Click here to switch to the map view.

The map label for this gene is aas

Identifier: 51597356

GI number: 51597356

Start: 3589925

End: 3592081

Strand: Reverse

Name: aas

Synonym: YPTB3042

Alternate gene names: 51597356

Gene position: 3592081-3589925 (Counterclockwise)

Preceding gene: 51597357

Following gene: 51597355

Centisome position: 75.71

GC content: 51.0

Gene sequence:

>2157_bases
ATGGCTTATCGCTTATTGCGTGCTCTTTTTCGTGGGTTATTCCGTGTCACCATTGATGGTGTCACCGACCAATTTAAGCA
TGAAAAATTAATTATTACGCCCAATCACGTCTCTTTCCTCGATGGGGCTTTATTAGCGCTATTTCTACCGATCAAGCCAG
TATTTGCTGTCTATACCAGTATTACTGACACCTGGTATATGCGTTGGCTAAAGCCTTATGTGGATTTTGTTGCGCTGGAT
CCGACCAACCCGATGGCCATCAAACATCTGGTCAGAATGGTCGAACAGGGCAGGCCAGTAGTCATTTTCCCTGAAGGGCG
CATCACTGTGACCGGCTCCTTGATGAAAATTTATGATGGGGCGGCATTTGTTGCGGCAAAATCAGGTGCGGCGGTGGTCC
CTATCCGTTTAGATGGCCCTGAATTTACTCATTTTGGGCGATTGCAGGGCGTGCTAAAAACACGCTGGTTCCCAAAAATC
AGTATTCATGTGTTACCGGCCACCACCATTCCTATGCCACAAGCGCCACGCTCGCGCGAACGGCGAGTTCTGGCCGGTGA
GCACCTGCATACCATTATGATGGCGGCCCGCATGGCCACGGTGCCACGGGAAACGCTGTTTGAAGCGTTGCTATCGGCAC
AAACCCGCTATGGTCGCTTTAAACCTTGCATTGAAGATGTCTCATTTAAAGAGGACAGCTACCAGACGCTACTGAAGAAA
ACGCTCGGTGTGAGCCGTATTTTGCAACGCTTTACCGTGCCGGGTGAGCATGTCGGGATGTTGCTGCCCAATGCCACCAT
TACTGCGGCTGCTATTTTTGGCGCATCGTTACGTGGACGAATTCCGGCACTGCTCAACTACACCTCGGGTGCTAAAGGGC
TACAGAGCGCTATCATTGCGGCTTCACTTAAAACCATCGTCACCTCGCGCCAGTTTTTGGAAAAAGGCAAACTGACGCAC
CTGCCGGAACAGGTCAATGAGGTGAACTGGGTCTATCTGGAAGATTTAAAAGACACGGTGACACTGACGGATAAGCTGTG
GATCTTATTCCACTTGTGTTTCCCGCGTAGGGCGATGTTGCCGCAGCAGGCTGATGACAGCGCGTTAATCTTGTTTACCT
CTGGATCGGAAGGCAACCCTAAAGGCGTGGTGCATTCTCATGCCAGTTTGTTGGCTAACGTCGAACAAATCCGAACCATT
GCTGACTTCACGCCACGTGATCGCTTCATGTCATCATTGCCGCTGTTTCATGCTTTTGGTCTGACGGTGGGATTATTCAC
ACCACTGATGACCGGTAGCCGAGTATTCCTTTACCCTAGTCCGCTGCATTACCGCGTGGTACCTGAACTGGTATATGACC
GTAACTGTACCGTGCTCTTTGGGACCTCAACATTCTTGGGGAATTATGCGCGCTTTGCTCATCCATATGATTTCGCCCGC
GTGCGTTATGTGGTTGCTGGCGCTGAAAAGTTGGCTGAAAGTACCAAACAGATTTGGCAGGATAAATTTGGTATCCGTAT
TCTGGAAGGGTATGGCGTAACCGAGTGCGCGCCCGTTGTGGCGATTAACGTACCGATGGCGGCTAAAGTGAACACGGTAG
GGCGCATTTTACCGGGGATGGAAGCCCGATTGATTAACGTACCGGGGATTGCTCAAGGTGGCCGCTTACAATTACGCGGC
CCTAATATTATGCGTGGTTACTTACGGGTAGAGAATCCCGGTGTATTGGAGCAGCCATCAGCAGAAAATGCTCAGGGTGA
ACTTGACGCTAATTGGTATGACACCGGTGATATTGTGACCCTCGACGAACAAGGGTTCTGCGCGATCCGTGGCCGGGTGA
AACGTTTTGCTAAGTTGGCTGGGGAGATGGTATCACTGGAGAGCGTTGAACAATTGGCAATAAGCCTTTCACCGGAAGGG
CAACATGCAGCAGCGGCTAAAACTGACAGTGCGAAAGGTGAAGCATTGGTGCTGTTTACCACTGACAGTGAGATAACCCG
TGAACGGTTAATCAAAGCGGCACGGGAAAATGGTGTGCCTGAACTGGCGGTGCCGCGCGATATCCGGGTCGTGAAAGCTC
TCCCCTTATTAGGCAGCGGTAAACCTGACTTCGTCACGTTGGGCAAAATGGCACAAGATCCGGAGATGAGCGTATGA

Upstream 100 bases:

>100_bases
CGCTCTCCTAACCATATTGTTAGTGTGCTATTAACGACACACCCGCCATTATTATAGTATTCTCTATTTTTCAAATTCAT
TGAGTTATAGGGATATAGAC

Downstream 100 bases:

>100_bases
GTCAGGACGTATTAGCAGATAAGCCTTTGTTATCTCGGAGCATGGTCGCGGTACTCTGTGCTCAGTTTTTCTCCGCTTTC
GGGGATAATGCCCTGCTGTT

Product: bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 718; Mature: 717

Protein sequence:

>718_residues
MAYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTSITDTWYMRWLKPYVDFVALD
PTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKI
SIHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKK
TLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTIVTSRQFLEKGKLTH
LPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADDSALILFTSGSEGNPKGVVHSHASLLANVEQIRTI
ADFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFAR
VRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLINVPGIAQGGRLQLRG
PNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEG
QHAAAAKTDSAKGEALVLFTTDSEITRERLIKAARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV

Sequences:

>Translated_718_residues
MAYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTSITDTWYMRWLKPYVDFVALD
PTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKI
SIHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKK
TLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTIVTSRQFLEKGKLTH
LPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADDSALILFTSGSEGNPKGVVHSHASLLANVEQIRTI
ADFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFAR
VRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLINVPGIAQGGRLQLRG
PNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEG
QHAAAAKTDSAKGEALVLFTTDSEITRERLIKAARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV
>Mature_717_residues
AYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTSITDTWYMRWLKPYVDFVALDP
TNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKIS
IHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKKT
LGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTIVTSRQFLEKGKLTHL
PEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADDSALILFTSGSEGNPKGVVHSHASLLANVEQIRTIA
DFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFARV
RYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLINVPGIAQGGRLQLRGP
NIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEGQ
HAAAAKTDSAKGEALVLFTTDSEITRERLIKAARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=357, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI187761345, Length=402, Percent_Identity=26.1194029850746, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI187761343, Length=402, Percent_Identity=26.1194029850746, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI57165412, Length=407, Percent_Identity=26.5356265356265, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI57165410, Length=407, Percent_Identity=26.2899262899263, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1789201, Length=715, Percent_Identity=70.7692307692308, Blast_Score=1072, Evalue=0.0,
Organism=Escherichia coli, GI1788107, Length=514, Percent_Identity=25.2918287937743, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI145693145, Length=355, Percent_Identity=27.887323943662, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1786810, Length=355, Percent_Identity=23.6619718309859, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=344, Percent_Identity=27.6162790697674, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=345, Percent_Identity=28.1159420289855, Blast_Score=113, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71994690, Length=508, Percent_Identity=25.1968503937008, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71994703, Length=508, Percent_Identity=25.1968503937008, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71994694, Length=508, Percent_Identity=25.1968503937008, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560308, Length=375, Percent_Identity=25.6, Blast_Score=96, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17510401, Length=486, Percent_Identity=22.8395061728395, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=378, Percent_Identity=22.7513227513227, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17559526, Length=520, Percent_Identity=22.8846153846154, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71985884, Length=306, Percent_Identity=25.8169934640523, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=389, Percent_Identity=23.6503856041131, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17557194, Length=329, Percent_Identity=23.7082066869301, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=352, Percent_Identity=25.5681818181818, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320852, Length=349, Percent_Identity=25.5014326647564, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859661, Length=281, Percent_Identity=28.1138790035587, Blast_Score=99, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355181, Length=547, Percent_Identity=24.3144424131627, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24581924, Length=548, Percent_Identity=21.5328467153285, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922652, Length=282, Percent_Identity=24.468085106383, Blast_Score=79, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 79418; Mature: 79286

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTS
CHHHHHHHHHHHHHHEEECCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITDTWYMRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDG
HHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEEHHHHCC
AAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRE
EEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCC
RRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKK
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHH
TLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIA
HHCHHHHHHHHCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHH
ASLKTIVTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAML
HHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHCC
PQQADDSALILFTSGSEGNPKGVVHSHASLLANVEQIRTIADFTPRDRFMSSLPLFHAFG
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHH
LTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFAR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHCHHHHCCCCHHHH
VRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCC
EARLINVPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVT
CEEEEECCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCEEE
LDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFT
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEE
TDSEITRERLIKAARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
AYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTS
HHHHHHHHHHHHHHEEECCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITDTWYMRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDG
HHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEEHHHHCC
AAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRE
EEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCC
RRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKK
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHH
TLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIA
HHCHHHHHHHHCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHH
ASLKTIVTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAML
HHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHCC
PQQADDSALILFTSGSEGNPKGVVHSHASLLANVEQIRTIADFTPRDRFMSSLPLFHAFG
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHH
LTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFAR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHCHHHHCCCCHHHH
VRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCC
EARLINVPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVT
CEEEEECCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCEEE
LDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFT
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEE
TDSEITRERLIKAARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA