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The map label for this gene is goaG

Identifier: 51597126

GI number: 51597126

Start: 3318037

End: 3319350

Strand: Reverse

Name: goaG

Synonym: YPTB2810

Alternate gene names: 51597126

Gene position: 3319350-3318037 (Counterclockwise)

Preceding gene: 51597138

Following gene: 51597125

Centisome position: 69.96

GC content: 53.58

Gene sequence:

>1314_bases
ATGGCATACCGGCAGGAGCGAATCATGAGTCACCGTGAATTGGAACAACGCAGAAAAGAGGCGACCCCACGTGGGATTGG
TGTGTTATGTGATTTCTATGCGGTACGGGCTGAAAATGCCACGCTGTGGGATGAACAGGGGCGGGAATATATCGATTTTA
CGGCGGGTATTGCGACACTCAATATCGGACACCGCCACCCGAAAGTGATGGCCGCTGTGCGCCAACAACTGGACCAGTTT
ACCCATACTGCCTATCAGGTGGTGCCTTACGCCAGTTATGTCACATTGGCAGAGAAAATTAATTCGCTAGCCCCTATTTC
TGATTCAAATATGACGGCAGCGGGCAACAGTAAAACCGCTTTTTTCACCACTGGGGTCGAAGCGATAGAAAATGCCGTGA
AAATAGCGCGTGCGGCGACTGGCCGCCCTGGTGTGATTGCTTTCTCCGGGGCATTTCATGGCCGAACCTTATTGGCGATG
GCGCTGACCGGTAGAGCGGTGCCGTACAAAGTCGGTTTTGGCCCGTTCCCTGCCTCCATTTTTCACGCCCTCTATCCCAA
TGAGTTGTATGGCGTGAGTGTTGAAGAGGCCATCAGCAGTGTTGAGCGCCTGTTTCGTTGTGATATCAGTCCGACACAAG
TGGCGGCCATTCTATTTGAGCCGATTCAGGGCGAGGGTGGTTTTAATATCGCCCCGCCGGAATTTGTCAGTGCTTTGCGC
ACCCTGTGTGATGAGCACGGTATTTTGCTGATTGCCGATGAAGTACAAACGGGGTTTGCCCGTACAGGCAAGTTATTTGC
CATGGAATATTATCCCGACACCAAAGTTGATGTGATCACCATGGCGAAAAGCCTTGGGGGCGGTATGCCAATTTCCGCGG
TCACGGGGCGGGCCGACATTATGGATGCCCCGTTGCCGGGGAGTTTGGGCGGTACTTATGCCGGTAACCCACTGGCGGTG
GCTGCGTCACTGGTGGTGCTCGATATTATTGCGGAAGAGAAGTTATGCGAGCGCGCCCTGATTTTAGGCGCGAAGTTGGT
CGACGTACTGGAAAAAGCCCAAATGAGCAATGCGGCCATTGTGGGCATTCGTGCGCGTGGATCCATGGTGGCGGTGGAAT
TTAACGATCCCGTCAGCGGTAAACCGTCACCAGAACTGACGCGCGCCTATCAACGTCAGGCACTGGAAGAGGGGCTGTTA
CTCCTGAGTTGCGGTGTCCACAGCAACGTGATCCGCTTCCTCTACCCATTGACCATTCCCGACAAGCAATTTAAACAGGC
GATGAATATTCTTACCCGCCTACTGGCGAGCTAA

Upstream 100 bases:

>100_bases
AAAACCGAGACTAGGTTAATTAATATACAAATTAATCGACGAATTAGTCATTACGAACCGAGACAGTCATCCACATACGC
CCCCGTGGGGGGATTGACCC

Downstream 100 bases:

>100_bases
AGGTTTTATCTCACTGATCTCGAAACGTTAACCCGTTACCAGGAGCCACAGCATGTTTAAAATAATAACACTGACTACGC
TGCTCGCCGGATGGGTATTT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MAYRQERIMSHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATLNIGHRHPKVMAAVRQQLDQF
THTAYQVVPYASYVTLAEKINSLAPISDSNMTAAGNSKTAFFTTGVEAIENAVKIARAATGRPGVIAFSGAFHGRTLLAM
ALTGRAVPYKVGFGPFPASIFHALYPNELYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALR
TLCDEHGILLIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADIMDAPLPGSLGGTYAGNPLAV
AASLVVLDIIAEEKLCERALILGAKLVDVLEKAQMSNAAIVGIRARGSMVAVEFNDPVSGKPSPELTRAYQRQALEEGLL
LLSCGVHSNVIRFLYPLTIPDKQFKQAMNILTRLLAS

Sequences:

>Translated_437_residues
MAYRQERIMSHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATLNIGHRHPKVMAAVRQQLDQF
THTAYQVVPYASYVTLAEKINSLAPISDSNMTAAGNSKTAFFTTGVEAIENAVKIARAATGRPGVIAFSGAFHGRTLLAM
ALTGRAVPYKVGFGPFPASIFHALYPNELYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALR
TLCDEHGILLIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADIMDAPLPGSLGGTYAGNPLAV
AASLVVLDIIAEEKLCERALILGAKLVDVLEKAQMSNAAIVGIRARGSMVAVEFNDPVSGKPSPELTRAYQRQALEEGLL
LLSCGVHSNVIRFLYPLTIPDKQFKQAMNILTRLLAS
>Mature_436_residues
AYRQERIMSHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATLNIGHRHPKVMAAVRQQLDQFT
HTAYQVVPYASYVTLAEKINSLAPISDSNMTAAGNSKTAFFTTGVEAIENAVKIARAATGRPGVIAFSGAFHGRTLLAMA
LTGRAVPYKVGFGPFPASIFHALYPNELYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALRT
LCDEHGILLIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADIMDAPLPGSLGGTYAGNPLAVA
ASLVVLDIIAEEKLCERALILGAKLVDVLEKAQMSNAAIVGIRARGSMVAVEFNDPVSGKPSPELTRAYQRQALEEGLLL
LSCGVHSNVIRFLYPLTIPDKQFKQAMNILTRLLAS

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=31.25, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=32, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=28.9411764705882, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI37574042, Length=424, Percent_Identity=28.0660377358491, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24119277, Length=426, Percent_Identity=26.5258215962441, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=27.5534441805226, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=27.7078085642317, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI188536080, Length=444, Percent_Identity=27.4774774774775, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679950, Length=444, Percent_Identity=27.4774774774775, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679946, Length=444, Percent_Identity=27.4774774774775, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1787560, Length=429, Percent_Identity=65.2680652680653, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1789016, Length=427, Percent_Identity=50.1170960187354, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=34.1404358353511, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=33.0049261083744, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI145693181, Length=408, Percent_Identity=33.578431372549, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=32.378223495702, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786991, Length=412, Percent_Identity=27.1844660194175, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=31.7191283292978, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI32564660, Length=431, Percent_Identity=32.0185614849188, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=469, Percent_Identity=30.7036247334755, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=31.6151202749141, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=434, Percent_Identity=25.3456221198157, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=418, Percent_Identity=31.3397129186603, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324432, Length=414, Percent_Identity=31.4009661835749, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321456, Length=419, Percent_Identity=25.7756563245823, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=25.2307692307692, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=30.0480769230769, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28574759, Length=448, Percent_Identity=28.3482142857143, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=27.9017857142857, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21356575, Length=406, Percent_Identity=26.6009852216749, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281366494, Length=373, Percent_Identity=28.1501340482574, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667139, Length=373, Percent_Identity=28.1501340482574, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667143, Length=373, Percent_Identity=28.1501340482574, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 47240; Mature: 47109

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00636 DNAJ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYRQERIMSHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATL
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEHHCCCEEEEECCCEEEE
NIGHRHPKVMAAVRQQLDQFTHTAYQVVPYASYVTLAEKINSLAPISDSNMTAAGNSKTA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEE
FFTTGVEAIENAVKIARAATGRPGVIAFSGAFHGRTLLAMALTGRAVPYKVGFGPFPASI
EEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCCHHHH
FHALYPNELYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALR
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCCHHHHHHHH
TLCDEHGILLIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADI
HHHCCCCEEEEECCHHCCHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEECCCCCC
MDAPLPGSLGGTYAGNPLAVAASLVVLDIIAEEKLCERALILGAKLVDVLEKAQMSNAAI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VGIRARGSMVAVEFNDPVSGKPSPELTRAYQRQALEEGLLLLSCGVHSNVIRFLYPLTIP
EEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCC
DKQFKQAMNILTRLLAS
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AYRQERIMSHRELEQRRKEATPRGIGVLCDFYAVRAENATLWDEQGREYIDFTAGIATL
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEHHCCCEEEEECCCEEEE
NIGHRHPKVMAAVRQQLDQFTHTAYQVVPYASYVTLAEKINSLAPISDSNMTAAGNSKTA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEE
FFTTGVEAIENAVKIARAATGRPGVIAFSGAFHGRTLLAMALTGRAVPYKVGFGPFPASI
EEECCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCCHHHH
FHALYPNELYGVSVEEAISSVERLFRCDISPTQVAAILFEPIQGEGGFNIAPPEFVSALR
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCCHHHHHHHH
TLCDEHGILLIADEVQTGFARTGKLFAMEYYPDTKVDVITMAKSLGGGMPISAVTGRADI
HHHCCCCEEEEECCHHCCHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEECCCCCC
MDAPLPGSLGGTYAGNPLAVAASLVVLDIIAEEKLCERALILGAKLVDVLEKAQMSNAAI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VGIRARGSMVAVEFNDPVSGKPSPELTRAYQRQALEEGLLLLSCGVHSNVIRFLYPLTIP
EEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCC
DKQFKQAMNILTRLLAS
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]