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The map label for this gene is lolE

Identifier: 51596762

GI number: 51596762

Start: 2884141

End: 2885388

Strand: Reverse

Name: lolE

Synonym: YPTB2440

Alternate gene names: 51596762

Gene position: 2885388-2884141 (Counterclockwise)

Preceding gene: 51596763

Following gene: 51596761

Centisome position: 60.81

GC content: 48.8

Gene sequence:

>1248_bases
ATGGGGGTTTCGCCACTTTCACTTCTTATCGGTTTACGGTTTAGCCGTGGTCGCCGTCGTGGCGGTATGGTGTCGTTAAT
CTCCGTGATTTCTACGTTAGGTATCGCCTTGGGTGTGGCAGTGCTTATTGTGGGGTTAAGTGCGATGAACGGCTTCGAAC
GTGAGTTGAAAAATCGTATTTTAGCGGTGGTGCCTCACGGCGAAATTGCCGTGGTTAATCAGCCGTTCAGCGGTTGGCCA
CAAACCTTACAGCGTATCGAAAAGGTGCCCGGTATCGTGGCTGCTGCGCCTTATATTAATTTTACTGGTTTGATTGAAAA
CAGTACGCAACTGCGGGCAGTGCAGGTCAAAGGTGTGGATCCCGAGGCCGAACAGCATCTCAGTGCGTTGCCCAGCTTCG
TTCTTGACAATGCCTGGAGCCATTTTAAGGCCGGGCAACAACAGATTATTTTAGGTAAAGGGTTGGCTGATACCTTGGGG
GTGAAGCAAGGCAATTGGTTGACGGTGATGATCCCTAACAGCGATCCTGAGATGAAATTGCTGCAACCTAAGCGCATCCG
TTTACAGGTTGCCGGTATTTTTCAACTGAGTGGTCAGTTGGATCACAGTTTGGCATTAGTGCCTCTAATCGATGCACAAC
AATATCTTGATATGGGTGATAGTGTCACGGGTATCGCCATCAAAGTGAATGATGTTTACAACGCCAATCAACTGGTACGT
AACGCGGGTGAAGTGAGTAACGCATACGTTTATATCAGTAGCTGGATTGGGACCTATGGCTATATGTACCGTGATATCCA
AATGATCCGCACTATCATGTATTTAGCGATGGTACTCGTGATCGGCGTCGCCAGTTTTAATATTGTGTCAACGTTGGTCA
TGGCGGTTAAAGATAAAAGTAGCGATATCGCAGTATTACGTACATTAGGTGCCAAAGATGGTCTGATTCGCGCCATCTTC
ATTTGGTATGGCCTGTTGGCTGGCCTTATTGGCAGTATCAGCGGGGCCGTGATAGGGGTTATCGTCTCCCTACAGTTGAC
CACCATAATCCGCGGGCTAGAAAAGATGGTCGGGCATCAATTTTTGTCGAGCGATATCTATTTCATTGATTTTCTACCGT
CAGAGTTGCATTGGTTTGATGTGGCTTGTGTGTTGGCAACGGCACTGGTGCTCAGCTTGATTGCCAGTTGGTATCCGGCA
CGTCGCGCCAGCCGTATTGATCCGGCACGGGTCCTCAGCGGGCAGTAA

Upstream 100 bases:

>100_bases
TGGTGACTCACGATTTACAATTAGCGAAACGGATGAGCCGTCAACTTGAAATGCGAGATGGTCAGCTACAACACCATTTG
ACGCTGGTGGGGGCCGAGTG

Downstream 100 bases:

>100_bases
TTGAAGAAAGGCAAGCTTATGTATTACGGTTTTGATATGGGCGGGACCAAAATAGAGCTAGGCGTTTTTGATGAAAACCT
GCAGCGAATATGGCATAAGC

Product: outer membrane-specific lipoprotein transporter subunit LolE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MGVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNRILAVVPHGEIAVVNQPFSGWP
QTLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGVDPEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTLG
VKQGNWLTVMIPNSDPEMKLLQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLVR
NAGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDKSSDIAVLRTLGAKDGLIRAIF
IWYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGHQFLSSDIYFIDFLPSELHWFDVACVLATALVLSLIASWYPA
RRASRIDPARVLSGQ

Sequences:

>Translated_415_residues
MGVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNRILAVVPHGEIAVVNQPFSGWP
QTLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGVDPEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTLG
VKQGNWLTVMIPNSDPEMKLLQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLVR
NAGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDKSSDIAVLRTLGAKDGLIRAIF
IWYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGHQFLSSDIYFIDFLPSELHWFDVACVLATALVLSLIASWYPA
RRASRIDPARVLSGQ
>Mature_414_residues
GVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNRILAVVPHGEIAVVNQPFSGWPQ
TLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGVDPEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTLGV
KQGNWLTVMIPNSDPEMKLLQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLVRN
AGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDKSSDIAVLRTLGAKDGLIRAIFI
WYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGHQFLSSDIYFIDFLPSELHWFDVACVLATALVLSLIASWYPAR
RASRIDPARVLSGQ

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=411, Percent_Identity=79.5620437956204, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI1787360, Length=413, Percent_Identity=27.3607748184019, Blast_Score=132, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45083; Mature: 44951

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNRI
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCE
LAVVPHGEIAVVNQPFSGWPQTLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGVD
EEEECCCCEEEECCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEECCCCEEEEEEEECCC
PEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTLGVKQGNWLTVMIPNSDPEMKL
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCEEEEEECCCCCCCEE
LQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLVR
CCCCEEEEEEEEEEEECCCCCCCEEEEEECCHHHHHCCCCCCEEEEEEEECCCCHHHHHH
NAGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDKS
HCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDIAVLRTLGAKDGLIRAIFIWYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGHQ
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLSSDIYFIDFLPSELHWFDVACVLATALVLSLIASWYPARRASRIDPARVLSGQ
HHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC
>Mature Secondary Structure 
GVSPLSLLIGLRFSRGRRRGGMVSLISVISTLGIALGVAVLIVGLSAMNGFERELKNRI
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCE
LAVVPHGEIAVVNQPFSGWPQTLQRIEKVPGIVAAAPYINFTGLIENSTQLRAVQVKGVD
EEEECCCCEEEECCCCCCCHHHHHHHHHCCCEEEECCCCEEEEEECCCCEEEEEEEECCC
PEAEQHLSALPSFVLDNAWSHFKAGQQQIILGKGLADTLGVKQGNWLTVMIPNSDPEMKL
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCEEEEEECCCCCCCEE
LQPKRIRLQVAGIFQLSGQLDHSLALVPLIDAQQYLDMGDSVTGIAIKVNDVYNANQLVR
CCCCEEEEEEEEEEEECCCCCCCEEEEEECCHHHHHCCCCCCEEEEEEEECCCCHHHHHH
NAGEVSNAYVYISSWIGTYGYMYRDIQMIRTIMYLAMVLVIGVASFNIVSTLVMAVKDKS
HCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDIAVLRTLGAKDGLIRAIFIWYGLLAGLIGSISGAVIGVIVSLQLTTIIRGLEKMVGHQ
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLSSDIYFIDFLPSELHWFDVACVLATALVLSLIASWYPARRASRIDPARVLSGQ
HHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]