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The map label for this gene is dalD

Identifier: 51596568

GI number: 51596568

Start: 2650602

End: 2651993

Strand: Direct

Name: dalD

Synonym: YPTB2244

Alternate gene names: 51596568

Gene position: 2650602-2651993 (Clockwise)

Preceding gene: 51596566

Following gene: 51596572

Centisome position: 55.86

GC content: 50.5

Gene sequence:

>1392_bases
ATGAATACTGACCTGAAATCACCCCCTGCTGTGTGGCTGCATATTGGTGCTGGCTCCTTCCACCGAGCCCATCAGGCTTG
GTATTTACACCGTTTGTTAGCCTCAGGCGATGACCGTTGGACTATCGCTTTGGCCAATATTCGTGATGACGCCATCCCAC
TACTGGACACATTGCGGGCGCAACACGGTGAATATGTCTTGGAAACGGTCACACCAAGCGGTGAACGCCAGTATGAAAAG
ATAACATCACTGCGCAATATCATTCCTTGGGATAAAGCGCTAGATCATCTGGTAGCGCAAGGGAGTAAACCCGAAACTCG
CGTGATCTCTTTCACCGTAACGGAGGGGGGCTACTATTTAGATAATCAATTTAATCTGCAACAGGACAATAGCGATATTC
AGGCCGATCTTAGAGGAGATTGCCGCACGATTTACGGGGCAATTAGCCGTATCTTGCAACAACGGCAACAGGATAAGAGT
GGCCCGGTCACTCTACTGAACTGCGATAACTTGCGTCACAACGGTGAACGATTCCGCCATGGCTTATTAGAGTTTCTTGC
TCTACGAGGTCAACAAAGCCTATTAAACTGGGTGACAAGCCAGACCCGCAGCCCGAATACCATGGTTGATCGTATCACCC
CGCGCCCATCAGCCGATATCGCGCAGCGGGTGTTGGAAAAAACCGGGATCGTAGATAACGCTCCGGTGATGGGGGAATCA
TTTATTCAATGGGTTATTGAGGATGATTTTATTGCTGGCCGCCCGGCACTGGAGAGCGTTGGGGCGGAAATGGTCACCTC
GGTTTTGCCTTATGAAGAAGCCAAAATCCGCATTCTGAACGCCAGCCACAGTTGTATTGCTTGGGCGGGCAGCTTGATTG
GGCAATGTTATATTCATGAAAGTACCCAAACCGACGCTATCCGCCAGATGGCTTATGACTATGTCACGCAAGATGTCATT
CCCTCCCTGACGCCCAGCCCACTTGATTTAGCCCATTACCGCGATGTGGTACTGGAACGTTTCAGTAATCCGTATATTCG
CGATACGAACCAGCGTGTCGCCGCCGATGGATTTTCCAAAATCCCCGGATTTATCACCCCCACGCTGATCGAGTGTTACC
AACGTGGCGGAGTGCCTACCGCTACCGCAATGTTGCCCGCATTATTCTTCGTATTTATGGAAAGTTGGCACCAAGGCACT
CTGCCGTATGAATATCAGGATGGTATTCTGGACCCAGCAGCCGTCCATACCATGTTTCAGTCTTCTGACCCTGCAGGCTT
ATTTGCCCGTGATAGCGCCCTTTTCGGGCCGCTGGCCAATGATGATCAGTTCGAACAGTTATTACGCCAGTCCATAAATC
GTGTCTCTGCTTGGGTTAGCACTAACCGTTAA

Upstream 100 bases:

>100_bases
GGCAAAAGTTACATTAACCTACACGAAAGGGCAAATGCCCAAATATTGAATTTATGCCCAAACAATAACTGTAGCACCTT
CTGTAATTGTGGAGATTATT

Downstream 100 bases:

>100_bases
TCCCTGAGGAGGGCCTTGGGGGGCGGCGCGTTTAGGGGGCGGGGGATCTCCGGTGATAAATGATCGTCAGTAATTAATGA
TCAGCCGTAATTAACGATCA

Product: mannitol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRAQHGEYVLETVTPSGERQYEK
ITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYLDNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKS
GPVTLLNCDNLRHNGERFRHGLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
FIQWVIEDDFIAGRPALESVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHESTQTDAIRQMAYDYVTQDVI
PSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSKIPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGT
LPYEYQDGILDPAAVHTMFQSSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR

Sequences:

>Translated_463_residues
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRAQHGEYVLETVTPSGERQYEK
ITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYLDNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKS
GPVTLLNCDNLRHNGERFRHGLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
FIQWVIEDDFIAGRPALESVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHESTQTDAIRQMAYDYVTQDVI
PSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSKIPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGT
LPYEYQDGILDPAAVHTMFQSSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR
>Mature_463_residues
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRAQHGEYVLETVTPSGERQYEK
ITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYLDNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKS
GPVTLLNCDNLRHNGERFRHGLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
FIQWVIEDDFIAGRPALESVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHESTQTDAIRQMAYDYVTQDVI
PSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSKIPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGT
LPYEYQDGILDPAAVHTMFQSSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=374, Percent_Identity=34.4919786096257, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1788497, Length=356, Percent_Identity=33.1460674157303, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1787823, Length=360, Percent_Identity=32.5, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI48994885, Length=414, Percent_Identity=22.2222222222222, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790028, Length=365, Percent_Identity=23.013698630137, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324401, Length=456, Percent_Identity=32.4561403508772, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6320765, Length=456, Percent_Identity=32.4561403508772, Blast_Score=223, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.11 [H]

Molecular weight: Translated: 51988; Mature: 51988

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
QHGEYVLETVTPSGERQYEKITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYL
HCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCEEE
DNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKSGPVTLLNCDNLRHNGERFRH
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHH
GLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
HHHHHHHHCCHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHH
FIQWVIEDDFIAGRPALESVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEC
STQTDAIRQMAYDYVTQDVIPSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSK
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHCCHHH
IPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGTLPYEYQDGILDPAAVHTMFQ
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHC
SSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTDLKSPPAVWLHIGAGSFHRAHQAWYLHRLLASGDDRWTIALANIRDDAIPLLDTLRA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
QHGEYVLETVTPSGERQYEKITSLRNIIPWDKALDHLVAQGSKPETRVISFTVTEGGYYL
HCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCEEE
DNQFNLQQDNSDIQADLRGDCRTIYGAISRILQQRQQDKSGPVTLLNCDNLRHNGERFRH
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHH
GLLEFLALRGQQSLLNWVTSQTRSPNTMVDRITPRPSADIAQRVLEKTGIVDNAPVMGES
HHHHHHHHCCHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHH
FIQWVIEDDFIAGRPALESVGAEMVTSVLPYEEAKIRILNASHSCIAWAGSLIGQCYIHE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEC
STQTDAIRQMAYDYVTQDVIPSLTPSPLDLAHYRDVVLERFSNPYIRDTNQRVAADGFSK
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHCCHHH
IPGFITPTLIECYQRGGVPTATAMLPALFFVFMESWHQGTLPYEYQDGILDPAAVHTMFQ
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHC
SSDPAGLFARDSALFGPLANDDQFEQLLRQSINRVSAWVSTNR
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]