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The map label for this gene is ydeN [H]

Identifier: 51597400

GI number: 51597400

Start: 3640406

End: 3642013

Strand: Direct

Name: ydeN [H]

Synonym: YPTB3086

Alternate gene names: 51597400

Gene position: 3640406-3642013 (Clockwise)

Preceding gene: 51597399

Following gene: 51597401

Centisome position: 76.73

GC content: 48.82

Gene sequence:

>1608_bases
ATGAAGTTACCCGCAGGAAAAAGAAGCCTGTTGGCAGGGATGATCGCTGCCGCTGGTATGAGTATGACACCTGTGACTCT
GGCGGCACCGGCAGAAAAACCCAATGTATTGCTGGTAATCATGGATGATCTGGGTACCGGGCAGTTAGATTTCACCCTCA
ATAATCTGGATAAAAAAGCACTAAGCCAGCGCCCAGTTCCCGTGCGCTATCAAGGCGATCTGGACAAGATGATCGATGCG
GCACAGCGGGCGATGCCGCATGTGTCTTTGTTGGCCAAAAACGGGGTCAAAATGACCAATGCGTTTGTGGCGCATCCGGT
ATGCGGGCCTTCGCGCGCGGGTATTTATACAGGTCGCCACCCAACCAGTTTTGGTACTTACAGTAATGATGATGCCATGC
AGGGGATCCCACTGGATATTAAACTGCTGCCCGCCTTGTTTCAGGAGCATGGCTATGCAACCGCAAATATCGGGAAATGG
CACAACGCACGCATAGAGAAAAAAGCGTTCGTCGCCGATGAGGTCAAAAGCCGCGATTATCACGACAACATGATCTCCGT
CAGCGCCCCCGGATATGCACCTGAAAAACGGGGTTTTGACTATTCCTACAGTTATTACGCCTCAGGCGCGGCATTGTGGC
ACTCTCCGGCCATCTGGCAAAACAGTAAAAATATTGCCGCCCCAGGCTATCTGACCCATAACCTGACGGATGAAACGCTG
AAATTTATTGATGACTCAGGGAAAAAACCGTTTTTCATCAGCCTGGCTTACAGCGTGCCACATATTCCATTAGAGCAAGC
ATCACCCGCGAAATATATGGATCGGTTTAATACCGGCAACGTTGAAGCAGATAAATATTTTGCTGCCATTAATGCCGCAG
ACGAGGGGATTGGTAGAATTGTTCAGCACTTACAAGAAAAAGGTGAGCTGGATAACACACTGATTTTCTTCATTTCGGAT
AACGGGGCGGTTCATGAATCCCCAATGCCAATGAATGGCATGGACCGTGGACATAAAGGACAAATGTATAACGGGGGGGT
GCATATTCCCTTCGTCGCTTACTGGCCAAAACAGATCCCCGCAGGTACGCAAAGTGATGCATTGGTGAGTGCATTAGATA
TTTTACCGACGGCATTGAAAGCCGCGGGTATTGCCATCCCAGCGGAGATGAGAGTGGATGGTAAAGATATTCTGCCGGTA
CTGGCAGGTAAGGAACAAACCTCGCCGCATCAATATATGTACTGGGCTGGGCCGGGGGCAAAGCATTACAGCGATGAGAA
TCAGTCATTCTGGCATGACTACTGGAAATGGATCACTTACGAACATCAACAGGCGCCTAAAAATGATCATGTAGAGACAT
TATCGAAAGCCTCTTGGGCAATCCGCGATCAGGAGTGGGCGCTCTACTTCTATGATGACGGCACCAATACGCCAAAATTA
TTTAATGATAAGCATGATCCCATGGAATCAAAGGATTTAGCTGATCAGTACCCTGAGCGTGTCAGTGCAATGAAAGCGGC
ATTCTATGATTGGATCAAAGATAAACCCAAACCCGTGGCTTGGGGGCAAGATCGCTATCAGATCTTAGCAAGCTCCGCGA
AAAGTTAA

Upstream 100 bases:

>100_bases
TGATGCAGGCCATGTGCCAGATTATTCAACGCGGGGGCATTGCTGCGGACATTATGCCGCAACTGACACAGCCTAAATAA
CGCTTGAGGAACACATAATA

Downstream 100 bases:

>100_bases
GCTCGTGCGGTGTAACGGGGAGATAAGGTGGAGCGAGTGTTCTTAGCCCCCTCTTTTATCCCCTCTTACCCCTCTTTTTA
TTACCGTTCTCCTTATCCTA

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MKLPAGKRSLLAGMIAAAGMSMTPVTLAAPAEKPNVLLVIMDDLGTGQLDFTLNNLDKKALSQRPVPVRYQGDLDKMIDA
AQRAMPHVSLLAKNGVKMTNAFVAHPVCGPSRAGIYTGRHPTSFGTYSNDDAMQGIPLDIKLLPALFQEHGYATANIGKW
HNARIEKKAFVADEVKSRDYHDNMISVSAPGYAPEKRGFDYSYSYYASGAALWHSPAIWQNSKNIAAPGYLTHNLTDETL
KFIDDSGKKPFFISLAYSVPHIPLEQASPAKYMDRFNTGNVEADKYFAAINAADEGIGRIVQHLQEKGELDNTLIFFISD
NGAVHESPMPMNGMDRGHKGQMYNGGVHIPFVAYWPKQIPAGTQSDALVSALDILPTALKAAGIAIPAEMRVDGKDILPV
LAGKEQTSPHQYMYWAGPGAKHYSDENQSFWHDYWKWITYEHQQAPKNDHVETLSKASWAIRDQEWALYFYDDGTNTPKL
FNDKHDPMESKDLADQYPERVSAMKAAFYDWIKDKPKPVAWGQDRYQILASSAKS

Sequences:

>Translated_535_residues
MKLPAGKRSLLAGMIAAAGMSMTPVTLAAPAEKPNVLLVIMDDLGTGQLDFTLNNLDKKALSQRPVPVRYQGDLDKMIDA
AQRAMPHVSLLAKNGVKMTNAFVAHPVCGPSRAGIYTGRHPTSFGTYSNDDAMQGIPLDIKLLPALFQEHGYATANIGKW
HNARIEKKAFVADEVKSRDYHDNMISVSAPGYAPEKRGFDYSYSYYASGAALWHSPAIWQNSKNIAAPGYLTHNLTDETL
KFIDDSGKKPFFISLAYSVPHIPLEQASPAKYMDRFNTGNVEADKYFAAINAADEGIGRIVQHLQEKGELDNTLIFFISD
NGAVHESPMPMNGMDRGHKGQMYNGGVHIPFVAYWPKQIPAGTQSDALVSALDILPTALKAAGIAIPAEMRVDGKDILPV
LAGKEQTSPHQYMYWAGPGAKHYSDENQSFWHDYWKWITYEHQQAPKNDHVETLSKASWAIRDQEWALYFYDDGTNTPKL
FNDKHDPMESKDLADQYPERVSAMKAAFYDWIKDKPKPVAWGQDRYQILASSAKS
>Mature_535_residues
MKLPAGKRSLLAGMIAAAGMSMTPVTLAAPAEKPNVLLVIMDDLGTGQLDFTLNNLDKKALSQRPVPVRYQGDLDKMIDA
AQRAMPHVSLLAKNGVKMTNAFVAHPVCGPSRAGIYTGRHPTSFGTYSNDDAMQGIPLDIKLLPALFQEHGYATANIGKW
HNARIEKKAFVADEVKSRDYHDNMISVSAPGYAPEKRGFDYSYSYYASGAALWHSPAIWQNSKNIAAPGYLTHNLTDETL
KFIDDSGKKPFFISLAYSVPHIPLEQASPAKYMDRFNTGNVEADKYFAAINAADEGIGRIVQHLQEKGELDNTLIFFISD
NGAVHESPMPMNGMDRGHKGQMYNGGVHIPFVAYWPKQIPAGTQSDALVSALDILPTALKAAGIAIPAEMRVDGKDILPV
LAGKEQTSPHQYMYWAGPGAKHYSDENQSFWHDYWKWITYEHQQAPKNDHVETLSKASWAIRDQEWALYFYDDGTNTPKL
FNDKHDPMESKDLADQYPERVSAMKAAFYDWIKDKPKPVAWGQDRYQILASSAKS

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=407, Percent_Identity=28.7469287469287, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI59797060, Length=476, Percent_Identity=27.7310924369748, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI45430057, Length=420, Percent_Identity=25.7142857142857, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI146229331, Length=402, Percent_Identity=26.6169154228856, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI146229329, Length=402, Percent_Identity=26.6169154228856, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI6005990, Length=402, Percent_Identity=26.6169154228856, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI146229324, Length=402, Percent_Identity=26.6169154228856, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI53831991, Length=297, Percent_Identity=27.6094276094276, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI109389362, Length=480, Percent_Identity=25.4166666666667, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI38569405, Length=539, Percent_Identity=23.191094619666, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI38569407, Length=397, Percent_Identity=24.9370277078086, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI31742482, Length=282, Percent_Identity=25.886524822695, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI146229327, Length=298, Percent_Identity=27.1812080536913, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI71852586, Length=183, Percent_Identity=31.6939890710383, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI157266309, Length=252, Percent_Identity=25, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI71852584, Length=184, Percent_Identity=31.5217391304348, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI58743319, Length=197, Percent_Identity=24.3654822335025, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI87081924, Length=514, Percent_Identity=39.4941634241245, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1790233, Length=417, Percent_Identity=26.1390887290168, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790112, Length=361, Percent_Identity=23.5457063711911, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI115533416, Length=526, Percent_Identity=22.8136882129278, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI115533418, Length=462, Percent_Identity=23.1601731601732, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666109, Length=415, Percent_Identity=25.7831325301205, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281366397, Length=423, Percent_Identity=26.0047281323877, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI281366395, Length=423, Percent_Identity=26.0047281323877, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24666163, Length=423, Percent_Identity=26.0047281323877, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24666175, Length=411, Percent_Identity=24.8175182481752, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI281363223, Length=437, Percent_Identity=24.2562929061785, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: 3.1.6.- [C]

Molecular weight: Translated: 59388; Mature: 59388

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPAGKRSLLAGMIAAAGMSMTPVTLAAPAEKPNVLLVIMDDLGTGQLDFTLNNLDKKA
CCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECHHHHHH
LSQRPVPVRYQGDLDKMIDAAQRAMPHVSLLAKNGVKMTNAFVAHPVCGPSRAGIYTGRH
HHCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHCCCEEHHHEEECCCCCCCCCCEECCCC
PTSFGTYSNDDAMQGIPLDIKLLPALFQEHGYATANIGKWHNARIEKKAFVADEVKSRDY
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHCCCC
HDNMISVSAPGYAPEKRGFDYSYSYYASGAALWHSPAIWQNSKNIAAPGYLTHNLTDETL
CCCEEEEECCCCCCHHCCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCEEECCCCHHHH
KFIDDSGKKPFFISLAYSVPHIPLEQASPAKYMDRFNTGNVEADKYFAAINAADEGIGRI
HHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEECCCHHHHHHH
VQHLQEKGELDNTLIFFISDNGAVHESPMPMNGMDRGHKGQMYNGGVHIPFVAYWPKQIP
HHHHHHCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCEECCCEEEEEEEECCCCCC
AGTQSDALVSALDILPTALKAAGIAIPAEMRVDGKDILPVLAGKEQTSPHQYMYWAGPGA
CCCCCHHHHHHHHHHHHHHHHCCEECCHHEEECCCCCHHEECCCCCCCCCCEEEECCCCC
KHYSDENQSFWHDYWKWITYEHQQAPKNDHVETLSKASWAIRDQEWALYFYDDGTNTPKL
CCCCCCCCHHHHHHHHHHEEEHHCCCCCHHHHHHHHHHHEEECCCEEEEEEECCCCCCCC
FNDKHDPMESKDLADQYPERVSAMKAAFYDWIKDKPKPVAWGQDRYQILASSAKS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MKLPAGKRSLLAGMIAAAGMSMTPVTLAAPAEKPNVLLVIMDDLGTGQLDFTLNNLDKKA
CCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECHHHHHH
LSQRPVPVRYQGDLDKMIDAAQRAMPHVSLLAKNGVKMTNAFVAHPVCGPSRAGIYTGRH
HHCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHCCCEEHHHEEECCCCCCCCCCEECCCC
PTSFGTYSNDDAMQGIPLDIKLLPALFQEHGYATANIGKWHNARIEKKAFVADEVKSRDY
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHCCCC
HDNMISVSAPGYAPEKRGFDYSYSYYASGAALWHSPAIWQNSKNIAAPGYLTHNLTDETL
CCCEEEEECCCCCCHHCCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCEEECCCCHHHH
KFIDDSGKKPFFISLAYSVPHIPLEQASPAKYMDRFNTGNVEADKYFAAINAADEGIGRI
HHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEECCCHHHHHHH
VQHLQEKGELDNTLIFFISDNGAVHESPMPMNGMDRGHKGQMYNGGVHIPFVAYWPKQIP
HHHHHHCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCEECCCEEEEEEEECCCCCC
AGTQSDALVSALDILPTALKAAGIAIPAEMRVDGKDILPVLAGKEQTSPHQYMYWAGPGA
CCCCCHHHHHHHHHHHHHHHHCCEECCHHEEECCCCCHHEECCCCCCCCCCEEEECCCCC
KHYSDENQSFWHDYWKWITYEHQQAPKNDHVETLSKASWAIRDQEWALYFYDDGTNTPKL
CCCCCCCCHHHHHHHHHHEEEHHCCCCCHHHHHHHHHHHEEECCCEEEEEEECCCCCCCC
FNDKHDPMESKDLADQYPERVSAMKAAFYDWIKDKPKPVAWGQDRYQILASSAKS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]