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The map label for this gene is manA

Identifier: 51596511

GI number: 51596511

Start: 2572799

End: 2573974

Strand: Reverse

Name: manA

Synonym: YPTB2185

Alternate gene names: 51596511

Gene position: 2573974-2572799 (Counterclockwise)

Preceding gene: 51596513

Following gene: 51596510

Centisome position: 54.25

GC content: 48.72

Gene sequence:

>1176_bases
ATGCTAAAAATGAATAACGCAGTTCAAAACTATGCTTGGGGCAGTACTGATGCCCTGACCCAGCTTTATGGCATACCTAA
CCCACAAGGAATGCCAATGGCTGAACTGTGGATGGGGGCGCACCCGAAAAGCAGTTCCCAGGTTCTTGACGCAAATGGCC
AGTGGCATTCATTACGTGATGTGATTGATCAAGATCCAGATAACACGCTGGGGAGTGATATTTTCAAGCGCTTTGGTGAA
CTGCCATTCCTGTTCAAAGTACTTTGTGCAGCTCAACCTCTATCGATTCAGGTTCACCCGAGCAAAGCGGCAGCAGAGGT
CGGTTTTGCTAAAGAAAACCAGGCAGGTATCCCACTGGATGCGGCTGAGCGCAATTATAAAGATGCGAACCATAAGCCTG
AGCTGGTTTATGCCCTCACCCCTTTTCAGGCAATGAATGGTTTTCGCACACTAGAAGATATCCAGGCGCTGTTACAACCA
CTAGCAGCGGCACACCCTGATATTGCCGCGTTCTTGCGCCAACCCGATACTGAGCATTTAGCCAGTTTATTTGCCAGCTT
ACTCAGTATGAGCGGTGAGACAAAAACGCGGGCACTCGGTATTCTGAAAGCGGCATTGAATAGCCAACTCGGAGAGCCTT
GGGATACGATCCGCAGCATTTCGTGTTTTTATCCCGATGACAGCGGGTTGTTCTCCCCACTACTGCTTAATGTCGTGACA
TTGCAACCGGGTGAGGCCATGTTCCTTTATGCCGAAACACCGCACGCTTACCTCAATGGGGTTGCATTAGAGGTCATGGC
AAACTCGGATAATGTGTTGAGAGCCGGGCTAACGCCGAAGTTTATTGATATTCCAGAGTTAATGTCCAATCTGCAATTTA
TCCCTAAACCGGCTAATGCCCTACTCACAACACCAAAGCAACAGGGTAATGAACTGATATTCCCTATTCCTGTCGAGGAC
TTCGCTTTCTCACTGCATACCTTGGTGGCTGAACCACACGTTCTGGCACAACACAGTGCGGCAATTATTTTTTGTGTTGA
AGGCTGTGCGGTGCTGAAAAAACAAGAGCAAGAAATTACGCTGCACCCTGGTGAGTCTTGCTTCATATCGGCTAAGGAAT
CACCTGTAACCGTGCAAGGGGGGGGTTCAATTGCTCGTGTTTATAACGCGGTGTGA

Upstream 100 bases:

>100_bases
ACTAATGGCTTATTTTTTCAGGGTTTGCTATCCAGAACCGGTTAATCACTGGCTAACGCGCAGCCTTATTTTAGTCCTTT
GCAAACGGCAGATCATAAAC

Downstream 100 bases:

>100_bases
ACTAACTTAATGAATTTGTTGTCAATAAATAGCTTCTCACCATAAATTGAAGGCTCTGTCGCGATTAAGTCCTTGTTACG
GTCGCGATAATATTTGTGTA

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRDVIDQDPDNTLGSDIFKRFGE
LPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQP
LAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNVVT
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVED
FAFSLHTLVAEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGGGSIARVYNAV

Sequences:

>Translated_391_residues
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRDVIDQDPDNTLGSDIFKRFGE
LPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQP
LAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNVVT
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVED
FAFSLHTLVAEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGGGSIARVYNAV
>Mature_391_residues
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRDVIDQDPDNTLGSDIFKRFGE
LPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQP
LAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNVVT
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVED
FAFSLHTLVAEPHVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGGGSIARVYNAV

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=409, Percent_Identity=36.4303178484108, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1787899, Length=391, Percent_Identity=70.843989769821, Blast_Score=565, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71997620, Length=405, Percent_Identity=32.0987654320988, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17557650, Length=340, Percent_Identity=30.2941176470588, Blast_Score=132, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320839, Length=434, Percent_Identity=31.5668202764977, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21356061, Length=397, Percent_Identity=29.4710327455919, Blast_Score=148, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42514; Mature: 42514

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRD
CCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCEEECCCCHHHHHH
VIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLD
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCCCCC
AAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHL
HHHCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHH
ASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNVVT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCHHHHHHEEEE
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANA
ECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEEECCCCCEECHHHHHHCCEECCCCCHH
LLTTPKQQGNELIFPIPVEDFAFSLHTLVAEPHVLAQHSAAIIFCVEGCAVLKKQEQEIT
EEECCHHCCCEEEEECCHHHHHHHHHHHHCCCHHHHCCCCEEEEEECCHHHHHCCCCEEE
LHPGESCFISAKESPVTVQGGGSIARVYNAV
ECCCCCEEEECCCCCEEEECCCCHHHHHHCC
>Mature Secondary Structure
MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRD
CCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCEEECCCCHHHHHH
VIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLD
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCCCCC
AAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHL
HHHCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHH
ASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNVVT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCHHHHHHEEEE
LQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANA
ECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEEECCCCCEECHHHHHHCCEECCCCCHH
LLTTPKQQGNELIFPIPVEDFAFSLHTLVAEPHVLAQHSAAIIFCVEGCAVLKKQEQEIT
EEECCHHCCCEEEEECCHHHHHHHHHHHHCCCHHHHCCCCEEEEEECCHHHHHCCCCEEE
LHPGESCFISAKESPVTVQGGGSIARVYNAV
ECCCCCEEEECCCCCEEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]