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The map label for this gene is dxr

Identifier: 51597314

GI number: 51597314

Start: 3538029

End: 3539225

Strand: Reverse

Name: dxr

Synonym: YPTB2999

Alternate gene names: 51597314

Gene position: 3539225-3538029 (Counterclockwise)

Preceding gene: 51597315

Following gene: 51597313

Centisome position: 74.59

GC content: 46.37

Gene sequence:

>1197_bases
ATGAAGCAACTGACTATTCTTGGCTCTACTGGCTCCATCGGCAACAGCACGTTGAGTGTTGTGCGTGCAAACCCTGAATT
ATTTAAAGTCACGGCGTTAGTTGCCGGGCGTAATGTCAGGGAAATGGCGCAGCAATGCCTTGAGTTCTCCCCCCGCTATG
CAGCTATGTCTGATGAACACTCAGCTAAATCACTGCGTTTATTGTTGGCAGAACAGGGTTCAGACACCGAGGTCTATTCC
GGTGAAACGGCTGCCTGCGAATTGGCAGCTTTAGATGATGTCGATCAAGTGATGGCCGCGATTGTTGGCATTGCTGGTTT
ACCCTCAACATTGGCCGCTATTCGTGCAGGTAAACAAGTCTTGCTTGCCAATAAAGAGTCGCTGATTACCTGCGGTAAAC
TCTTTATGGATGAGGTTAAACGCAGCCGTGCTCAATTACTGCCAATTGATAGCGAGCATAACGCGATTTTTCAGAGTTTG
CCTGAAAGAATTCAGCGCCAATTAGGCTATTCTTCATTAAATGAAAATGGCGTTTCACGGATTATTTTGACTGGCTCTGG
TGGCCCATTTCGTGAAACTCCACTTTCGCAGTTTTCTGATGTCACCCCAGATCAAGCTTGTGCTCATCCAAATTGGTCTA
TGGGGCGGAAAATTTCTGTCGACTCAGCGACGATGATGAATAAAGGCCTGGAGTATGTTGAGGCTCGATGGTTATTTAAT
GCCAGCGCAGAACAGATAGAGGTTGTGTTACATCCGCAGTCTGTTATTCACTCGATGGTTCGCTATCATGACGGAAGTAT
CCTGGCACAAATGGGGACTCCAGACATGCGGACACCGATTGCACATGCGATGGCTTACCCAATGCGAGTTAGCTCAGGTG
TTGCGCCATTGGATTTTTGCAAAGTAGGCGCGCTGACCTTTACAACCCCGGATTATCAACGTTATCCGTGCTTAAAGTTG
GCCATAGACGCCTGTAATGCGGGGCAGGCAGCGACAACAGCGCTGAATGCAGCAAATGAAATTTCAGTCATGGCATTTTT
AGATTCAAAAATTCGTTTCACTGATATTGAAGTGATTAACCGTACTGTTGTTGAAGGTTTATTATTATCAGAACCTACCA
GTGTGGAAGAGGTGTTGGTGATTGATCGCAAAGCTCGTGATGTCGCGGCCCAAGTCATTGCAAAATTAAATAATTAA

Upstream 100 bases:

>100_bases
TCGGCAGTCACTCGCCATAAAACCTGGAACGATGGTATCGTTTGCCATGCAGGCAAATTGATATCTCGCCTATCACCAAA
CAGTTATTCAGAGCGCCCTC

Downstream 100 bases:

>100_bases
ACCAGGTTCGCTGATCCGGTCATTTGTTAGGGAAAGGCTGAGATGGTATAGTCAACCCTATCAATGGATAGATAGACTGT
TGATTAGTGACCCAATAGGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEHSAKSLRLLLAEQGSDTEVYS
GETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQVLLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSL
PERIQRQLGYSSLNENGVSRIILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYVEARWLFN
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFCKVGALTFTTPDYQRYPCLKL
AIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVINRTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN

Sequences:

>Translated_398_residues
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEHSAKSLRLLLAEQGSDTEVYS
GETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQVLLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSL
PERIQRQLGYSSLNENGVSRIILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYVEARWLFN
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFCKVGALTFTTPDYQRYPCLKL
AIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVINRTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN
>Mature_398_residues
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEHSAKSLRLLLAEQGSDTEVYS
GETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQVLLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSL
PERIQRQLGYSSLNENGVSRIILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYVEARWLFN
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFCKVGALTFTTPDYQRYPCLKL
AIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVINRTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=71.969696969697, Blast_Score=582, Evalue=1e-167,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43102; Mature: 43102

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEH
CCEEEEEECCCCCCCCEEEEEECCCCCEEEEHHHHCCCHHHHHHHHHHCCCCEECCCCCC
SAKSLRLLLAEQGSDTEVYSGETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQV
CHHHHEEHEECCCCCCEEECCCCCEEEEHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCEE
LLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSLPERIQRQLGYSSLNENGVSR
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYVEARWLFN
EEEECCCCCCCCCCHHHHCCCCCCHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHEEC
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFC
CCCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCHHHCCCCCCHHHH
KVGALTFTTPDYQRYPCLKLAIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVIN
HCCEEEECCCCCCCCCHHHEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCEEEHHHHHH
RTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN
HHHHHHHHHCCCCCCHHEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEH
CCEEEEEECCCCCCCCEEEEEECCCCCEEEEHHHHCCCHHHHHHHHHHCCCCEECCCCCC
SAKSLRLLLAEQGSDTEVYSGETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQV
CHHHHEEHEECCCCCCEEECCCCCEEEEHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCEE
LLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSLPERIQRQLGYSSLNENGVSR
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYVEARWLFN
EEEECCCCCCCCCCHHHHCCCCCCHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHEEC
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFC
CCCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCHHHCCCCCCHHHH
KVGALTFTTPDYQRYPCLKLAIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVIN
HCCEEEECCCCCCCCCHHHEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCEEEHHHHHH
RTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN
HHHHHHHHHCCCCCCHHEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA