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The map label for this gene is qacE

Identifier: 51596576

GI number: 51596576

Start: 2658626

End: 2658964

Strand: Reverse

Name: qacE

Synonym: YPTB2252

Alternate gene names: 51596576

Gene position: 2658964-2658626 (Counterclockwise)

Preceding gene: 51596581

Following gene: 51596574

Centisome position: 56.04

GC content: 45.43

Gene sequence:

>339_bases
ATGATAATGAGCAGTTTTGTCTATTTATTTATGGCGATTATTGCCGAAGTAGTTGCAACGACGATGCTAAAAGCATCCGA
TGGTTTTTCTCGATTAGTCCCTTCAGTGGTGGTCGTGATTGGTTATGGTATTGCTTTTTGGGGGCTTTCGCAGGTAGTCA
AAACCATGCCGCTGGGTATTGCTTATGCGATTTGGTCCGGTTTGGGGATTGTACTGGTCTCAATCGCTGCCACCTTTATG
TATCAACAAAAGCTGGATTGGGCGGCGGTTGTCGGTATGGCGCTGATTATTTCGGGTGTTATGGTGATTAACCTCCTGTC
CAAGACACCGATGCATTAA

Upstream 100 bases:

>100_bases
CCAACTCACTGACTTGTAAAGCCGCTGTGAAGCCGGTGTCAATTTAATGAAGATTTAACTTTGTACGGGCATAATGTCGC
CCTTATGTTGAAATGAGAGA

Downstream 100 bases:

>100_bases
TCTGACATCCTTATTTTCCGCGTTACCGTTGATTGGACGATAACGCGGAGCCAAACGTGCTACTTAATATCTAACTGATG
TATTCCCTCAATAGCTAATA

Product: DMT superfamily multiple drug (quaternary ammonium compounds) efflux pump

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MIMSSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGIAYAIWSGLGIVLVSIAATFM
YQQKLDWAAVVGMALIISGVMVINLLSKTPMH

Sequences:

>Translated_112_residues
MIMSSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGIAYAIWSGLGIVLVSIAATFM
YQQKLDWAAVVGMALIISGVMVINLLSKTPMH
>Mature_112_residues
MIMSSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGIAYAIWSGLGIVLVSIAATFM
YQQKLDWAAVVGMALIISGVMVINLLSKTPMH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=110, Percent_Identity=50.9090909090909, Blast_Score=115, Evalue=9e-28,
Organism=Escherichia coli, GI1787883, Length=98, Percent_Identity=35.7142857142857, Blast_Score=63, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 12033; Mature: 12033

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
8.0 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
8.0 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMSSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAIWSGLGIVLVSIAATFMYQQKLDWAAVVGMALIISGVMVINLLSKTPMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIMSSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAIWSGLGIVLVSIAATFMYQQKLDWAAVVGMALIISGVMVINLLSKTPMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]