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The map label for this gene is ntpA

Identifier: 51596363

GI number: 51596363

Start: 2402311

End: 2402754

Strand: Direct

Name: ntpA

Synonym: YPTB2037

Alternate gene names: 51596363

Gene position: 2402311-2402754 (Clockwise)

Preceding gene: 51596362

Following gene: 51596364

Centisome position: 50.63

GC content: 52.03

Gene sequence:

>444_bases
ATGAATTATAAACGCCCCGAGTCGGTTCTGGTCGTCATCTATGCCAAATCCAGCGGGCGAGTGTTGATGTTGCAACGGCG
CGATGATCCTGATTTTTGGCAGTCGGTGACCGGCAGTCTGGAAGAGGGGGAGGCTCCGTTGCAAACCGCACAGCGCGAAG
TAAAGGAAGAAGTCGGCATTGACATTCTGGGTGAAAATCTGGTGTTGCTCGACTGTCAGCGCTGTGTGGAGTTTGAACTC
TTTGCGCATTTGCGCCGTCGCTATGCTCCGGGAATTACGCGTAACAAAGAACATTGGTTCTGTTTGGCGTTGCCGGAGGA
GCGGGATATCGTGATTACTGAGCATCTCGCCTACCAGTGGTTGGATGCGGCAGAGGCTGCCGTATTGACCAAGTCCTGGA
GTAATCAACAAGCGATTGAAGAGTATGTTCTTTATTCCGTCTAG

Upstream 100 bases:

>100_bases
ATGCGCCAAGTTTTGCCAACCCGGCCTCGTTGCAAGAGTTGTCCATTAGCGTGGTGGCGAAGAAAGGCACTACAGATGCT
GGGGCAGAAGAGAATCAGTA

Downstream 100 bases:

>100_bases
ACCCAACGCTGTCACGTCAGGTGTGAAGGGTATCATTAGGCTATTTTGGAGATTCTTATGGCAGGTCATAGTAAATGGGC
CAACACAAAACACCGCAAAG

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MNYKRPESVLVVIYAKSSGRVLMLQRRDDPDFWQSVTGSLEEGEAPLQTAQREVKEEVGIDILGENLVLLDCQRCVEFEL
FAHLRRRYAPGITRNKEHWFCLALPEERDIVITEHLAYQWLDAAEAAVLTKSWSNQQAIEEYVLYSV

Sequences:

>Translated_147_residues
MNYKRPESVLVVIYAKSSGRVLMLQRRDDPDFWQSVTGSLEEGEAPLQTAQREVKEEVGIDILGENLVLLDCQRCVEFEL
FAHLRRRYAPGITRNKEHWFCLALPEERDIVITEHLAYQWLDAAEAAVLTKSWSNQQAIEEYVLYSV
>Mature_147_residues
MNYKRPESVLVVIYAKSSGRVLMLQRRDDPDFWQSVTGSLEEGEAPLQTAQREVKEEVGIDILGENLVLLDCQRCVEFEL
FAHLRRRYAPGITRNKEHWFCLALPEERDIVITEHLAYQWLDAAEAAVLTKSWSNQQAIEEYVLYSV

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=142, Percent_Identity=73.943661971831, Blast_Score=229, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 17043; Mature: 17043

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKRPESVLVVIYAKSSGRVLMLQRRDDPDFWQSVTGSLEEGEAPLQTAQREVKEEVGI
CCCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
DILGENLVLLDCQRCVEFELFAHLRRRYAPGITRNKEHWFCLALPEERDIVITEHLAYQW
EEECCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEHHHHHHH
LDAAEAAVLTKSWSNQQAIEEYVLYSV
HHHHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNYKRPESVLVVIYAKSSGRVLMLQRRDDPDFWQSVTGSLEEGEAPLQTAQREVKEEVGI
CCCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
DILGENLVLLDCQRCVEFELFAHLRRRYAPGITRNKEHWFCLALPEERDIVITEHLAYQW
EEECCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEHHHHHHH
LDAAEAAVLTKSWSNQQAIEEYVLYSV
HHHHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]