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The map label for this gene is cdr [H]

Identifier: 51597041

GI number: 51597041

Start: 3217167

End: 3218813

Strand: Reverse

Name: cdr [H]

Synonym: YPTB2722

Alternate gene names: 51597041

Gene position: 3218813-3217167 (Counterclockwise)

Preceding gene: 51597042

Following gene: 51597038

Centisome position: 67.84

GC content: 42.2

Gene sequence:

>1647_bases
ATGGGAAAAACAATTGTTATCGTCGGTGGTGTTGCCGGTGGTGCCAGTGCTGCTGCTCGCCTGCGCCGTTTAAATGAATA
TGACAATATTATTATTCTAGAAAGAGGCGAGTATATCTCTTTTGCCAACTGTGGCTTGCCTTATTATATCGGTGGTGTTA
TTACCGAAAGAGATAAACTTTTAATCCAAACGCCAGAGAAAATGAAGGATAGATTTAATATTGATGTCAGAACTGAAAAT
GAAGTCGTTGATATAGACAGTGCGAGTAAAACCATTACTGTGATTAATCATAAAGTGGGTAAGGAAGAGTTTATACAATA
TGACACATTAATTCTATCGCCGGGTGCCCGTCCTTTTATTCCAGACATTGCCGGTCTGTCAGTAAATAGCTCTGTATTTA
CCCTGCGTAATATGTTAGATACAGACAATATTAAAGCGTATCTAATTTCCGCTACACCTGAAGCTGTCACCATTATTGGT
GGTGGTTTTATCGGATTGGAAATGGCGGAGAATCTGGTGAGTAGTGGGTTGAAAGTCACTATTATTGAATTATCAAATCA
AATTCTTTCGCCACTTGATTATGAAATGGCAGCGATTGTCGAAAAGCATTTAAAAGACAACGGCGTTGATGTGATAAAAA
ATGACGCAGTGGTACAGTTCGATGAATCTGCACATCAAATACATTTGAAATCAGGGAAAATTATTACCACCGACATGGTC
ATTCTGGCGATAGGTGTCGAACCTGAAAATGACTTGGCAAAGAAAGCTCATCTGGATTTGGGGATCAGAGGGAGCATCTT
GGTTAATGAGAAATTACAGACGAGTGTAGCGGATATTTATGCTATCGGTGATGCTATCCAGGTTGTCGATTATATCAATG
GTCAGGCAACGTATATTCCACTGGCCTGGCCGGCTAACCGGCAAGGCAGATTATTGGCTGATATTATTAATGGCCGTGAT
GTGCGCTATCACGGAACATTAGGCACTGCGATTGCCAAAGTACTTGATCTTAGCGCCGCCTGTACGGGTAACAACGAACG
TCTGTTAAAGCGTTTGGCGATCCCTTATCAAGTTGTTCATATTCATGGGATGTCACATGCGAGTTATTATCCTGGCGCTC
ATCAGATTTCATTGAAATTATTATTCTCGCCAGAGAACGGGCGTATTCTTGGTGCACAGGCTGTTGGTCAGGGGGGGACA
GATAAACGCATTGATGTGTTGGCGACCGCGATCAAAGGCAGGCTGACTATCTATGATCTTCCCGACTTAGAATTGGCTTA
TGCCCCACCTTATTCGTCAGCAAAAGATCCGGTCAATATGTTGGGTTATGTTGCAGAAAATATCTCGAATGGCGATGTGA
TGACGAAGCAATGGCATGAAGTGGATGCCTTTATGGCTGATGGGGGGATTATTATTGATGTACGAGATGAGGCGGAGTTT
ATCTCCGGCAGTATAAAAACTGCGGTGAATATCCCTCTGTCTGAATTGCGTCAAAAATTGGCATTAATACCCCAAGATAA
AAAGATACTGGTGACTTGCCAGGTTGGGCTAAGAGGGTACATTGCTGCAAGAATTCTGTCTCAATATGGCTATACCGTGG
CTAATTTAGATGGGGGATATTTGACCTTTAATTATGCTAATGCTTGA

Upstream 100 bases:

>100_bases
CATATTTAACAAGAAGCTATTATAAAGAAGTCACTGTTTAATAACCAATAGGCCATTTTCAAACTGGAAGTGGCCGTCCT
AATCTGAGTGATAAAGAGTT

Downstream 100 bases:

>100_bases
TGTTTATTTTGTATAAAAAGGGCATCTATACCCAAAATAATTCGCGTTGCAGTAAGGCAGTCAGGGCAGCTAACTCCCCT
GCAGCGTGAAGGACGATGGG

Product: pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MGKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKLLIQTPEKMKDRFNIDVRTEN
EVVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFIPDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIG
GGFIGLEMAENLVSSGLKVTIIELSNQILSPLDYEMAAIVEKHLKDNGVDVIKNDAVVQFDESAHQIHLKSGKIITTDMV
ILAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIPLAWPANRQGRLLADIINGRD
VRYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVHIHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGT
DKRIDVLATAIKGRLTIYDLPDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEF
ISGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGYLTFNYANA

Sequences:

>Translated_548_residues
MGKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKLLIQTPEKMKDRFNIDVRTEN
EVVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFIPDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIG
GGFIGLEMAENLVSSGLKVTIIELSNQILSPLDYEMAAIVEKHLKDNGVDVIKNDAVVQFDESAHQIHLKSGKIITTDMV
ILAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIPLAWPANRQGRLLADIINGRD
VRYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVHIHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGT
DKRIDVLATAIKGRLTIYDLPDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEF
ISGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGYLTFNYANA
>Mature_547_residues
GKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKLLIQTPEKMKDRFNIDVRTENE
VVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFIPDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIGG
GFIGLEMAENLVSSGLKVTIIELSNQILSPLDYEMAAIVEKHLKDNGVDVIKNDAVVQFDESAHQIHLKSGKIITTDMVI
LAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIPLAWPANRQGRLLADIINGRDV
RYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVHIHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGTD
KRIDVLATAIKGRLTIYDLPDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEFI
SGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGYLTFNYANA

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=316, Percent_Identity=26.5822784810127, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI226437568, Length=316, Percent_Identity=26.5822784810127, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI65787454, Length=316, Percent_Identity=26.5822784810127, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1789065, Length=259, Percent_Identity=31.2741312741313, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082354, Length=309, Percent_Identity=27.5080906148867, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788892, Length=290, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789765, Length=341, Percent_Identity=24.9266862170088, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786307, Length=309, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789915, Length=222, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24639257, Length=288, Percent_Identity=26.0416666666667, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281359715, Length=288, Percent_Identity=26.0416666666667, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281359713, Length=288, Percent_Identity=26.0416666666667, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639250, Length=288, Percent_Identity=26.0416666666667, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18543267, Length=288, Percent_Identity=26.0416666666667, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639252, Length=288, Percent_Identity=26.0416666666667, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585130, Length=290, Percent_Identity=24.1379310344828, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24581020, Length=254, Percent_Identity=29.1338582677165, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573993, Length=254, Percent_Identity=29.1338582677165, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 59548; Mature: 59417

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKL
CCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEECCEEECCCEE
LIQTPEKMKDRFNIDVRTENEVVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFI
EEECCHHHHHHEEEEEECCCCEEEECCCCCEEEEEECCCCHHHHHEEEEEEECCCCCCCC
PDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIGGGFIGLEMAENLVSSGLKVT
CCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCEEHHHHHHHHHHCCCEEE
IIELSNQILSPLDYEMAAIVEKHLKDNGVDVIKNDAVVQFDESAHQIHLKSGKIITTDMV
EEEECHHHCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEECCCCEEEEECCCCEEEEEEE
ILAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIP
EEEEECCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEHHHCCCCEEEEE
LAWPANRQGRLLADIINGRDVRYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVH
EECCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEE
IHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGTDKRIDVLATAIKGRLTIYDL
EECCCCCCCCCCCEEEEEEEEEECCCCEEEEEHCCCCCCCCCHHHHHHHHHCCEEEEEEC
PDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEF
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHEEECCCEEEEECCCHHH
ISGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGY
HCCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCE
LTFNYANA
EEEEECCC
>Mature Secondary Structure 
GKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKL
CCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEECCEEECCCEE
LIQTPEKMKDRFNIDVRTENEVVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFI
EEECCHHHHHHEEEEEECCCCEEEECCCCCEEEEEECCCCHHHHHEEEEEEECCCCCCCC
PDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIGGGFIGLEMAENLVSSGLKVT
CCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCEEHHHHHHHHHHCCCEEE
IIELSNQILSPLDYEMAAIVEKHLKDNGVDVIKNDAVVQFDESAHQIHLKSGKIITTDMV
EEEECHHHCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEECCCCEEEEECCCCEEEEEEE
ILAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIP
EEEEECCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEHHHCCCCEEEEE
LAWPANRQGRLLADIINGRDVRYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVH
EECCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEE
IHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGTDKRIDVLATAIKGRLTIYDL
EECCCCCCCCCCCEEEEEEEEEECCCCEEEEEHCCCCCCCCCHHHHHHHHHCCEEEEEEC
PDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEF
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHEEECCCEEEEECCCHHH
ISGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGY
HCCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCE
LTFNYANA
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA