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The map label for this gene is sufC

Identifier: 51596636

GI number: 51596636

Start: 2728841

End: 2729587

Strand: Reverse

Name: sufC

Synonym: YPTB2312

Alternate gene names: 51596636

Gene position: 2729587-2728841 (Counterclockwise)

Preceding gene: 51596637

Following gene: 51596635

Centisome position: 57.53

GC content: 45.38

Gene sequence:

>747_bases
ATGTTAAGTATTAAGAATTTAAAAGTTAGCGTTGAAGGTAATGAAATCCTCAAAGGTTTAGATCTGGAGATCAAACCGGG
TGAAGTACACGCTATCATGGGGCCGAACGGCTCAGGGAAAAGTACTTTATCAGCGGCATTGGCAGGGCGTGAAGAGTATG
AAGTCACCGAAGGTGAAGTCACTTTTAAAGGAAAAGACTTACTCGAACTCGCGCCAGAAGATCGTGCAGGGGAAGGTGTC
TTTTTGGCTTTCCAGTATCCGGTAGAAATCCCCGGTGTCAGTAACCATTTCTTCCTGCAAACCTCGGTTAATGCCGTGCG
TAAATATCGTCAGCAGGCGCCATTGGACCGCTTTGATTTCTCTGATTTTATTGAAGAAAAAATTGCCTTGCTGAAAATGC
CAGCTGATTTGCTGACCCGCTCGGTCAATGTGGGTTTCTCCGGTGGTGAGAAGAAACGTAATGATATTCTGCAGATGGCA
GCATTAGAGCCTTCGTTGTGTATTCTGGATGAGACAGATTCTGGGCTGGATATTGATGCACTGAAAATCGTGGCCAATGG
CGTTAACTCACTGCGCAATGAGAACCGCTCATTTATTATCGTTACCCACTACCAACGTATTCTGGATTACGTTAAACCTG
ATTTCGTCCATGTGTTGTATCAGGGGCGGATCATTAAATCGGGTGATTTCACGTTAGTGAAACAGTTGGAGGAGCAAGGC
TATGGCTGGCTTACCGACCAACAGTAA

Upstream 100 bases:

>100_bases
AGGCCCGCGGATGGGATGAGTAACGAGAGCGCCAACCCCCTGCCGTCTGAAAGATGAAGGTATAAATAAAGTTTTGCGTC
ACGGCGCACCAAGGAACTCT

Downstream 100 bases:

>100_bases
CGTTCTGGAAAGACAGCGGCTAGAACAGCAGCGACAAGAACAACAGCGGATTGATGCATTAAAGCATTTCGGTCAGTTGT
TTAAGCAGCGTCAGATCGAA

Product: cysteine desulfurase ATPase component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLSIKNLKVSVEGNEILKGLDLEIKPGEVHAIMGPNGSGKSTLSAALAGREEYEVTEGEVTFKGKDLLELAPEDRAGEGV
FLAFQYPVEIPGVSNHFFLQTSVNAVRKYRQQAPLDRFDFSDFIEEKIALLKMPADLLTRSVNVGFSGGEKKRNDILQMA
ALEPSLCILDETDSGLDIDALKIVANGVNSLRNENRSFIIVTHYQRILDYVKPDFVHVLYQGRIIKSGDFTLVKQLEEQG
YGWLTDQQ

Sequences:

>Translated_248_residues
MLSIKNLKVSVEGNEILKGLDLEIKPGEVHAIMGPNGSGKSTLSAALAGREEYEVTEGEVTFKGKDLLELAPEDRAGEGV
FLAFQYPVEIPGVSNHFFLQTSVNAVRKYRQQAPLDRFDFSDFIEEKIALLKMPADLLTRSVNVGFSGGEKKRNDILQMA
ALEPSLCILDETDSGLDIDALKIVANGVNSLRNENRSFIIVTHYQRILDYVKPDFVHVLYQGRIIKSGDFTLVKQLEEQG
YGWLTDQQ
>Mature_248_residues
MLSIKNLKVSVEGNEILKGLDLEIKPGEVHAIMGPNGSGKSTLSAALAGREEYEVTEGEVTFKGKDLLELAPEDRAGEGV
FLAFQYPVEIPGVSNHFFLQTSVNAVRKYRQQAPLDRFDFSDFIEEKIALLKMPADLLTRSVNVGFSGGEKKRNDILQMA
ALEPSLCILDETDSGLDIDALKIVANGVNSLRNENRSFIIVTHYQRILDYVKPDFVHVLYQGRIIKSGDFTLVKQLEEQG
YGWLTDQQ

Specific function: Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May f

COG id: COG0396

COG function: function code O; ABC-type transport system involved in Fe-S cluster assembly, ATPase component

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI42741659, Length=223, Percent_Identity=26.457399103139, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787972, Length=248, Percent_Identity=83.0645161290323, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1788761, Length=227, Percent_Identity=30.3964757709251, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786345, Length=228, Percent_Identity=28.5087719298246, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787370, Length=232, Percent_Identity=26.7241379310345, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786698, Length=207, Percent_Identity=28.0193236714976, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789864, Length=240, Percent_Identity=25, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787143, Length=236, Percent_Identity=24.1525423728814, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17541710, Length=236, Percent_Identity=27.9661016949153, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17558664, Length=228, Percent_Identity=27.1929824561404, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646699, Length=216, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533592, Length=226, Percent_Identity=29.2035398230088, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193209708, Length=217, Percent_Identity=28.110599078341, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71996809, Length=215, Percent_Identity=26.5116279069767, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=236, Percent_Identity=29.2372881355932, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=215, Percent_Identity=29.3023255813954, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193202349, Length=224, Percent_Identity=29.0178571428571, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324498, Length=205, Percent_Identity=26.8292682926829, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641342, Length=249, Percent_Identity=24.8995983935743, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR010230 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 27606; Mature: 27606

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIKNLKVSVEGNEILKGLDLEIKPGEVHAIMGPNGSGKSTLSAALAGREEYEVTEGEV
CCCEEEEEEEECHHHHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCEE
TFKGKDLLELAPEDRAGEGVFLAFQYPVEIPGVSNHFFLQTSVNAVRKYRQQAPLDRFDF
EECCCCCEEECCCCCCCCEEEEEEECCEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCCH
SDFIEEKIALLKMPADLLTRSVNVGFSGGEKKRNDILQMAALEPSLCILDETDSGLDIDA
HHHHHHHHHHHCCCHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
LKIVANGVNSLRNENRSFIIVTHYQRILDYVKPDFVHVLYQGRIIKSGDFTLVKQLEEQG
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCHHHEEEEEECEEEECCCHHHHHHHHHCC
YGWLTDQQ
CCEECCCC
>Mature Secondary Structure
MLSIKNLKVSVEGNEILKGLDLEIKPGEVHAIMGPNGSGKSTLSAALAGREEYEVTEGEV
CCCEEEEEEEECHHHHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCEE
TFKGKDLLELAPEDRAGEGVFLAFQYPVEIPGVSNHFFLQTSVNAVRKYRQQAPLDRFDF
EECCCCCEEECCCCCCCCEEEEEEECCEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCCH
SDFIEEKIALLKMPADLLTRSVNVGFSGGEKKRNDILQMAALEPSLCILDETDSGLDIDA
HHHHHHHHHHHCCCHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
LKIVANGVNSLRNENRSFIIVTHYQRILDYVKPDFVHVLYQGRIIKSGDFTLVKQLEEQG
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCHHHEEEEEECEEEECCCHHHHHHHHHCC
YGWLTDQQ
CCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 10322040 [H]