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The map label for this gene is bepF [H]

Identifier: 51597607

GI number: 51597607

Start: 3942590

End: 3943900

Strand: Reverse

Name: bepF [H]

Synonym: YPTB3307

Alternate gene names: 51597607

Gene position: 3943900-3942590 (Counterclockwise)

Preceding gene: 51597614

Following gene: 51597606

Centisome position: 83.12

GC content: 52.78

Gene sequence:

>1311_bases
ATGTTTACACTGAATTGGGTTCGGTCCACGCCAATTTTTTACGTGCCGCGAACCCTACGCTCTCGGCTAATCTTACGCTC
TCCACTAATCTTACGCTCTCCGCGAATGGGGCCTTTGCGGGCAAAGCAACACCGCCATTCTTTACTGTCCCATGCGCTTT
TTCTGCTCATACTCGGGGCGGGCTCTGTGAGTGCGGCCACCGCGCCTTTACCTGCCGTAACCGTCGCGGTAGTCGCGTCA
ATAACACCAGACAATGCCGTGCAATATCTTGGGCGGATTGAGGCGATTCAAGCGGTTGATGTGACTACCCGCACCGAAGG
ATTTATCGCCCGCCGTCTGTTTACTGAAGGGAAAATGGTCAAGCAGGGGGAACTGTTATATGAAATTGATCCCGCTTTGC
ATCAAGCATCGGTGGCGCAAGCACAGGCGCAACTCGACAGCGCGACTGCCAGCGCCAATCATGCACAGGTGAACCTCACG
CGTTTACAACGCTTGGGTAATAACCGTTCTGTCAGCCAGGCGGAGGTGGATGAAGCACAGGCACAGCGAGATATCAGCCG
GGCAGCGGTGGCGCAGGCGCAGGCTAACCTACAGATTCAGCAGTTACAGCTCAGCTTCACCCAAATTCATGCGCCAATCA
GTGGGCAAATGGGTCACAGCCGTTTTAATGTGGGCAGCCTGATTAATCCCGCTAGCGGCACTTTGGTCAATATTGTGCAA
CTCGATCCGATTCGGGTGGCGATTGCCGTCAATGAACGGGATTACATTACCGCGACCTATCAACGCGCTGTCGCCCGTGA
AAAAAATATTGAAAACCCCTTGCTCCTTCTGGGGACTTTTACCCCTCGCATTCAACTGGCAAATGGTAAGCAATATCCAG
AGAGTGGTGTTTTTGAATCGGTGGATAACCAAATTGATAAGCAGACGGGAACGGTCATTATCCGTACTCGTTTTGCCAAC
CCTCGCCATTTGTTGCTGCCCGGTGGCGTAGTCAATGTGTCATTGGCTGCAGACGACGCCAAACCTGTGACGGTCATCCC
GATTGCTGCTTTACAACAGAATAAACAGGGCCATTTTGTGCTGGTAGTGACCGATAAAGCGGTGGTCGAAGTGCGCCCAG
TGACCCTGGGTGAACAGTTCGAACAGCAATATGCGGTGACAGATGGGGTGAAGGTGGGTGAAAAAGTCATTGTAGCGGGG
CTACAGCATGTCCGACCGGGTATGGCGGTGAACGCCAGCACGGTTAATGATGGAACTGTAAATGATGGAACTGTGAATGA
TCGCGTTGCAGCGCCATTGACGGCTAATTAA

Upstream 100 bases:

>100_bases
ATCTTGTTTCATGGGATCTTCGTTTCATGTGATCTTATTTAATAAGATCAGGTTTAACACCAAGCCGTTCTATCCCGCCG
AGAGTAAGGAATAAATCACC

Downstream 100 bases:

>100_bases
GGGGAAGACCAGATGTTGCATTTCTTTATTCGTCGCCCCAAGTTTGCCATTGTTATCGCATTGGTGATCACCCTGGTTGG
CTGGGTTTCACTGTATGTTA

Product: HlyD family drug efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MFTLNWVRSTPIFYVPRTLRSRLILRSPLILRSPRMGPLRAKQHRHSLLSHALFLLILGAGSVSAATAPLPAVTVAVVAS
ITPDNAVQYLGRIEAIQAVDVTTRTEGFIARRLFTEGKMVKQGELLYEIDPALHQASVAQAQAQLDSATASANHAQVNLT
RLQRLGNNRSVSQAEVDEAQAQRDISRAAVAQAQANLQIQQLQLSFTQIHAPISGQMGHSRFNVGSLINPASGTLVNIVQ
LDPIRVAIAVNERDYITATYQRAVAREKNIENPLLLLGTFTPRIQLANGKQYPESGVFESVDNQIDKQTGTVIIRTRFAN
PRHLLLPGGVVNVSLAADDAKPVTVIPIAALQQNKQGHFVLVVTDKAVVEVRPVTLGEQFEQQYAVTDGVKVGEKVIVAG
LQHVRPGMAVNASTVNDGTVNDGTVNDRVAAPLTAN

Sequences:

>Translated_436_residues
MFTLNWVRSTPIFYVPRTLRSRLILRSPLILRSPRMGPLRAKQHRHSLLSHALFLLILGAGSVSAATAPLPAVTVAVVAS
ITPDNAVQYLGRIEAIQAVDVTTRTEGFIARRLFTEGKMVKQGELLYEIDPALHQASVAQAQAQLDSATASANHAQVNLT
RLQRLGNNRSVSQAEVDEAQAQRDISRAAVAQAQANLQIQQLQLSFTQIHAPISGQMGHSRFNVGSLINPASGTLVNIVQ
LDPIRVAIAVNERDYITATYQRAVAREKNIENPLLLLGTFTPRIQLANGKQYPESGVFESVDNQIDKQTGTVIIRTRFAN
PRHLLLPGGVVNVSLAADDAKPVTVIPIAALQQNKQGHFVLVVTDKAVVEVRPVTLGEQFEQQYAVTDGVKVGEKVIVAG
LQHVRPGMAVNASTVNDGTVNDGTVNDRVAAPLTAN
>Mature_436_residues
MFTLNWVRSTPIFYVPRTLRSRLILRSPLILRSPRMGPLRAKQHRHSLLSHALFLLILGAGSVSAATAPLPAVTVAVVAS
ITPDNAVQYLGRIEAIQAVDVTTRTEGFIARRLFTEGKMVKQGELLYEIDPALHQASVAQAQAQLDSATASANHAQVNLT
RLQRLGNNRSVSQAEVDEAQAQRDISRAAVAQAQANLQIQQLQLSFTQIHAPISGQMGHSRFNVGSLINPASGTLVNIVQ
LDPIRVAIAVNERDYITATYQRAVAREKNIENPLLLLGTFTPRIQLANGKQYPESGVFESVDNQIDKQTGTVIIRTRFAN
PRHLLLPGGVVNVSLAADDAKPVTVIPIAALQQNKQGHFVLVVTDKAVVEVRPVTLGEQFEQQYAVTDGVKVGEKVIVAG
LQHVRPGMAVNASTVNDGTVNDGTVNDRVAAPLTAN

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=349, Percent_Identity=32.6647564469914, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1789929, Length=375, Percent_Identity=29.8666666666667, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1786668, Length=370, Percent_Identity=31.8918918918919, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI87082036, Length=322, Percent_Identity=33.5403726708075, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87081796, Length=391, Percent_Identity=23.5294117647059, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 47144; Mature: 47144

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTLNWVRSTPIFYVPRTLRSRLILRSPLILRSPRMGPLRAKQHRHSLLSHALFLLILGA
CEEEEEECCCCEEEECHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
GSVSAATAPLPAVTVAVVASITPDNAVQYLGRIEAIQAVDVTTRTEGFIARRLFTEGKMV
CCCCCCCCCCCCEEEEHEEECCCHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHCCCEE
KQGELLYEIDPALHQASVAQAQAQLDSATASANHAQVNLTRLQRLGNNRSVSQAEVDEAQ
ECCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCHHHHHHHH
AQRDISRAAVAQAQANLQIQQLQLSFTQIHAPISGQMGHSRFNVGSLINPASGTLVNIVQ
HHHHHHHHHHHHHHCCCEEEHEEEEHHHEECCCCCCCCCCEECCCCCCCCCCCCEEEEEE
LDPIRVAIAVNERDYITATYQRAVAREKNIENPLLLLGTFTPRIQLANGKQYPESGVFES
ECCEEEEEEECCCCEEHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCCCCCCHHH
VDNQIDKQTGTVIIRTRFANPRHLLLPGGVVNVSLAADDAKPVTVIPIAALQQNKQGHFV
HHHHHHHCCCEEEEEEECCCCCEEEECCCEEEEEEECCCCCCEEEEEEHHHCCCCCCCEE
LVVTDKAVVEVRPVTLGEQFEQQYAVTDGVKVGEKVIVAGLQHVRPGMAVNASTVNDGTV
EEEECCEEEEEECCCCCHHHHHHHHHHCCCHHCHHHHHHHHHHCCCCCEEECCCCCCCCC
NDGTVNDRVAAPLTAN
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFTLNWVRSTPIFYVPRTLRSRLILRSPLILRSPRMGPLRAKQHRHSLLSHALFLLILGA
CEEEEEECCCCEEEECHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
GSVSAATAPLPAVTVAVVASITPDNAVQYLGRIEAIQAVDVTTRTEGFIARRLFTEGKMV
CCCCCCCCCCCCEEEEHEEECCCHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHCCCEE
KQGELLYEIDPALHQASVAQAQAQLDSATASANHAQVNLTRLQRLGNNRSVSQAEVDEAQ
ECCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCHHHHHHHH
AQRDISRAAVAQAQANLQIQQLQLSFTQIHAPISGQMGHSRFNVGSLINPASGTLVNIVQ
HHHHHHHHHHHHHHCCCEEEHEEEEHHHEECCCCCCCCCCEECCCCCCCCCCCCEEEEEE
LDPIRVAIAVNERDYITATYQRAVAREKNIENPLLLLGTFTPRIQLANGKQYPESGVFES
ECCEEEEEEECCCCEEHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCCCCCCHHH
VDNQIDKQTGTVIIRTRFANPRHLLLPGGVVNVSLAADDAKPVTVIPIAALQQNKQGHFV
HHHHHHHCCCEEEEEEECCCCCEEEECCCEEEEEEECCCCCCEEEEEEHHHCCCCCCCEE
LVVTDKAVVEVRPVTLGEQFEQQYAVTDGVKVGEKVIVAGLQHVRPGMAVNASTVNDGTV
EEEECCEEEEEECCCCCHHHHHHHHHHCCCHHCHHHHHHHHHHCCCCCEEECCCCCCCCC
NDGTVNDRVAAPLTAN
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]