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The map label for this gene is tolC

Identifier: 51597698

GI number: 51597698

Start: 4037356

End: 4038750

Strand: Direct

Name: tolC

Synonym: YPTB3400

Alternate gene names: 51597698

Gene position: 4037356-4038750 (Clockwise)

Preceding gene: 51597691

Following gene: 51597699

Centisome position: 85.09

GC content: 46.95

Gene sequence:

>1395_bases
ATGAAGAAACTGCTCCCCCTTCTTATCGGGCTGAGTCTGGCTGGTTTCAGCACCATGAGCCAGGCAGAGAACTTGCTGCA
AGTTTATAAGCAAGCCAGGGATAGTAACCCGGATTTACGTAAATCCGCTGCTGATCGCGATGCCGCATATGAAAAAATCA
ATGAAGTACGCAGTCCACTGTTGCCACAACTTGGTTTAAGTGCCGGCTATACACATGCCAATGGATTTCGTGACGCGTCT
AACAGCCCAGATAGCAATACCACATCAGGCTCTCTAAAACTGACCCAGACAATTTTTGACATGTCTAAATGGCGCGCCCT
GACCTTACAGGAAAAAGTGGCTGGGATTCAGGATGTGACATTCCAGACCAGCGAACAGCAACTGATTCTTAACACTGCAA
CGGCTTATTTCAACGTACTCAGAGCGATTGACAGCCTCTCTTATACTGAAGCGCAGAAACAATCGGTCTATCGTCAGTTG
GATCAAACAACTCAACGTTTTAATGTGGGTTTAGTGGCCATTACTGATGTGCAGAACGCCCGAGCCAGCTACGATACCGT
GTTAGCGGCAGAAGTGGCCGCCCGTAATAATCTGGATAACGCACTAGAGAGCTTGCGCCAGATTACTGGTGTTTATTATC
CCGAATTGGCATCGTTGAATGTAGAACGATTGAAGACTCAACGCCCAGATGCGGTTAATAACCTATTGAAAGAAGCTGAA
AAACGTAACCTTTCTTTGCTTTCTGCCCGTTTGAGCCAAGACTTGGCACGTGAGCAAATTAAGTCTGCGGAAACGGGCTA
TATGCCAACCGTCGATTTGACCGCCTCATCTTCGATAACCAATACCCGTTACAGTGGCGGAACCCCCAGTTCTCAACAGG
TAAATAATGATTCCGGCCAGAACCAAATTGGCGTGCAATTTAGCTTACCGCTGTACAGCGGTGGTGCCACCAATTCTGCG
GTGAAACAAGCGCAGTATAATTTCGTTGGTGCCAGTGAGTTGTTGGAAAGTGCACATCGCAATATGGTGCAAACGCTTCG
CTCATCATTTAATAATATTTCAGCCTCAATCAGCAGCATCAATGCTTATCAGCAAGTGGTTATTTCTAACCAAAGCTCTT
TGGATGCAATGGAAGCTGGCTATCAGGTAGGCACCCGTACCATTCTGGATGTTTTGACTGCAACGACTAACCTGTATCAG
TCCAAACAACAATTGGCTGATGCTCGTTATAACTATTTAATCAATCAGTTAAATATCAAGTCGGCACTGGGGACGTTGAA
TATGAACGACCTGATGGCACTAAACGCCGTATTGGATAAACCGGTCCCGACGTCAGCGGCTGCTCTGGCACCAGAGAATA
CTCGCCAAACTGTCGCTACACCACGCGCTCAGTAA

Upstream 100 bases:

>100_bases
CAATCGGCCACCTTATCCCATTGGCAGACTCTGATAGAATCGTCAACAATTCGTCTATCGACAGCTACCATGTAACATTG
CTGCACAACAAGGATTGCAA

Downstream 100 bases:

>100_bases
TCAGTAATAACCCACTCCGTCAGCGGTTTGGCTTCACCGGGCACAGTCATTGGCTGCGCCCGGTTTATTTTTTGCCTCCC
TCGATTTTACGACCAAACGT

Product: outer membrane channel protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKSAADRDAAYEKINEVRSPLLPQLGLSAGYTHANGFRDAS
NSPDSNTTSGSLKLTQTIFDMSKWRALTLQEKVAGIQDVTFQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQL
DQTTQRFNVGLVAITDVQNARASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQNQIGVQFSLPLYSGGATNSA
VKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSINAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQ
SKQQLADARYNYLINQLNIKSALGTLNMNDLMALNAVLDKPVPTSAAALAPENTRQTVATPRAQ

Sequences:

>Translated_464_residues
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKSAADRDAAYEKINEVRSPLLPQLGLSAGYTHANGFRDAS
NSPDSNTTSGSLKLTQTIFDMSKWRALTLQEKVAGIQDVTFQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQL
DQTTQRFNVGLVAITDVQNARASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQNQIGVQFSLPLYSGGATNSA
VKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSINAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQ
SKQQLADARYNYLINQLNIKSALGTLNMNDLMALNAVLDKPVPTSAAALAPENTRQTVATPRAQ
>Mature_464_residues
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKSAADRDAAYEKINEVRSPLLPQLGLSAGYTHANGFRDAS
NSPDSNTTSGSLKLTQTIFDMSKWRALTLQEKVAGIQDVTFQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQL
DQTTQRFNVGLVAITDVQNARASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQNQIGVQFSLPLYSGGATNSA
VKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSINAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQ
SKQQLADARYNYLINQLNIKSALGTLNMNDLMALNAVLDKPVPTSAAALAPENTRQTVATPRAQ

Specific function: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=460, Percent_Identity=74.5652173913043, Blast_Score=664, Evalue=0.0,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50617; Mature: 50617

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKSAADRDAAYEKINEVRSPL
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
LPQLGLSAGYTHANGFRDASNSPDSNTTSGSLKLTQTIFDMSKWRALTLQEKVAGIQDVT
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHCE
FQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQLDQTTQRFNVGLVAITDVQNA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
RASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHH
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
NQIGVQFSLPLYSGGATNSAVKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSI
CEEEEEEECCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQSKQQLADARYNYLINQLNIK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALGTLNMNDLMALNAVLDKPVPTSAAALAPENTRQTVATPRAQ
HHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKSAADRDAAYEKINEVRSPL
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
LPQLGLSAGYTHANGFRDASNSPDSNTTSGSLKLTQTIFDMSKWRALTLQEKVAGIQDVT
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHCE
FQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQLDQTTQRFNVGLVAITDVQNA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
RASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHH
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
NQIGVQFSLPLYSGGATNSAVKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSI
CEEEEEEECCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQSKQQLADARYNYLINQLNIK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALGTLNMNDLMALNAVLDKPVPTSAAALAPENTRQTVATPRAQ
HHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8801424 [H]