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The map label for this gene is yfhK [H]

Identifier: 51597192

GI number: 51597192

Start: 3402973

End: 3404409

Strand: Reverse

Name: yfhK [H]

Synonym: YPTB2876

Alternate gene names: 51597192

Gene position: 3404409-3402973 (Counterclockwise)

Preceding gene: 51597195

Following gene: 51597191

Centisome position: 71.75

GC content: 48.43

Gene sequence:

>1437_bases
ATGATTTCGTTGAAAAGATGGCGTTTATTCCCCCGTTCTTTACGTCAATTAGTCCTTATGGCATTTCTATTGGTGCTGCT
ACCTTTATTGGTGCTGGCATATCAGGCCTATCAAAGTCTGGACCATCTGAGTACTCAAGCCGCCGATATTAACCGTACAA
CGCTTGCAGATGCTCGCCGTAGCGAGGCCATGACCAGTGTCGCGCTTGAGATGGAGCGTAGCTATCGTCAATATTGTGTG
TTGGATGATGCAACACTGGCGACGTTATATCAGCATCAGCGTAAGCAATATACTCAAATGCTCATGGCCCACGCCCCTAT
ACTCCCGGATGCCCGCTATTACCAGACGCTGCAAGGATTGTTGAATCAGCTTACTGATATTAAATGTAAAAACAGCGGCC
CTGACAAAGAAGCATCCATTTTATTAGAGCAGTTCTCTCGCTCAAATGCCGAAATGGTACAAGCGACTCGCGATGTTATT
TTTTCTCGTGGTCAACAGTTACAGAAAGATATCGCCGAACGTGGGCAATTTTTCGGCTGGCAGTCCCTTTTACTGTTTCT
GGTCAGTGTGCTGCTGGTGGTTCTTTTTACCCGCATGATCATCGGCCCCGTCAAAGGCATTGAGAGAATGATTAACCGCC
TTGGCGAAGGGCGTTCTCTGGGCAATACGGCGCTGTTTAAAGGACCTCGAGAATTACGCTCATTGGCACAGCGTATCATT
TGGCTTAGTGAACGTTTAGCCTGGCTAGAGTCACAGCGCCATGAATTTTTACGCCATATCTCCCATGAATTAAAAACGCC
CCTCGCCAGTATGCGTGAAGGGACGGAGCTCTTGGCCGATGAGGTTGCCGGGCCATTAACACAAGATCAACAAGAGGTGG
TGGCGATCCTTGATCACAGTAGCCGCCATTTGCAGCAATTGATTGAGCAATTACTGGACTATAACCGTAAGTTAGCTGAT
GGCCCCGGCGAACCTGAACATGTTGATCTGGCCGAAATGGTCGGGAATGTGATTTCTGCCCACAGTTTACCTGCGCGCGC
GAAGATGATTCGTACCGAGACTGAGCTCGATGCGCGCATTTGTTGGGCAGAGCCTACATTATTAATGCGGGTATTGGATA
ATCTCTACTCCAATGCGGTGCACTATGGTGAGGAATCCGGTACCATTTGGATTTGTAGCCGTCAGGTGAATGATCGGGTA
CAAATTGATGTTGCGAATACCGGGGCACCAATCCCAACTTCAGAAGAAATAATGATATTTGAGCCTTTTTTCCAAGGAAG
TCATCAGCGAAAAGGGGCTGTCAAAGGTAGCGGGCTTGGGCTGAGCATTGCTCAGGATTGTATCCGGCGTATGCAAGGTG
ATTTGCAACTGGTAACCGTTGACTACGCCGCCGTCTGCTTCCGTATTGAATTGCCATTAACCGCCGAGAATGAATGA

Upstream 100 bases:

>100_bases
CCAAAGGATGCGGTGGTGGATAGGGCAGCATAAATTGGGGAGCAGGCATTGTAATCTTGGCTGAGTCAGTTAGCATCACA
TCAAAGTGATAGGTAATGAG

Downstream 100 bases:

>100_bases
ATAATGTACAAGTGGTCTATACGCTGTGTGATTAAAAAGACCGTCTCTTTGTCATATCCGATATCTAGTGGAGTCGTGAA
ACAGACCGGTCTCTCTGGCA

Product: two-component system sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSTQAADINRTTLADARRSEAMTSVALEMERSYRQYCV
LDDATLATLYQHQRKQYTQMLMAHAPILPDARYYQTLQGLLNQLTDIKCKNSGPDKEASILLEQFSRSNAEMVQATRDVI
FSRGQQLQKDIAERGQFFGWQSLLLFLVSVLLVVLFTRMIIGPVKGIERMINRLGEGRSLGNTALFKGPRELRSLAQRII
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTQDQQEVVAILDHSSRHLQQLIEQLLDYNRKLAD
GPGEPEHVDLAEMVGNVISAHSLPARAKMIRTETELDARICWAEPTLLMRVLDNLYSNAVHYGEESGTIWICSRQVNDRV
QIDVANTGAPIPTSEEIMIFEPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMQGDLQLVTVDYAAVCFRIELPLTAENE

Sequences:

>Translated_478_residues
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSTQAADINRTTLADARRSEAMTSVALEMERSYRQYCV
LDDATLATLYQHQRKQYTQMLMAHAPILPDARYYQTLQGLLNQLTDIKCKNSGPDKEASILLEQFSRSNAEMVQATRDVI
FSRGQQLQKDIAERGQFFGWQSLLLFLVSVLLVVLFTRMIIGPVKGIERMINRLGEGRSLGNTALFKGPRELRSLAQRII
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTQDQQEVVAILDHSSRHLQQLIEQLLDYNRKLAD
GPGEPEHVDLAEMVGNVISAHSLPARAKMIRTETELDARICWAEPTLLMRVLDNLYSNAVHYGEESGTIWICSRQVNDRV
QIDVANTGAPIPTSEEIMIFEPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMQGDLQLVTVDYAAVCFRIELPLTAENE
>Mature_478_residues
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSTQAADINRTTLADARRSEAMTSVALEMERSYRQYCV
LDDATLATLYQHQRKQYTQMLMAHAPILPDARYYQTLQGLLNQLTDIKCKNSGPDKEASILLEQFSRSNAEMVQATRDVI
FSRGQQLQKDIAERGQFFGWQSLLLFLVSVLLVVLFTRMIIGPVKGIERMINRLGEGRSLGNTALFKGPRELRSLAQRII
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTQDQQEVVAILDHSSRHLQQLIEQLLDYNRKLAD
GPGEPEHVDLAEMVGNVISAHSLPARAKMIRTETELDARICWAEPTLLMRVLDNLYSNAVHYGEESGTIWICSRQVNDRV
QIDVANTGAPIPTSEEIMIFEPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMQGDLQLVTVDYAAVCFRIELPLTAENE

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=469, Percent_Identity=72.2814498933902, Blast_Score=658, Evalue=0.0,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=29.6943231441048, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789808, Length=295, Percent_Identity=26.7796610169492, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790861, Length=254, Percent_Identity=32.2834645669291, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=29.7413793103448, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788549, Length=255, Percent_Identity=27.4509803921569, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=28.125, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786783, Length=253, Percent_Identity=27.6679841897233, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=28.0172413793103, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=25.3571428571429, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=270, Percent_Identity=25.5555555555556, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=22.5225225225225, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=215, Percent_Identity=26.9767441860465, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=25.974025974026, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1788279, Length=308, Percent_Identity=24.025974025974, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54221; Mature: 54221

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSTQAADINRTTLADARR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SEAMTSVALEMERSYRQYCVLDDATLATLYQHQRKQYTQMLMAHAPILPDARYYQTLQGL
HHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LNQLTDIKCKNSGPDKEASILLEQFSRSNAEMVQATRDVIFSRGQQLQKDIAERGQFFGW
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QSLLLFLVSVLLVVLFTRMIIGPVKGIERMINRLGEGRSLGNTALFKGPRELRSLAQRII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHH
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTQDQQEVVAILDHS
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
SRHLQQLIEQLLDYNRKLADGPGEPEHVDLAEMVGNVISAHSLPARAKMIRTETELDARI
HHHHHHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEE
CWAEPTLLMRVLDNLYSNAVHYGEESGTIWICSRQVNDRVQIDVANTGAPIPTSEEIMIF
ECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEE
EPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMQGDLQLVTVDYAAVCFRIELPLTAENE
EHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHEEEEEECCCCCCCC
>Mature Secondary Structure
MISLKRWRLFPRSLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSTQAADINRTTLADARR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SEAMTSVALEMERSYRQYCVLDDATLATLYQHQRKQYTQMLMAHAPILPDARYYQTLQGL
HHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LNQLTDIKCKNSGPDKEASILLEQFSRSNAEMVQATRDVIFSRGQQLQKDIAERGQFFGW
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QSLLLFLVSVLLVVLFTRMIIGPVKGIERMINRLGEGRSLGNTALFKGPRELRSLAQRII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHH
WLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTQDQQEVVAILDHS
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
SRHLQQLIEQLLDYNRKLADGPGEPEHVDLAEMVGNVISAHSLPARAKMIRTETELDARI
HHHHHHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEE
CWAEPTLLMRVLDNLYSNAVHYGEESGTIWICSRQVNDRVQIDVANTGAPIPTSEEIMIF
ECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEE
EPFFQGSHQRKGAVKGSGLGLSIAQDCIRRMQGDLQLVTVDYAAVCFRIELPLTAENE
EHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]