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The map label for this gene is hscB

Identifier: 51597172

GI number: 51597172

Start: 3382744

End: 3383268

Strand: Reverse

Name: hscB

Synonym: YPTB2856

Alternate gene names: 51597172

Gene position: 3383268-3382744 (Counterclockwise)

Preceding gene: 51597173

Following gene: 51597171

Centisome position: 71.31

GC content: 50.48

Gene sequence:

>525_bases
ATGGATTATTTTACGTTATTCGGGTTGCCGGCTCGCTATTTGATTGACGGCAACCAACTCACCACGCGTTACCAGGAGTT
GCAACGTCAATTCCACCCCGATCGCTTTGCCACCCAGCCCGAGCGTGAGCGTTTGGCCTCAATGCAGCAGGCTGCAACCA
TCAATGATGCTTACCAAACGCTCAAGCACCCGTTAAAACGTGCCGAGTATATGCTATCTTTGCAGGGTTTTGATTTAGGC
AACGAACAACACACTATGCGTGATACCGCGTTTCTGATGGAACAGTTGGAATTACGTGAGGAGCTTGATGCCATTGAGCG
CAAACCCGATGCTGAAACTTTACTGGCTGAATTTAGCCGCCGTTTGGCGCAGATGACAACAACGCGCACGCAGCAAATGG
TTGAGCAACTGGATGCGCAGCTATGGGTGCAGGCAGCGGATACGGTACGCAAATTGCGCTTTCTGGATAAGTTGCAGCAG
CAAGTTGAACAGTTGGAAGAGCGCTTGTTTGACGATTTTGCCTGA

Upstream 100 bases:

>100_bases
TTCCTGCCCCAGATGTTTGTTGCTCTGTTCCGCTCTCTTTTGCCAAAAGGGAGCGAAACAGATCTCAGCTTAGCCATTAC
AACAACTTCCAGAGCATGCT

Downstream 100 bases:

>100_bases
TTCAAATATCTCATTTGATTAATAAAAAACAAATAAAATTCAAGTGATTAATTATTATATTCCCTTAGTAATTGATGTTG
TAGCTAGGTAGCAAGCAAAT

Product: co-chaperone HscB

Products: NA

Alternate protein names: Hsc20

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MDYFTLFGLPARYLIDGNQLTTRYQELQRQFHPDRFATQPERERLASMQQAATINDAYQTLKHPLKRAEYMLSLQGFDLG
NEQHTMRDTAFLMEQLELREELDAIERKPDAETLLAEFSRRLAQMTTTRTQQMVEQLDAQLWVQAADTVRKLRFLDKLQQ
QVEQLEERLFDDFA

Sequences:

>Translated_174_residues
MDYFTLFGLPARYLIDGNQLTTRYQELQRQFHPDRFATQPERERLASMQQAATINDAYQTLKHPLKRAEYMLSLQGFDLG
NEQHTMRDTAFLMEQLELREELDAIERKPDAETLLAEFSRRLAQMTTTRTQQMVEQLDAQLWVQAADTVRKLRFLDKLQQ
QVEQLEERLFDDFA
>Mature_174_residues
MDYFTLFGLPARYLIDGNQLTTRYQELQRQFHPDRFATQPERERLASMQQAATINDAYQTLKHPLKRAEYMLSLQGFDLG
NEQHTMRDTAFLMEQLELREELDAIERKPDAETLLAEFSRRLAQMTTTRTQQMVEQLDAQLWVQAADTVRKLRFLDKLQQ
QVEQLEERLFDDFA

Specific function: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward hscA

COG id: COG1076

COG function: function code O; DnaJ-domain-containing proteins 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain

Homologues:

Organism=Homo sapiens, GI50301234, Length=162, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1788876, Length=171, Percent_Identity=66.0818713450292, Blast_Score=224, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17541320, Length=146, Percent_Identity=28.7671232876712, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI161084223, Length=170, Percent_Identity=25.2941176470588, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSCB_YERP3 (A7FFX4)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400152.1
- ProteinModelPortal:   A7FFX4
- SMR:   A7FFX4
- STRING:   A7FFX4
- GeneID:   5384424
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1171
- eggNOG:   COG1076
- HOGENOM:   HBG751004
- OMA:   LNDAYQT
- ProtClustDB:   PRK05014
- BioCyc:   YPSE349747:YPSIP31758_1171-MONOMER
- HAMAP:   MF_00682
- InterPro:   IPR001623
- InterPro:   IPR009073
- InterPro:   IPR004640
- InterPro:   IPR015609
- Gene3D:   G3DSA:1.10.287.110
- Gene3D:   G3DSA:1.20.1280.20
- PANTHER:   PTHR11821
- SMART:   SM00271
- TIGRFAMs:   TIGR00714

Pfam domain/function: PF00226 DnaJ; PF07743 HSCB_C; SSF46565 DnaJ_N; SSF47144 HSC20_C

EC number: NA

Molecular weight: Translated: 20650; Mature: 20650

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00636 DNAJ_1; PS50076 DNAJ_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYFTLFGLPARYLIDGNQLTTRYQELQRQFHPDRFATQPERERLASMQQAATINDAYQT
CCCHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHH
LKHPLKRAEYMLSLQGFDLGNEQHTMRDTAFLMEQLELREELDAIERKPDAETLLAEFSR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RLAQMTTTRTQQMVEQLDAQLWVQAADTVRKLRFLDKLQQQVEQLEERLFDDFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYFTLFGLPARYLIDGNQLTTRYQELQRQFHPDRFATQPERERLASMQQAATINDAYQT
CCCHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHH
LKHPLKRAEYMLSLQGFDLGNEQHTMRDTAFLMEQLELREELDAIERKPDAETLLAEFSR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RLAQMTTTRTQQMVEQLDAQLWVQAADTVRKLRFLDKLQQQVEQLEERLFDDFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA