Click here to switch to the map view.

The map label for this gene is sspH1 [H]

Identifier: 51597058

GI number: 51597058

Start: 3239683

End: 3240822

Strand: Direct

Name: sspH1 [H]

Synonym: YPTB2740

Alternate gene names: 51597058

Gene position: 3239683-3240822 (Clockwise)

Preceding gene: 51597048

Following gene: 51597059

Centisome position: 68.28

GC content: 35.96

Gene sequence:

>1140_bases
ATGGGTTTAAATTGTTTTGGTATCAGTTTTTCATCACCGAATATTACTTTAGATAGTGATTCTACTCACCAGAAATTGTC
AAAATCTGACTATCACGCTATATGGAAAAAATGGGAGAACGCTGCGATTCCCGGCGAAGGGGAACAGCGTGATATGGCCG
TAGAGGCAATGAAAATCCATTTAAAAAATAAAAATGCCACCGAACTCAACCTCAACAATCTTGGTTTACGCTCATTGCCC
GATATTTTACCTCCTTGTACAAAACTGAACGTCTCAAATAATTATCTAACTGAACTGCCGCTGTTGCCAGCTAATCTGAC
ACATCTCAATTTAGCCAATAATCAATTGACTAATATCTCCGGCCATTTTCCACTGCCCGATAATTTGACACACCTCAATT
TAGCCAATAATCAATTAACTAATATCTCCAGCCATTTTCCACTGCTGGGTAATTTGACACACCTCGACTTAGCCAATAAT
CAATTGGTAGAACTTCCTATGCATTTTCTAACACAGTTAGACAGGTTAGAAAAATTTACCGTTGCGTACAATAAATTAAC
CGAACTCCCTGAGCTCCCTAATACCTTAGAGTCACTAAATGCAGATAATAATCAGCTACACTGCTTGCCAGAAAAATTGC
CAACATCTCTGCGTTTAATCACAGCAAGTAACAACCAAATCACCCAGTTACCTGAAGCTATTTTTGATTTATTTAGTGAC
AGTAAAATCGTACTGAAGAATAATCCACTAACTGAAAAGACGTATTATTTTCCATATGGTTCCATTGTGCCAAATATATT
AATGTCCCCCTCATGCCTAACAAAACTTAAATATTCATCCTATGAACCACTCAGTGAGATCGTAAAACACTGGCTGACAC
CAGAGCAACAACAATTTTTAGAAAAAAAATGGTTAGAAATAGAAAAAGATCCAGAATCAGAAGGATTCACAAAATATCTT
AACCAACTCATTAACATACCAAAATTAGTACACAAGCCAAGACCAAATCCCCAGCTACATGTTCGAGATATTAGTGATTT
TTCTAAACAGAAGATGAAAAAAACATTATTAGACATAGTAAATTCCTGTTCCCTGCGTCAGGCGATATTTTTAAAATATA
ACACTAAACCAAATTTATAA

Upstream 100 bases:

>100_bases
AGAAAAACTTAAAAAATAATTTAATATCAGTTTTTTCCCTTATACAGGAAGCCGTATTTATCAAGCAGTATGCCCCTGTT
AAAATAAGGAGCTTACTGTT

Downstream 100 bases:

>100_bases
GTTAACACCCTGTCCCCCATCAGCGATAACTCAGTGGTGGGGACAGGGTAACCTATAGCCAGACTCAAGCGCTTACGGCG
ATATTACTGCTGAATCACGG

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: Salmonella secreted protein H1; Secreted effector protein sspH1 [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MGLNCFGISFSSPNITLDSDSTHQKLSKSDYHAIWKKWENAAIPGEGEQRDMAVEAMKIHLKNKNATELNLNNLGLRSLP
DILPPCTKLNVSNNYLTELPLLPANLTHLNLANNQLTNISGHFPLPDNLTHLNLANNQLTNISSHFPLLGNLTHLDLANN
QLVELPMHFLTQLDRLEKFTVAYNKLTELPELPNTLESLNADNNQLHCLPEKLPTSLRLITASNNQITQLPEAIFDLFSD
SKIVLKNNPLTEKTYYFPYGSIVPNILMSPSCLTKLKYSSYEPLSEIVKHWLTPEQQQFLEKKWLEIEKDPESEGFTKYL
NQLINIPKLVHKPRPNPQLHVRDISDFSKQKMKKTLLDIVNSCSLRQAIFLKYNTKPNL

Sequences:

>Translated_379_residues
MGLNCFGISFSSPNITLDSDSTHQKLSKSDYHAIWKKWENAAIPGEGEQRDMAVEAMKIHLKNKNATELNLNNLGLRSLP
DILPPCTKLNVSNNYLTELPLLPANLTHLNLANNQLTNISGHFPLPDNLTHLNLANNQLTNISSHFPLLGNLTHLDLANN
QLVELPMHFLTQLDRLEKFTVAYNKLTELPELPNTLESLNADNNQLHCLPEKLPTSLRLITASNNQITQLPEAIFDLFSD
SKIVLKNNPLTEKTYYFPYGSIVPNILMSPSCLTKLKYSSYEPLSEIVKHWLTPEQQQFLEKKWLEIEKDPESEGFTKYL
NQLINIPKLVHKPRPNPQLHVRDISDFSKQKMKKTLLDIVNSCSLRQAIFLKYNTKPNL
>Mature_378_residues
GLNCFGISFSSPNITLDSDSTHQKLSKSDYHAIWKKWENAAIPGEGEQRDMAVEAMKIHLKNKNATELNLNNLGLRSLPD
ILPPCTKLNVSNNYLTELPLLPANLTHLNLANNQLTNISGHFPLPDNLTHLNLANNQLTNISSHFPLLGNLTHLDLANNQ
LVELPMHFLTQLDRLEKFTVAYNKLTELPELPNTLESLNADNNQLHCLPEKLPTSLRLITASNNQITQLPEAIFDLFSDS
KIVLKNNPLTEKTYYFPYGSIVPNILMSPSCLTKLKYSSYEPLSEIVKHWLTPEQQQFLEKKWLEIEKDPESEGFTKYLN
QLINIPKLVHKPRPNPQLHVRDISDFSKQKMKKTLLDIVNSCSLRQAIFLKYNTKPNL

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down- modula

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm. Localizes predominantly to the host nucleus [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 LRR (leucine-rich) repeats [H]

Homologues:

Organism=Homo sapiens, GI21361633, Length=342, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI110825984, Length=223, Percent_Identity=30.0448430493274, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI90991702, Length=206, Percent_Identity=28.1553398058252, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 43159; Mature: 43028

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLNCFGISFSSPNITLDSDSTHQKLSKSDYHAIWKKWENAAIPGEGEQRDMAVEAMKIH
CCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEHEEE
LKNKNATELNLNNLGLRSLPDILPPCTKLNVSNNYLTELPLLPANLTHLNLANNQLTNIS
ECCCCCCEEECCCCCCHHHHHHCCCCCEEECCCCCEEECCCCCCCCEEEEECCCCCCCCC
GHFPLPDNLTHLNLANNQLTNISSHFPLLGNLTHLDLANNQLVELPMHFLTQLDRLEKFT
CCCCCCCCCEEEEECCCCHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
VAYNKLTELPELPNTLESLNADNNQLHCLPEKLPTSLRLITASNNQITQLPEAIFDLFSD
HHHHHHHHCCCCCCHHHHCCCCCCEEEECHHHCCCEEEEEEECCCCHHHHHHHHHHHHCC
SKIVLKNNPLTEKTYYFPYGSIVPNILMSPSCLTKLKYSSYEPLSEIVKHWLTPEQQQFL
CEEEEECCCCCCCEEECCCHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCHHHHHH
EKKWLEIEKDPESEGFTKYLNQLINIPKLVHKPRPNPQLHVRDISDFSKQKMKKTLLDIV
HHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHH
NSCSLRQAIFLKYNTKPNL
HCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
GLNCFGISFSSPNITLDSDSTHQKLSKSDYHAIWKKWENAAIPGEGEQRDMAVEAMKIH
CCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEHEEE
LKNKNATELNLNNLGLRSLPDILPPCTKLNVSNNYLTELPLLPANLTHLNLANNQLTNIS
ECCCCCCEEECCCCCCHHHHHHCCCCCEEECCCCCEEECCCCCCCCEEEEECCCCCCCCC
GHFPLPDNLTHLNLANNQLTNISSHFPLLGNLTHLDLANNQLVELPMHFLTQLDRLEKFT
CCCCCCCCCEEEEECCCCHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
VAYNKLTELPELPNTLESLNADNNQLHCLPEKLPTSLRLITASNNQITQLPEAIFDLFSD
HHHHHHHHCCCCCCHHHHCCCCCCEEEECHHHCCCEEEEEEECCCCHHHHHHHHHHHHCC
SKIVLKNNPLTEKTYYFPYGSIVPNILMSPSCLTKLKYSSYEPLSEIVKHWLTPEQQQFL
CEEEEECCCCCCCEEECCCHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCHHHHHH
EKKWLEIEKDPESEGFTKYLNQLINIPKLVHKPRPNPQLHVRDISDFSKQKMKKTLLDIV
HHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHH
NSCSLRQAIFLKYNTKPNL
HCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10564523; 10861017 [H]