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The map label for this gene is trpE

Identifier: 51596456

GI number: 51596456

Start: 2506825

End: 2508390

Strand: Reverse

Name: trpE

Synonym: YPTB2130

Alternate gene names: 51596456

Gene position: 2508390-2506825 (Counterclockwise)

Preceding gene: 51596457

Following gene: 51596455

Centisome position: 52.87

GC content: 50.51

Gene sequence:

>1566_bases
ATGATGCAAACATCACGTCCTACTTTACAGTTACTAACCGCTAGCGCCTGTTACCGCGATGACCCGACAGCGCTGTTTCA
TCAATTATGTGGTGCCCGCCCCGCGACCCTGTTGCTTGAGTCTGCAGAAGTTGACAACAAGCAGAATCTGAAAAGCCTGT
TGGTCATCGACAGTGCCTTGCGTATCACGGCATTAGGGCAAACCGTCACTCTCGAAGCATTGACCCGTAATGGGGCTTCT
TTATTACCACTGCTGGATGCCAGTCTGCCCACTGAAGTCGATATTCAGGTTCGTCCGAATGGCCGAGAGTTAACTTTCCC
GTTAATAAATGAAGTCCAGGATGAGGATTCACGCTTACAGTCCTTATCTGTTTTTGATGCTTTACGTCAATTATTAACAC
TGGTTAATACCCCACTTGCCGAGCGTGAGGCCCTGTTTTTGGGCGGTTTGTTCGCTTACGATTTAGTCGCTGGTTTTGAA
AATTTGCCTCCGTTGCGTCAGGATCAACGCTGCCCTGACTTCTGTTTCTATTTAGCCGAGACATTGCTGGTTTTGGATCA
TCAGCATCGTTCAACTCGCTTGCAGGCCAGCCTGTTCACGCCAGACAGTTCAGAGTATCAGCGCCTGGCGACCCGTTTAG
AGCAACTCAGCCACCAGTTACAACAAGCGCCACACCCCATTCCTGCCACCTCCGTGCCAGAGATGGCGTTACAGTGTAAC
CAATCAGATGAAGAGTATTGCAACGTTGTCAGTGAATTGCAGGTAGCAATCCGTGAAGGTGAGATTTTCCAGGTGGTCCC
ATCCCGCCGTTTTACGCTGCCCTGCCCATCACCGCTGGCGGCCTATCAGACACTGAAAGACCATAATCCCAGCCCCTACA
TGTTTTTCATGCAAGACAATGATTTTTCTCTGTTTGGCGCATCACCTGAGAGCGCACTGAAATACGATGCCAGCAACCGT
CAAATTGAGATTTACCCGATTGCGGGTACTCGTCCACGCGGTCGTCGTCCTAATGGAGAACTCGATCGTGATTTAGACAG
CCGTATCGAGTTGGAAATGCGTACTGACCATAAAGAGATGGCAGAACATTTAATGTTGGTGGATCTGGCTCGTAACGATC
TGGCACGTATTTGCGAACCCGGTAGCCGCTATGTTGCAGATTTAACCAAAGTTGACCGTTACTCTTTTGTCATGCATCTG
GTGTCCCGCGTGATTGGCACTCTGCGTCAAGATTTAGATGTGCTGCATGCTTATCAAGCGTGTATGAACATGGGTACGCT
AAGCGGTGCGCCCAAAGTACGGGCCATGCAATTGATTGCCAGTAATGAAGGCTCACGCCGTGGCAGCTACGGCGGTGCAG
TGGGCTACTTCACTGCTCACGGTGATTTGGATACCTGCATTGTGATTCGTTCTGCCTACGTAGAGGACGGCATCGCCACC
GTACAAGCGGGTGCAGGGGTGGTTTTGGACTCAGTTCCACAAGCAGAAGCTGATGAAACTCGGAATAAAGCCAGAGCCGT
ACTGCGCGCCATTGCCACTGCCCATCATGCCAAGGAGATTTTCTAA

Upstream 100 bases:

>100_bases
ATCAGACAGTGCAGATTGCTTCAGCCCGCTAATAGCGGGTTTTTTTATGGATAGATTCCAGCGTAATAATTTTTCAGGGC
CTCTTTTTTAGGATCACTCA

Downstream 100 bases:

>100_bases
TGGCCGATATCCTACTGCTCGATAATATCGACTCCTTTACCTACAACCTGGTGGACCAACTTCGTTCCAGTGGTCATCGC
GTCGTGATTTACCGTAACCA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MMQTSRPTLQLLTASACYRDDPTALFHQLCGARPATLLLESAEVDNKQNLKSLLVIDSALRITALGQTVTLEALTRNGAS
LLPLLDASLPTEVDIQVRPNGRELTFPLINEVQDEDSRLQSLSVFDALRQLLTLVNTPLAEREALFLGGLFAYDLVAGFE
NLPPLRQDQRCPDFCFYLAETLLVLDHQHRSTRLQASLFTPDSSEYQRLATRLEQLSHQLQQAPHPIPATSVPEMALQCN
QSDEEYCNVVSELQVAIREGEIFQVVPSRRFTLPCPSPLAAYQTLKDHNPSPYMFFMQDNDFSLFGASPESALKYDASNR
QIEIYPIAGTRPRGRRPNGELDRDLDSRIELEMRTDHKEMAEHLMLVDLARNDLARICEPGSRYVADLTKVDRYSFVMHL
VSRVIGTLRQDLDVLHAYQACMNMGTLSGAPKVRAMQLIASNEGSRRGSYGGAVGYFTAHGDLDTCIVIRSAYVEDGIAT
VQAGAGVVLDSVPQAEADETRNKARAVLRAIATAHHAKEIF

Sequences:

>Translated_521_residues
MMQTSRPTLQLLTASACYRDDPTALFHQLCGARPATLLLESAEVDNKQNLKSLLVIDSALRITALGQTVTLEALTRNGAS
LLPLLDASLPTEVDIQVRPNGRELTFPLINEVQDEDSRLQSLSVFDALRQLLTLVNTPLAEREALFLGGLFAYDLVAGFE
NLPPLRQDQRCPDFCFYLAETLLVLDHQHRSTRLQASLFTPDSSEYQRLATRLEQLSHQLQQAPHPIPATSVPEMALQCN
QSDEEYCNVVSELQVAIREGEIFQVVPSRRFTLPCPSPLAAYQTLKDHNPSPYMFFMQDNDFSLFGASPESALKYDASNR
QIEIYPIAGTRPRGRRPNGELDRDLDSRIELEMRTDHKEMAEHLMLVDLARNDLARICEPGSRYVADLTKVDRYSFVMHL
VSRVIGTLRQDLDVLHAYQACMNMGTLSGAPKVRAMQLIASNEGSRRGSYGGAVGYFTAHGDLDTCIVIRSAYVEDGIAT
VQAGAGVVLDSVPQAEADETRNKARAVLRAIATAHHAKEIF
>Mature_521_residues
MMQTSRPTLQLLTASACYRDDPTALFHQLCGARPATLLLESAEVDNKQNLKSLLVIDSALRITALGQTVTLEALTRNGAS
LLPLLDASLPTEVDIQVRPNGRELTFPLINEVQDEDSRLQSLSVFDALRQLLTLVNTPLAEREALFLGGLFAYDLVAGFE
NLPPLRQDQRCPDFCFYLAETLLVLDHQHRSTRLQASLFTPDSSEYQRLATRLEQLSHQLQQAPHPIPATSVPEMALQCN
QSDEEYCNVVSELQVAIREGEIFQVVPSRRFTLPCPSPLAAYQTLKDHNPSPYMFFMQDNDFSLFGASPESALKYDASNR
QIEIYPIAGTRPRGRRPNGELDRDLDSRIELEMRTDHKEMAEHLMLVDLARNDLARICEPGSRYVADLTKVDRYSFVMHL
VSRVIGTLRQDLDVLHAYQACMNMGTLSGAPKVRAMQLIASNEGSRRGSYGGAVGYFTAHGDLDTCIVIRSAYVEDGIAT
VQAGAGVVLDSVPQAEADETRNKARAVLRAIATAHHAKEIF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=520, Percent_Identity=75.9615384615385, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1788114, Length=365, Percent_Identity=32.0547945205479, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI87082077, Length=297, Percent_Identity=26.5993265993266, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=377, Percent_Identity=39.2572944297082, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6324361, Length=300, Percent_Identity=29, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57883; Mature: 57883

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQTSRPTLQLLTASACYRDDPTALFHQLCGARPATLLLESAEVDNKQNLKSLLVIDSAL
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHHHH
RITALGQTVTLEALTRNGASLLPLLDASLPTEVDIQVRPNGRELTFPLINEVQDEDSRLQ
HEEECCCEEEEHHHHCCCCCEEHHHCCCCCCEEEEEECCCCCEEEHHHHHHHCCHHHHHH
SLSVFDALRQLLTLVNTPLAEREALFLGGLFAYDLVAGFENLPPLRQDQRCPDFCFYLAE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
TLLVLDHQHRSTRLQASLFTPDSSEYQRLATRLEQLSHQLQQAPHPIPATSVPEMALQCN
HHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCC
QSDEEYCNVVSELQVAIREGEIFQVVPSRRFTLPCPSPLAAYQTLKDHNPSPYMFFMQDN
CCHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCHHHHHHHHHCCCCCCEEEEEECC
DFSLFGASPESALKYDASNRQIEIYPIAGTRPRGRRPNGELDRDLDSRIELEMRTDHKEM
CEEEECCCCHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHH
AEHLMLVDLARNDLARICEPGSRYVADLTKVDRYSFVMHLVSRVIGTLRQDLDVLHAYQA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CMNMGTLSGAPKVRAMQLIASNEGSRRGSYGGAVGYFTAHGDLDTCIVIRSAYVEDGIAT
HHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHCCHHH
VQAGAGVVLDSVPQAEADETRNKARAVLRAIATAHHAKEIF
HHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMQTSRPTLQLLTASACYRDDPTALFHQLCGARPATLLLESAEVDNKQNLKSLLVIDSAL
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHHHH
RITALGQTVTLEALTRNGASLLPLLDASLPTEVDIQVRPNGRELTFPLINEVQDEDSRLQ
HEEECCCEEEEHHHHCCCCCEEHHHCCCCCCEEEEEECCCCCEEEHHHHHHHCCHHHHHH
SLSVFDALRQLLTLVNTPLAEREALFLGGLFAYDLVAGFENLPPLRQDQRCPDFCFYLAE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
TLLVLDHQHRSTRLQASLFTPDSSEYQRLATRLEQLSHQLQQAPHPIPATSVPEMALQCN
HHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCC
QSDEEYCNVVSELQVAIREGEIFQVVPSRRFTLPCPSPLAAYQTLKDHNPSPYMFFMQDN
CCHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCHHHHHHHHHCCCCCCEEEEEECC
DFSLFGASPESALKYDASNRQIEIYPIAGTRPRGRRPNGELDRDLDSRIELEMRTDHKEM
CEEEECCCCHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHH
AEHLMLVDLARNDLARICEPGSRYVADLTKVDRYSFVMHLVSRVIGTLRQDLDVLHAYQA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CMNMGTLSGAPKVRAMQLIASNEGSRRGSYGGAVGYFTAHGDLDTCIVIRSAYVEDGIAT
HHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHCCHHH
VQAGAGVVLDSVPQAEADETRNKARAVLRAIATAHHAKEIF
HHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11371633; 4598537; 366432; 7007652 [H]