCQQHDDEVEAGLEHLH
ALYQVMRHDRREPGQLSELKFGLECGGSDGLSGITANPLLGRFSDYVIANDGTSVLTEVPEMFGAERILMSRCRDEATFE
KTVSMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEEKSLGCTQKAGQSQVVDVLKYGERLQRPGLNLLSAPGNDAVAT
SALAGAGCHMVLFSTGRGTPYGGFVPTVKLATNSELAAKKPHWIDFDAGKLIHGTSMDTLLNEFVDLIVEIANGKPARNE
VNDFRELAIFKSGVTL
>Mature_496_residues
MQNIIKIHPLDNVAVALQDLAADERIESGEFSVKLAQPVVRGHKFALTAIEPGQMIVKYGLPIGHALTLIQPGEHIHSQN
AKTNLSDLDEYEYQPEFSSLPPQMADRDVQIYRRPKGEVGIRNELWIIPTVGCVNGIARQIQQRFLKETQDAEGIDGVYL
FSHPFGCSQLGQDHENTRTMLQNMVRHPNAGAVLVIGLGCENNQVDVFQTTLGKVDEERVRFMVCQQHDDEVEAGLEHLH
ALYQVMRHDRREPGQLSELKFGLECGGSDGLSGITANPLLGRFSDYVIANDGTSVLTEVPEMFGAERILMSRCRDEATFE
KTVSMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEEKSLGCTQKAGQSQVVDVLKYGERLQRPGLNLLSAPGNDAVAT
SALAGAGCHMVLFSTGRGTPYGGFVPTVKLATNSELAAKKPHWIDFDAGKLIHGTSMDTLLNEFVDLIVEIANGKPARNE
VNDFRELAIFKSGVTL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=492, Percent_Identity=78.8617886178862, Blast_Score=818, Evalue=0.0,
Organism=Escherichia coli, GI1789516, Length=499, Percent_Identity=31.4629258517034, Blast_Score=206, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 54533; Mature: 54533

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNIIKIHPLDNVAVALQDLAADERIESGEFSVKLAQPVVRGHKFALTAIEPGQMIVKYG
CCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCEEEEEEECCCCEEEEEC
LPIGHALTLIQPGEHIHSQNAKTNLSDLDEYEYQPEFSSLPPQMADRDVQIYRRPKGEVG
CCCCCEEEEECCCHHHHCCCCCCCHHHHHHHCCCCCHHCCCHHHCCCCCEEEECCCCCCC
IRNELWIIPTVGCVNGIARQIQQRFLKETQDAEGIDGVYLFSHPFGCSQLGQDHENTRTM
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHCCCCHHHHHH
LQNMVRHPNAGAVLVIGLGCENNQVDVFQTTLGKVDEERVRFMVCQQHDDEVEAGLEHLH
HHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHH
ALYQVMRHDRREPGQLSELKFGLECGGSDGLSGITANPLLGRFSDYVIANDGTSVLTEVP
HHHHHHHHCCCCCCCHHHHEECCCCCCCCCCCCCCCCCHHHCCCCEEEECCCHHHHHHHH
EMFGAERILMSRCRDEATFEKTVSMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEEKS
HHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHCC
LGCTQKAGQSQVVDVLKYGERLQRPGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTP
CCCHHHCCHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHCCCEEEEEEECCCCCC
YGGFVPTVKLATNSELAAKKPHWIDFDAGKLIHGTSMDTLLNEFVDLIVEIANGKPARNE
CCCCCCEEEEECCCCCCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCHHH
VNDFRELAIFKSGVTL
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQNIIKIHPLDNVAVALQDLAADERIESGEFSVKLAQPVVRGHKFALTAIEPGQMIVKYG
CCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCEEEEEEECCCCEEEEEC
LPIGHALTLIQPGEHIHSQNAKTNLSDLDEYEYQPEFSSLPPQMADRDVQIYRRPKGEVG
CCCCCEEEEECCCHHHHCCCCCCCHHHHHHHCCCCCHHCCCHHHCCCCCEEEECCCCCCC
IRNELWIIPTVGCVNGIARQIQQRFLKETQDAEGIDGVYLFSHPFGCSQLGQDHENTRTM
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHCCCCHHHHHH
LQNMVRHPNAGAVLVIGLGCENNQVDVFQTTLGKVDEERVRFMVCQQHDDEVEAGLEHLH
HHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHH
ALYQVMRHDRREPGQLSELKFGLECGGSDGLSGITANPLLGRFSDYVIANDGTSVLTEVP
HHHHHHHHCCCCCCCHHHHEECCCCCCCCCCCCCCCCCHHHCCCCEEEECCCHHHHHHHH
EMFGAERILMSRCRDEATFEKTVSMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEEKS
HHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHCC
LGCTQKAGQSQVVDVLKYGERLQRPGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTP
CCCHHHCCHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHCCCEEEEEEECCCCCC
YGGFVPTVKLATNSELAAKKPHWIDFDAGKLIHGTSMDTLLNEFVDLIVEIANGKPARNE
CCCCCCEEEEECCCCCCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCHHH
VNDFRELAIFKSGVTL
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 3038546 [H]